A new role for platelet-endothelial cell adhesion molecule-1 (CD31): Inhibition of TCR-mediated signal transduction

Journal of Immunology

Volumn 163, Issue 2, 1999, Pages 682-688

  Newton Nash, Debra K ^a   Newman, Peter J ^a  

^a BLOOD RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; MONOCLONAL ANTIBODY; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ARTICLE; CALCIUM MOBILIZATION; CELL LINE; CONTROLLED STUDY; CROSS LINKING; DOSE RESPONSE; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LIGATION; LYMPHOBLAST; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ANTIGENS, CD31; CALCIUM; CELL LINE, TRANSFORMED; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTRACELLULAR FLUID; JURKAT CELLS; LYMPHOCYTE ACTIVATION; PHOSPHORYLATION; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TYROSINE;

EID: 0033565294     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Qian, D., and A. Weiss. 1997. T cell antigen receptor signal transduction. Curr. Opin. Cell Biol. 9:205.
2. Saito, T. 1998. Negative regulation of T cell activation. Curr. Opin. Immunol. 10:313.
3. Neel, B. 1997. Role of phosphatases in lymphocyte activation. Curr. Opin. Immunol. 9:405.
4. Marengere, L. E. M., P. Waterhouse, G. S. Duncan, H.-W. Mittrucker, G.-S. Feng, and T. W. Mak. 1996. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272:1170.
5. Lee, K.-M., E. Chuang, M. Griffin, R. Khattri, D. K. Hong, W. Zhang, D. Straus, L. E. Samelson, C. B. Thompson, and J. A. Bluestone. 1998. Molecular basis of T cell inactivation by CTLA-4. Science 282:2263.
6. Burshtyn, D. N., A. M. Scharenberg, N. Wagtmann, S. Rajagopalan, K. Berrada, T. Yi, J.-P. Kinet, and E. O. Long. 1996. Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor. Immunity 4:77.
7. Fry, A. M., L. L. Lanier, and A. Weiss. 1996. Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C. J. Exp. Med. 184:295.
8. Newman, P. J., M. C. Berndt, J. Gorski, G. C. White, S. Lyman, C. Paddock, and W. A. Muller. 1990. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science 247:1219.
9. Sun, Q.-H., H. M. DeLisser, M. M. Zukowski, C. Paddock, S. M. Albelda, and P. J. Newman. 1996. Individually distinct Ig homology domains in PECAM-1 regulate homophilic binding and modulate receptor affinity. J. Biol. Chem. 271: 11090.
10. Sun, J., J. Williams, H.-C. Yan, K. M. Amin, S. M. Albelda, and H. M. DeLisser. 1996. Platelet endothelial cell adhesion molecule-1 (PECAM-1) homophilic adhesion is mediated by immunoglobulin-like domains 1 and 2 and depends on the cytoplasmic domain and the level of surface expression. J. Biol. Chem. 271: 18561.
11. DeLisser, H. M., P. J. Newman, and S. M. Albelda. 1994. Molecular and functional aspects of PECAM-1/CD31. Immunol. Today 15:490.
12. Newman, P. J. 1999. Switched at birth: a new family for PECAM-1. J. Clin. Invest. 103:5.
13. Jackson, D. E., C. M. Ward, R. Wang, and P. J. Newman. 1997. The protein-tyrosine phosphatase SHP-2 binds PECAM-1 and forms a distinct signaling complex during platelet aggregation: evidence for a mechanistic link between PECAM-1 and integrin-mediated cellular signaling. J. Biol. Chem. 272:6986.
14. Varon, D., B. Shenkman, R. Dardik, I. Tamarin, N. Savion, D. Jackson, and P. J. Newman. 1996. Engagement of platelet PECAM-I Ig-domain 6 by specific monoclonal antibodies promotes platelet activation in vitro. Tissue Antigens 48:469.
15. Varon, D., D. E. Jackson, B. Shenkman, R. Dardik, I. Tamarin, N. Savion, and P. J. Newman. 1998. Platelet/endothelial cell adhesion molecule-1 serves as a co-stimulatory agonist receptor that modulates integrin-dependent adhesion and aggregation of human platelets. Blood 91:500.
16. Osawa, M., M. Masuda, N. Harada, R. B. Lopes, and K. Fujiwara. 1997. Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) in mechanically stimulated vascular endothelial cells. Eur. J. Cell Biol. 72:229.
