Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling

Journal of Biological Chemistry

Volumn 281, Issue 9, 2006, Pages 5426-5434

  Yu, Wen Mei ^a   Daino, Hanako ^a   Chen, Jing ^a   Bunting, Kevin D ^a   Qu, Cheng Kui ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DISEASES; MOLECULAR DYNAMICS; ONCOLOGY;

DEPHOSPHORYLATION; LEUKEMIGENESIS; MUTATIONS; SHP-2 PHOSPHATASE;

CELLS;

GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; INTERLEUKIN 3; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; PROTEIN TYROSINE PHOSPHATASE SHP 2; STAT5 PROTEIN; GAB2 PROTEIN, MOUSE; GRB2 PROTEIN, MOUSE; JAK2 PROTEIN, HUMAN; JAK2 PROTEIN, MOUSE; JANUS KINASE 2; ONCOPROTEIN; PHOSPHOPROTEIN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; SIGNAL PEPTIDE; SRC HOMOLOGY 2 (SH2) DOMAIN CONTAINING PHOSPHATASES; SRC HOMOLOGY-2 (SH2) DOMAIN-CONTAINING PHOSPHATASES;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; CELL FUNCTION; CONTROLLED STUDY; DNA SYNTHESIS; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; LEUKEMIA; MOUSE; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL CYCLE; CELL TRANSPLANTATION; CYTOLOGY; ENZYME ACTIVATION; GENETICS; HEMATOPOIETIC STEM CELL; METABOLISM; MUTATION; PHYSIOLOGY;

ANIMALIA;

ANIMALS; CELL CYCLE; CELL TRANSPLANTATION; CELLS, CULTURED; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GRB2 ADAPTOR PROTEIN; HEMATOPOIETIC STEM CELLS; HUMANS; INTERLEUKIN-3; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JANUS KINASE 2; LEUKEMIA; MICE; MICE, INBRED C57BL; MUTATION; ONCOGENE PROTEIN V-AKT; PHOSPHOPROTEINS; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR;

EID: 33646842917     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M507622200     Document Type: Article

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