GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines

European Journal of Biochemistry

Volumn 269, Issue 4, 2002, Pages 1199-1208

  Matkó, János ^a,d   Bodnár, Andrea ^a   Vereb, György ^a   Bene, László ^a   Vámosi, György ^a   Szentesi, Gergely ^a   Szöllösi, János ^a   Gáspár Jr , Rezsõ ^a   Horejsi, Václav ^b   Waldmann, Thomas A ^c   Damjanovich, Sándor ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^c NATIONAL CANCER INSTITUTE   (United States)

^d EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

Cell proliferation; Cytokine receptors; Fluorescence energy transfer; Lipid rafts; T lymphocytes

Indexed keywords

CD48 ANTIGEN; CHOLESTEROL; DETERGENT; GANGLIOSIDE GM1; HLA DR ANTIGEN; INTERLEUKIN 15; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 2 RECEPTOR GAMMA; INTERLEUKIN 7; INTERLEUKIN 9; METHYL BETA CYCLODEXTRIN; RECEPTOR SUBUNIT; STAT PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENERGY TRANSFER; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LEUKEMIA CELL LINE; LYMPHOMA CELL LINE; MOLECULE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; T CELL LEUKEMIA; T CELL LYMPHOMA;

ANTIGENS, CD; G(M1) GANGLIOSIDE; GLYCOPROTEINS; HLA ANTIGENS; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LEUKEMIA, T-CELL; LYMPHOMA, T-CELL; MEMBRANE MICRODOMAINS; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-2; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 18244402689     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0014-2956.2002.02759.x     Document Type: Article

References (53)

1. The interleukin-2 receptor
2. Biology of the interleukin-2 receptor
3. Heterodimerization of the IL-2 receptor beta- and gamma-chain cytoplasmic domains is required for signalling
4. Jaks and STATs: Biological implications
5. IL-15: A pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels
6. Cytokines: Shared receptors, distinct functions
7. Endocytosis of interleukin 2 receptors in human T lymphocytes: Distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains
8. Regulation of signal transduction and signal diversity by receptor oligomerization
9. T-cell receptors for cytokines: Targets for immunotherapy of leukemia/lymphoma
10. Molecular basis for two different affinity states of the interleukin 2 receptor: Affinity conversion model
11. Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225, K6 T cells and their modulation by IL-2, IL-7, and IL-15: A fluorescence resonance energy transfer study
12. Cholesterol-dependent clustering of IL-2Ralpha and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts
13. Membrane compartmentation is required for efficient T cell activation
14. GPI-microdomains: A role in signalling via immunoreceptors
15. Membrane organization in immunoglobulin E receptor signaling
16. Luminescence spectroscopic approaches in studying cell surface dynamics
17. Fluorescence energy transfer measurements on cell surfaces: A critical comparison of steady-state fluorimetric and flow cytometric methods
18. Flow cytometric measurement of fluorescence resonance energy transfer on cell surfaces. Quantitative evaluation of the transfer efficiency on a cell-by-cell basis
19. Energy transfer methods for detecting molecular clusters on cell surfaces
20. FRET microscopy: Digital imaging of fluorescence resonance energy transfer. Applications in cell biology
21. GPI-anchored proteins are organized in submicron domains at the cell surface
22. Supramolecular receptor structures in the plasma membrane of lymphocytes revealed by flow cytometric energy transfer, scanning force-and transmission electron-microscopic analyses
23. IL-2R alpha on one cell can present IL-2 to IL-2R beta/gamma (c) on another cell to augment IL-2 signaling
24. Flow cytometric resonance energy transfer measurements support the association of a 95-kDa peptide termed T27 with the 55-kDa Tac peptide
25. The IL-2 receptor alpha-chain alters the binding of IL-2 to the beta-chain
26. Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY
27. Theory for establishing proximity relations in biological membranes by excitation energy transfer measurements
28. Two-dimensional receptor patternsin the plasma membrane of cells. A critical evaluation of their identification, origin and information content
29. Modification of membrane cholesterol level affects expression and clustering of class I HLA molecules at the surface of JY human lymphoblasts
30. Fluidity parameters of lipid regions determined by fluorescence polarization
31. Microdomain-dependent regulation of Lck and Fyn protein-tyrosine kinases in T lymphocyte plasma membranes
32. Detection of intracellular phosphorylated STAT-1 by flow cytometry
33. Functional rafts in cell membranes
34. Clusters of glycolipid and glycosylphosphatidyl-inositol-anchored proteins in lymphoid cells: Accumulation of actin regulated by local tyrosine phosphorylation
35. Membrane rafts and signaling by the multichain immune recognition receptors
36. Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane
37. Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
38. HLA class I and II antigens are partially co-clustered in the plasma membrane of human lymphoblastoid cells
39. Domains in cell plasma membranes investigated by near-field scanning optical microscopy
40. Flow cytometry resonance energy transfer suggests an association between low-affinity interleukin 2 binding sites and HLA class I molecules
41. Interaction of class I human leukocyte antigen (HLA-I) molecules with insulin receptors and its effect on the insulin-signaling cascade
42. Detection and spatial distribution of IL-2 receptors on mouse T-lymphocytes by immunogold-labeledligands
43. Distinct association of transferrin receptor with HLA class I molecules on HUT-102B and JY cells
44. Isolation of high-affinity murine interleukin 2 receptors as detergent-resistant membrane complexes
45. Trafficking of spontaneously endocytosed MHC proteins
46. Cell surface organization by the membrane skeleton
47. The interaction of lymphocyte membrane proteins with the lymphocyte cytoskeletal matrix
48. Association of various T cell-surface molecules with the cytoskeleton. Effect of cross-linking and activation
49. The interleukin 2 receptor (IL-2R): The IL-2R alpha subunit alters the function of the IL-2R beta subunit to enhance IL-2 binding and signaling by mechanisms that do not require binding of IL-2 to IL-2R alpha subunit
50. Cooperative interactions between the interleukin 2 receptor alpha and beta chains alter the interleukin 2-binding affinity of the receptor subunits
51. Immobilization of glycosylphosphatidylinositol-anchored proteins inhibits T cell growth but not function
52. Role of lipid rafts in regulating interleukin-2 receptor signaling
53. Interleukin 2 receptors and detergent-resistant membrane domains define a chlatrin-independent endocytic pathway