Gab1, SHP2, and protein kinase a are crucial for the activation of the endothelial NO synthase by fluid shear stress

Circulation Research

Volumn 97, Issue 12, 2005, Pages 1236-1244

  Dixit, Madhulika ^a   Loot, Annemarieke E ^a   Mohamed, Annisuddin ^a   Fisslthaler, Beate ^a   Boulanger, Chantal M ^b   Ceacareanu, Bogdan ^c   Hassid, Aviv ^c   Busse, Rudi ^a   Fleming, Ingrid ^a,d  

^a GOETHE UNIVERSITY   (Germany)

^b HÔPITAL LARIBOISIÈRE   (France)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^d UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Akt; Blood flow; Endothelial nitric oxide synthase; Mechanotransduction; Protein kinase A

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN GAB1; PROTEIN P85; PROTEIN TYROSINE PHOSPHATASE SHP 2; TYROSINE; UNCLASSIFIED DRUG; ACETYLCHOLINE; GAB1 PROTEIN, MOUSE; PHOSPHOPROTEIN; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE; SIGNAL PEPTIDE; SRC HOMOLOGY 2 (SH2) DOMAIN CONTAINING PHOSPHATASES; SRC HOMOLOGY-2 (SH2) DOMAIN-CONTAINING PHOSPHATASES;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SHEAR STRESS; SIGNAL TRANSDUCTION; SWINE; VASODILATATION; ANIMAL; BLOOD FLOW; C57BL MOUSE; CELL CULTURE; DRUG EFFECT; MECHANICAL STRESS; METABOLISM; MUTATION; PHOSPHORYLATION; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ACETYLCHOLINE; ANIMALS; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED C57BL; MUTATION; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS C-AKT; REGIONAL BLOOD FLOW; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; SWINE; TYROSINE; VASODILATION;

EID: 33644694921     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000195611.59811.ab     Document Type: Article

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