The protein tyrosine phosphatase Shp-2 regulates RhoA activity

Current Biology

Volumn 10, Issue 23, 2000, Pages 1523-1526

  Schoenwaelder, Simone M ^a   Petch, Leslie A ^b   Williamson, David ^a   Shen, Randy ^c   Feng, Gen Sheng ^c   Burridge, Keith ^b,d  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c BURNHAM INSTITUTE   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; BIOLOGICAL FUNCTIONS; CALPEPTIN; CELL ADHESION; PROTEIN TYROSINE PHOSPHATASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN;

EID: 0034735945     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00831-9     Document Type: Article

References (21)

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4. Bidirectional signaling between the cytoskeleton and integrins
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6. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
7. Phosphotyrosine phosphatases with SH2 domains: Regulators of signal transduction
8. Protein tyrosine phosphatases in signal transduction
9. 2-terminal mitogen-activated protein kinases
10. Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration and focal adhesion
11. Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2
12. Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2
13. Tyrosine phosphatase SHP-2 is involved in regulation of platelet-derived growth factor-induced migration
14. Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility
15. Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2
16. The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development
17. Rho GTPases and signaling networks
18. Integrin engagement suppresses RhoA activity via a c-src-dependent mechanism
19. Molecular characterisation of domains required for the specific interactions between Shp-2 phosphatase and JAK tyrosine kinases
20. Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases
21. A novel regulator of p21-activated kinases