Targeting Src homology 2 domain-containing tyrosine phosphatase (SHP-1) into lipid rafts inhibits CD3-induced T cell activation

Journal of Immunology

Volumn 166, Issue 6, 2001, Pages 3975-3982

  Su, M W C ^a   Yu, C L ^a   Burakoff, S J ^a   Jin, Y J ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD45 ANTIGEN; LIPID; PROTEIN TYROSINE PHOSPHATASE; SUCROSE;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DENSITY GRADIENT; ENZYME ACTIVITY; ENZYME REGULATION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOCYTE MEMBRANE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 0035869308     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.6.3975     Document Type: Article

References (43)

1. Tyrosine kinases and tyrosine-based activation motifs: Current research on activation via the T cell antigen receptor
2. Complex complexes: Signaling at the TCR
3. The ζ-chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein
4. ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCRζ chain
5. The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation
6. Integration of T cell receptor-dependent signaling pathways by adapter proteins
7. Adapter proteins in lymphocyte antigen-receptor signaling
8. T cell antigen-receptor signal transduction
9. T cell antigen receptor signal transduction pathways
10. Membrane compartmentation and the response to antigen
11. T lymphocyte costimulation mediated by reorganization of membrane microdomains
12. Engagement of GPI-linked CD48 contributes to TCR signals and cytoskeletal reorganization: A role for lipid rafts in T cell activation
13. Membrane rafts and signaling by the multichain immune recognition receptors
14. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
15. The glycophosphatidylinositol-anchored Thy-1 molecule interacts with the p60fyn protein tyrosine kinase in T cells
16. fyn
17. GPI-anchored cell-surface molecules complexed to protein tyrosine kinases
18. Signal transduction and glycophosphatidylinositol-linked proteins (lyn, lck, CD4, CD45, G proteins, and CD55) selectively localize in Triton-insoluble plasma membrane domains of human leukemic cell lines and normal granulocytes
19. Phorbol ester-induced disruption of the CD4-Lck complex occurs within a detergent-resistant microdomain of the plasma membrane: Involvement of the translocation of activated protein kinase C isoforms
20. Membrane compartmentation is required for efficient T cell activation
21. lck associated with glycolipid-enriched membrane domains
22. CD45: An emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development
23. The emerging field of receptor-mediated inhibitory signaling: SHP or SHIP?
24. Role of phosphatases in lymphocyte activation
25. Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness
26. Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase
27. TCR signaling thresholds regulating T cell development and activation are dependent upon SHP-1
28. A new function for a phosphotyrosine phosphatase: Linking GRB2-Sos to a receptor tyrosine kinase
29. The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development
30. Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3′-kinase
31. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4
32. Molecular basis of T cell inactivation by CTLA-4
33. Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases
34. Regulation of tyrosine phosphorylation in isolated T cell membrane by inhibition of protein tyrosine phosphatases
35. Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling
36. lck phosphorylation and ZAP-70 binding to T cell receptor ζ-chain
37. CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: Involvement of SH2-containing phosphotyrosine phosphatase SHP-1
38. Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells
39. High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages
40. A family of proteins that inhibit signalling through tyrosine kinase receptors
41. Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2
42. Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins
43. Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs