Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: Implications in the formation of neurofibrillary tangles of Alzheimer's disease

Journal of Neurochemistry

Volumn 82, Issue 5, 2002, Pages 1137-1147

  Yamamoto, Akira ^a,b   Shin, Ryong Woon ^a   Hasegawa, Kazuhiro ^c   Naiki, Hironobu ^c   Sato, Hiroyuki ^d   Yoshimasu, Fumio ^b   Kitamoto, Tetsuyuki ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF FUKUI   (Japan)

^d Japanese Red Cross Kyushu Block Blood Center   (Japan)

Author keywords

protein; Aluminum; Alzheimer's disease; Iron; Phosphorylation; Protein aggregation

Indexed keywords

ALUMINUM; FERRIC ION; FERROUS ION; PHOSPHATE; TAU PROTEIN;

ALZHEIMER DISEASE; ARTICLE; ELECTRON MICROSCOPY; HUMAN; HUMAN TISSUE; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PHOSPHORYLATION;

ALUMINUM; BRAIN CHEMISTRY; FERRIC COMPOUNDS; FERROUS COMPOUNDS; HUMANS; IMMUNOBLOTTING; IRON; MACROMOLECULAR SUBSTANCES; PHOSPHATES; PHOSPHORYLATION; PROTEIN BINDING; REDUCING AGENTS; SARCOSINE; TAU PROTEINS;

EID: 0036724204     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01061.x     Document Type: Article

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