SHP-2 Phosphatase Negatively Regulates the TRIF Adaptor Protein-Dependent Type I Interferon and Proinflammatory Cytokine Production

Immunity

Volumn 25, Issue 6, 2006, Pages 919-928

  An, Huazhang ^a   Zhao, Wei ^a   Hou, Jin ^b   Zhang, Yan ^a   Xie, Yun ^c   Zheng, Yuejuan ^c   Xu, Hongmei ^a   Qian, Cheng ^a   Zhou, Jun ^c   Yu, Yizhi ^a   Liu, Shuxun ^a   Feng, Gensheng ^d   Cao, Xuetao ^a,b,c  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b Tsinghua University   (China)

^c ZHEJIANG UNIVERSITY   (China)

^d BURNHAM INSTITUTE   (United States)

Author keywords

CELLIMMUNO; MOLIMMUNO; SIGNALING

Indexed keywords

ADAPTOR PROTEIN; BETA INTERFERON; CYTOKINE; INTERFERON; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN TRIF; PROTEIN TYROSINE PHOSPHATASE SHP 2; TANK BINDING KINASE 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REPORTER GENE; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CELLS, CULTURED; CYTOKINES; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; INTERFERON TYPE I; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; SHP1 PROTEIN TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33845438110     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2006.10.014     Document Type: Article

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