Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling

Molecular Cell

Volumn 8, Issue 4, 2001, Pages 759-769

  Lu, Wei ^a   Gong, Delquin ^b   Bar Sagi, Dafna ^b   Cole, Philip A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHONIC ACID DERIVATIVE; PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE; TYROSINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0034758469     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00369-0     Document Type: Article

References (56)

1. Recruitment of the protein-tyrosine phosphatase SHP-2 to the C-terminal tyrosine of the prolactin receptor and to the adaptor protein Gab2
2. Structurally modified firefly luciferase. Effects of amino acid substitution at position 286
3. Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression
4. Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras
5. The role of SHP-2 in MAPK activation by leptin receptors
6. Preparation of 4-[bis(tert-butoxy)phosphorylmethyl]-N-(fluoren-9-ylmethoxycarbonyl)-DL- phenylalanine. A hydrolytically stable analog of O-phosphotyrosine potentially suitable for peptide synthesis
7. Nonhydrolyzable phosphotyrosyl mimetics for the preparation of phosphatase-resistant SH2 domain inhibitors
8. Protein-tyrosine phosphatases: Structure, mechanism, and inhibitor discovery
9. SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells
10. Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1
11. Substrate specificities of catalytic fragments of protein tyrosine phosphatases (HPTPb, LAR, and CD45) toward phosphotyrosylpeptide substrates and thiophosphorylated peptides as inhibitors
12. Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway
13. Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo
14. Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2
15. Semisynthesis of cytotoxic proteins using a modified protein splicing element
16. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases
17. Identification of a human src homology 2-containing protein-tyrosine-phosphatase: A putative homolog of Drosophila corkscrew
18. Binding of SHP-2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
19. Crystal structure of the tyrosine phosphatase SHP-2
20. Signaling-2000 and beyond
21. Use of the two hybrid system to detect the association of the protein-tyrosine-phosphatase, SHPTP2, with another SH2-containing protein, Grb7
22. The stress response to ionizing radiation involves c-Abl-dependent phosphorylation of SHPTP1
23. Identification of a putative Syp substrate, the PDGF beta receptor
24. Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor
25. Genetic basis of hypo-responsiveness of A/J mice to interleukin-3
26. A new function for phosphotyrosine phosphatase: Linking Grb2-Sos to a receptor tyrosine kinase
27. Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2
28. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
29. Expressed protein ligation: A general method for protein engineering
30. Protein tyrosine phosphatases in signal transduction
31. A general method for site-specific incorporation of unnatural amino acids into proteins
32. Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction
33. Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps
34. Corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso
35. Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains
36. Src homology domain 2-containing tyrosine phosphatase 2 associates with intercellular adhesion molecule 1 to regulate cell survival
37. Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing SHP-2 mutant cells
38. Genetic evidence that SHP-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals
39. pp60v-src phosphorylates and activates low molecular weight phosphotyrosine-protein phosphatase
40. The SH2 tyrosine phosphatase SHP-2 is required for mammalian limb development
41. Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase SHP-2
42. α-Fmoc-(O,O-di-t-butyl)phosphono-p-methylphenylalanine
43. Tyrosine kinases: Modular signaling enzymes with tunable specificities
44. Domain interactions in protein tyrosine kinase Csk
45. Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, grb-2, HCP, SHC, Syk, and Vav
46. Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2
47. Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1
48. Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1
49. Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132
50. Purification of protein-tyrosine phosphatases from human placenta
51. From form to function: Signaling by protein tyrosine phosphatases
52. Combinatorial control of the specificity of protein tyrosine phosphatases
53. Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation
54. Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage
55. Protein-tyrosine phosphatase SHP-2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway
56. Phosphotyrosine displacement mechanism for activation of Src by PTPalpha