Diverse biochemical properties of Shp2 mutants: Implications for disease phenotypes

Journal of Biological Chemistry

Volumn 280, Issue 35, 2005, Pages 30984-30993

  Keilhack, Heike ^a,c   David, Frank S ^a,b   McGregor, Malcolm ^c   Cantley, Lewis C ^a,d   Neel, Benjamin G ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Serono Repro Biology Institute   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; MATHEMATICAL MODELS; PATHOLOGY; PHOSPHATES; TUMORS;

INTRACELLULAR SIGNALING; PATHOGENIC SHP2 MUTATIONS;

DISEASES;

PROTEIN PTPN11; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOSOMAL DOMINANT DISORDER; BINDING AFFINITY; BIOCHEMISTRY; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE MUTATION; HEMATOLOGIC MALIGNANCY; MATHEMATICAL MODEL; NONHUMAN; NOONAN SYNDROME; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STIMULUS RESPONSE;

CALORIMETRY; ENZYME ACTIVATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; MODELS, THEORETICAL; MUTATION; NOONAN SYNDROME; PHENOTYPE; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE-PHOSPHATASE; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 24744465207     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M504699200     Document Type: Article

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