Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells

Nature Immunology

Volumn 8, Issue 12, 2007, Pages 1313-1323

  Takenaka, Katsuto ^a   Prasolava, Tatiana K ^b   Wang, Jean C Y ^a   Mortin Toth, Steven M ^b   Khalouei, Sam ^b   Gan, Olga I ^a   Dick, John E ^a,c   Danska, Jayne S ^b,c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD47 ANTIGEN; LIGAND; REGULATOR PROTEIN; SIGNAL REGULATORY PROTEIN ALPHA; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENGRAFTMENT; EXPERIMENTAL MODEL; GENE EXPRESSION; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC STRAIN; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOMODULATION; MACROPHAGE; MOLECULAR GENETICS; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; PROTEIN BINDING; SCID MOUSE; XENOTRANSPLANTATION;

ANIMALS; ANTIGENS, DIFFERENTIATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; POLYMORPHISM, GENETIC; RECEPTORS, IMMUNOLOGIC;

EID: 36248956243     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1527     Document Type: Article

References (51)

1. Thomas, E.D. et al. One hundred patients with acute leukemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation. Blood 49, 511-533 (1977).
2. Storb, R., Prentice, R.L. & Thomas, E.D. Marrow transplantation for treatment of aplastic anemia. An analysis of factors associated with graft rejection. N. Engl. J. Med. 296, 61-66 (1977).
3. Gale, R.P. et al. Prevention of graft rejection following bone marrow transplantation. Blood 57, 9-12 (1981).
4. Suda, T., Arai, F. & Hirao, A. Hematopoietic stem cells and their niche. Trends Immunol. 26, 426-433 (2005).
5. Lapidot, T., Dar, A. & Kollet, O. How do stem cells find their way home? Blood 106, 1901-1910 (2005).
6. Murphy, W.A, Kumar, V. & Bennett, M. Rejection of bone marrow allografts by mice with severe combined immune deficiency [SCID). Evidence that natural killer cells can mediate the specificity of marrow graft rejection. J. Exp. Med. 165, 1212-1217 (1987).
7. + cells. Blood 106, 1259-1261 (2005).
8. Wang, J.C.Y. et al. In Hematopoiesis - A Developmental Approach (ed. Zon, L.I.) 99-118 (Oxford University Press, New York, 2001).
9. Dorshkind, K., Pollack, S.B., Bosma, M.J. & Phillips, R.A. Natural killer (NK) cells are present in mice with severe combined immunodeficiency (scid). J. Immunol. 134, 3798-3801 (1985).
10. Shultz, L.D. et al. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J. Immunol. 154, 180-191 (1995).
11. 2 microglobulin-null mice. J. Clin. Invest. 107, 199-206 (2001).
12. Greiner, D.L. et al. Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice. Am. J. Pathol. 146, 888-902 (1995).
13. Larochelle, A. et al. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy. Nat. Med. 2, 1329-1337 (1996).
14. O'Brien, B.A., Huang, Y., Geng, X., Dutz, J.P. & Finegood, D.T. Phagocytosis of apoptotic cells by macrophages from NOD mice is reduced. Diabetes 51, 2481-2488 (2002).
15. Ogasawara, K. et al. Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity 18, 41-51 (2003).
16. Piganelli, J.D., Martin, T. & Haskins, K. Splenic macrophages from the NOD mouse are detective in the ability to present antigen. Diabetes 47, 1212-1218 (1998).
17. Anderson, M.S. & Bluestone, J.A. The NOD mouse: A model of immune dysregulation. Annu. Rev. Immunol. 24, 447-485 (2005).
18. Acha-Orbea, H. & McDevitt, H.O. The first external domain of the nonobese diabetic mouse class II I-A β chain is unique. Proc. Natl. Acad. Sci. USA 84, 2435-2439 (1987).
19. Kissler, S. et al. In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes. Nat. Genet. 38, 479-483 (2006).
20. Vijayakrishnan, L. et al. An autoimmune disease-associated CTLA-4 splice variant lackingthe B7 binding domain signals negatively in T cells. Immunity 20, 563-575 (2004).
21. Yamanouchi, J. et al. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat. Genet. 39, 329-337 (2007).
22. Shinkai, Y. et al. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68, 855-867 (1992).
23. + cytolytic T cells. Nature 344, 742-746 (1990).
24. Kagi, D. et al. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369, 31-37 (1994).
