Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

Journal of Experimental Medicine

Volumn 184, Issue 3, 1996, Pages 839-852

  Pani, Giovanni ^a,b   Fischer, Klaus Dieter ^a   Mlinaric Rascan, Irena ^a   Siminovitch, Katherine A ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL MATURATION; CONTROLLED STUDY; DEPHOSPHORYLATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; T LYMPHOCYTE; THYMOCYTE;

EID: 0029787216     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.3.839     Document Type: Article

References (53)

1. Weiss, A., and D.R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell. 76:263-274.
2. Chan, A.C., N.S.C. van Oers, A. Tran, L. Turka, C.-L. Law, J.C. Ryan, E.A. Clark, and A. Weiss. 1994. Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J. Ininiiinol. 152:4758-1766.
3. Ho\ve, L.R., and A. Weiss. 1995. Multiple kinases mediate T-cell receptor signalling. Trends Bioclicni. Sei. 20:59-64.
4. Irving, U.A., and A. Weiss. 1991. The cytoplasmic domain of the T cell receptor £-chain is sufficient to couple to receptorassociated signal transduction pathways. Cell. 64:891-901.
5. Sancho, L., R. Franco, T. Chatila, C. Hall, and C. Terhorst. 1993. The T cell receptor associated CD3-e protein is phosphorylated upon T cell activation in the two tyrosine residues of a conserved signal transduction motif. Enr.J. Inmmnol. 23: 1636-1642.
6. Wange, R.L., S.N. Malek, S. Desiderio, and L.E. Samelson. 1993. Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor £and CD3e from activated Jurkat T cells. J. Biol. Client. 268:19797-19801.
7. Neumeister, E.N., Y. Zlui, S. Richard, C. Terhorst, A.C. Chan, and A.S. Shaw. 1995. Binding of ZAP-70 to phosphorylated T-cell receptor £and T| enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins. Mol. Cell. Biol. I5:3171-3178.
8. Nishibe, S., M.I. Wahl, S.M.T. Hernandez-Sotomayor, N.K. Tonks, S.G. Rhee, and G. Carpenter. 1990. Increase of the catalytic activity of phospholipase C-'yl by tyrosine phosphorylation. Science (Wash. DC). 250:1253-1256.
9. Reif, K., L. Buday.J. Downward, and D.A. Cantrell. 1994. SH3 domains of the adaptor molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases. J. Biol. Client. 269:14081-14087. . ,;
10. Rozakis-Adcock, M.,J. McGlade, G. Mbamalu, G. Pellicci, R. Daly, W. Li, A. Batzer, S. Thomas, J. Brugge, P-G. Pellicci, and A. Pawson. 1992. Association of the She and Grb2/Seni5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature (Loud.). 360: 689-692.
11. Koretzky, G.A.J. Picus, M.L. Thomas, and A. Weiss. 1990. Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway. Nature (Land.). 346:66-68.
12. McFarland, E.D., T.R. Hurley, J.T. Pingel, B.M. Sefton, A. Shaw, and M.L. Thomas. 1993. Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor. Pwc. Natl. AcaiL Sei. USA. 90:1402-1406.
13. Kishihara, K., J. Penning, V.A. Wallace, T.M. Kundig, K. Kawai, A. Wakehani, E. Timms, K. Pfeffer, P.S. Ohashi, M.L. Thomas, et al. 1993. Normal B cell development but impaired T cell maturation in CD45-exon 6 protein tyrosine phosphatase-deficient mice. Cell. 74:143-156.
14. Secrist.J.P., L.A. Burns, L. Karnitz, G.A. Koretzky, and R.T. Abraham. 1993. Stimulatory effect of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events. J. Bid. Clicni. 268:5886-5893.
15. Pani, G.', M. Kozlowski, J.C. Cambier, G.B. Mills, and K.A. Siminovitch. 1995. Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signalling./ E.\p. Mcd. 181: 2077-2084.
16. Cyster, J.G., and C.C. Goodnow. 1995. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signalling in B lymphocytes and determines thresholds for negative selection. Immunity. 2:13-24.
17. Doody, G.M., L.B. Justement, C.C. Delibrias, K.J. Matthews, J. Lin, M.L. Thomas, and D.T. Fearon. 1995. A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. Science (Wash. DC). 269:242-244.
