Inhibition of IFN-α signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 29, 2005, Pages 10267-10272

  Du, Zhimei ^a   Shen, Yuhong ^c   Yang, Wentian ^d   Mecklenbrauker, Ingrid ^c   Neel, Benjamin G ^d   Ivashkiv, Lionel B ^a,b  

^a Weill Cornell Graduate School of Biomedical Sciences   (United States)

^b HOSPITAL FOR SPECIAL SURGERY   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Interferon; Macrophage; Stat

Indexed keywords

ALPHA INTERFERON; ALPHA INTERFERON RECEPTOR; CYTOKINE; FC RECEPTOR; JANUS KINASE; PHOSPHATASE; PROTEIN KINASE C; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; PROTEIN TYROSINE PHOSPHATASE SHP 2; STAT PROTEIN; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; ENZYME ACTIVITY; GENE ACTIVATION; GENE EXPRESSION; GROWTH REGULATION; IMMUNOMODULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INTERFERON-ALPHA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE GLYCOPROTEINS; MICE; MICROSCOPY, CONFOCAL; NIH 3T3 CELLS; PROTEIN KINASE C; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTORS, CELL SURFACE; RECEPTORS, FC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 22544474648     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0408854102     Document Type: Article

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