Role of Gab l in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen- activated protein kinase activation

Molecular and Cellular Biology

Volumn 20, Issue 10, 2000, Pages 3695-3704

  Itoh, Motoyuki ^a,b   Yoshida, Yuichi ^a   Nishida, Keigo ^a   Narimatsu, Masahiro ^a   Hibi, Masahiko ^a   Hirano, Toshio ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; CYTOKINE RECEPTOR; GAB1 PROTEIN, MOUSE; GLYCOPROTEIN GP 130; GROWTH PROMOTOR; IL6ST PROTEIN, MOUSE; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; PHOSPHOPROTEIN;

ARTICLE; EMBRYO; ENZYME ACTIVATION; ENZYME ANALYSIS; HEART DEVELOPMENT; MOUSE; NONHUMAN; PLACENTA DEVELOPMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; SKIN; ANIMAL; GENETICS; HEART; HEART MUSCLE; HETEROZYGOTE; HOMOZYGOTE; LETHAL GENE; METABOLISM; MOUSE MUTANT; PATHOLOGY; PLACENTA; PRENATAL DEVELOPMENT;

ANIMALS; ANTIGENS, CD; CYTOKINE RECEPTOR GP130; CYTOKINES; ENZYME ACTIVATION; GENES, LETHAL; GROWTH SUBSTANCES; HEART; HETEROZYGOTE; HOMOZYGOTE; MEMBRANE GLYCOPROTEINS; MICE; MICE, MUTANT STRAINS; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIUM; PHOSPHOPROTEINS; PLACENTA; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION; SKIN;

EID: 0033624921     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.10.3695-3704.2000     Document Type: Article

References (40)

