Neuronal SIRT1 activation as a novel mechanism underlying the prevention of alzheimer disease amyloid neuropathology by calorie restriction

Journal of Biological Chemistry

Volumn 281, Issue 31, 2006, Pages 21745-21754

  Qin, Weiping ^a   Yang, Tianle ^c   Ho, Lap ^a,b   Zhao, Zhong ^a   Wang, Jun ^a   Chen, Linghong ^a   Zhao, Wei ^a   Thiyagarajan, Meenakshisundaram ^a   MacGrogan, Donal ^a   Rodgers, Joseph T ^d   Puigserver, Pere ^d   Sadoshima, Junichi ^e   Deng, Haiteng ^f   Pedrini, Steven ^g   Gandy, Samuel ^g   Sauve, Anthony A ^c   Pasinetti, Giulio M ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^f ROCKEFELLER UNIVERSITY   (United States)

^g THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; DISEASES; ENZYMES; NEUROLOGY; PATHOLOGY;

CALORIE RESTRICTION (CR); NEUROPATHOLOGY; NICOTINAMIDE ADENINE DINUCLEOTIDE(NAD); SIRTUIN;

ACTIVATION ANALYSIS;

ALPHA SECRETASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROTEIN SERINE THREONINE KINASE; RHO KINASE; SERINE THREONINE RHO KINASE ROCK1; SIRT1 ENZYME; SIRTUIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOID NEUROPATHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; IN VITRO STUDY; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALZHEIMER DISEASE; AMYLOID; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CALORIC RESTRICTION; ENDOPEPTIDASES; ENZYME ACTIVATION; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; NEURONS; PROTEIN-SERINE-THREONINE KINASES; SIRTUINS;

EID: 33746824192     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M602909200     Document Type: Article

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