17. Sagawa, K., W. Swaim, J. Zhang, E. Unsworth, and R. P. Siraganian. 1997. Aggregation of the high affinity IgE receptor results in the tyrosine phosphorylation of the surface adhesion protein PECAM-1 (CD31). J. Biol. Chem. 272:13412.
18. Sagawa, K., T. Kimura, M. Swieter, and R. P. Siraganian. 1997. The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31). J. Biol. Chem. 272:31086.
19. c-src. Biochem. J. 299:613.
20. Jackson, D. E., K. R. Kupcho, and P. J. Newman. 1997. Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of Platelet/endothelial cell adhesion molecule-1 (PECAM-1) that are required for the cellular association and activation of the protein-tyrosine phosphalase, SHP-2. J. Biol. Chem. 272:24868.
21. Masuda, M., M. Osawa, H. Shigematsu, N. Harada, and K. Fujiwara. 1997. Platelet endothelial cell adhesion molecule-1 is a major SH-PTP2 binding protein in vascular endothelial cells. FEBS Lett. 408:331.
22. Hua, C. T., J. R. Gamble, M. A. Vadas, and D. E. Jackson. 1998. Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). J. Biol. Chem. 273:28332.
23. Cao, M. Y., M. Huber, N. Beauchemin, J. Famiglietti, S. M. Albelda, and A. Veillette. 1998. Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases. J. Biol. Chem. 273:15765.
24. 1 integrin-mediated adhesion. J. Exp. Med. 176:245.
25. Stockinger, H., W. Schreiber, O. Majdic, W. Holler, D. Maurer, and W. Knapp. 1992. Phenotype of human T cells expressing CD31, a molecule of the immunoglobulin supergene family. Immunology 75:53.
26. -) CD4-positive T-cells. Tissue Antigens 38:208.
27. Torimoto, Y., D. M. Rothstein, N. H. Dang, S. F. Schlossman, and C. Morimoto. 1992. CD31, a novel cell surface marker for CD4 cells of suppressor lineage, unaltered by state of activation. J. Immunol. 148:388.
28. Sanders, M. E., M. W. Makgoba, C. H. June, H. A. Young, and S. Shaw. 1989. Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor-mediated activation. Eur. J. Immunol. 19:803.
29. Weiss, A., R. L. Wiskocil, and J. D. Stobo. 1984. The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL-2 production reflects events ocurring at a pre-translational levle. J. Immunol. 133:123.
30. Gootenberg, J. E., F. W. Ruscetti, J. W. Mier, A. Gazdar, and R. C. Gallo. 1981. Human cutaneous T cell lymphoma and leukemia cell lines produce and respond to T cell growth factor. J. Exp. Med. 154:1403.
31. Chen, T.-R. 1992. Karyotypic derivation of H9 cell line expressing human immunodeficiency virus susceptibility. J. Natl. Cancer Inst. 84:1922.
32. Yan, H.-C., J. M. Pilewski, Q. Zhang, H. M. DeLisser, L. Romer, and S. M. Albelda. 1995. Localization of multiple functional domains on human PECAM-1 (CD31) by monoclonal antibody epitope mapping. Cell Adhes. Commun. 3:45.
33. Zehnder, J. L., K. Hirai, M. Shatsky, J. L. McGregor, L. J. Levitt, and L. L. K. Leung. 1992. The cell adhesion molecule CD31 is phosphorylated after cell activation: down-regulation of CD31 in activated T lymphocytes. J. Biol. Chem. 267:5243.
34. Blery, M., J. Delon, A. Trautmann, A. Cambiaggi, L. Olcese, R. Biassoni, L. Moretta, P. Chavrier, A. Moretta, M. Daeron, and E. Vivier. 1997. Reconstituted killer cell inhibitory receptors for major histocompatibility complex class I molecules control mast cell activation induced via immunoreceptor tyrosine-based activation motifs. J. Biol. Chem. 272:8989.
35. Blery, M., H. Kubagawa, C.-C. Chen, F. Vely, M. D. Cooper, and E. Vivier. 1998. The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1. Proc. Natl. Acad. Sci. USA 95:2446.
36. Maeda, A., M. Kurosaki, M. Ono, T. Takai, and T. Kurosaki. 1998. Requirement of SH2-containing protein lyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal. J. Exp. Med. 187:1355.
37. Smith, K. G. C., D. M. Tarlinton, G. M. Doody, M. L. Hibbs, and D. T. Fearon. 1998. Inhibition of the B cell by CD22: a requirement for Lyn. J. Exp. Med. 187:807.