1. Baker, J., J. P. Liu, E. J. Robertson, and A. Efstratiadis. 1993. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75:73-82.
2. Bennett, A. M., T. L. Tang, S. Sugimoto, C. T. Walsh, and B. G. Neel. 1994. Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras. Proc. Natl. Acad. Sci. USA 91:7335-7339.
3. Bladt, F., D. Riethmacher, S. Isenmann, A. Aguzzi, and C. Birchmeier. 1995. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 376:768-771.
4. Cheng, A. M., T. M. Saxton, R. Sakai, S. Kulkarni, G. Mbamalu, W. Vogel, C. G. Tortorice, R. D. Cardiff, J. C. Cross, W. J. Muller, and T. Pawson. 1998. Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell 95:793-803.
5. Daub, H., C. Wallasch, A. Lankenau, A. Herrlich, and A. Ullrich. 1997. Signal characteristics of G protein-transactivated EGF receptor. EMBO J. 16:7032-7044.
6. Fukada, T., M. Hibi, Y. Yamanaka, M. Takahashi-Tezuka, Y. Fujitani, T. Yamaguchi, K. Nakajima, and T. Hirano. 1996. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity 5:449-460.
7. Gu, H., J. C. Pratt, S. J. Burakoff, and B. G. Neel. 1998. Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Mol. Cell 2:729-740.
8. Heldin, C. H. 1995. Dimerization of cell surface receptors in signal transduction. Cell 80:213-223.
9. Herbst, R., P. M. Carroll, J. D. Allard, J. Schilling, T. Raabe, and M. A. Simon. 1996. Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling. Cell 85: 899-909.
10. Higuchi, O., K. Mizuno, G. F. Vande Woude, and T. Nakamura. 1992. Expression of c-met proto-oncogene in COS cells induces the signal transducing high-affinity receptor for hepatocyte growth factor. FEBS Lett. 301: 282-286.
11. Hirano, T., K. Nakajima, and M. Hibi. 1997. Signaling mechanisms through gp130: a model of the cytokine system. Cytokine Growth Factor Rev. 8:241-252.
12. Holgado-Madruga, M., D. R. Emlet, D. K. Moscatello, A. K. Godwin, and A. J. Wong. 1996. A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature 379:560-554.
13. Holgado-Madruga, M., D. K. Moscatello, D. R. Emlet, R. Dieterich, and A. J. Wong. 1997. Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor. Proc. Natl. Acad. Sci. USA 94:12419-12424.
14. Ihle, J. N. 1996. STATs: signal transducers and activators of transcription. Cell 84:331-334.
15. Karlsson, L., C. Bondjers, and C. Betsholtz. 1999. Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Development 126:2611-2621.
16. Leveen, P., M. Pekny, S. Gebre-Medhin, B. Swolin, E. Larsson, and C. Betsholtz. 1994. Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities. Genes Dev. 8:1875-1887.
17. Li, W., R. Nishimura, A. Kashishian, A. G. Batzer, W. J. H. Kim, J. A. Cooper, and J. Schlessinger. 1994. A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol. Cell. Biol. 14:509-517.
18. Luetteke, N. C., T. H. Qiu, R. L. Peiffer, P. Oliver, O. Smithies, and D. C. Lee. 1993. TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell 73:263-278.
19. Maina, F., F. Casagranda, E. Audero, A. Simeone, P. M. Comoglio, R. Klein, and C. Ponzetto. 1996. Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. Cell 87:531-542.
20. Mann, G. B., K. J. Fowler, A. Gabriel, E. C. Nice, R. L. Williams, and A. R. Dunn. 1993. Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell 73:249-261.
21. Mountford, P., B. Zevnik, A. Duwel, J. Nichols, M. Li, C. Dani, M. Robertson, I. Chambers, and A. Smith. 1994. Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression. Proc. Natl. Acad. Sci. USA 91:4303-4307.
22. Murakami, H., T. Iwashita, N. Asai, Y. Shimono, Y. Iwata, K. Kawai, and M. Takahashi. 1999. Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by Ret with the MEN 2B mutation. Biochem. Biophys. Res. Commun. 262:68-75.
23. Nakajima, K., Y. Yamanaka, K. Nakae, H. Kojima, M. Ichiba, N. Kiuchi, T. Kitaoka, T. Fukada, M. Hibi, and T. Hirano. 1996. A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. EMBO J. 15:3651-3658.
24. Nishida, K., Y. Yoshida, M. Itoh, T. Fukada, T. Ohtani, T. Shirogane, T. Atsumi, M. Takahashi-Tezuka, K. Ishihara, M. Hibi, and T. Hirano. 1999. Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. Blood 93:1809-1816.
25. Ohlsson, R., P. Falck, M. Hellstrom, P. Lindahl, H. Bostrom, G. Franklin, L. Ahrlund-Richter, J. Pollard, P. Soriano, and C. Betsholtz. 1999. PDGFB regulates the development of the labyrinthine layer of the mouse fetal placenta. Dev. Biol. 212:124-136.
26. Pawson, T., and J. D. Scott. 1997. Signaling through scaffold, anchoring, and adaptor proteins. Science 278:2075-2080.
27. Raabe, T., J. Riesgo-Escovar, X. Liu, B. S. Bausenwein, P. Deak, P. Maroy, and E. Hafen. 1996. DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila. Cell 85:911-920.
28. Rozakis-Adcock, M., J. McGlade, G. Mbamalu, G. Pelicci, R. Daly, W. Li, A. Batzer, S. Thomas, J. Brugge, P. G. Pelicci, J. Schlessinger, and T. Pawson. 1992. Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature 360:689-692.
29. Saxton, T. M., M. Henkemeyer, S. Gasca, R. Shen, D. J. Rossi, F. Shalaby, G. S. Feng, and T. Pawson. 1997. Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J. 16:2352-2364.
30. Schmidt, C., F. Bladt, S. Goedecke, V. Brinkmann, W. Zschlesche, M. Sharpe, E. Gherardi, and C. Birchmeier. 1995. Scatter factor/hepatocyte growth factor is essential for liver development. Nature 373:699-702.
31. Shi, Z. Q., W. Lu, and G. S. Feng. 1998. The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases. J. Biol. Chem. 273:4904-4908.
32. Soriano, P. 1994. Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes Dev. 8:1888-1896.
33. Takahashi-Tezuka, M., Y. Yoshida, T. Fukada, T. Ohtani, Y. Yamanaka, K. Nishida, K. Nakajima, M. Hibi, and T. Hirano. 1998. Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase. Mol. Cell. Biol. 18:4109-4117.
34. Threadgill, D. W., A. A. Dlugosz, L. A. Hansen, T. Tennenbaum, U. Lichti, D. Yee, C. LaMantia, T. Mourton, K. Herrup, R. C. Harris, J. A. Barnard, S. H. Yuspa, R. J. Coffey, and T. Magnuson. 1995. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269:230-234.
35. Uehara, Y., O. Minowa, C. Mori, K. Shiota, J. Kuno, T. Noda, and N. Kitamura. 1995. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature 373:702-705.
36. Ware, C. B., M. C. Horowitz, B. R. Renshaw, J. S. Hunt, D. Liggitt, S. A. Koblar, B. C. Gliniak, H. J. McKenna, T. Papayannopoulou, B. Thoma, L. Cheng, P. J. Donovan, J. J. Peschon, P. F. Bartlett, C. R. Willis, B. D. Wright, M. K. Carpenter, B. L. Davison, and D. P. Gearing. 1995. Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. Development 121:1283-1299.
37. Weidner, K. M., S. Di Cesare, M. Sachs, V. Brinkmann, J. Behrens, and W. Birchmeier. 1996. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 384:173-176.
38. Wickrema, A., S. Uddin, A. Sharma, F. Chen, Y. Alsayed, S. Ahmad, S. T. Sawyer, G. Krystal, T. Yi, K. Nishada, M. Hibi, T. Hirano, and L. C. Platanias. 1999. Engagement of Gab1 and Gab2 in erythropoietin signaling. J. Biol. Chem. 274:24469-24474.
39. Wong, L., and G. R. Johnson. 1996. Epidermal growth factor induces coupling of protein-tyrosine phosphatase 1D to GRB2 via the COOH-terminal SH3 domain of GRB2. J. Biol. Chem. 271:20981-20984.
40. Zhao, C., D. H. Yu, R. Shen, and G. S. Feng. 1999. Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1. J. Biol. Chem. 274:19649-19654.