Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways

Circulation

Volumn 117, Issue 11, 2008, Pages 1423-1435

  Kontaridis, Maria I ^a,c   Yang, Wentian ^a,f   Bence, Kendra K ^a,g   Cullen, Darragh ^b   Wang, Bo ^b   Bodyak, Natalya ^c   Ke, Qingen ^c   Hinek, Aleksander ^d,e   Kang, Peter M ^c   Liao, Ronglih ^b   Neel, Benjamin G ^a,h  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d Hospital for Sick Children

^e UNIVERSITY OF TORONTO   (Canada)

^f BROWN UNIVERSITY   (United States)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

^h PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Cardiomyopathies; Heart diseases; Molecular biology; Myocardium; Myocytes; Signal transduction

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PTPN11 PROTEIN, MOUSE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; ENZYME ACTIVITY; GENE DELETION; HEART DISEASE; HEART FUNCTION; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART PROTECTION; HYPERTROPHY; MOUSE; NONHUMAN; PERINATAL PERIOD; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; ANTIBODY SPECIFICITY; C57BL MOUSE; CARDIOMEGALY; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; LEOPARD SYNDROME; MALE; MOUSE MUTANT; NOONAN SYNDROME; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESSURE;

ANIMALS; CARDIOMEGALY; CARDIOMYOPATHY, DILATED; LEOPARD SYNDROME; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, ANIMAL; MYOCYTES, CARDIAC; NOONAN SYNDROME; ORGAN SPECIFICITY; PHENOTYPE; PRESSURE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 41649085870     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.107.728865     Document Type: Article

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