Tyrosyl Phosphorylation of Shp2 Is Required for Normal ERK Activation in Response to Some, but Not All, Growth Factors

Journal of Biological Chemistry

Volumn 278, Issue 43, 2003, Pages 41677-41684

  Araki, Toshiyuki ^a   Nawa, Hiroyuki ^b   Neel, Benjamin G ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; ENZYME KINETICS; GROWTH KINETICS; MUTAGENESIS; PROTEINS;

MULTIPLE RECEPTORS;

BIOCHEMISTRY;

EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; GROWTH FACTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; RETROVIRUS VECTOR; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

3T3 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BINDING SITES; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTORS; GRB2 ADAPTOR PROTEIN; GROWTH SUBSTANCES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN-TYROSINE-PHOSPHATASE; PROTEINS; SOMATOMEDINS; TYROSINE;

ANIMALIA; UNIDENTIFIED RETROVIRUS;

EID: 0142211311     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306461200     Document Type: Article

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