Cutting edge: Gab2 mediates an inhibitory phosphatidylinositol 3'-kinase pathway in T cell antigen receptor signaling

Journal of Immunology

Volumn 165, Issue 8, 2000, Pages 4158-4163

  Pratt, J C ^a   Igras, V E ^a   Maeda, H ^a   Baksh, S ^a   Gelfand, E W ^a   Burakoff, S J ^a   Neel, B G ^a   Gu, H ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOCKING PROTEIN; ENZYME INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; NUCLEAR FACTOR; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN GAB2; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME BINDING; ENZYME INHIBITION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0034667783     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.8.4158     Document Type: Article

References (20)

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4. Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion
5. A negative role for phosphoinositide 3-kinase in T-cell antigen receptor function
6. + T cells
7. Phosphoinositide 3-kinase regulation of T cell receptor-mediated interleukin-2 gene expression in normal T cells
8. Cloning of p97/Gab2, the major SHP-2 binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
9. The docking molecule Gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines
10. Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors
11. Engagement of Gab1 and Gab2 in erythropoietin signaling
12. The IRS-signaling system: A network of docking proteins that mediate insulin and cytokine action
13. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
14. Transcriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells: Convergence of costimulatory signals and differences from transformed T cells
15. The small GTP-binding protein Rho potentiates AP-1 transcription in T cells
16. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase
17. The tumor suppressor, PTEN/MMACl, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-triphosphate
18. A conserved inositol phospholipid binding site within the pleckstrin homology domain of the Gab1 docking protein is required for epithelial morphogenesis
19. A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
20. Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1