SH2 Domain-Containing Protein-Tyrosine Phosphatases

Handbook of Cell Signaling, Second Edition

Volumn 2, Issue , 2009, Pages 771-809

  Neel, Benjamin G ^a   Chan, Gordon ^a   Dhanji, Salim ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79956039791     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-374145-5.00098-X     Document Type: Chapter

References (495)

1. S-H Shen, L Bastien, BI Posner and P Chrétien (1991) A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases. Nature 352 736-739.
2. J Plutzky, B Neel, R Rosenberg, R Eddy, M Byers, S Jani-Sait, et al. (1992) Chromosomal localization of an SH2-containing tyrosine phosphatase. Genomics 13 869-872.
3. TL Yi, JL Cleveland and JN Ihle (1992) Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12–p13. Mol Cell Biol 12(2), p836-846.
4. RJ Matthews, DB Bowne, E Flores and ML Thomas (1992) Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences. Mol Cell Biol 12 2396-2405.
5. RM Freeman Jr., J Plutzky and BG Neel (1992) Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. Proc Natl Acad Sci USA 89(23), 11,239-11,243.
6. G-S Feng, C-C Hui and T Pawson (1993) SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 259 1607-1611.
7. W Vogel, R Lammers, J Huang and A Ullrich (1993) Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Science 259(5101), 1611-1614.
8. S Ahmad, D Banville, Z Zhao, E Fischer and S Shen (1993) A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc Natl Acad Sci USA 90(6), 2197-2201.
9. M Adachi, m Sekiya, T Miyachi, K Matsuno, y Hinoda, K Imai, et al. (1992) Molecular cloning of novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2. FEBS Letts 314 335-339.
10. TL Tang, RM Freeman, AM O’Reilly, BG Neel and SY Sokol (1995) The SH2-containing protein tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development. Cell 80 473-483.
11. C Park, MK La, N Tonks and M Hayman (1996) Cloning and expression of the chicken protein tyrosine phosphatase SH-PTP2. Gene 177(1–2), 93-97.
12. C Jopling, D van Geemen and J den Hertog (2007) Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects. PLoS Genet 3(12), e225.
13. M Adachi, EH Fisher, J Ihle, K Imai, F Jirik, B Neel, et al. (1996) Mammalian SH2-containing protein tyrosine phophatases. Cell 85 15.
14. LA Perkins, I Larsen and N Perrimon (1992) corkscrew endodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso. Cell 70 225-236.
15. LA Perkins, MR Johnson, MB Melnick and N Perrimon (1996) The non-receptor protein tyrosine phosphatase Corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila. Dev Biol 180 63-81.
16. MJ Gutch, AJ Flint, J Keller, NK Tonks and MO Hengartner (1997) The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis, embryogenesis and vulval development. Genes Dev 12 571-585.
17. LA Perkins and M Melnick (1995) Corkscrew, an essential protein tyrosine phosphatase required for multiple developmental decisions in Drosophila. W Merlevede (Ed.) Advances of protein phosphatases Philadelphia: Coronet Books Inc 355-385.
18. Y Yeung, KL Berg, FJ Pixley, RH Angeletti and ER Stanley (1992) Protein tyrosine phosphatase-1C is rapidly phosphorylated on tyrosine in macrophages in response to colony stimulating factor-1. J Biol Chem 267 23,447-23,450.
19. RJ Lechleider, RM Freeman and BG Neel (1993) Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2. J Biol Chem 268 13,434-13,438.
20. T Yi and JN Ihle (1993) Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand. Mol Cell Biol 13(6), 3350-3358.
21. U Lorenz, KS Ravichandran, D Pei, CT Walsh, SJ Burakoff and BG Neel (1994) Lck-dependent tyrosyl phosphorylation of the phosphotyosine phosphatase SH-PTP1 in murine T cells. Mol Cell Biol 14 1824-1834.
22. P Bouchard, Z Zhao, D Banville, F Dumas, EH Fischer and SH Shen (1994) Phosphorylation and identification of a major tyrosine phosphorylation site in protein tyrosine phosphatase 1C. J Biol Chem 269(30), 19,585-19,589.
23. T Uchida, T Matozaki, T Noguchi, T Yamao, K Horita, T Suzuki, et al. (1994) Insulin stimulates the phosphorylation of Tyr538 and the catalytic activity of PTP1C, a protein tyrosine phosphatase with Src homology-2 domains. J Biol Chem 269 12,220-12,228.
24. AM Bennett, TL Tang, S Sugimoto, CT Walsh and BG Neel (1994) Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras. Proc Natl Acad Sci USA 91(15), 7335-7339.
25. W Vogel and A Ullrich (1996) Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via Tyrosine 584. Cell Growth Diff 7 1589-1597.
26. AO Walter, ZY Peng and CA Cartwright (1999) The Shp-2 tyrosine phosphatase activates the Src tyrosine kinase by a non-enzymatic mechanism. Oncogene 18(11), 1911-1920.
27. G Craggs and S Kellie (2001) A functional nuclear localization sequence in the C-terminal domain of Shp-1. J Biol Chem 276 23,719-23,725.
28. W Yang, M Tabrizi and T Yi (2002) A bipartite NLS at the SHP-1 C-terminus mediates cytokine-induced SHP-1 nuclear localization in cell growth control. Blood Cells Mol Dis 28 63-74.
29. T Yi, JL Cleveland and JN Ihle (1992) Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12–13. Mol Cell Biol 12(2), 836-846.
30. D Banville, R Stocco and SH Shen (1995) Human protein tyrosine phosphatase 1C (PTPN6) gene structure: alternative promoter usage and exon skipping generate multiple transcripts. Genomics 27 165-173.
31. HW Tsui, K Hasselblatt, A Martin, SC Mok and FWL Tsui (2002) Molecular mechanisms underlying SHP-1 gene expression. Eur J Biochem 269 3057-3064.
32. Y-J J.in, C-L Yu and SJ Burakoff (1999) Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activity. J Biol Chem 274 28,301-28,307.
33. JV Ravetch and LL Lanier (2000) Immune inhibitory receptors. Science 290 84-89.
34. M Daeron, S Jaeger, L Du Pasquier and E Vivier (2008) Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future. Immunol Rev 224 11-43.
35. T Noguchi, T Matozaki, Y Fujioka, T Yamao, M Tsuda, T Takada, et al. (1996) Characterization of a 115-kDa protein that binds to SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in Chinese hamster ovary cells. J Biol Chem 271 27,652-27,658.
36. Y Fujioka, T Matozaki, T Noguchi, A Iwamatsu, T Yamao, N Takahashi, et al. (1996) A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol Cell Biol 16 6887-6899.
37. A Kharitonenkov, Z Chen, I Sures, H Wang, J Schilling and A Ullrich (1997) A family of proteins that inhibit signaling though tyrosine kinase receptors. Nature 386 181-186.
38. JF Timms, K Carlberg, H Gu, H Chen, S Kamatkar, MJ Nadler, et al. (1998) Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages. Mol Cell Biol 18(7), 3838-3850.
39. H Gu, JC Pratt, SJ Burakoff and BG Neel (1998) Cloning and characterization of the major SHP-2 binding protein in hematopoietic cells (p97) reveals a novel pathway for cytokine-induced gene activation. Mol Cell 2(6), 729-740.
40. BG Neel, H Gu and L Pao (2003) The ‘Shp”ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem Sci 28 284-293.
41. DN Burshtyn, AM Scharenberg, N Wagtmann, S Rajagopalan, K Berrada, T Yi, et al. (1996) Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor. Immunity 4 77-85.
42. L Olcese, P Lang, F Vely, A Cambiaggi, D Marguet, M Blery, et al. (1996) Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases. J Immunol 156(12), p4531-4534.
43. DN Burshtyn, W Yang, T Yi and EO Long (1997) A novel phosphotyrosine motif with a critical amino acid at position-2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1. J Biol Chem 272 13,066-13,072.
44. DN Burshtyn, AS Lam, M Weston, N Gupta, PA Warmerdam and EO Long (1999) Conserved residues amino-terminal of cytoplasmic tyrosines contribute to the SHP-1-mediated inhibitory function of killer cell Ig-like receptors. J Immunol 162(2), 897-902.
45. ML Thomas (1995) Of ITAMs and ITIMs: turning on and off the B cell antigen receptor. J Exp Med 181 1953-1956.
46. JC Cambier (1997) Inhibitory receptors abound? Proc Natl Acad Sci USA 94 5993-5995.
47. E Vivier and M Daeron (1997) Immunoreceptor tyrosine-based inhibition motifs. Immunol Today 18(6), 286-291.
48. D De Souza, LJ Fabri, A Nash, DJ Hilton, NA Nicola and M Baca (2002) SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities. Biochemistry 41 9229.
49. KD Beebe, P Wang, G Arabaci and D Pei (2000) Determination of the binding specificity of the SH2 domains of protein tyrosine phosphatase SHP-1 through the screening of a combinatorial phosphotyrosyl peptide library. Biochemistry 39 13,251-13,260.
50. MC Sweeney, AS Wavreille, J Park, JP Butchar, S Tridandapani and D Pei (2005) Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains. Biochemistry 44(45), 14,932-14,947.
51. AS Wavreille, M Garaud, Y Zhang and D Pei (2007) Defining SH2 domain and PTP specificity by screening combinatorial peptide libraries. Methods 42(3), 207-219.
52. D Imhof, AS Wavreille, A May, M Zacharias, S Tridandapani and D Pei (2006) Sequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position. J Biol Chem 281(29), 20,271-20,282.
53. LEM Marengere, P Waterhouse, GS Duncan, H-W Mittrucker, G-S Feng and TW Mak (1996) Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272 1170-1173.
54. J Schmitz, M Weissenbach, S Haan, PC Heinrich and F Schaper (2000) SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J Biol Chem 275 12,848-12,856.
55. SE Nicholson, D De Souza, LJ Fabri, J Corbin, TA Willson, JG Zhang, et al. (2000) Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc Natl Acad Sci USA 97(12), 6493-6498.
56. A Sasaki, H Yasukawa, T Shouda, T Kitamura, I Dikic and A Yoshimura (2000) CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J Biol Chem 275 29,338-29,347.
57. C Bjorbaek, HJ Lavery, SH Bates, RK Olson, SM Davis, JS Flier, et al. (2000) SOCS3 mediates feedback inhibition of the leptin receptor via tyr985. J Biol Chem 275 40,649-40,657.
58. S Eyckerman, D Broekaert, A Verhee, J Vanderkerckhove and J Tavernier (2000) Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor. FEBS Letts 486 33-37.
59. R Philosof-Oppenheimer, CS Hampe, K Schlessinger, M Fridkin and I Pecht (2000) An immunoreceptor tyrosine-based inhibitory motif, with serine at site Y-2, binds SH2-domain-containing phosphatases. Eur J Biochem 267 703-711.
60. F Vely, S Olivero, L Olcese, A Moretta, JE Damen, L Liu, et al. (1997) Differential association of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based inhibition motifs. Eur J Immunol 27 1994-2000.
61. SJ Famiglietti, K Nakamura and JC Cambier (1999) Unique features of SHIP, SHP-1 and SHP-2 binding to FCgammaRIIb revealed by surface plasmon resonance analysis. Immunol Letts 68 35-40.
62. F Vely, A Trautmann and E Vivier (2000) BIAcore analysis to test phosphopeptide-SH2 domain interactions. Methods Mol Biol 121 313-321.
63. P Bruhns, P Marchetti, WH Fridman, E Vivier and M Daeron (1999) Differential roles of N- and C-terminal immunoreceptor tyrosine-based inhibition motifs during inhibition of cell activation by killer cell inhibitory receptors. J Immunol 162 3168-3175.
64. M Baca (2004) Analysis of SH2 ligands and identification of sites of interaction. Methods Mol Biol 249 111-120.
65. I Daigle, S Yousefi, M Colonna, DR Green and HU Simon (2002) Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils. Nat Med 8(1), 61-67.
66. C Qin, AS Wavreille and D Pei (2005) Alternative mode of binding to phosphotyrosyl peptides by Src homology-2 domains. Biochemistry 44(36), 12,196-12,202.
67. RD Case, E Piccione, G Wolf, AM Benett, RJ Lechleider, BG Neel, et al. (1994) SH-PTP2/Syp SH2 domain binding specificity is defined by direct interactions with platelet-derived growth factor beta-receptor, epidermal growth factor receptor, and insulin receptor substrate-1- derived phosphopeptides. J Biol Chem 269(14), 10,467-10,474.
68. RJ Lechleider, S Sugimoto, AM Bennett, AS Kashishian, JA Cooper, SE Shoelson, et al. (1993) Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site 1009, on the human platelet-derived growth factor β. J Biol Chem 268 21,478-21,481.
69. S Sugimoto, TJ Wandless, SE Shoelson, BG Neel and CT Walsh (1993) Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine containing peptides derived from insulin receptor substrate-1. J Biol Chem 268 2733-2736.
70. D Pei, U Lorenz, U Klingmuller, BG Neel and CT Walsh (1994) Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains. Biochemistry 33 15,483-15,493.
71. D Barford and BG Neel (1998) Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2. Structure 6(3), 249-254.
72. S Pluskey, TJ Wandless, CT Walsh and SE Shoelson (1995) Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains. J Biol Chem 270 2900-2987.
73. R Townley, S-H Shen, D Banville and C Ramachandran (1993) Inhibition of the activity of protein tyrosine phosphatase 1C by its SH2 domains. Biochemistry 32 13,414-13,418.
74. MJ Pregel, S-H Shen and AC Storer (1995) Regulation of protein tyrosine phosphatase 1C: opposing effects of the two src homology 2 domains. Protein Eng 12 1309-1316.
75. P Hof, S Pluskey, S Dhe-Paganon, MJ Eck and SE Shoelson (1998) Crystal structure of the tyrosine phosphatase SHP-2. Cell 92(4), 441-450.
76. AM O’Reilly, S Pluskey, SE Shoelson and BG Neel (1999) Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps. Mol Cell Biol 20 299-311.
77. J Yang, X Liang, T Niu, W Meng, Z Zhao and GW Zhou (1998) Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1. J Biol Chem 273 199-207.
78. C Frank, C Burkhardt, D Imhof, J Ringel, O Zschornig, K Wieligmann, et al. (2004) Effective dephosphorylation of Src substrates by SHP-1. J Biol Chem 279(12), 11,375-11,383.
79. W Lu, D Gong, D Bar-Sagi and PA Cole (2001) Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling. Mol Cell 8 759-769.
80. Z Zhang, K Shen, W Lu and PA Cole (2003) The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation. J Biol Chem 278(7), 4668-4674.
81. AW Poole and ML Jones (2005) A SHPing tale: perspectives on the regulation of SHP-1 and SHP-2 tyrosine phosphatases by the C-terminal tail. Cell Signal 17(11), 1323-1332.
82. RY Li, F Gaits, A Ragab, JM Ragab-Thomas and H Chap (1995) Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein. EMBO J 14 2519-2526.
83. Z Zhao, S-H Shen and EH Fischer (1994) Phorbol ester-induced expression, phosphorylation, and translocation of protein-tyrosine-phosphatase 1C in HL-60 cells. Proc Natl Acad Sci USA 91 5007-5011.
84. JH Brumell, CK Chan, J Butler, N Borregaard, KA Siminovitch, S Grinstein, et al. (1997) Regulation of Src homology 2-containing tyrosine phosphatase 1 during activation of human neutrophils. J Immunol 272 875-882.
85. ML Jones, JD Craik, JM Gibbins and AW Poole (2004) Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus. J Biol Chem 279(39), 40,475-40,483.
86. Z Zhao, R Larocque, WT Ho, EH Fischer and SH Shen (1994) Purification and characterization of PTP2C, a widely distributed protein tyrosine phosphatase containing two SH2 domains. J Biol Chem 269 8780-8785.
87. V Strack, J Krutzfeldt, M Kellerer, A Ullrich, R Lammers and H-U Haring (2002) The protein-tyrosine phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms α, β1, β2, and eta. Biochemistry 41 603-608.
88. Z Du, Y Shen, W Yang, I Mecklenbrauker, BG Neel and LB Ivashkiv (2005) Inhibition of IFN-α signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway. Proc Natl Acad Sci USA 102(29), 10,267-10,272.
89. P Peraldi, Z Zhao, C Filloux, E Fischer and E Van Obberghen (1994) Protein-tyrosine-phosphatase 2C is phosphorylated and inhibited by 44-kDa mitogen-activated protein kinase. Proc Natl Acad Sci USA 91 5002-5006.
90. Z Zhao, S-H Shen and EH Fischer (1993) Stimulation by phospholipids of a protein-tyrosine-phosphatase containing two src homology 2 domains. Proc Natl Acad Sci USA 90 4251-4255.
91. C Frank, H Keilhack, F Opitz, O Zschornig and F-D Bohmer (1999) Binding of phosphatidic acid to the protein-tyrosine phosphatase SHP-1 as a basis for activity modulation. Biochemistry 38 11,993-12,002.
92. A Kosugi, J Sakakura, K Yasuda, M Ogata and T Hamaoka (2001) Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts. Immunity 14 669-680.
93. MW-C Su, C-L Yu, SJ Burakoff and Y-J Jin (2001) Targeting src homology 2 domain-containing tyrosine phosphatase (SHP-1) into lipid rafts inhibits CD3-induced T cell activation. J Immunol 166 3975.
94. RA Lacalle, E Mira, C Gomez-Mouton, S Jimenez-Baranda, C Martinez-A and S Manes (2002) Specific SHP-2 partitioning in raft domains triggers integrin activation via Rho activation. J Cell Biol 157 277-289.
95. VC Fawcett and U Lorenz (2005) Localization of Src homology 2 domain-containing phosphatase 1 (SHP-1) to lipid rafts in T lymphocytes: functional implications and a role for the SHP-1 carboxyl terminus. J Immunol 174(5), 2849-2859.
96. PA Ram and DJ Waxman (1997) Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase. J Biol Chem 272(28), 17,694-17,702.
97. T Finkel, M Serrano and MA Blasco (2007) The common biology of cancer and ageing. Nature 448(7155), 767-774.
98. NK Tonks (2006) Protein tyrosine phosphatases: from genes, to function, to disease. Nat Rev Mol Cell Biol 7(11), 833-846.
99. T-C Meng, T Fukada and NK Tonks (2002) Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol Cell 9 387-399.
100. M Valius and A Kazlauskas (1993) Phospholipase C-gamma1 and phosphotidylinositol 3-kinase are the downstream mediators of the PDGF receptor’s mitogenic signal. Cell 73 321-334.
101. S Roche, J McGlade, M Jones, GD Gish, J Pawson and SA Courtneidge (1996) Requirement of phospholipase C†, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways. EMBO J 18 4940-4948.
102. ZQ Shi, W Lu and GS Feng (1998) The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases. J Biol Chem 273(9), 4904-4908.
103. J Kwon, CK Qu, JS Maeng, R Falahati, C Lee and MS Williams (2005) Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP. EMBO J 24(13), 2331-2341.
104. DK Singh, D Kumar, Z Siddiqui, SK Basu, V Kumar and KV Rao (2005) The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal. Cell 121(2), 281-293.
105. AB Goldfine, DC Simonson, F Folli, ME Patti and CR Kahn (1995) In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus. Mol Cell Biochem 153(1–2), 217-231.
106. SM Schoenwaelder, LA Petch, D Williamson, R Shen, GS Feng and K Burridge (2000) The protein tyrosine phosphatase Shp-2 regulates RhoA activity. Curr Biol 10 1523-1526.
107. L Chen, SS Sung, ML Yip, HR Lawrence, Y Ren, WC Guida, et al. (2006) Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol 70(2), 562-570.
108. HR Lawrence, R Pireddu, L Chen, Y Luo, SS Sung, AM Szymanski, et al. (2008) Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem 51(16), 4948-4956.
109. K Hellmuth, S Grosskopf, CT Lum, M Wurtele, N Roder, JP von Kries, et al. (2008) Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking. Proc Natl Acad Sci USA 105(20), 7275-7280.
110. HW Tsui, KA Siminovitch, L deSouza and FWL Tsui (1993) Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nat Genet 4 124-129.
111. LD Shultz, PA Schweitzer, TV Rajan, T Yi, JN Ihle, RJ Matthews, et al. (1993) Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell 73 1445-1454.
112. LD Shultz (1991) Hematopoiesis and models of immunodeficiency. Sem Immunol 3 397-408.
113. BG Neel (1993) Structure and function of SH2-domain containing tyrosine phosphatases. Sem Cell Biol 4 419-432.
114. FWL Tsui and HW Tsui (1994) Molecular basis of the motheaten phenotype. Immunol Rev 136 185-206.
115. JS Bignon and KA Siminovitch (1994) Identification of PTP1C mutation as a genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function. Clin Immunol Immunopathol 73 168-179.
116. LD Shultz, TV Rajan and DL Greiner (1997) Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency. Trends Biotechnol 15 302-307.
117. K Takahashi, K Miyakawa, AA Wynn, K-I Nakayama, YY Myint, M Naito, et al. (1998) Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice. Am J Pathol 152 445-456.
118. K Nakayama, K Takahashi, L Shultz, K Miyakawa and K Tomita (1997) Abnormal development and differentiation of macrophages and dendritic cells in viable motheaten mutant mice deficient in haematopoietic cell phosphatase. Intl J Exp Pathol 78(4), 245-257. [published erratum appears in Intl J Exp Pathol 1997;78(5):364]
119. S Umeda, W Beamer, K Takagi, M Naito, S Hayashi, H Yonemitsu, et al. (1999) Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density. Am J Pathol 155(1), 223-233.
120. CC Yu, HW Tsui, BY Ngan, MJ Shulman, GE Wu and FW Tsui (1996) B and T cells are not required for the viable motheaten phenotype. J Exp Med 183 371-380.
121. GC Koo, H Rosen, A Sirotina, XD Ma and LD Shultz (1993) Anti-CD11b antibody prevents immunopathologic changes in viable motheaten bone marrow chimeric mice. J Immunol 151 6733-6741.
122. DL Greiner, I Goldschneider, KL Komschlies, ES Medlock, FJ Bollum and L Shultz (1986) Defective lymphopoiesis in bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. J Exp Med 164 1129-1144.
123. KL Komschlies, DL Greiner, L Shultz and I Goldschneider (1987) Defective lymphopoieses in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. J Exp Med 166 1162-1167.
124. U Lorenz, KS Ravichandran, SJ Burakoff and BG Neel (1996) Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness. Proc Natl Acad Sci USA 93 9624-9629.
125. G Pani, K-D Fischer, IM Rascan and KA Siminovitch (1996) Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. J Exp Med 184 839-852.
126. DR Plas, CB Willians, GJ Jersh, LS White, JM White, S Paust, et al. (1999) The tyrosine phosphatase SHP-1 regulates thymocyte positive selection. J Immunol 162 5680-5684.
127. KG Johnson, FG LeRoy, LK Borysiewicz and RJ Matthews (1999) TCR signaling thresholds regulating T cell development and activation are dependent upon SHP-1. J Immunol 162 3802-3813.
128. JD Carter, BG Neel and U Lorenz (1999) The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds. Intl Immunol 11 1999-2014.
129. J Zhang, AK Somani, D Yuen, Y Yang, PE Love and KA Siminovitch (1999) Involvement of the SHP-1 tyrosine phosphatase in regulation of T cell selection. J Immunol 163 3012-3021.
130. LD Shultz and CL Sidman (1987) Genetically determined murine models of immunodeficiency. Annu Rev Immunol 5 367-403.
131. D D’Ambrosio, KL Hippen, SA Minskoff, I Mellman, G Pani, KA Siminovitch, et al. (1995) Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. Science 268 293-297.
132. G Pani, M Kozlowski, JC Cambier, GB Mills and KA Siminovitch (1995) Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J Exp Med 181 2077-2084.
133. JG Cyster and CC Goodnow (1995) Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity 2 1-20.
134. EA Clark, LD Shultz and SB Pollack (1981) Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics 12 601-613.
135. MC Nakamura, EC Niemi, MJ Fisher, LD Shultz, WE Seaman and JC Ryan (1997) Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase. J Exp Med 185(4), 673-684.
136. LD Shultz, CL Bailer and DR Coman (1983) Hematopoietic stem cell function in motheaten mice. Exp Hematol 11 667-680.
137. LD Shultz, DR Coman, CL Bailey, WG Beamer and CL Sidman (1984) “Viable motheaten,” a new allele at the motheaten locus. Am J Pathol 116 179-192.
138. G van Zant and L Shultz (1989) Hematologic abnormalities of the immunodeficient mouse mutant, viable motheaten (mev). Exp Hematol 17 81-87.
139. RF Paulson, S Vesely, KA Siminovitch and A Bernstein (1996) Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1. Nat Genet 13 309-315.
140. U Lorenz, AD Bergemann, HN Steinberg, JG Flanagan, X Li, SJ Galli, et al. (1996) Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1. J Exp Med 184 1111-1126.
141. BA Croker, BR Lawson, M Berger, C Eidenschenk, AL Blasius, EM Moresco, et al. (2008) Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci USA 105(39), 15,028-15,033.
142. LI Pao, KP Lam, JM Henderson, JL Kutok, M Alimzhanov, L Nitschke, et al. (2007) B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity. Immunity 27(1), 35-48.
143. JB Duffy and N Perrimon (1994) The torso pathway in Drosophila: lessons on receptor tyrosine kinase signaling and pattern formation. Dev Biol 166 380-395.
144. M Furriols and J Casanova (2003) In and out of Torso RTK signalling. EMBO J 22(9), 1947-1952.
145. JD Allard, HC Chang, R Herbst, H McNeill and MA Simon (1996) The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf. Development 122 1137-1146.
146. MRJ Hamlet and LA Perkins (2001) Analysis of Corkscrew signaling in the Drosophila epidermal growth factor receptor pathway during myogenesis. Genetics 159 1073-1087.
147. JL Schutzman, CZ Borland, JC Newman, MK Robinson, M Kokel and MJ Stern (2001) The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in Fibroblast Growth Factor signal transduction. Mol Cell Biol 21 8104-8116.
148. NA Hopper (2006) The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans. Genetics 173(1), 163-175.
149. JM Arrandale, A Gore-Willse, S Rocks, JM Ren, J Zhu, A Davis, et al. (1996) Insulin signaling in mice expressing reduced levels of Syp. J Biol Chem 271 21,353-21,358.
150. TM Saxton, M Henkemeyer, S Gasca, R Shen, DJ Rossi, F Shalaby, et al. (1997) Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J 16(9), 2352-2364.
151. T Saxton and T Pawson (1999) Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2. Proc Natl Acad Sci USA 96(7), 3790-3795.
152. TP Yamaguchi, K Harpal, M Henkemeyer and J Rossant (1994) Fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev 8 3032-3044.
153. CK Qu, WM Yu, B Azzarelli, S Cooper, HE Broxmeyer and GS Feng (1998) Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells. Mol Cell Biol 18(10), 6075-6082.
154. T Saxton, B Ciruna, D Holmyard, S Kulkarni, K Harpal, J Rossant, et al. (2000) The SH2 tyrosine phosphatase Shp2 is required for mammalian limb development. Nat Genet 24 420-423.
155. CK Qu, ZQ Shi, R Shen, FY Tsai, SH Orkin and GS Feng (1997) A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development. Mol Cell Biol 17(9), 5499-5507.
156. RJ Chan, SA Johnson, Y Li, MC Yoder and GS Feng (2003) A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis. Blood 102(6), 2074-2080.
157. T Tauchi, G-S Feng, MS Marshall, R Shen, C Mantel, T Pawson, et al. (1994) The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells. J Biol Chem 269 25,206-25,211.
158. ZQ Shi, DH Yu, M Park, M Marshall and GS Feng (2000) Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity. Mol Cell Biol 20 1526-1536.
159. W Yang, LD Klaman, B Chen, T Araki, H Harada, SM Thomas, et al. (2006) An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival. Dev Cell 10(3), 317-327.
160. LE Stephens, AE Sutherland, IV Klimanskaya, A Andrieux, J Meneses, RA Pedersen, et al. (1995) Deletion of b1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Genes Dev 9 1883-1895.
161. EE Zhang, E Chapeau, K Hagihara and GS Feng (2004) Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc Natl Acad Sci USA 101(45), 16,064-16,069.
162. SH Bates, WH Stearns, TA Dundon, M Schubert, AWK Tso, Y Wang, et al. (2003) STAT3 signaling is required for leptin regulation of energy balance but not reproduction. Nature 421 856-859.
163. M Krajewska, S Banares, EE Zhang, X Huang, M Scadeng, US Jhala, et al. (2008) Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase. Am J Pathol 172(5), 1312-1324.
164. Y Ke, EE Zhang, K Hagihara, D Wu, Y Pang, R Klein, et al. (2007) Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality. Mol Cell Biol 27(19), 6706-6717.
165. AS Gauthier, O Furstoss, T Araki, R Chan, BG Neel, DR Kaplan, et al. (2007) Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome. Neuron 54(2), 245-262.
166. M Fornaro, PM Burch, W Yang, L Zhang, CE Hamilton, JH Kim, et al. (2006) SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth. J Cell Biol 175(1), 87-97.
167. MI Kontaridis, W Yang, KK Bence, D Cullen, B Wang, N Bodyak, et al. (2008) Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways. Circulation 117(11), 1423-1435.
168. Y Ke, J Lesperance, EE Zhang, EA Bard-Chapeau, RG Oshima, WJ Muller, et al. (2006) Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated STAT5 activation. J Biol Chem 281(45), 34,374-34,380.
169. EA Bard-Chapeau, J Yuan, N Droin, S Long, EE Zhang, TV Nguyen, et al. (2006) Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection. Mol Cell Biol 26(12), 4664-4674.
170. TV Nguyen, Y Ke, EE Zhang and GS Feng (2006) Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals. J Immunol 177(9), 5990-5996.
171. HE Chen, S Chang, T Trub and BG Neel (1996) Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatse SHPTP1. Mol Cell Biol 16 3685-3697.
172. KL Berg, KA Siminovitch and ER Stanley (1999) SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophages. J Biol Chem 274 35,855-35,865.
173. H Jiao, W Yang, K Berrada, M Tabrizi, L Shultz and T Yi (1997) Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: detection of potential HCP substrates in GM-CSF signal transduction. Exp Hematol 25(7), 592-600.
174. N Carpino, D Wisniewski, A Strife, D Marshak, R Kobayashi, B Stillman, et al. (1997) p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell 88 197-204.
175. A Di Cristofano, A Niki, M Zhao, FG Karnell, B Clarkson, WS Pear, et al. (2001) p62dok, a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210bcr−abl. J Exp Med 194 275-284.
176. Y Yamanashi and D Baltimore (1997) Identification of the Abl- and rasGAP-associated 62-kDa protein as a docking protein, Dok. Cell 88(2), 205-211.
177. KL Berg, K Carlberg, LR Rohrschneider, KA Siminovitch and ER Stanley (1998) The major SHP-1-binding tyrosine phosphorylated protein in macrophages is a member of the KIR/LIR family and an SHP-1 substrate. Oncogene 17 2535-2541.
178. C Saginario, H Sterling, C Beckers, R Kobayashi, M Solimena, E Ullu, et al. (1998) MFR, a putative receptor mediating the fusion of macrophages. Mol Cell Biol 18(11), 6213-6223.
179. A Veillette, E Thibaudeau and S Latour (1998) High expression of inhibitory receptor Shps-1 and its association with protein-tyrosine phosphatase Shp-1 in macrophages. J Biol Chem 273 22,719-22,728.
180. JF Timms, KD Swanson, A Marie-Cardine, M Raab, CE Rudd, B Schraven, et al. (1999) SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages. Curr Biol 9 927-930.
181. H An, J Hou, J Zhou, W Zhao, H Xu, Y Zheng, et al. (2008) Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. Nat Immunol 9(5), 542-550.
182. AO Hardin, EA Meals, T Yi, KM Knapp and BK English (2006) SHP-1 inhibits LPS-mediated TNF and iNOS production in murine macrophages. Biochem Biophys Res Commun 342(2), 547-555.
183. Z Zhang, E Jimi and AL Bothwell (2003) Receptor activator of NF-kappa B ligand stimulates recruitment of SHP-1 to the complex containing TNFR-associated factor 6 that regulates osteoclastogenesis. J Immunol 171(7), 3620-3626.
184. S Gottipati, NL Rao and WP Fung-Leung (2008) IRAK1: a critical signaling mediator of innate immunity. Cell Signal 20(2), 269-276.
185. S Uematsu, S Sato, M Yamamoto, T Hirotani, H Kato, F Takeshita, et al. (2005) Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction. J Exp Med 201(6), 915-923.
186. BA Diebold and GM Bokoch (2005) Rho GTPases and the control of the oxidative burst in polymorphonuclear leukocytes. Curr Top Microbiol Immunol 291 91-111.
187. M David III, E Petricoin, C Benjamin, R Pine, MJ Weber and AC Larner (1995) Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins. Science 269(5231), 1721-1723.
188. TI Roach, SE Slater, LS White, X Zhang, PW Majerus, EJ Brown, et al. (1998) The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages. Curr Biol 8(18), 1035-1038.
189. T Roach, S Slater, M Koval, L White, E Mcfarland, M Okumura, et al. (1997) CD45 regulates src family member kinase activity associated with macrophage integrin-mediated adhesion. Curr Biol 7 408-417.
190. EK Griffiths, C Krawczyk, YY Kong, M Raab, SJ Hyduk, D Bouchard, et al. (2001) Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Science 293 2260-2263.
191. AJ Hunter, N Ottoson, N Boerth, GA Koretzky and Y Shimizu (2000) A novel function for the SLAP-130/FYB adapter protein in b1 integrin-signalling and T lymphocyte migration. J Immunol 164 1143-1147.
192. EJ Peterson, ML Woods, SA Dmowski, G Derimanov, MS Jordan, JN Wu, et al. (2001) Coupling of the TCR to integrin activation by SLAP130/Fyb. Science 293 2263-2265.
193. M Krause, AS Sechi, M Konradt, D Monner, FB Gertler and J Wehland (2000) Fyn-binding protein (Fub)/SLP-76-associated protein (SLAP), Ena/Vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. J Cell Biol 149 181-194.
194. L Simeoni, S Kliche, J Lindquist and B Schraven (2004) Adaptors and linkers in T and B cells. Curr Opin Immunol 16(3), 304-313.
195. D Ilic, Y Furuta, S Kanazawa, N Takeda, K Sobue, N Nakatsuji, et al. (1995) Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377(6549), 539-544.
196. SK Mitra and DD Schlaepfer (2006) Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 18(5), 516-523.
197. K Inagaki, T Yamao, T Noguchi, T Matozaki, K Fukunaga, T Takada, et al. (2000) SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility. EMBO J 19(24), 6721-6731.
198. CH Kim, C-K Qu, G Hangoc, S Cooper, N Anzai, G-S Feng, et al. (1999) Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein-tyrosine phosphatase SHP-1 in chemokine responses. J Exp Med 190 681-690.
199. I Dikic, G Tokiwa, S Lev, SA Courtneidge and J Schlessinger (1996) A role for Pyk2 and Src in linking G-coupled receptors with MAP kinase activation. Nature 383 547-550.
200. HD Gresham, BM Dale, JW Potter, PW Chang, CM Vines, CA Lowell, et al. (2000) Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr. J Exp Med 191(3), 515-528.
201. P Jiang, CF Lagenaur and V Narayanan (1999) Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J Biol Chem 274(2), 559-562.
202. FP Lindberg, HD Gresham, E Schwarz and EJ Brown (1993) Molecular cloning of integrin–associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in avb3-dependent ligand binding. J Cell Biol 123 485-496.
203. PA Oldenborg, A Zheleznyak, YF Fang, CF Lagenaur, HD Gresham and FP Lindgerg (2000) Role of CD47 as a marker of self on red blood cells. Science 288 2051-2054.
204. P-A Oldenborg, HD Gresham and FP Lindberg (2001) CD47-Signal Regulatory Protein a (SIRPa) regulates Fcg and complement receptor-mediated phagocytosis. J Exp Med 193 855-861.
205. T Yamao, T Noguchi, O Takeuchi, U Nishiyama, H Morita, T Hagiwara, et al. (2002) Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1. J Biol Chem 277(42), 39,833-39,839.
206. K Takenaka, TK Prasolava, JC Wang, SM Mortin-Toth, S Khalouei, OI Gan, et al. (2007) Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells. Nat Immunol 8(12), 1313-1323.
207. K Ide, H Wang, H Tahara, J Liu, X Wang, T Asahara, et al. (2007) Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages. Proc Natl Acad Sci USA 104(12), 5062-5066.
208. P Tapley, NK Shevde, PA Schweitzer, M Gallina, SW Christianson, IL Lin, et al. (1997) Increased G-CSF responsiveness of bone marrow cells from hematopoietic cell phosphatase deficient viable motheaten mice. Exp Hematol 25(2), p122-131.
209. AC Ward, SPMA Oomen, L Smith, J Gits, D van Leeuwen, AA Soede-Bobok, et al. (2000) The SH2 domain-containing protein tyrosine phosphatase SHP-1 is induced by granulocyte colony-stimulating factor (G-CSF) and modulates signaling from the G-CSF receptor. Leukemia 14 1284-1291.
210. F Dong, Y Qiu, T Yi, IP Touw and AC Larner (2001) The carboxyl terminus of the granulocyte colony-stimulating factor receptor, truncated in patients with severe congenital neutropenia/acute myeloid leukemia, is required for SH2-containing phosphatase-1 suppression of STAT activation. J Immunol 167 6447-6452.
211. SH Jia, J Parodo, A Kapus, OD Rotstein and JC Marshall (2008) Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8. J Biol Chem 283(9), 5402-5413.
212. J Kruger, JR Butler, V Cherapanov, Q Dong, H Ginzberg, A Govindarajan, et al. (2000) Deficiency of Src homology 2-containing phosphatase 1 results in abnormalities in murine neutrophil function: studies in motheaten mice. J Immunol 165 5847-5849.
213. B Kautz, R Kakar, E David and EA Eklund (2001) SHP1 protein-tyrosine phosphatase inhibits gp91PHOX and p67PHOX expression by inhibiting interaction of PU.1, IRF1, interferon consensus sequence-binding protein, and CREB-binding protein with homologous Cis elements in the CYBB and NCF2 genes. J Biol Chem 276(41), 37,868-37,878.
214. EA Eklund, I Goldenberg, Y Lu, J Andrejic and R Kakar (2002) SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells. J Biol Chem 277(39), 36,878-36,888.
215. W Huang, G Saberwal, E Horvath, C Zhu, S Lindsey and EA Eklund (2006) Leukemia-associated, constitutively active mutants of SHP2 protein tyrosine phosphatase inhibit NF1 transcriptional activation by the interferon consensus sequence binding protein. Mol Cell Biol 26(17), 6311-6332.
216. S Lindsey, W Huang, H Wang, E Horvath, C Zhu and EA Eklund (2007) Activation of SHP2 protein-tyrosine phosphatase increases HoxA10-induced repression of the genes encoding gp91(PHOX) and p67(PHOX). J Biol Chem 282(4), 2237-2249.
217. EO Long (1999) Regulation of immune responses through inhibitory receptors. Annu Rev Immunol 17 875-905.
218. LI Pao, K Badour, KA Siminovitch and BG Neel (2007) Nonreceptor protein-tyrosine phosphatases in immune cell signaling. Annu Rev Immunol 25 473-523.
219. KA Siminovitch and BG Neel (1998) Regulation of B cell signal transduction by SH2-containing protein-tyrosine phosphatases. Semin Immunol 10(4), 329-347.
220. J Zhang, A-K Somani and KA Siminovitch (2000) Role of the Shp-1 tyrosine phosphatase in the negative regulation of cell signaling. Sem Immunol 12 361-378.
221. DD Billadeau and PJ Leibson (2002) ITAMs versus ITIMs: striking a balance during cell regulation. J Clin Invest 109 161-168.
222. I Tamir, JM Dal Porto and JC Cambier (2000) Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: regulators of B cell signal transduction. Curr Opin Immunol 12 307-315.
223. D Allman and S Pillai (2008) Peripheral B cell subsets. Curr Opin Immunol 20(2), 149-157.
224. L Nitschke, R Carsetti, B Ocker, G Kohler and MC Lamers (1997) CD22 is a negative regulator of B cell receptor signaling. Curr Biol 7 133-143.
225. TL O’Keefe, GT Williams, SL Davies and MS Neuberger (1996) Hyperresponsive B cells in CD22-deficient mice. Science 274(5288), 798-801.
226. KL Otipoby, KB Andersson, KE Draves, SJ Klaus, AG Farr, JD Kerner, et al. (1996) CD22 regulates thymus-independent responses and the lifespan of B cells. Nature 384(6610), 634-637.
227. C Pan, N Baumgarth and JR Parnes (1999) CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation. Immunity 11 495-506.
228. G Bikah, J Carey, JR Ciallella, A Tarakhovsky and S Bondada (1996) CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells. Science 274 1906-1909.
229. CL Haga, GR Ehrhardt, RJ Boohaker, RS Davis and MD Cooper (2007) Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment. Proc Natl Acad Sci USA 104(23), 9770-9775.
230. M Ono, S Bolland, P Tempst and JV Ravetch (1996) Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcgRIIB. Nature 383 263-266.
231. M Ono, H Okada, S Bolland, S Yanagi, T Kurosaki and JV Ravetch (1997) Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling. Cell 90 293-301.
232. MJ Nadler, B Chen, S Anderson, H Wortis and BG Neel (1997) Protein-tyrosine phosphatase SHP-1 is dispensible for FcgRIIB-mediated inhibition of B cell antigen receptor activation. J Biol Chem 272 20,038-20,043.
233. N Gupta, AM Scharenberg, DN Burshtyn, N Wagtmann, MN Lioubin, LA Rohrschneider, et al. (1997) Negative signaling pathways of the killer cell inhibitory receptor and Fc gamma RIIb1 require distinct phosphatases. J Exp Med 186 473-478.
234. S Sato, AS Miller, M Inaoki, CB Bock, PJ Jansen, LK Tang, et al. (1996) CD22 is both a positive and negative regulator of lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. Immunity 5 551-562.
235. MJS Nadler, PA McLean, BG Neel and HH Wortis (1997) B cell antigen receptor-evoked calcium influx is enhanced in CD22-deficient B cell lines. J Immunol 159 4233-4243.
236. J Chen, PA McLean, BG Neel, G Okunade, GE Shull and HH Wortis (2004) CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity. Natur Immunol 5 651-657.
237. WL Dean, D Chen, PC Brandt and TC Vanaman (1997) Regulation of platelet plasma membrane Ca2+-ATPase by cAMP-dependent and tyrosine phosphorylation. J Biol Chem 272(24), 15,113-15,119.
238. O Inoue, K Suzuki-Inoue, WL Dean, J Frampton and SP Watson (2003) Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2. J Cell Biol 160(5), 769-780.
239. TC Wan, M Zabe and WL Dean (2003) Plasma membrane Ca2+-ATPase isoform 4b is phosphorylated on tyrosine 1176 in activated human platelets. Thromb Haemost 89(1), 122-131.
240. K Mizuno, Y Tagawa, K Mitomo, Y Arimura, N Hatano, T Katagiri, et al. (2000) Src homology region 2 (SH2) domain-containing phosphatase-1 dephosphorylates B cell linker protein/SH2 domain leukocyte protein of 65kDa and selectively regulates c-Jun NH2-terminal kinase activation in B cells. J Immunol 165 1344-1351.
241. S Sato, PJ Jansen and TF Tedder (1997) CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling. Proc Natl Acad Sci USA 94 13,158-13,162.
242. M Kon-Kozlowski, G Pani, T Pawson and KA Siminovitch (1996) The tyrosine phosphatase PTP1C associates with Vav, Grb 2, and mSos1 in hematopoietic cells. J Biol Chem 271 3856-3862.
243. CC Stebbins, C Watzl, BD Billadeau, PJ Leibson, DN Burshtyn and EO Long (2003) Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity. Mol Cell Biol 23 6291-6299.
244. B Binstadt, D Billadeau, D Jevremovic, B Williams, N Fang, T Yi, et al. (1998) SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors. J Biol Chem 273(42), 27,518-27,523.
245. K Mizuno, Y Tagawa, N Watanabe, M Ogimoto and H Yakura (2005) SLP-76 is recruited to CD22 and dephosphorylated by SHP-1, thereby regulating B cell receptor-induced c-Jun N-terminal kinase activation. Eur J Immunol 35(2), 644-654.
246. B Cuevas, Y Lu, S Watt, R Kumar, J Zhang, KA Siminovitch, et al. (1999) SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity. J Biol Chem 274(39), 27,583-27,589.
247. A Maeda, AM Scharenberg, S Tsukada, JB Bolen, JP Kinet and T Kurosaki (1999) Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1. Oncogene 18(14), 2291-2297.
248. LB Dustin, DR Plas, J Wong, YT Hu, C Soto, AC Chan, et al. (1999) Expression of dominant negative src-homology domain 2-containing protein-tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation. J Immunol 162 2717-2724.
249. Z Yu, M Maoui, ZJ Zhao, Y Li and SH Shen (2006) SHP-1 dephosphorylates 3BP2 and potentially downregulates 3BP2-mediated T cell antigen receptor signaling. FEBS J 273(10), 2195-2205.
250. T Baba, N Fusaki, N Shinya, A Iwamatsu and N Hozumi (2003) Myosin is an in vivo substrate of the protein tyrosine phosphatase (SHP-1) after mIgM cross-linking. Biochem Biophys Res Commun 304(1), 67-72.
251. M Blery, H Kubagawa, C-C Chen, F Vely, MD Cooper and E Vivier (1998) PIR-B is an inhibitory receptor that recruits SHP-1. Proc Natl Acad Sci 95(5), 2446-2451.
252. K Hayami, D Fukuta, Y Nishikawa, Y Yamashita, M Inui, Y Ohyama, et al. (1997) Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors. J Biol Chem 272 7320-7327.
