SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons

Cell Metabolism

Volumn 8, Issue 1, 2008, Pages 38-48

  Li, Ying ^a,b   Xu, Wei ^a   McBurney, Michael W ^c   Longo, Valter D ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

HUMDISEASE; SIGNALING

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RAS PROTEIN; SIRTUIN 1; SOMATOMEDIN C;

ACETYLATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; HOMOZYGOTE; KNOCKOUT MOUSE; LIFESPAN; LIPID OXIDATION; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SACCHAROMYCES CEREVISIAE; SENSITIZATION; SIGNAL TRANSDUCTION;

ANIMALS; CEREBRAL CORTEX; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURONS; OXIDATIVE STRESS; PHOSPHOPROTEINS; RAS PROTEINS; RATS; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION; SIRTUINS;

MAMMALIA; MUS;

EID: 45549096918     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2008.05.004     Document Type: Article

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