A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Cell

Volumn 89, Issue 5, 1997, Pages 693-702

  Kouhara, H ^a   Hadari, Y R ^a   Spivak Kroizman, T ^a   Schilling, J ^b   Bar Sagi, D ^c   Lax, I ^a   Schlessinger, J ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b SUGEN INC   (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; DNA SYNTHESIS; EMBRYO; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0030706168     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80252-4     Document Type: Article

References (29)

1. Bar-Sagi, D., and Feramisco, J.R. (1985). Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. Cell 42, 841-848.
2. Basilico, C., and Moscatelli, D. (1992). The FGF family of growth factors and oncogenes. Adv. Cancer Res. 59, 115-165.
3. Batzer, A.G., Rotin, D., Ureña, J.M., Skolnik, E.Y., and Schlessinger, J. (1994). Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. Mol. Cell. Biol. 14, 5192-5201.
4. Blaikie, P., Immanuel, D., Wu, J., Li, N., Yajnik, V., and Margolis, B. (1994). A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. J. Biol. Chem. 269, 32031-32034.
5. Borg, J.P., Ooi, J., Levy, E., and Margolis, B. (1996). The Pl domain of X11 and FE65 bind to distinct site on the YENPTY motif of amyloid precursor protein. Mol. Cell. Biol., 16, 6229-6241.
6. Clark, S.G., Stern, M.J., and Horvitz, H.R. (1992). C. elegans cell-signaling gene Sem-5 encodes a protein with SH2 and SH3 domains Nature 356, 340-344.
7. Dikic, I., Tokiwa, G., Lev, S., Courtneidge, S.A., and Schlessinger, J. (1996). A role for Pyk2 and Src in linking G protein coupled receptor with MAP kinase activation. Nature 383, 547-550.
8. Goh, K.C., Lim, Y.P., Ong, S.H., Siak, C.B., Cao, X., Tan, Y.H., and Guy, G.R. (1996). Identification of p90, a prominent tyrosine-phosphorylated protein in fibroblast growth factor-stimulated cells, as 80K-H. J. Biol. Chem. 277, 5832-5838.
9. Gustafson, T.A., He, W., Craparo, A., Schaub, C.D., and O'Neill, T.J. (1995). Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol. Cell. Biol. 15, 2500-2508.
10. Inglese, J., Glickman, J.F., Lorenz, W., Caron, M.G., and Lefkowitz, R.J. (1992). Isoprenylation of a protein kinase. Requirement of farnesylation/α-carboxyl methylation for full enzymatic activity of rhodopsin kinase. J. Biol. Chem. 267, 1422-1425.
11. Jaye, M., Schlessinger, J., and Dionne, C.A. (1992). Fibroblast growth factor receptor tyrosinekinases: molecular analysis and signal transduction. Biochim. Biophys. Acta. 1135, 185-199.
12. Kavanaugh, W.M., and Williams, L.T. (1994). An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. Science 266, 1862-1865.
13. Lemmon, M.A., Ferguson, K.M., and Schlessinger, J. (1996). PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell 85, 621-624.
14. Lowenstein, E.J., Daly, R.J., Batzer, A.G., Li, W., Margolis, B., Lammers, R., Ullrich, A., Skolnik, E.Y., Bar-Sagi, D., and Schlessinger, J. (1992). The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 70, 431-442.
15. Milligan, G., Parenti, M., and Magee, A.I. (1995). The dynamic role of palmitoylation in signal transduction. Trends Biochem. Sci. 20, 181-186.
16. Mohammadi, M., Honegger, A.M., Rotin, D., Fischer, R., Bellot, F., Li, W., Dionne, C.A., Jaye, M., Rubinstein, M., and Schlessinger, J. (1991). A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-γ1. Mol. Cell. Biol. 11, 5068-5078.
17. Mohammadi, M., Dionne, C.A., Li, W., Li, N., Spivak, T., Honegger, A.M., Jaye, M., and Schlessinger, J. (1992). Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Nature 358, 681-684.
18. Mohammadi, M., Dikic, I., Sorokin, A., Burgess, W.H., Jaye, M., and Schlessinger, J. (1996). Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction. Mol. Cell. Biol. 16, 977-989.
19. Noda, M., Ko, M., Ogura, A., Liu, D.-g., Amano, T., Takano, T., and Ikawa, Y. (1985). Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line. Nature 318, 73-75.
20. O'Neill, T.J., Craparo, A., and Gustafson, T.A. (1994). Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two hybrid system. Mol. Cell. Biol. 14, 6433-6442.
21. Pawson, T., and Schlessinger, J. (1993). SH2 and SH3 domains. Curr. Biol. 3, 434-442.
22. 2+ flux but not mitogenesis. Nature 358, 678-681.
23. βγ, subunits and lipid. J. Biol. Chem. 270, 11707-11710.
24. Rabin, S.J., Cleghon, V.,and Kaplan, D.R. (1993). SNT, a differentiation specific target of neurotrophic factor-induced tyrosine kinase activity in Neurons and PC12 cells. Mol. Cell. Biol. 13, 2203-2213.
25. Resh, M.D. (1994). Myristylation and palmitylation of Src family members: the fats of the matter. Cell 76, 411-413.
26. Schlessinger, J. (1994). SH2/SH3 signaling proteins. Curr. Opin. Genet. Dev. 4, 25-30.
27. Schlessinger, J., Lax, I., and Lemmon, M. (1995). Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors? Cell 83, 357-360.
28. Skolnik, E.Y., Batzer, A., Li, N., Lee, C.-H., Lowenstein, E., Mohammadi, M., Margolis, B., and Schlessinger, J. (1993). The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Science 260, 1953-1955.
29. Vihinen, M., Zvelebil, M.J., Zhu, Q., Brooimans, R.A., Ochs, H.D., gres, B.J., Nilsson, L., Waterfield, M.D., and Smith, C.I.E. (1995). Structural basis for pleckstrin homology domain mutations in X-linked agammaglobulinemia. Biochemistry 34, 1475-1481.