Adapter molecule Grb2-associated binder 1 is specifically expressed in marginal zone B cells and negatively regulates thymus-independent antigen-2 responses

Journal of Immunology

Volumn 168, Issue 10, 2002, Pages 5110-5116

  Itoh, Shousaku ^a   Itoh, Motoyuki ^a   Nishida, Keigo ^a   Yamasaki, Satoru ^a   Yoshida, Yuichi ^a   Narimatsu, Masahiro ^a   Park, Sung Joo ^a   Hibi, Masahiko ^a   Ishihara, Katsuhiko ^a   Hirano, Toshio ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; GRB2 ASSOCIATED BINDER 1; GROWTH FACTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 4; INTERLEUKIN 5; PHOSPHOTYROSINE; THYMUS INDEPENDENT ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CELL FRACTIONATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENETIC TRANSFECTION; HEMATOPOIESIS; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN;

EID: 0037093980     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.10.5110     Document Type: Article

References (42)

1. T cell-independent antigens type 2
2. T cell independent antigens
3. The Toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells
4. A model for induction of T cell-independent humoral immunity in response to polysaccharide antigens
5. B-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms
6. The expression of B cell surface receptors. III. The murine low-affinity IgE Fc receptor is not expressed on Ly 1 or "Ly 1-like" B cells
7. Mouse complement receptors type 1 (CR1; CD35) and type 2 (CR2;CD21): Expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL/lpr mice
8. Comparative in vitro analysis of proliferation, Ig secretion, and Ig class switching by murine marginal zone and follicular B cells
9. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses
10. high lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells
11. Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response
12. A Grb2-associated docking protein in EGF- and insulin-receptor signalling
13. Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors
14. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
15. Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor
16. Signal characteristics of G protein-transactivated EGF receptor
17. Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase
18. Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation
19. Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T-and B-cell antigen receptors
20. Engagement of Gab1 and Gab2 in erythropoietin signaling
21. The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor
22. The Gab1 docking protein links the B cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase
23. Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation
24. Essential role of Gab1 for signaling by the c-Met receptor in vivo
25. Deletion of bone marrow stromal cell antigen-1 (CD157) gene impaired systemic thymus independent-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses
26. E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination
27. Dextranconjugated anti-Ig antibodies as a model for T cell-independent type 2 antigenmediated stimulation of Ig secretion in vitro. I. Lymphokine dependence
28. Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
29. Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1
30. Gab3, a new DOS/Gab family member, facilitates macrophage differentiation
31. Cutting edge: Gab2 mediates an inhibitory phosphatidylinositol 3′-kinase pathway in T cell antigen receptor signaling
32. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens
33. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk
34. Nuclear factor κB is required for the development of marginal zone B lymphocytes
35. Aiolos regulates B cell activation and maturation to effector state
36. The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21
37. Antigen receptor proximal signaling in splenic B-2 cell subsets
38. B-cell subsets and the mature preimmune repertoire: Marginal zone and B1 B cells as part of a "natural immune memory."
39. -/- mice
40. Immunological studies on PD-1 deficient mice: Implication of PD-1 as a negative regulator for B cell responses
41. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
42. T-independent immune response: New aspects of B cell biology