Integrin α2β1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCγ2

Journal of Cell Biology

Volumn 160, Issue 5, 2003, Pages 769-780

  Inoue, Osamu ^a   Suzuki Inoue, Katsue ^a   Dean, William L ^b   Frampton, Jon ^c   Watson, Steve P ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b University of Louisville School of Medicine   (United States)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Blood platelets; Cell spreading; FAK; Inregrin 2 1; PLC 2

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM ION; COLLAGEN; FC RECEPTOR; FOCAL ADHESION KINASE; GLYCOPROTEIN; GLYCOPROTEIN VI; INTEGRIN; PHOSPHOLIPASE C; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 2; CATION TRANSPORT PROTEIN; ENZYME PRECURSOR; FIBRINOGEN RECEPTOR; PEPTIDE FRAGMENT; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEIN; PLASMA MEMBRANE CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; PLATELET MEMBRANE GLYCOPROTEIN VI; PROTEIN KINASE SYK; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SLP 76 SIGNAL TRANSDUCING ADAPTOR PROTEINS; SLP-76 SIGNAL TRANSDUCING ADAPTOR PROTEINS; TYROSINE;

ANIMAL CELL; ARTICLE; BLEEDING TIME; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL SPREADING; CONTROLLED STUDY; ENZYME ACTIVATION; FILOPODIUM; HUMAN; HUMAN CELL; LAMELLIPODIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THROMBOCYTE ADHESION; THROMBOGENESIS; ANIMAL; BLOOD CLOTTING; CALCIUM SIGNALING; CELL CULTURE; CELL MOTION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; PHYSIOLOGY; PSEUDOPODIUM; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ADHESIVENESS; ULTRASTRUCTURE;

ANIMALIA; THROMBUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOOD COAGULATION; BLOOD PLATELETS; CALCIUM SIGNALING; CALCIUM-TRANSPORTING ATPASES; CATION TRANSPORT PROTEINS; CELL MOVEMENT; CELLS, CULTURED; COLLAGEN; ENZYME PRECURSORS; HUMANS; INTEGRIN ALPHA2BETA1; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; PEPTIDE FRAGMENTS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEINS; PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASES; PLATELET ADHESIVENESS; PLATELET MEMBRANE GLYCOPROTEINS; PROTEIN-TYROSINE KINASES; PSEUDOPODIA; RECEPTORS, FC; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TYROSINE;

EID: 0037416053     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200208043     Document Type: Article

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