Docking Protein Gab2 Is Phosphorylated by ZAP-70 and Negatively Regulates T Cell Receptor Signaling by Recruitment of Inhibitory Molecules

Journal of Biological Chemistry

Volumn 276, Issue 48, 2001, Pages 45175-45183

  Yamasaki, Sho ^a   Nishida, Keigo ^b   Hibi, Masahiko ^b,d   Sakuma, Machie ^a   Shiina, Ritsuko ^a   Takeuchi, Arata ^a   Ohnishi, Hiroshi ^c   Hirano, Toshio ^b   Saito, Takashi ^a  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c MITSUBISHI KASEI INST OF LIFE SCI   (Japan)

^d RIKEN Center for Biosystems Dynamics Research   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; ENZYMES; IMMUNOLOGY;

INHIBITORY SIGNALS;

CELLS;

ADAPTOR PROTEIN; CHIMERIC PROTEIN; CYTOKINE RECEPTOR; DOCKING PROTEIN; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 2; LAT PROTEIN; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN; PLECKSTRIN; PROTEIN CD3 ZETA; PROTEIN GAB2; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE PHOSPHATASE SHP 2; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; ANTIGENS, DIFFERENTIATION, T LYMPHOCYTE; CARRIER PROTEIN; CD3 ANTIGEN; CD3 ANTIGEN, ZETA CHAIN; CD69 ANTIGEN; CYTOKINE; DNA; GAB1 PROTEIN; LEUKOCYTE ANTIGEN; LUCIFERASE; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; RECEPTORS, ANTIGEN, T CELL; SH PROTEIN TYROSINE PHOSPHATASE; SH PROTEIN-TYROSINE PHOSPHATASE; SYP PROTEIN; T LYMPHOCYTE ANTIGEN; TYROSINE; ZAP 70 KINASE; ZAP-70 KINASE;

ANIMAL CELL; ARTICLE; BINDING SITE; CYTOKINE PRODUCTION; DELETION MUTANT; ENZYME BINDING; HYBRIDOMA; LEUKEMIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE; ANIMAL; BIOSYNTHESIS; CELL LINE; DOSE RESPONSE; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; LEUKEMIA CELL LINE; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; MUTATION; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; SERODIAGNOSIS; SRC HOMOLOGY DOMAIN; WESTERN BLOTTING;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMAL; ANTIGENS, CD; ANTIGENS, CD3; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; BINDING SITES; BLOTTING, WESTERN; CARRIER PROTEINS; CELL LINE; CYTOKINES; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HUMAN; HYBRIDOMAS; INTERLEUKIN-2; JURKAT CELLS; LUCIFERASE; LYMPHOCYTE ACTIVATION; MICE; MUTATION; PHOSPHOPROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASE; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; TRANSFECTION; TYROSINE;

EID: 0035976967     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M105384200     Document Type: Article

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