18. D'Ambrosio, D., K.L. Hippen, S.A. MinskofF, I. Mellman, G. Pani, K.A. Siminovitch, and J.C. Gambier. 1995. Recruitment and activation of PTP1C in negative regulation of antigen receptor signalling by Fc gammaRIIl. Science (Wash. DC). 268:293-297.
19. Klingmnller, U., U. Lorenz, L.C. Cantley, B.C. Neel, and H.F. Lodish. 1995. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of Jak2 and termination of proliferative signals. Cell. 80:729-738.
20. Yi, T., A.F.-F. Mui, G. Krystal, and J.N. Ihle. 1993. Haemopoietïc cell phosphatase associates with the interleukin (IL-3) receptor chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis. AA'J. Cell I3iol. 13: 7577-7586.
21. Kozlowski, M., I. Mlinaric-Rascan, G.S. Feng, R. Shen, T. Pawson, and K.A. Siminovitch. 1993. Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J. Exp. Med. 178:2157-2163.
22. Shultz, L.D., P.A. Schweitzer, T.V. Rajan, T. Yi, J.N. Ihle, R.J. Matthews, M.L. Thomas, and D.R. Beier. 1993. Mutations at the iiiurine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hep) gene. Cell. 73:1445-1454.
23. Margolis, B., P. Hu, S. Kutzav, W. Li, J.M. Oliver, A. Ullrich, A. Weiss, andj. Schlessinger. 1992. Tyrosine phosphorylation of Vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature (Loud.). 356:71-74.
24. Ria, F., D.M. Chan, M.T. Scherer, J.A. Smith, and M.L. Gefter. 1990. Immunological activity of covalently linked T cell epitopes. Nature (Loud.). 343:381-383.
25. Koo, G.G., H. Rosen, A. Sirotina, X.D. Ma, and L.D. Shultz. 1993. Anti-CDllb antibody prevents immunopathologic changes in viable niotheaten bone marrow chimeric mice.J. Illuminai. 151:6733-6741.
26. Medlock, E.S., I. Goldschneider, D.L. Greiner, and L. Shultz. 1987. Defective lymphopoiesis in the bone marrow of niotheaten (me/me) and viable niotheaten (mrv//Hfv) mice. II. Description of a micro-environmental defect for the generation of terminal deoxynucleotidyl-transferase-positive bone marrow cells in vitro. J. Immune]. 138:3590-3597.
27. Hayashi, S.-I., P.L. Witte, L.D. Shultz, and P.W. Kincade. 1988. Lymphohaemopoiesis in culture is prevented by interaction with adherent bone marrow cells from mutant viable niotheaten mice.J. Iiiiiiiiinol. 140:2139-2147.
28. Davies, A.A., S.C. Ley, and MJ. Crumpton. 1992. CDS is phosphorylated on tyrosine after stimulation of the T-cell antigen receptor complex. Proc. Natl. Acad. Sei. USA. 89:63686372.
29. Osman, N., A.I. Lazarovits, and MJ. Crumpton. 1993. Physical association of CD5 and the T cell receptor/CD3 antigen complex on the surface of human T lymphocytes. Enr.J. Immuiiol. 23:1173-1176.
30. Raab, M., M. Yamamoto, and C.E. Rudd. 1994. The T-cell antigen CDS acts as a receptor and substrate for the proteintyrosine kinase p56kk. Mol. Cell Biol. 14:2862-2870.
31. Kon-Kozlowski, M., G. Pani, T. Pawson, and K.A. Siminovitch. 1996. The tyrosine phosphatase PTP1C associates with Vav, Grb2 and mSosl in haematopoietic cells. J. Biol. Clicin. 271:3856-3862.
32. Gulbins, E., R.M. Coggeshall, G. Baier, S. Katzav, P. Bum, and A. Altman. 1993. Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation. Science (Wash. DC). 260:822-825.
33. Fischer, K.-D., A. Zmudinas, S. Gardner, M. Barbacid, A. Bernstein, and C. Guidos. 1995. Defective T-cell receptor signalling and positive selection of Vav-deficient CDCD8+ thymocytes. Nature (Loud.). 374:474-476.
34. Tarakhovsky, A., M. Turner, S. Schaal, P.J. Mee, L.P. Duddy, K. Rajewsky, and V.L.I. Tybulewicz. 1995. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature (Loud.). 374:467-470.
35. Lowenstein, E.J., RJ. Daly, A.G. Batzer, W. Li, B. Margolis, R. Lammers, A. Ullrich, E.Y. Skolnik, D. Bar-Sagi, and J. Schlessinger. 1993. Guanine-nucleotide-releasing factor hSosl binds to Grb2 and links receptor kinases jto Ras signaling. Nature (Loud.). 363:85-87.