253. JJ Perez-Villar, GS Whitney, MA Bowen, DH Hewgill, AA Aruffo and SB Kanner (1999) CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1. Mol Cell Biol 19(4), 2903-2912.
254. T Bellon, F Kitzig, J Sayos and M Lopez-Botet (2002) Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor. J Immunol 168(7), 3351-3359.
255. Z Chen, L Chen, S-W Qiao, T Nagaishi and RS Blumberg (2008) Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70. J Immunol 180(9), 6085-6093.
256. T Nagaishi, L Pao, SH Lin, H Iijima, A Kaser, SW Qiao, et al. (2006) SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms. Immunity 25(5), 769-781.
257. N Watanabe, M Gavrieli, JR Sedy, J Yang, F Fallarino, SK Loftin, et al. (2003) BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol 4(7), 670-679.
258. JM Chemnitz, RV Parry, KE Nichols, CH June and JL Riley (2004) SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation. J Immunol 173(2), 945-954.
259. RV Parry, JM Chemnitz, KA Frauwirth, AR Lanfranco, I Braunstein, SV Kobayashi, et al. (2005) CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol 25(21), 9543-9553.
260. DR Plas, R Johnson, JT Pingel, RJ Matthews, M Dalton, G Roy, et al. (1996) Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science 272 1173-1176.
261. MS Sozio, MA Mathis, JA Young, S Walchli, LA Pitcher, PC Wrage, et al. (2004) PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit. J Biol Chem 279(9), 7760-7769.
262. GG Chiang and BM Sefton (2001) Specific dephosphorylation of the Lck tyrosine kinase at Tyr 394 by the SHP-1 protein tyrosine phosphatase. J Biol Chem 276 23,173-23,178.
263. M Raab and CE Rudd (1996) Hematopoietic cell phosphatase (HCP) regulates p56LCK phosphorylation and ZAP-70 binding to T cell receptor zeta chain. Biochem Biophys Res Commun 222(1), 50-57.
264. I Stefanova, B Hemmer, M Vergelli, R Martin, WE Biddison and RN Germain (2003) TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nat Immunol 4(3), 248-254.
265. O Feinerman, J Veiga, JR Dorfman, RN Germain and G Altan-Bonnet (2008) Variability and robustness in T cell activation from regulated heterogeneity in protein levels. Science 321(5892), 1081-1084.
266. JG Sathish, G Dolton, FG Leroy and RJ Matthews (2007) Loss of Src homology region 2 domain-containing protein tyrosine phosphatase-1 increases CD8+ T cell-APC conjugate formation and is associated with enhanced in vivo CTL function. J Immunol 178(1), 330-337.
267. ME Keir and AH Sharpe (2005) The B7/CD28 costimulatory family in autoimmunity. Immunol Rev 204 128-143.
268. T Avril, H Floyd, F Lopez, E Vivier and PR Crocker (2004) The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells. J Immunol 173(11), 6841-6849.
269. BA Binstadt, KM Brumbaugh, CJ Dick, AM Scharenberg, BL Williams, M Colonna, et al. (1996) Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Immunity 5 629-638.
270. MC Yu, LL Su, L Zou, Y Liu, N Wu, L Kong, et al. (2008) An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells. Nat Immunol 9(8), 898-907.
271. TS Migone, NA Cacalano, N Taylor, T Yi, TA Waldmann and JA Johnston (1998) Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells. Proc Natl Acad Sci USA 95(7), 3845-3850.
272. Y Liu, MJ Kruhlak, JJ Hao and S Shaw (2007) Rapid T cell receptor-mediated SHP-1 S591 phosphorylation regulates SHP-1 cellular localization and phosphatase activity. J Leukoc Biol 82(3), 742-751.
273. M Sankarshanan, Z Ma, T Iype and U Lorenz (2007) Identification of a novel lipid raft-targeting motif in Src homology 2-containing phosphatase 1. J Immunol 179(1), 483-490.
274. J Matko, A Bodnar, G Vereb, L Bene, G Vamosi, G Szentesi, et al. (2002) GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines. Eur J Biochem 269(4), 1199-1208.
275. Z Huang, JM Coleman, Y Su, M Mann, J Ryan, LD Shultz, et al. (2005) SHP-1 regulates STAT6 phosphorylation and IL-4-mediated function in a cell type-specific manner. Cytokine 29(3), 118-124.
276. M Kashiwada, CC Giallourakis, P-Y Pan and PB Rothman (2001) Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation. J Immunol 167 6382-6387.
277. T Kamata, M Yamashita, M Kimura, K Murata, M Inami, C Shimizu, et al. (2003) src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation. J Clin Invest 111(1), 109-119.
278. C Deng, A Minguela, RZ Hussain, AE Lovett-Racke, C Radu, ES Ward, et al. (2002) Expression of the tyrosine phosphatase SRC homology 2 domain-containing protein tyrosine phosphatase 1 determines T cell activation threshold and severity of experimental autoimmune encephalomyelitis. J Immunol 168(9), 4511-4518.
279. WM Yu, S Wang, AD Keegan, MS Williams and CK Qu (2005) Abnormal Th1 cell differentiation and IFN-gamma production in T lymphocytes from motheaten viable mice mutant for Src homology 2 domain-containing protein tyrosine phosphatase-1. J Immunol 174(2), 1013-1019.
280. A Taylor, M Akdis, A Joss, T Akkoç, R Wenig, M Colonna, et al. (2007) IL-10 inhibits CD28 and ICOS costimulations of T cells via src homology 2 domain-containing protein tyrosine phosphatase 1. J Allergy Clin Immunol 120(1), 76-83.
281. I-K Park, LD Shultz, JJ Letterio and JD Gorham (2005) TGF-β1 inhibits T-bet induction by IFN-γ in murine CD4+ T Cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1. J Immunol 175(9), 5666-5674.
282. JD Carter, GM Calabrese, M Naganuma and U Lorenz (2005) Deficiency of the Src homology region 2 domain-containing phosphatase 1 (SHP-1) causes enrichment of CD4+CD25+ regulatory T cells. J Immunol 174(11), 6627-6638.
283. X Su, T Zhou, Z Wang, P Yang, RS Jope and JD Mountz (1995) Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis. Immunity 2(4), p353-362.
284. X Su, T Zhou, PA Yang, Z Wang and JD Mountz (1996) Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defect. J Immunol 156 4198-4208.
285. H Takayama, MH Lee and Y Shirota-Someya (1996) Lack of requirement for SHP-1 in both Fas-mediated and perforin-mediated cell death induced by CTL. J Immunol 157 3943-3948.
286. T Yi, J Zhang, O Miura and JN Ihle (1995) Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites. Blood 85(1), 87-95.
287. U Klingmuller, U Lorenz, LC Cantley, BG Neel and HF Lodish (1995) Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 80 729-738.
288. A De La Chappelle, A-L Traskelin and E Juvonen (1993) Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis. Proc Natl Acad Sci USA 90 4495-4499.
289. H Zang, K Sato, H Nakajima, C McKay, PA Ney and JN Ihle (2001) The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis. EMBO J 20 3156-3166.
290. L Su, Z Zhao, P Bouchard, D Banville, EH Fischer, EG Krebs, et al. (1996) Positive effect of overexpressed protein-tyrosine phosphatase PTP1C on mitogen-activated signaling in 293 cells. J Biol Chem 271(17), 10,385-10,390.
291. H Keilhack, M Muller, SA Bohmer, C Frank, KM Weidner, W Birchmeier, et al. (2001) Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1. J Cell Biol 152 325-334.
292. C Duchesne, S Charland, C Asselin, C Nahmias and N Rivard (2003) Negative regulation of beta-catenin signaling by tyrosine phosphatase SHP-1 in intestinal epithelial cells. J Biol Chem 278(16), 14,274-14,283.
293. F Lopez, JP Esteve, L Buscail, N Delesque, N Saint-Laurent, M Theveniau, et al. (1997) The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling. J Biol Chem 272(39), 24,448-24,454.
294. C Bousquet, N Delesque, F Lopez, N Saint-Laurent, JP Esteve, K Bedecs, et al. (1998) sst2 somatostatin receptor mediates negative regulation of insulin receptor signaling through the tyrosine phosphatase SHP-1. J Biol Chem 273(12), 7099-7106.
295. F Lopez, G Ferjoux, P Cordelier, N Saint-Laurent, JP Esteve, N Vaysse, et al. (2001) Neuronal nitric oxide synthase: a substrate for SHP-1 involved in sst2 somatostatin receptor growth inhibitory signaling. FASEB J 15(12), 2300-2302.
296. MJ Dubois, S Bergeron, HJ Kim, L Dombrowski, M Perreault, B Fournes, et al. (2006) The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis. Nat Med 12(5), 549-556.
297. SQ Zhang, WG Tsiaras, T Araki, G Wen, L Minichiello, R Klein, et al. (2002) Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2. Mol Cell Biol 22(12), 4062-4072.
298. M Holgado-Madruga, DR Emlet, DK Moscatello, AK Godwin and AJ Wong (1996) A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature 379 560-564.
299. KM Weidner, S Di Cesare, M Sachs, V Brinkmann, J Behrens and W Birechmeier (1996) Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 384 173-176.
300. MF White and L Yenush (1998) The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Curr Top Microbiol Immunol 228 179-208.
301. H Kouhara, Y Hadari, T Spivak-Kroizman, J Schilling, D Bar-Sagi, I Lax, et al. (1997) A lipid-anchored Grb2-binding protein that links FGF-Receptor activation to the Ras/MAPK Signaling pathway. Cell 89 693-702.
302. M Itoh, Y Yoshida, K Nishida, M Narimatsu, M Hibi and T Hirano (2000) Role of Gab1 in heart, placenta and skin development and growth factor- and cytokine-induced extracellular signal-related kinase mitogen-activated protein kinase activation. Mol Cell Biol 20 2695-2704.
303. M Sachs, H Brohmann, D Zechner, T Muller, J Hulsken, I Walther, et al. (2000) Essential role of Gab1 for signaling by the c-Met receptor in vivo. J Cell Biol 150 1375-1384.
304. YR Hadari, N Gotoh, H Kouhara, I Lax and J Schlessinger (2001) Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways. Proc Natl Acad Sci USA 98 8578-8583.
305. CR Maroun, MA Naujokas, M Holgado-Madruga, AJ Wong and M Park (2000) The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the Met receptor tyrosine kinase. Mol Cell Biol 20 8513-8525.
306. U Schaeper, NH Gehring, KP Fuchs, M Sachs, B Kempkes and W Birchmeier (2000) Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses. J Cell Biol 149 1419-1432.
307. V Petit, U Nussbaumer, C Dossenbach and M Affolter (2004) Downstream-of-FGFR is a fibroblast growth factor-specific scaffolding protein and recruits Corkscrew upon receptor activation. Mol Cell Biol 24(9), 3769-3781.
308. T Noguchi, T Matozaki, K Horita, Y Fujioka and M Kasuga (1994) Role of SH-PTP2, a protein-tyrosine phosphatase with src homology 2 domains, in insulin-stimulated ras activation. Mol Cell Biol 14 6674-6682.
309. SQ Zhang, W Yang, MI Kontaridis, TG Bivona, G Wen, T Araki, et al. (2004) Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. Mol Cell 13(3), 341-355.
310. W Li, R Nishimura, A Kashishian, AG Batzer, WJ Kim, JA Cooper, et al. (1994) A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol Cell Biol 14(1), 509-517.
311. MJ Welham, U Dechert, KB Leslie, F Jirik and JW Schrader (1994) Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3′-kinase. J Biol Chem 269 23,764-23,768.
312. AM O’Reilly and BG Neel (1998) Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction. Mol Cell Biol 18 161-177.
313. JD Allard, R Herbst, PM Carroll and MA Simon (1998) Mutational analysis of the SRC homology 2 domain protein-tyrosine phosphatase Corkscrew. J Biol Chem 273(21), 13,129-13,135.
314. T Araki, H Nawa and BG Neel (2003) Tyrosyl phosphorylation of Shp2 is required for normal Erk activation in response to some but not all growth factors. J Biol Chem 278 41,677-41,684.
315. XM Zheng, RJ Resnick and D Shalloway (2000) A phosphotyrosine displacement mechanism for activation of Src by PTPalpha. EMBO J 19(5), 964-978.
316. GS Feng (1999) Shp-2 tyrosine phosphatase: signaling one cell or many. Exp Cell Res 253 47-54.
317. RA Klinghoffer and A Kazlauskas (1995) Identification of a putative Syp substrate, the PDGF beta receptor. J Biol Chem 270(38), 22,208-22,217.
318. V Cleghon, P Feldmann, C Ghiglione, TD Copeland, N Perrimon, DA Hughes, et al. (1998) Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway. Mol Cell 2 719-727.
319. YM Agazie and MJ Hayman (2003) Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling. Mol Cell Biol 23 7875-7886.
320. R Herbst, PM Carroll, JD Allard, J Schilling, T Raabe and MA Simon (1996) Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling. Cell 85(6), 899-909.
321. R Herbst, X Zhang, J Qin and MA Simon (1999) Recruitment of the protein tyrosine phosphatase CSW by DOS is an essential step during signaling by the sevenless receptor tyrosine kinase. EMBO J 18 6950-6951.
322. BS Bausenwein, M Schmidt, B Mielke and T Raabe (2000) In vivo functional analysis of the daughter of sevenless protein in receptor tyrosine kinase signaling. Mech Dev 90 205-215.
323. SQ Zhang, WG Tsiaris, T Araki, G Wen, L Minichiello, R Klein, et al. (2002) Receptor-specific regulation of phosphatidyl 3′-kinase activation by the protein tyrosine phosphatase Shp2. Mol Cell Biol 22 4062-4072.
324. S Yamasaki, K Nishida, Y Yoshida, M Itoh, M Hibi and T Hirano (2003) Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2. Oncogene 22 1546-1556.
325. A Montagner, A Yart, M Dance, B Perret, JP Salles and P Raynal (2005) A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation. J Biol Chem 280(7), 5350-5360.
326. JM Cunnick, L Mei, A. Doupnik cA and J Wu (2001) Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2. J Biol Chem 276 24,380-24,387.
327. JM Cunnick, S Meng, Y Ren, C Desponts, HG Wang, JY Djeu, et al. (2002) Regulation of the mitogen-activated protein kinase signaling pathway by SHP2. J Biol Chem 277(11), 9498-9504.
328. CJ Wu, DM O’Rourke, GS Feng, GR Johnson, Q Wang and MI Greene (2001) The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors. Oncogene 20(42), 6018-6025.
329. A Bertotti, PM Comoglio and L Trusolino (2006) Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth. J Cell Biol 175(6), 993-1003.
330. S Mitola, B Brenchio, M Piccinini, L Tertoolen, L Zammataro, G Breier, et al. (2006) Type I collagen limits VEGFR–2 signaling by a SHP2 protein-tyrosine phosphatase-dependent mechanism 1. Circ Res 98(1), 45-54.
331. Y Ren, S Meng, L Mei, ZJ Zhao, R Jove and J Wu (2004) Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor. J Biol Chem 279 8497-8505.
332. H Hanafusa, S Torii, T Yasunaga, K Matsumoto and E Nishida (2004) Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty. J Biol Chem 279(22), 22,992-22,995.
333. LA Jarvis, SJ Toering, MA Simon, MA Krasnow and RK Smith-Bolton (2006) Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases. Development 133(6), 1133-1142.
334. JM Mason, DJ Morrison, MA Basson and JD Licht (2006) Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling. Trends Cell Biol 16 46-54.
335. T Wakioka, A Sasaki, R Kato, T Shouda, A Matsumoto, K Miyoshi, et al. (2001) Spred is a Sprouty-related suppressor of Ras signalling. Nature 412(6847), 647-651.
336. R Kato, A Nonami, T Taketomi, T Wakioka, A Kuroiwa, Y Matsuda, et al. (2003) Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. Biochem Biophys Res Commun 302(4), 767-772.
337. A Nonami, R Kato, K Taniguchi, D Yoshiga, T Taketomi, S Fukuyama, et al. (2004) Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells. J Biol Chem 279(50), 52,543-52,551.
338. K Taniguchi, R Kohno, T Ayada, R Kato, K Ichiyama, T Morisada, et al. (2007) Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling. Mol Cell Biol 27(12), 4541-4550.
339. J Burks and YM Agazie (2006) Modulation of alpha-catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3. Oncogene 25(54), 7166-7179.
340. S Kolli, CI Zito, MH Mossink, EA Wiemer and AM Bennett (2004) The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. J Biol Chem 279(28), 29,374-29,385.
341. V Vasioukhin, C Bauer, L Degenstein, B Wise and E Fuchs (2001) Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell 104(4), 605-617.
342. XS Hou, T-B Chou, MB Melnick and N Perrimon (1995) The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway. Cell 81 63-71.
343. JA Lorenzen, SE Baker, F Denhez, MB Melnick, DL Brower and LA Perkins (2001) Nuclear import of activated D-ERK by DIM-7, an importin family member encoded by the gene moleskin. Development 128 1403-1414.
344. DR Mattoon, B Lamothe, I Lax and J Schlessinger (2004) The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway. BMC Biol 2 24.
345. CI Zito, H Qin, J Blenis and AM Bennett (2007) SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway. J Biol Chem 282(10), 6946-6953.
346. LS Argetsinger, JL Kouadio, H Steen, A Stensballe, ON Jensen and C Carter-Su (2004) Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity. Mol Cell Biol 24(11), 4955-4967.
347. EP Feener Jr., F Rosario, SL Dunn, Z Stancheva and MG Myers (2004) Tyrosine phosphorylation of JAK2 in the JH2 domain inhibits cytokine signaling. Mol Cell Biol 24(11), 4968-4978.
348. M Funakoshi-Tago, S Pelletier, T Matsuda, E Parganas and JN Ihle (2006) Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of JAK2. EMBO J 25(20), 4763-4772.
349. MD Godeny, J Sayyah, D Von Der Linden, M Johns, DA Ostrov, J Caldwell-Busby, et al. (2007) The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for JAK2-dependent signaling via the angiotensin II type AT1 receptor. Cell Signal 19(3), 600-609.
350. T Matsuda, J Feng, BA Witthuhn, Y Sekine and JN Ihle (2004) Determination of the transphosphorylation sites of JAK2 kinase. Biochem Biophys Res Commun 325(2), 586-594.
351. J Feng, BA Witthuhn, T Matsuda, F Kohlhuber, IM Kerr and JN Ihle (1997) Activation of JAK2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop. Mol Cell Biol 17(5), 2497-2501.
352. H Yasukawa, H Misawa, H Sakamoto, M Masuhara, A Sasaki, T Wakioka, et al. (1999) The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. Embo J 18(5), 1309-1320.
353. J Frantsve, J Schwaller, DW Sternberg, J Kutok and DG Gilliland (2001) Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation. Mol Cell Biol 21(10), 3547-3557.
354. S Kamizono, t Hanada, H Yasukawa, S Minoguchi, R Kato, M Minoguchi, et al. (2001) The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. J BiolChem 276 12,530-12,538.
355. D Ungureanu, P Saharinen, I Junttila, DJ Hilton and O Silvennoinen (2002) Regulation of JAK2 through the ubiquitin-proteasome pathway involves phosphorylation of JAK2 on Y1007 and interaction with SOCS-1. Mol Cell Biol 22(10), 3316-3326.
356. S Ali, Z Nouhi, N Chughtai and S Ali (2003) SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor. J Biol Chem 278 52,021-52,031.
357. U Lehmann, J Schmitz, M Weissenbach, RM Sobota, M Hortner, K Friederichs, et al. (2003) SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. J Biol Chem 278(1), 661-671.
358. NC Tebbutt, AS Giraud, M Inglese, B Jenkins, P Waring, FJ Clay, et al. (2002) Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med 8(10), 1089-1097.
359. BJ Jenkins, D Grail, T Nheu, M Najdovska, B Wang, P Waring, et al. (2005) Hyperactivation of STAT3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling. Nat Med 11(8), 845-852.
360. BJ Jenkins, AW Roberts, M Najdovska, D Grail and M Ernst (2005) The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis. Blood 105(9), 3512-3520.
361. WD Fairlie, D De Souza, NA Nicola and M Baca (2003) Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2. Biochem J 372(Pt 2), 495-502.
362. WM Yu, TS Hawley, RG Hawley and CK Qu (2003) Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling. Oncogene 22(38), 5995-6004.
363. WM Yu, H Daino, J Chen, KD Bunting and CK Qu (2006) Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling. J Biol Chem 281(9), 5426-5434.
364. MG Mohi, IR Williams, CR Dearolf, G Chan, JL Kutok, S Cohen, et al. (2005) Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations. Cancer Cell 7(2), 179-191.
365. M You, DH Yu and GS Feng (1999) Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated JAK/STAT pathway. Mol Cell Biol 19(3), 2416-2424.
366. TR Wu, YK Hong, XD Wang, MY Ling, AM Dragoi, AS Chung, et al. (2002) SHP-2 is a dual-specificity phosphatase involved in STAT1 dephosphorylation at both tyrosine and serine residues in nuclei. J Biol Chem 277(49), 47572-47580.
367. CL Yu, YJ Jin and SJ Burakoff (2000) Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation. J Biol Chem 275(1), 599-604.
368. Y Chen, R Wen, S Yang, J Schuman, EE Zhang, T Yi, et al. (2003) Identification of Shp-2 as a STAT5A phosphatase. J Biol Chem 278(19), 16,520-16,527.
369. J Chen, WM Yu, KD Bunting and CK Qu (2004) A negative role of SHP-2 tyrosine phosphatase in growth factor-dependent hematopoietic cell survival. Oncogene 23(20), 3659-3669.
370. H Wheadon, C Edmead and MJ Welham (2003) Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2). Biochem J 376(Pt 1), 147-157.
371. M Yu, J Luo, W Yang, Y Wang, M Mizuki, Y Kanakura, et al. (2006) The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway. J Biol Chem 281(39), 28,615-28,626.
372. M You, LM Flick, D Yu and GS Feng (2001) Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor. J Exp Med 193 101-110.
373. A Kobielak and E Fuchs (2006) Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin. Proc Natl Acad Sci USA 103(7), 2322-2327.
374. T Holtschke, J Lohler, Y Kanno, T Fehr, N Giese, F Rosenbauer, et al. (1996) Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell 87(2), 307-317.
375. I Konieczna, E Horvath, H Wang, S Lindsey, G Saberwal, L Bei, et al. (2008) Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia. J Clin Invest 118(3), 853-867.
376. DH Yu, CK Qu, O Henegariu, X Lu and GS Feng (1998) Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion. J Biol Chem 273(33), 21,125-21,131.
377. E-S Oh, H Gu, T Saxton, J Timms, S Hausdorff, E Frevert, et al. (1999) Regulation of early events in integrin signaling by the protein-tryosine phosphatase SHP-2. Mol Cell Biol 19 3205-3215.
378. G von Wichert, B Haimovich, GS Feng and MP Sheetz (2003) Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2. EMBO J 22(19), 5023-5035.
