Modulation of the nuclear factor κB pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor

Journal of Experimental Medicine

Volumn 193, Issue 1, 2001, Pages 101-109

  You, M ^a   Flick, L M ^a   Yu, D ^a   Feng, G S ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

IL 1; IL 6; Shp 2; TNF; Tyrosine phosphatase

Indexed keywords

CELL SURFACE RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; PHOSPHATASE; PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; CYTOKINE RELEASE; FIBROBLAST; IMMUNE RESPONSE; IMMUNOREGULATION; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; INTERLEUKIN-1; INTERLEUKIN-6; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; NF-KAPPA B; PHENOTYPE; PROTEIN-TYROSINE-PHOSPHATASE; SHP1 PROTEIN TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035176070     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.193.1.101     Document Type: Article

References (34)

1. Biologic basis for interleukin-1 in disease
2. Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases
3. Regulation of expression of interleukin-6. Molecular and clinical studies
4. Interleukin-1 signal transduction
5. Two TNF receptors
6. Tumor necrosis factor receptor-associated factors (TRAFs) - A family of adapter proteins that regulates life and death
7. IRAK: A kinase associated with the interleukin-1 receptor
8. Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production
9. Activation of interleukin-6 gene expression through the NF-kappa B transcription factor
10. Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence
11. Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines
12. The NF-kappa B and I kappa B proteins: New discoveries and insights
13. Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation
14. Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes
15. Mitogen-activated protein kinase cascades and regulation of gene expression
16. Towards an understanding of the signal transduction pathways for interleukin 1
17. Shp-2 tyrosine phosphatase: Signaling one cell or many
18. Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2
19. A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development
20. The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases
21. Protein tyrosine phosphatase Shp-2 regulates cell spreading, migration and focal adhesion
22. Downregulation of platelet-derived growth factor receptor-β in Shp-2 mutant fibroblast cell lines
23. Shp-2 tyrosine phosphatase functions as a negative regulator in the interferon-stimulated Jak/STAT pathway
24. The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor
25. Interleukin 1 (IL1) and tumour necrosis factor (TNF) signal transduction
26. Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin
27. Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation
28. The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development
29. Induction of NF-kappaB by the Akt/PKB kinase
30. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
31. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
32. Multiple signals converging on NF-kappaB
33. Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity
34. p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor