Substrate-specific activation of sirtuins by resveratrol

Journal of Biological Chemistry

Volumn 280, Issue 17, 2005, Pages 17038-17045

  Kaeberlein, Matt ^a   McDonagh, Thomas ^b   Heltweg, Birgit ^c   Hixon, Jeffrey ^b   Westman, Eric A ^a   Caldwell, Seth D ^a   Napper, Andrew ^b   Curtis, Rory ^b   DiStefano, Peter S ^b   Fields, Stanley ^a   Bedalov, Antonio ^a,c   Kennedy, Brian K ^d  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Elixir Pharmaceuticals Inc   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; PROTEINS; RNA; YEAST;

POTENTIAL CALORIE RESTRICTION MIMETIC; RESVERATROL; SIRTUIN ACTIVATOR; YEAST STRAIN;

ALCOHOLS;

RESVERATROL; SIRTUIN; ANTIOXIDANT; FUNGAL PROTEIN; HISTONE DEACETYLASE; NICOTINAMIDE; PEPTIDE; PROTEIN P53; RIBOSOME DNA; SILENT INFORMATION REGULATOR PROTEIN; SIR2 PROTEIN, S CEREVISIAE; SIRT1 PROTEIN, HUMAN; STILBENE DERIVATIVE;

AGING; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOCHEMISTRY; CALORIC RESTRICTION; CONTROLLED STUDY; DEACETYLATION; DNA RECOMBINATION; DRUG PROTEIN BINDING; ENZYME SUBSTRATE; EUKARYOTE; FLUORESCENCE; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIFESPAN; LONGEVITY; NONHUMAN; PRIORITY JOURNAL; RED WINE; TELOMERE; BINDING COMPETITION; CHEMICAL MODEL; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; ENZYME SPECIFICITY; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; KINETICS; METABOLISM; PROTEIN BINDING; TIME;

EUKARYOTA;

ANTIOXIDANTS; BINDING, COMPETITIVE; DNA, RIBOSOMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FUNGAL PROTEINS; GENE SILENCING; HISTONE DEACETYLASES; HUMANS; KINETICS; MODELS, CHEMICAL; NIACINAMIDE; PEPTIDES; PROTEIN BINDING; RECOMBINATION, GENETIC; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; STILBENES; SUBSTRATE SPECIFICITY; TELOMERE; TIME FACTORS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 20444431507     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500655200     Document Type: Article

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