25. Shultz, L.D. et al. NOD/LtSz-Rag1 null mice: An immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells. J. Immunol. 164, 2496-2507 (2000).
26. Prochazka, M., Serreze, D.V., Frankel, W.N. & Leiter, E.H. NOR/Lt mice: MHC-matched diabetes-resistant control strain for NOD mice. Diabetes 41, 98-106 (1992).
27. Serreze, ON, Prochazka, M., Reifsnyder, P.C., Bridgett M.M. & Leiter, E.H. Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene. J. Exp. Med, 180, 1553-1558 (1994).
28. Barclay, A.N. & Brown, M.H. The SIRP family of receptors and immune regulation. Nat. Rev. Immunol. 6, 457-464 (2006).
29. Sano, S., Ohnishi, H. & Kubota, M. Gene structure of mouse BIT/SHPS-1. Biochem. J. 344, 667-675 (1999).
30. van den Nieuwenhof, I.M., Renardel de Lavalette, C., Diaz, N., van Die, I. & van den Berg, T.K. Differential galactosylation of neuronal and haematopoietic signal regulatory protein-α determines its cellular binding-specificity. J. Cell Sci. 114, 1321-1329 (2001).
31. Seiffert, M. et al. Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counter-receptor CD47. Blood 94, 3633-3643 (1999).
32. - hematopoietic cell Is. Blood 97, 2741-2749 (2001).
33. Vernon-Wilson, E.F. et al. CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP(OX41) and human SIRPα1. Eur. J. Immunol. 30, 2130-2137 (2000).
34. Hatherley, D., Harlos, K.,Vunlop, D.C., Stuart, D.I. Barclay, A.N. The structure of 6e macrophage signal regulatory protein α (SIRPα) inhibitory receptor reveals a binding face reminicent of that used by T cell receptors. J. Biol. Chem. 282, 14567-14575 (2007),
35. Veillette, A., Thibaudeau, E. & Latour, S. High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages. J. Biol. Chem. 273, 22719-22728 (1998).
36. Oldenborg, P.A., Gresham, H.D. & Lindberg, F.P. CD47-signal regulatory protein it (SIRPα) regulates Fcγ and complement receptor-mediated phagocytopis. J. Exp. Med. 193, 855-862 (2001).
37. Blazar, B.R. et al. CD47 (integrin-associated protein) engagement of dendritic cell and macrophage counterreceptors is required to prevent the clearance of donor lymphohematopoietic cells. J. Exp. Med. 194, 541-549 (2001).
38. Smith, R.E. et al. A nover MyD-1 (SIRP-1α) signaling pathway that inhibits LPS-induced TNFα production by monocytes. Blood 102 2532-2540 (2003).
39. 2-dependent pathways. Mol. Cell. Biol. 25, 7181-7192 (2005).
40. + cells. Exp. Hematol. 31, 551-558 (2003).
41. Hauser, S.P., Waldron, J.A., Upuda, K.B. & Lipschitz, D.A. Morphological characterization of stromal cell types in hematopoietically active long-term murine bone marrow cultures. J. Histochem. Cytochem. 43, 371-379 (1995).
42. ++/CD38-progenitor cells in long-term cultures and semisolid assays. Blood 81, 2916-2924 (1993).
43. Subramanian, S., Parthasarathy, R., Sen, S., Boder, E.T. & Discher, D.E. Species-and cell type-specific interactions between CD47 and human SIRPα Blood 107, 2548-2556 (2006).
44. Latour, S. et al. Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-α: Down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation. J. Immunol. 167, 2547-2554 (2001).
45. Brown, E.J. & Frazier, W.A. Integrin-associated protein (CD47) and its ligands. Trends Cell Biol. 11, 130-135 (2001).
46. Oldenborg, P.A. et al. Role of CD47 as a marker of self on red blood cells. Science 288, 2051-2054 (2000).
47. Gardai, S.J. et al. Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell 123, 321-334 (2005).
48. Ide, K. et al. Role for CD47-SIRPα signaling in xenograft rejection by macrophages. Proc. Natl. Acad. Sci. USA 104, 5062-5066 (2007).
49. Pozzilli, P., Signore, A., Williams, A.J. & Beales, P.E. NOD mouse colonies around the world - recent facts and figures. Immunol. Today 14, 193-196 (1993).
50. Gan, O.I. et al. Characterization and retroviral transduction of an early human lymphomyeloid precursor assayed in nonswitched long-term culture-on murine stroma. Exp. Hematol. 27, 1097-1106 (1999).
51. + bone marrow and cord blood-derived SCID-repopulating cells with third-generation lentiviral vectors. Mol. Ther. 1, 566-573 (2000).