38. Valiante, N. M., J. H. Phillips, L. L. Lanier, and P. Parham. 1996. Killer cell inhibitory receptor recognition of human leukocyte antigen (HLA) class I blocks formation of a pp36/PLCγ signaling complex in human natural killer (NK) cells. J. Exp Med. 184:2243.
39. Colonna, M., F. Navarro, T. Bellon, M. Llano, P. Garcia, J. Samaridis, L. Angman, M. Cella, and M. Lopez-Botet. 1997. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J. Exp. Med. 186:1809.
40. Berridge, M. J., and R. F. Irvine. 1989. Inositol phosphates and cell signalling. Nature 341:197.
41. Putney, J. W., Jr., and G. St. J. Bird. 1993. The signal for capacitative calcium entry. Cell 75:199.
42. 3 and dissociation from calcium release. Cell 89:973.
43. Lu, T. T., M. Barreuther, S. Davis, and J. A. Madri. 1997. Platelet endothelial cell adhesion molecule-1 is phosphorylatable by c-Src, binds Src-Src homology 2 domain, and exhibits immunoreceptor tyrosine-based activation motif-like properties. J. Biol. Chem. 272:14442.
44. Songyang, Z., S. E. Shoelson, M. Chaudhuri, G. Gish, T. Pawson, W. G. Haser, F. King, T. Roberts, S. Ratnofsky, R. J. Lechleider, et al. 1993. SH2 domains recognize specific phosphopeptide sequences. Cell 72:767.
45. Burshtyn, D. N., W. Yang, T. Yi, and E. O. Long. 1997. A novel phosphotyrosine motif with a critical amino acid at position -2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1. J. Biol. Chem. 272:13066.
46. Gurubhagavatula, I., Y. Amrani, D. Pratico, F. L. Ruberg, S. M. Albelda, and R. A. Panettieri. 1998. Engagement of human PECAM-1 (CD31) on human endothelial cells increases intracellular calcium ion concentration and stimulates prostacyclin release. J. Clin. Invest. 101:212.
47. Li, W., R. Nishimura, A. Kashishian, A. G. Batzer, W. J. H. Kim, J. A. Cooper, and J. Schlessinger. 1994. A new function for a phosphotyrosine phosphatase: Linking GRB2- Sos to a receptor tyrosine kinase. Mol. Cell. Biol. 14:509.
48. Bennett, A. M., T. L. Tang, S. Sugimoto, C. T. Walsh, and B. G. Neel. 1994. Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor β to Ras. Proc. Natl. Acad. Sci. USA 91:7335.
49. Xiao, S., D. W. Rose, T. Sasaoka, H. Maegawa, T. R. Burke, Jr., P. P. Roller, S. E. Shoelson, and J. M. Olefsky. 1994. Syp (SH-PTP2) Is a positive mediator of growth factor-stimulated mitogenic signal transduction. J. Biol. Chem. 269:21244.
50. Welham, M. J., U. Dechert, K. B. Leslie, F. Jirik, and J. W. Schrader. 1994. Interteukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3′-kinase. J. Biol. Chem. 269:23764.
51. Noguchi, T., T. Matozaki, K. Horita, Y. Fujioka, and M. Kasuga. 1994. Role of SH-PTP2, a protein-tyrosine phosphatase with src homology 2 domains, in insulin-stimulated ras activation. Mol. Cell. Biol. 14:6674.
52. Levine, B. L., Y. Ueda, A. Faith, and C. H. June. 1996. Signal transduction properties of the T cell activation monoclonal antibody panel: ubiquitous increase in cellular substrate tyrosine phosphorylation in the absence of detectable calcium mobilization. Tissue Antigens 48:319.
53. Coggeshall, K. M. 1998. Inhibitory signaling by B cell FcγRIIb. Curr. Opin. Immunol. 10:306.
54. + signals and immunosuppression. Nature 383:837.
55. Negulescu, P. A., N. Shastri, and M. D. Cahalan. 1994. Intracellular calcium dependence of gene expression in single T lymphocytes. Proc. Natl. Acad. Sci. USA 91:2873.
56. Valitutti, S., M. Dessing, K. Aktories, H. Gallati, and A. Lanzavecchia. 1995. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy: role of T cell actin cytoskeleton. J. Exp. Med. 181:577.
57. Wulfing, C., J. D. Rabinowitz, C. Beeson, M. D. Sjaastad, H. M. McConnell, and M. M. Davis. 1997. Kinetics and extent of T cell activation as measured with the calcium signal. J. Exp. Med. 185:1815.
58. Duncan, G. S., D. P. Andrew, H. Takimoto, S. A. Kaufman, H. Yoshida, J. Spellberg, J. Luis de la Pompa, A. Elia, A. Wakeham, B. Karan-Tamir, et al. 1999. Genetic evidence for functional redundancy of platelet/endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. J. Immunol. 162:3022.