Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation

Molecular and Cellular Biology

Volumn 21, Issue 10, 2001, Pages 3547-3557

  Frantsve, J ^a   Schwaller, J ^a   Sternberg, D W ^a   Kutok, J ^a   Gilliland, D G ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; PROTEASOME; PROTEIN JAK2 KINASE; PROTEIN KINASE; PROTEIN TEL JAK2; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE MARROW TRANSPLANTATION; CELL TRANSFORMATION; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INDUCTION; ENZYME INHIBITION; GENE ACTIVATION; GENE EXPRESSION; GENE MUTATION; HEMATOPOIETIC CELL; LATENT PERIOD; LEUKEMIA; LYMPHOPROLIFERATIVE DISEASE; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FAMILY; SIGNAL TRANSDUCTION;

ANIMALS; CARRIER PROTEINS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CYSTEINE ENDOPEPTIDASES; ENZYME ACTIVATION; HEMATOPOIETIC STEM CELLS; JANUS KINASE 2; MICE; MULTIENZYME COMPLEXES; ONCOGENE PROTEINS, FUSION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

ANIMALIA; MURINAE;

EID: 0035036625     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.10.3547-3557.2001     Document Type: Article

References (51)

1. TEL-JAK2 transgenic mice develop T-cell leukemia
2. Constitutive activation of JAKs and STATs in BCR-Abl expressing cell lines and peripheral blood cells derived from leukemic patients
3. Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells
4. bcr/abl gene of the Philadelphia chromosome
5. Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins
6. Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25)
7. A new protein containing an SH2 domain that inhibits JAK kinases
8. Kat: A high-efficiency retroviral transduction system for primary human T lymphocytes
9. B. lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues
10. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
11. Oligomerization of the ABL tyrosine kinase by the ETS protein TEL in human leukemia
12. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients
13. Versatile retroviral vectors for potential use in mice by an interleukin 6 retrovirus
14. Twenty proteins containing a C-terminal SOCS box form five structural classes
15. Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling
16. Transforming gene product of Rous sarcoma virus phosphorylates tyrosine
17. Signaling by the cytokine receptor superfamily in normal and transformed hematpoietic cells
18. Jaks and Stats in signaling by the cytokine receptor family
19. P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members
20. A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor
21. Transforming properties of chimeric TEL-JAK2 proteins in Ba/F3 cells
22. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
23. Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL
24. The P190, P210, and p230 forms of the BCR/ABL oncogene induce a similar chronic myeloid lerkemia-like syndrome in mice but have different lymphoid leukemogenic activity
25. Signal transduction and transforming properties of the TEL/TRKC fusions associated with t(12;15)p(13;q25) in congenital fibrosarcoma and acute myelogenous leukemia
26. Cloning and characterization of novel CIS family genes
27. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation
28. The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity
29. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3
30. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase
31. Structure and function of a new STAT-induced STAT inhibitor
32. p210BCR/ABL, p190BCR/ABL and TEL/ABL activate similar signal transduction pathways in hematopoietic cell lines
33. The novel activation of ABL by fusion to an ets-related gene, TEL
34. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia
35. Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders
36. Retroviral-mediated transfer of the green fluorescent protein gene into murine hematopoietic cells facilitates scoring and selection of transduced progenitors in vitro and identification of genetically modified cells in vivo
37. Mitogen-activated protein kinase kinase inhibition decreases growth hormone stimulated transcription mediated by STAT5
38. Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a
39. Chronic myeloid leukemia
40. Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myeloid and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion gene
41. Stat5a/b is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2
42. Stat5a/b contribute to interleukin1-induced B-cell precursor expansion, but abl and bcr/abl-induced transformation are independent of Stat5
43. A family of cytokine-inducible inhibitors of signalling
44. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
45. TEL/PDGFbetaR fusion protein activates STAT1 and STAT5: A common mechanism for transformation by tyrosine kinase fusion proteins
46. JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone
47. Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells
48. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
49. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
50. Requirement of serine phosphorylation for formation of STAT-promoter complexes
51. Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of JAK2