36. Egan, S.E., B.W. Giddings, M.W. Brooks, L. Buday, A.M. Siz.eland, and R.A. Weinberg. 1993. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature (Loud.). 363: 45-51.
37. Gale, N.N., S. Kaplan, EJ. Lowenstein, J. Schlessinger, and P. Bar-Sagi. 1993. Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Nature (Loud.). 363:88-92.
38. Katzav, S., M. Sutherland, G. Packham, T. Yi, and A. Weiss. 1994. The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav. J. Biol. Clmu. 269:3257932585.
39. Buday, L., S.E. Egan, P. Rodriguez Viciana, O.A. Cantrell, and J. Downward. 1994. A complex of Grb2 adaptor protein, Sos exchange factor and a 36-kDa membrane bound tyrosine phosphoprotein is implicated in Ras activation in T cells. J. Bhl. Chcm. 12:9019-9023.
40. Sieh, M., A. Batzer, J. Schlessinger, and A. Weiss. 1994. Grb-2 and phospholipase C-"yl associate with a 36-38-kilodaIton phosphotryosine protein after T-cell receptor stimulation. Mol. Cell Dial. 14:4435-4442.
41. Nel, A.E., S. Gupta, L. Lee, J.A. Ledbetter, and S. Kanner. 1995. Ligation of the T-cell antigen receptor (TCR) induces association of hSosl, ZAP-70, phospholipase C-"yl, and other phosphoproteins with Grb2 and the C-chain of the TCR.J. Biol. Chcm. 270:18428-18436.
42. Buday, L., P.H. Warne, andj. Downward, 1995. Downregulation of the Ras activation pathway by MAP kinase phosphorylation of SoS. Oncogcne. 11:1327-1371.
43. Huang, X., Y. Lui, K. Tanaka, K.G. Moore, and J.I. Hayashi. 1995. Cloning and characterization of Ink, a novel signal transduction protein that links T cell receptor activation signal to PLC-yl, Grb2 and PI3-kinase. Pivc. A7,;/J. AcaA. Sei. USA. '. 92:11618-11622.
44. Seger, R., and E. Krebs. 1995. The MAPK signaling cascade. PA'SEB (Pcd. Am. Soc. Exp. Biol.)J. 9:726-735.
45. Swan, K.A., J. Alberola-Illa, J.A. Gross, M.W. Appleby, K.A. Forbush, J.F. Thomas, and R.M. Perlmutter. 1995. Involvement of p21 Ras distinguishes positive and negative selection in thymocytes. EMBO (Eur. Mol. Biol. Organ.) J. 14:276-285.
46. Alberola-Illa, J., K.A. Forbursh, R. Seger, E.G. Krebs, and R.M. Perlmutter. 1995. Selective requirement for MAP kinase activation in thymocyte differentation. Nature (Land.). 373:620-623.
47. Plas, D.R., R.Johnson,J.T. Pingel, R.J. Matthews, M. Dalton, G. Roy, A.C. Chan, and M.L. Thomas. 1996. Direct regulation of Zap-70 by SHP-1 in T cell antigen receptor signaling. Science (Wash. DC). 272:1173-1176.
48. Tarakhovsky, A., S.B. Kanner, J. Hombach, J.A. Ledbetter, W. Müller, N. Killeen, and K. Rajewsky. 1995. A role for CDS in TCR-mediated signal transduction and thymocyte selection. Science (Wash. DC). 269:535-537.
49. Wu, Y., G. Pani, K.A. Siminovitch, and N. Hozumi. 1995. Antigen receptor-triggered apoptosis in immature B cell lines is associated with the binding of a 44-kDa phosphoprotein to the PTP1C tyrosine phosphatase. Eur. J. Iiiiiiiiinol. 25:22792284.
50. Bignon, J.S., and K.A. Siminovitch. 1994. Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatase in the regulation of haemopoietic cell differentiation and function. Clin. Iiiwiwiol. Iiiiiininopiilli. 73:168-179.
51. Li, W., R. Nishimura, A. Kashian, A.C. Batzer, W.J. Kirn, J.A. Cooper, and J. Schlessinger. 1994. A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol. Cell Biol. 14:509-517.
52. Pelicci, G., L. Lanfrancone, F. Grignani,J. McGIade, F. Cavallo, G. Forni, I. Nicoletti, J. Pawson, and P.G. Pelicci. 1992. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell. 70:93-104.
53. Ye, Z.S., and D. Baltimore. 1994. Binding of Vav to Grb-2 through dimerization of Src homology 3 domains. Proc. i\'atl. Acfid. Sei. USA. 91:12629-12633.