Involvement of SHP-1 tyrosine phosphatase in TCR-Mediated signaling pathways in lipid rafts

Immunity

Volumn 14, Issue 6, 2001, Pages 669-680

  Kosugi, Atsushi ^a   Sakakura, Junko ^a   Yasuda, Koubun ^a   Ogata, Masato ^a   Hamaoka, Toshiyuki ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; CHIMERIC PROTEIN; LAT PROTEIN; LIPID; MEMBRANE PROTEIN; PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; PROTEIN SHP 1 TYROSINE PHOSPHATASE; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; LEUKEMIA CELL LINE; MOLECULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 0034948374     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00146-7     Document Type: Article

References (40)

1. Grf40, a novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT
2. Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling
3. Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase Csk and is involved in regulation of T cell activation
4. Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1
5. Structure of detergent-resistant membrane domains: Does phase separation occur in biological membranes?
6. A role for lipid rafts in B cell antigen receptor signaling and antigen targeting
7. SHP-1 regulates lck-induced phosphatidylinositol 3-kinase phosphorylation and activity
8. LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway
9. The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells
10. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor
11. Regulation of tyrosine phosphorylation in isolated T cell membrane by inhibition of protein tyrosine phosphatases
12. Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases
13. Alteration of the myometrial plasma membrane cholesterol content with β-cyclodextrin modulates the binding affinity of the oxytocin receptor
14. The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells
15. Translocation of tyrosine-phosphorylated TCRζ chain to glycolipid-enriched membrane domains upon T cell activation
16. GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation
17. The hematopoietic-specific adaptor protein Gads functions T-cell signaling via interactions with the SLP-76 and LAT adaptors
18. Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness
19. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains
20. Role of phosphatases in lymphocyte activation
21. Regulation of phosphorylation level and distribution of PTP36, a putative protein tyrosine phosphatase, by cell-substrate adhesion
22. Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule
23. Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase
24. Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: A new function for Src homology 2 domains
25. CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: Involvement of SH2-containing phosphotyrosine phosphatase SHP-1
26. Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling
27. Surface expression of a T cell receptor β (TCR-β) chain in the absence of TCR-α, -δ, and -γ proteins
28. lck phosphorylation and ZAP-70 binding to T cell receptor ζ chain
29. lck associated with glycolipid-enriched membrane domains
30. Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid
31. Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain
32. Functional rafts in cell membranes
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34. T lymphocyte costimulation mediated by reorganization of membrane microdomains
35. Membrane compartmentation is required for efficient T cell activation
36. Protein tyrosine phosphatase containing SH2 domains: Characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13
37. Palmitoylation of either Cys-3 or Cys-5 is required for the biological activity of the Lck tyrosine protein kinase
38. Lat: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
39. LAT palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
40. Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling