In vivo functional analysis of the Daughter of Sevenless protein in receptor tyrosine kinase signaling

Mechanisms of Development

Volumn 90, Issue 2, 2000, Pages 205-215

  Bausenwein, Burkhard S ^a   Schmidt, Marc ^a   Mielke, Björn ^a   Raabe, Thomas ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Daughter of Sevenless; Multisite adaptor protein; PH domain; Receptor tyrosine kinase signaling

Indexed keywords

ADAPTOR PROTEIN; COMPLEMENTARY DNA; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN SUBUNIT; PROTEIN TYROSINE KINASE; TYROSINE;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DEVELOPMENT; FLY; GENE DELETION; GENE EXPRESSION; GENE ISOLATION; GENE MUTATION; GENETIC ANALYSIS; HISTOLOGY; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; PROTEIN STRUCTURE, FUNCTION AND VARIABILITY; SIGNAL TRANSDUCTION; TRANSGENE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL MEMBRANE; DROSOPHILA; DROSOPHILA PROTEINS; ENHANCER ELEMENTS (GENETICS); EYE PROTEINS; FEMALE; MALE; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); RECEPTOR PROTEIN-TYROSINE KINASES; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TYROSINE;

EID: 0033986633     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(99)00252-X     Document Type: Article

References (51)