379. K Inagaki, T Noguchi, T Matozaki, T Horikawa, K Fukunaga, M Tsuda, et al. (2000) Roles for the protein tyrosine phosphatase SHP-2 in cytoskeletal organization, cell adhesion and cell migration revealed by overexpression of a dominant negative mutant. Oncogene 19(1), 75-84.
380. S Manes, E Mira, C Gomez-Mouton, ZJ Zhao, RA Lacalle and AC Martinez (1999) Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility. Mol Cell Biol 19(4), 3125-3135.
381. H Miao, E Burnett, M Kinch, E Simon and B Wang (2000) Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat Cell Biol 2 62-69.
382. RK Vadlamudi, L Adam, D Nguyen, M Santos and R Kumar (2002) Differential regulation of components of the focal adhesion complex by heregulin: role of phosphatase SHP-2. J Cell Physiol 190 189-199.
383. R Tsutsumi, A Takahashi, T Azuma, H Higashi and M Hatakeyama (2006) Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA. Mol Cell Biol 26(1), 261-276.
384. TM Marin, CF Clemente, AM Santos, PK Picardi, VD Pascoal, I Lopes-Cendes, et al. (2008) Shp2 negatively regulates growth in cardiomyocytes by controlling focal adhesion kinase/Src and mTOR pathways. Circ Res 103(8), 813-824.
385. SJ Heasman and AJ Ridley (2008) Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 9(9), 690-701.
386. MI Kontaridis, S Eminaga, M Fornaro, CI Zito, R Sordella, J Settleman, et al. (2004) SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway. Mol Cell Biol 24 5340-5342.
387. R Sordella, W Jiang, GC Chen, M Curto and J Settleman (2003) Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. Cell 113(2), 147-158.
388. HH Lee and ZF Chang (2008) Regulation of RhoA-dependent ROCKII activation by Shp2. J Cell Biol 181(6), 999-1012.
389. M Tsuda, T Matozaki, K Fukunaga, Y Fujioka, A Imamoto, T Noguchi, et al. (1998) Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases. J Biol Chem 273(21), 13,223-13,229.
390. S Eminaga and AM Bennett (2008) Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPalpha and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation. J Biol Chem 283(22), 15,328-15,338.
391. Y Ling, LA Maile and DR Clemmons (2003) Tyrosine phosphorylation of the beta3-subunit of the alphaVbeta3 integrin is required for embrane association of the tyrosine phosphatase SHP-2 and its further recruitment to the insulin-like growth factor I receptor. Mol Endocrinol 17(9), 1824-1833.
392. DR Clemmons and LA Maile (2003) Minireview: integral membrane proteins that function coordinately with the insulin-like growth factor I receptor to regulate intracellular signaling. Endocrinology 144(5), 1664-1670.
393. Y Ling, LA Maile, J Badley-Clarke and DR Clemmons (2005) DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells. J Biol Chem 280(5), 3151-3158.
394. M Zhao, AA Schmitz, Y Qin, A Di Cristofano, PP Pandolfi and L Van Aelst (2001) Phosphoinositide 3-kinase-dependent membrane recruitment of p62(dok) is essential for its negative effect on mitogen-activated protein (MAP) kinase activation. J Exp Med 194(3), 265-274.
395. JA Frearson, T Yi and DR Alexander (1996) A tyrosine-phosphorylated 110-120-kDa protein associates with the C-terminal SH2 domain of phosphotyrosine phosphatase-1D in T cell receptor-stimulated T cells. Eur J Immunol 26 1539-1543.
396. JA Frearson and DR Alexander (1998) The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells. J Exp Med 187 1417-1426.
397. K Nishida, Y Yoshida, M Itoh, T Fukada, T Ohtani, T Shirogane, et al. (1999) Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. Blood 93(6), 1809-1816.
398. RJ Ingham, M Holgado-Madruga, C Siu, AJ Wong and MR Gold (1998) The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor. J Biol Chem 273(46), 30,630-30,637.
399. JC Pratt, VE Igras, H Maeda, S Baksh, EW Gelfand, SJ Burakoff, et al. (2000) Cutting edge: Gab2 mediates an inhibitory phosphatidylinositol 3'-kinase pathway in T cell antigen receptor signaling. J Immunol 165 4158-4163.
400. S Yamasaki, K Nishida, M Hibi, M Sakuma, R Shiina, A Takeuchi, et al. (2001) Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules. J Biol Chem 276 45,175-45,183.
401. S Yamasaki, K Nishida, M Sakuma, D Berry, CJ McGlade, T Hirano, et al. (2003) Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells. Mol Cell Biol 23 2515-2529.
402. S Itoh, M Itoh, K Nishida, S Yamasaki, Y Yoshida, M Narimatsu, et al. (2002) Adapter molecule Grb2-associated binder 1 is specifically expressed in marginal zone B cells and negatively regulates thymus-independent antigen-2 responses. J Immunol 168(10), 5110-5116.
403. C Nakaseko, S Miyatake, T Iida, S Hara, R Abe, H Ohno, et al. (1999) Cytotoxic lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane proximal region in the absence of the tyrosine motif in the cytoplasmic tail. J Exp Med 190 765-774.
404. T Cinek, A Sadra and JB Imboden (2000) Tyrosine-independent transmission of inhibitory signals by CTLA-4. J Immunol 164 5-8.
405. ML Baroja, D Luxenberg, T Chau, V Ling, CA Strathdee, BM Carreno, et al. (2000) The inhibitory function of CTLA-4 does not require its phosphorylation. J Immunol 164 49-55.
406. T Okazaki, A Maeda, H Nishimura, T Kurosaki and T Honjo (2001) PD-1 immunoreceptor inhibits B cell receptor-mediated signalling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc Natl Acad Sci USA 98 13,866-13,871.
407. DK Newton-Nash and PJ Newman (1999) A new role for platelet-endothelial cell adhesion molecule-1 (CD31): inhibition of TCR-mediated signal transduction. J Immunol 163(2), 682-688.
408. E Prager, G Staffler, O Majdic, M Saemann, S Godar, G Zlabinger, et al. (2001) Induction of hyporesponsiveness and impaired T lymphocyte activation by the CD31 receptor:ligand pathway in T cells. J Immunol 166(4), 2364-2371.
409. DK Newman, C Hamilton and PJ Newman (2001) Inhibition of antigen-receptor signaling by platelet endothelial cell adhesion molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56lck. Blood 97 2351-2357.
410. M Cicmil, JM Thomas, M Leduc, C Bon and JM Gibbins (2002) Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets. Blood 99 137-144.
411. RJ Salmond and DR Alexander (2006) SHP2 forecast for the immune system: fog gradually clearing. Trends Immunol 27(3), 154-160.
412. L Simeoni, JA Lindquist, M Smida, V Witte, B Arndt and B Schraven (2008) Control of lymphocyte development and activation by negative regulatory transmembrane adapter proteins. Immunol Rev 224 215-228.
413. S Yusa and KS Campbell (2003) Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2) can play a direct role in the inhibitory function of killer cell Ig-like receptors in human NK cells. J Immunol 170(9), 4539-4547.
414. H An, W Zhao, J Hou, Y Zhang, Y Xie, Y Zheng, et al. (2006) SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production. Immunity 25(6), 919-928.
415. M Dixit, AE Loot, A Mohamed, B Fisslthaler, CM Boulanger, B Ceacareanu, et al. (2005) Gab1, SHP2, and protein kinase A are crucial for the activation of the endothelial NO synthase by fluid shear stress. Circ Res 97(12), 1236-1244.
416. LK Tai, Q Zheng, S Pan, ZG Jin and BC Berk (2005) Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2. J Biol Chem 280(33), 29,620-29,624.
417. M Holgado-Madruga and AJ Wong (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol Cell Biol 23(13), 4471-4484.
418. L Yuan, WM Yu and CK Qu (2003) DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase. J Biol Chem 278(44), 42,812-42,820.
419. L Yuan, WM Yu, M Xu and CK Qu (2005) SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M arrest in catalytically dependent and independent manners, respectively. J Biol Chem 280(52), 42,701-42,706.
420. L Yuan, WM Yu, Z Yuan, CC Haudenschild and CK Qu (2003) Role of SHP-2 tyrosine phosphatase in the DNA damage-induced cell death response. J Biol Chem 278(17), 15,208-15,216.
421. AR Amin, VS Thakur, RK Paul, GS Feng, CK Qu, H Mukhtar, et al. (2007) SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG. Proc Natl Acad Sci USA 104(13), 5419-5424.
422. T Tenev, H Keilhack, S Tomic, B Stoyanov, M Stein-Gerlach, R Lammers, et al. (1997) Both SH2 domains are involved in interaction of SHP-1 with the epidermal growth factor receptor but cannot confer receptor-directed activity to SHP-1/SHP-2 chimera. J Biol Chem 272 5966-5973.
423. J Yang, Z Cheng, T Niu, X Liang, ZJ Zhao and GW Zhou (2000) Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1. J Biol Chem 275 4066-4071.
424. J Yang, Z Cheng, T Niu, X Liang, ZJ Zhao and GW Zhou (2001) Protein tyrosine phosphatase SHP-1 specifically recognizes C-terminal residues of its substrates via Helix aO. J Cell Biochem 83 14-20.
425. D Pei, BG Neel and CT Walsh (1993) Overexpression, purification, and characterization of Src homology 2-containing protein tyrosine phosphatase. Proc Natl Acad Sci, USA 90 1092-1096.
426. S Sugimoto, RJ Lechleider, SE Shoelson, BG Neel and CT Walsh (1993) Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2. J Biol Chem 268 22,771-22,776.
427. ZY Zhao, SH Shen and EH Fischer (1995) Structure, regulation and function of SH2 domain-containing protein tyrosine phosphatases. Adv Prot Phosphatases 9 301-321.
428. T Niu, X Liang, J Yang, Z Zhao and GW Zhou (1999) Kinetic comparison of the catalytic domains of SHP-1 and SHP-2. J Cell Biochem 72 145-150.
429. RJ Chan and GS Feng (2007) PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase. Blood 109(3), 862-867.
430. G Chan, D Kalaitzidis and BG Neel (2008) The tyrosine phosphatase Shp2 (PTPN11) in cancer. Cancer Metast Rev 27(2), 179-192.
431. MG Mohi and BG Neel (2007) The role of Shp2 (PTPN11) in cancer. Curr Opin Genet Dev 17(1), 23-30.
432. BD Gelb and M Tartaglia (2006) Noonan syndrome and related disorders: dysregulated RAS-mitogen activated protein kinase signal transduction. Hum Mol Genet 15 R220-R226.
433. M Bentires-Alj, MI Kontaridis and BG Neel (2006) Stops along the RAS pathway in human genetic disease. Nat Med 12(3), 283-285.
434. M Tartaglia, EL Mehler, R Goldberg, G Zampino, HG Brunner, H Kremer, et al. (2001) Mutations in PTPN11, encoding protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat Genet 29 465-468.
435. JA Noonan (1968) Hypertelorism with Turner phenotype. A new syndrome with associated congenital heart disease. Am J Dis Child 116(4), 373-380.
436. JA Noonan (1994) Noonan syndrome: an update and review for the primary pediatrician. Clin Pediatr 33 548-555.
437. JA Noonan (1999) Noonan syndrome revisited. J Pediatr 135 667-668.
438. MS Daoud, PR Dahl and WPD Su (1995) Noonan syndrome. Sem Dermatol 14 140-144.
439. SP Attard-Montalto, JE Kingston and T Eden (1994) Noonan’s syndrome and acute lymphoblastic leukemia. Med Pediatr Oncol 23 391-392.
440. B Bader-Meunier, G Tchernia, F Mielot, JL Fontaine, C Thomas, S Lyonnet, et al. (1997) Occurrence of myeloproliferative disorder in patients with Noonan syndrome. J Pediatr 130 885-889.
441. K Choong, MH Freedman, D Chitayat, EN Kelly, G Taylor and A Zipursky (1999) Juvenile myelomonocytic leukemia and Noonan Syndrome. J Pediatr Hematol Oncol 21 523-527.
442. KJ Klopfenstein, A Sommer and FB Ruymann (1999) Neurofibromatosis-Noonan syndrome and acute lymphoblastic leukemia: a report of two cases. J Pediatr Hematol Oncol 21 158-160.
443. S Schubbert, M Zenker, SL Rowe, S Boll, C Klein, G Bollag, et al. (2006) Germline KRAS mutations cause Noonan syndrome. Nat Genet 38(3), 331-336.
444. C Carta, F Pantaleoni, G Bocchinfuso, L Stella, I Vasta, A Sarkozy, et al. (2006) Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. Am J Hum Genet 79(1), 129-135.
445. AE Roberts, T Araki, KD Swanson, KT Montgomery, TA Schiripo, VA Joshi, et al. (2007) Germline gain-of-function mutations in SOS1 cause Noonan syndrome. Nat Genet 39(1), 70-74.
446. M Tartaglia, LA Pennacchio, C Zhao, KK Yadav, V Fodale, A Sarkozy, et al. (2007) Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Nat Genet 39(1), 75-79.
447. MA Razzaque, T Nishizawa, Y Komoike, H Yagi, M Furutani, R Amo, et al. (2007) Germline gain-of-function mutations in RAF1 cause Noonan syndrome. Nat Genet 39(8), 1013-1017.
448. B Pandit, A Sarkozy, LA Pennacchio, C Carta, K Oishi, S Martinelli, et al. (2007) Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. Nat Genet 39(8), 1007-1012.
449. M Tartaglia, CM Niemeyer, A Fragale, X Song, J Buechner, A Jung, et al. (2003) Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet 34 148-150.
450. ML Loh, S Vattikuti, S Schubbert, MG Reynolds, E Carlson, KH Lieuw, et al. (2004) Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis. Blood 103(6), 2325-2331.
451. ML Loh, MG Reynolds, S Vattikuti, RB Gerbing, TA Alonzo, E Carlson, et al. (2004) PTPN11 mutations in pediatric patients with acute myeloid leukemia: results from the Children’s Cancer Group. Leukemia 18(11), 1831-1834.
452. M Bentires-Alj, JG Paez, FS David, H Keilhack, B Halmos, K Naoki, et al. (2004) Activating mutations of the Noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Res 64(24), 8816-8820.
453. M Tartaglia, S Martinelli, G Cazzaniga, V Cordeddu, I Iavarone, M Spinelli, et al. (2004) Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia. Blood 104 307-313.
454. T Yamamoto, M Isomura, Y Xu, J Liang, H Yagasaki, Y Kamachi, et al. (2006) PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia. Leuk Res 30(9), 1085-1089.
455. S Martinelli, C Carta, E Flex, F Binni, EL Cordisco, S Moretti, et al. (2006) Activating PTPN11 mutations play a minor role in pediatric and adult solid tumors. Cancer Genet Cytogenet 166(2), 124-129.
456. T Sjoblom, S Jones, LD Wood, DW Parsons, J Lin, TD Barber, et al. (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314(5797), 268-274.
457. M Tartaglia, K Kalidas, A Shaw, X Song, DL Musat, I van der Burgt, et al. (2002) PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity. Am J Hum Genet 70 1555-1563.
458. K Kosaki, T Suzuki, K Muroya, T Hasegawa, S Sato, N Matsuo, et al. (2002) PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome. J Clin Endocrinol Metab 87(8), 3529-3533.
459. H Keilhack, FS David, M McGregor, LC Cantley and BG Neel (2005) Diverse biochemical properties of Shp2 mutants: implications for disease phenotypes. J Biol Chem 280 30,984-30,993.
460. D Miyamoto, M Miyamoto, A Takahashi, Y Yomogita, H Higashi, S Kondo, et al. (2008) Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors. Oncogene 27(25), 3508-3515.
461. B Chen, RT Bronson, LD Klaman, TG Hampton, JF Wang, PJ Green, et al. (2000) Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Nat Genet 24 296-299.
462. MK Webster and DJ Donoghue (1997) FGFR activation in skeletal disorders: too much of a good thing. Trends Genet 13 178-182.
463. T Araki, MG Mohi, FA Ismat, RT Bronson, IR Williams, JL Kutok, et al. (2004) Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. Nat Med 10(8), 849-857.
464. K Oishi, K Gaengel, S Krishnamoorthy, K Kamiya, I-K Kim, H Ying, et al. (2006) Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations. Hum Mol Genet 15 543-553.
465. RJ Chan, MB Leedy, V Munugalavadla, CS Voorhorst, Y Li, M Yu, et al. (2005) Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor. Blood 105(9), 3737-3742.
466. S Schubbert, K Lieuw, SL Rowe, CM Lee, X Li, ML Loh, et al. (2005) Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells. Blood 106(1), 311-317.
467. Y Ren, Z Chen, L Chen, NT Woods, GW Reuther, JQ Cheng, et al. (2007) Shp2E76K mutant confers cytokine-independent survival of TF-1 myeloid cells by up-regulating Bcl-XL. J Biol Chem 282(50), 36,463-36,473.
468. MC Digilio, E Conti, A Sarkozy, R Mingarelli, T Dottorini, B Marino, et al. (2002) Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene. Am J Hum Genet 71(2), 389-394.
469. E Legius, C Schrander-Stumpel, E Schollen, C Pulles-Heintzberger, M Gewillig and JP Fryns (2002) PTPN11 mutations in LEOPARD syndrome. J Med Genet 39(8), 571-574.
470. MI Kontaridis, KD Swanson, FS David, D Barford and BG Neel (2006) PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects. J Biol Chem 281(10), 6785-6792.
471. M Tartaglia, S Martinelli, L Stella, G Bocchinfuso, E Flex, V Cordeddu, et al. (2006) Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease. Am J Hum Genet 78(2), 279-290.
472. N Hanna, A Montagner, WH Lee, M Miteva, M Vidal, M Vidaud, et al. (2006) Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1. FEBS Letts 580(10), 2477-2482.
473. Oishi K, Zhang H, Gault WJ, Wang CJ, Tan CC, Kim IK, et al. Phosphatase-defective LEOPARD syndrome mutations in PTPN11 have gain-of-function effects during Drosophila development. Hum Mol Genet 2008. in press.
474. T Brummer, D Schramek, VM Hayes, HL Bennett, CE Caldon, EA Musgrove, et al. (2006) Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein. J Biol Chem 281(1), 626-637.
475. M Bentires-Alj, SG Gil, R Chan, ZC Wang, Y Wang, N Imanaka, et al. (2006) A role for the scaffolding adapter GAB2 in breast cancer. Nat Med 12(1), 114-121.
476. M Sattler, MG Mohi, YB Pride, LR Quinnan, NA Malouf, K Podar, et al. (2002) Critical role for Gab2 in transformation by BCR/ABL. Cancer Cell 1(5), 479-492.
477. J Chen, WM Yu, H Daino, HE Broxmeyer, BJ Druker and CK Qu (2007) SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl. Blood 109(2), 778-785.
478. M Scherr, A Chaturvedi, K Battmer, I Dallmann, B Schultheis, A Ganser, et al. (2006) Enhanced sensitivity to inhibition of SHP2, STAT5, and Gab2 expression in chronic myeloid leukemia (CML). Blood 107(8), 3279-3287.
479. HE Teal, S Ni, J Xu, LD Finkelstein, AM Cheng, RF Paulson, et al. (2006) GRB2-mediated recruitment of GAB2, but not GAB1, to SF-STK supports the expansion of Friend virus-infected erythroid progenitor cells. Oncogene 25(17), 2433-2443.
480. I Ischenko, O Petrenko, H Gu and MJ Hayman (2003) Scaffolding protein Gab2 mediates fibroblast transformation by the SEA tyrosine kinase. Oncogene 22(41), 6311-6318.
481. H Higashi, R Tsutsumi, S Muto, T Sugiyama, T Azuma, M Asaka, et al. (2002) SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 295 683-686.
482. R Tsutsumi, H Higashi, M Higuchi, M Okada and M Hatakeyama (2003) Attenuation of Helicobacter pylori CagA x SHP-2 signaling by interaction between CagA and C-terminal Src kinase. J Biol Chem 278(6), 3664-3670.
483. M Higuchi, R Tsutsumi, H Higashi and M Hatakeyama (2004) Conditional gene silencing utilizing the lac repressor reveals a role of SHP-2 in cagA-positive Helicobacter pylori pathogenicity. Cancer Sci 95(5), 442-447.
484. N Ohnishi, H Yuasa, S Tanaka, H Sawa, M Miura, A Matsui, et al. (2008) Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci USA 105(3), 1003-1008.
485. A Wickrema, F Chen, F Namin, T Yi, S Ahmad, S Uddin, et al. (1999) Defective expression of the SHP-1 phosphatase in polycythemia vera. Exp Hematol 27 1124-1132.
486. FA Asimakopoulos, S Hinshelwood, JG Gilbert, CC Delibrias, B Gottgens, DT Fearon, et al. (1997) The gene encoding hematopoietic cell phosphatase (SHP-1) is structurally and transcriptionally intact in polycythemia vera. Oncogene 14 1215-1222.
487. KJ Morgan and DG Gilliland (2008) A role for JAK2 mutations in myeloproliferative diseases. Annu Rev Med 59 213-222.
488. T Oka, T Yoshino, K Hayashi, N Ohara, T Nakanishi, Y Yamaai, et al. (2001) Reduction of hematopoietic cell-specific tyrosine phosphatase SHP-1 gene expression in nature killer cell lymphoma and various yypes of lymphomas/leukemias: combination analysis with cDNA expression array and tissue microarray. Am J Pathol 159 1495-1505.
489. F Leon, C Cespon, A Franco, M Lombardia, E Roldan, L Escribano, et al. (2002) SHP-1 Expression in peripheral T cells from patients with Sezary syndrome and in the T cell line HUT-78: implications in JAK3-mediated Signaling. Leukemia 16 1470-1477.
490. Q Zhang, PN Raghunath, E Vonderheid, N Odum and MA Wasik (2000) Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter. Am J Pathol 157(4), 1137-1146.
491. Nakase K, Cheng J, Zhu Q, Marasco WA. Mechanisms of SHP-1 P2 promoter regulation in hematopoietic cells and its silencing in HTLV-1-transformed T cells. J Leukoc Biol 2008. in press.
492. M Kurita-Taniguchi, A Fukui, K Hazeki, A Hirano, S Tsuji, M Matsumoto, et al. (2000) Functional modulation of human macrophages through CD46 (Measles Virus Receptor): production of IL-12 p40 and nitric oxide in association with recruitment of protein-tyrosine thosphatase SHP-1 to CD46. J Immunol 165 5143-5152.
493. IC Boulton and SD Gray-Owen (2002) Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes. Nat Immunol 3 229-236.
494. HS Lee, MA Ostrowski and SD Gray-Owen (2008) CEACAM1 dynamics during neisseria gonorrhoeae suppression of CD4+ T lymphocyte activation. J Immunol 180(10), 6827-6835.
495. N Tidow, B Kasper and K Welte (1999) SH2-containing protein tyrosine phosphatase SHP-1 and SHP-2 are dramatically increased at the protein level in neutrophils from patients with severe congenital neutropenia (Kostmann’s Syndrome). Exp Hematol 27 1038-1045.