1. Allard J.D., Chang H.C., Herbst R., McNeill H., Simon M.A. The SH2-containing tyrosine phosphatase corksrew is required during signaling by sevenless, Ras1 and Raf. Development. 122:1996;1137-1146.
2. Allard J.D., Herbst R., Carroll P.M., Simon M.S. Mutational analysis of the SRC homology 2 domain protein-tyrosine phosphatase corkscrew. J. Biol. Chem. 273:1998;13129-13135.
3. Bardelli A., Longati P., Gramaglia D., Stella M.C., Comoglio P.M. Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential. Oncogene. 15:1997;3103-3111.
4. Basler K., Christen B., Hafen E. Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye. Cell. 64:1991;1069-1082.
5. Bergmann A., Agapite J., McCall K., Steller H. The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell. 95:1998;331-341.
6. Boehni R., Riesgo-Escovar J., Oldham S., Brogiolo W., Stocker H., Andruss B.F., Beckingham K., Hafen E. Autonomous control of cell and organ size by chico, a Drosophila homolog of vertebrate IRS1-4. Cell. 97:1999;865-875.
7. Burks D.J., Pons S., Towery H., Smith-Hall J., Myers M.G., Yenush L., White M.F. Heterologous Pleckstrin homology domains do not couple IRS-1 to Insulin receptor. J. Biol. Chem. 272:1997;27716-27721.
8. Chen R.-H., Corbalan-Garcia S., Bar-Sagi D. The role of the PH domain in the signal dependent membrane tageting of Sos. EMBO J. 16:1997;1351-1359.
9. Cormack B.P., Valdivia R.H., Falkow S. FACS-optimized mutants of green fluorescent protein (GFP). Gene. 173:1996;33-38.
10. Dickson B., Sprenger F., Hafen E. Prepattern in the developing Drosophila eye revealed by an activated torso-sevenless chimeric receptor. Genes Dev. 6:1992;2327-2339.
11. Dickson B., Sprenger F., Morrison D., Hafen E. Raf functions downstream of Ras1 in the Sevenless signal transduction pathway. Nature. 360:1992;600-603.
12. Dickson B., Hafen E. Genetic dissection of the eye development in Drosophila. The Development of Drosophila melanogaster. 1993;Cold Spring Harbor Laboratory Press, New York.
13. Dominguez M., Hafen E. Genetic dissection of cell fate specification in the developing eye of Drosophila. Sem. Cell Dev. Biol. 7:1996;219-226.
14. Freeman M. Cell determination strategies in the Drosophila eye. Development. 124:1997;261-270.
15. Fruman D.A., Rameh L.E., Cantley L.C. Phosphoinositide binding domains: embracing 3-phosphate. Cell. 97:1999;817-820.
16. Gu H., Pratt J.C., Burakoff S.J., Neel B.G. Cloning of p97/Gab2, the major SHP-2 bindng protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Mol. Cell. 2:1998;729-740.
17. Herbst R., Carroll P.M., Allard J.D., Schilling J., Raabe T., Simon M.A. Daughter of Sevenless is a substrate of the phosphotyrosine phosphatase corkscrew and functions during sevenless signaling. Cell. 85:1996;899-909.
18. Holgado-Madruga M., Emlet R.D., Moscatello D.K., Godwin A.K., Wong A.J. A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature. 379:1996;560-564.
19. Huyer G.H., Alexander D.R. Immune signalling: SHP-2 docks at multiple ports. Curr. Biol. 9:1999;129-132.
20. Ingham R.J., Holgado-Madruga M., Siu C., Wong A.J., Gold M.R. The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor. J. Biol. Chem. 273:1998;30630-30637.
21. Isakoff S.J., Cardozo T., Andreev J., Li Z., Ferguson K.M., Abagyan R., Lemmon M.A., Aronheim A., Skolnik E.Y. Identification and analysis of PH domain-containing targets of phosphatidyinositol 3-kinase using a novel in vivo assay in yeast. EMBO J. 17:1998;5374-5387.
22. Klemenz R., Weber U., Gehring W.J. The white gene as a marker in a new P-element vector for gene tranfer in Drosophila. Nucleic Acids Res. 15:1987;3947-3959.
23. Kumar J.P., Tio M., Hsiung F., Akopyan S., Gabay L., Seger R., Shilo B.-Z., Moses K. Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation. Development. 125:1998;3875-3885.
24. Kurada P., White K. Ras promotes cell survival in Drosophila by downregulating hid expression. Cell. 95:1998;319-329.
25. Lehr S., Kotzka J., Herkner A., Klein E., Siethoff C., Knebel B., Noelle V., Bruenning J.C., Klein H.W., Meyer H.E., Krone W., Mueller-Wieland D. Identification of tyrosine phosphorylation sites in human Gab-1 protein by EGF receptor kinase in vitro. Biochemistry. 38:1999;151-159.
26. Lemmon M.A., Falasca M., Ferguson K.M., Schlessinger J. Regulatory recruitment of signalling molecules to the cell membrane by pleckstrin-homology domains. Trends Cell Biol. 7:1997;237-242.
27. Maroun C.R., Holgado-Madruga M., Royal I., Naujokas M.A., Fournier T.M., Wong A.J., Park M. The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell conatct and epithelial morphogenesis downstream from the Met receptor tyrosine kinase. Mol. Cell Biol. 19:1999;1784-1799.
28. Marshall C.J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell. 80:1995;179-185.
29. Myers M.G., Mendez R., Shi P., Pierce J.H., Rhoads R., White M.F. The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling. J. Biol. Chem. 273:1998;26908-26914.
30. Nguyen L., Holgado-Madruga M., Maroun C., Fixman E.D., Kamikura D., Fournier T., Charest A., Tremblay M.L., Wong A.J., Park M. Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor requires a functional Grb2 binding site involving tyrosine 1356. J. Biol. Chem. 272:1997;20811-20819.
31. Olivier J.P., Raabe T., Henkemeyer M., Dickson B., Mbamalu G., Margolis B., Schlessinger J., Hafen E., Pawson T. A Drosophila SH2-SH3 adapor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange. Sos. Cell. 73:1993;179-191.
32. Pawson T. Protein modules and signalling networks. Nature. 373:1995;573-579.
33. Perkins L.A., Johnson M.R., Melnick M.B., Perrimon N. The non-receptor protein tyrosine phosphatase Corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila. Dev. Biol. 180:1996;63-81.
34. 2+ and IP4 regulation. Mech. Dev. 81:1999;89-101.
35. Raabe T., Olivier J.P., Dickson B., Liu X., Gish G.D., Pawson T., Hafen E. Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila. EMBO J. 14:1995;2509-2518.
36. Raabe T., Riesgo-Escovar J., Liu X., Bausenwein B.S., Deak P., Maröy P., Hafen E. Dos, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila. Cell. 85:1996;911-920.
37. Salim K., Bottomley M.J., Querfurt E., Zvelebil M.J., Gout I., Scaife R., Margolis R.L., Gigg R., Smith C.I.E., Driscoll P.C., Waterfield M.D., Panayotou G. Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase. EMBO J. 15:1996;6241-6250.
38. Sawka-Verhelle D., Tartare-Deckert S., White M.F., VanObberghen E. IRS-2 binds to the insulin receptor through its PTB domain and through a newly identified domain comprising amino acids 591 to 786. J. Biol. Chem. 271:1996;5980-5983.
39. Shaw G. The pleckstrin homology domain: an intruiging multifunctional protein module. BioEssays. 18:1996;35-46.
40. Simon M.A., Dodson G.S., Rubin G.M. An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to Sevenless and Sos proteins in vitro. Cell. 73:1993;169-177.
41. Spencer S.A., Powell P.A., Miller D.T., Cagan R.L. Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina. Development. 125:1998;4777-4790.
42. Takahashi-Tezuka M., Yoshida Y., Fukada T., Ohtani T., Yamanaka Y., Nishida K., Nakajima K., Hibi M., Hirano T. Gab1 acts as an adaptor molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase. Mol. Cell. Biol. 18:1998;4109-4117.
43. Thackeray J.R., Gaines P.C.W., Ebert P., Carlson J.R. small wing encodes a phospholipase C-γ that acts as a negative regulator of R7 development in Drosophila. Development. 125:1998;5033-5042.
44. Tomlinson A., Bowtell D.D., Hafen E., Rubin G.M. Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disk of Drosophila. Cell. 51:1987;143-150.
45. Touhara K., Koch W.J., Hawes B.E., Lefkowitz R.J. Mutational analysis of the Pleckstrin Homology domain of the β-Adrenergic receptor kinase. J. Biol. Chem. 270:1995;17000-17005.
46. Van Vactor D., O'Reilly A.M., Neel B.G. Genetic analysis of protein tyrosine phosphatases. Curr. Opin. Gen. Dev. 8:1998;112-126.
47. Weidner K.M., DiCesare S., Sachs M., Brinkman V., Behrens J., Birchmeier W. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature. 384:1996;173-176.
48. Wolff T., Ready D.F. Pattern formation in the Drosophila retina. The Development of Drosophila melanogaster. 1993;1277-1326 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
49. Xu T., Rubin G.M. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development. 117:1993;1223-1237.
50. Yenush L., White M.F. The IRS-signalling system during insulin and cytokine action. BioEssays. 19:1997;491-500.
51. Zipursky S.L., Rubin G.M. Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila. Annu. Rev. Neurosci. 17:1994;373-397.