-
1
-
-
0033009891
-
Selection of the T cell repertoire
-
Sebzda E., Mariathasan S., Ohteki T., Jones R., Bachmann M.F., Ohashi P.S. Selection of the T cell repertoire. Annu Rev Immunol. 17:1999;829-874
-
(1999)
Annu Rev Immunol
, vol.17
, pp. 829-874
-
-
Sebzda, E.1
Mariathasan, S.2
Ohteki, T.3
Jones, R.4
Bachmann, M.F.5
Ohashi, P.S.6
-
2
-
-
0036884819
-
Regulation of B-cell fate by antigen-receptor signals
-
Niiro H., Clark E.A. Regulation of B-cell fate by antigen-receptor signals. Nat Rev Immunol. 2:2002;945-956
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 945-956
-
-
Niiro, H.1
Clark, E.A.2
-
3
-
-
0037375567
-
B-cell commitment: Deciding on the players
-
Hardy R.R. B-cell commitment: deciding on the players. Curr Opin Immunol. 15:2003;158-165
-
(2003)
Curr Opin Immunol
, vol.15
, pp. 158-165
-
-
Hardy, R.R.1
-
4
-
-
0031927280
-
Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc
-
Walk S.F., March M.E., Ravichandran K.S. Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc. Eur J Immunol. 28:1998;2265-2275
-
(1998)
Eur J Immunol
, vol.28
, pp. 2265-2275
-
-
Walk, S.F.1
March, M.E.2
Ravichandran, K.S.3
-
5
-
-
0035474473
-
Signaling via Shc family adapter proteins
-
Ravichandran K.S. Signaling via Shc family adapter proteins. Oncogene. 20:2001;6322-6330
-
(2001)
Oncogene
, vol.20
, pp. 6322-6330
-
-
Ravichandran, K.S.1
-
6
-
-
0037306480
-
Role of Shc in T-cell development and function
-
Zhang L., Lorenz U., Ravichandran K.S. Role of Shc in T-cell development and function. Immunol Rev. 191:2003;183-195
-
(2003)
Immunol Rev
, vol.191
, pp. 183-195
-
-
Zhang, L.1
Lorenz, U.2
Ravichandran, K.S.3
-
7
-
-
0033826512
-
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
-
Gu H., Maeda H., Moon J.J., Lord J.D., Yoakim M., Nelson B.H., Neel B.G. New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway. Mol Cell Biol. 20:2000;7109-7120
-
(2000)
Mol Cell Biol
, vol.20
, pp. 7109-7120
-
-
Gu, H.1
Maeda, H.2
Moon, J.J.3
Lord, J.D.4
Yoakim, M.5
Nelson, B.H.6
Neel, B.G.7
-
8
-
-
0036342137
-
A nonredundant role for the adapter protein Shc in thymic T cell development
-
The authors show that Shc is tyrosine phosphorylated after pre-TCR engagement in immature DN thymocytes. To further demonstrate the in vivo role of Shc in thymocyte development the authors use two genetic approaches. First, by conditional inactivation of the Shc1 genomic locus it is shown that Shc is required to transduce signals required for the transition from the DN3 to the DN4 stage through the pre-TCR. To further assess the role of Shc in T-cell development, the authors generated transgenic mice expressing a dominant-negative form of Shc in which the tyrosine residues Tyr239, Tyr240 and Tyr317 were mutated to phenylalanine. Similar to the conditional deletion, the expression of the dominant-negative Shc also results in a partial developmental block of DN thymocytes. The study thus demonstrates that Shc and signalling pathway(s) downstream of Shc are essential for optimal pre-TCR signalling and progression through the DN stage.
-
Zhang L., Camerini V., Bender T.P., Ravichandran K.S. A nonredundant role for the adapter protein Shc in thymic T cell development. Nat Immunol. 3:2002;749-755 The authors show that Shc is tyrosine phosphorylated after pre-TCR engagement in immature DN thymocytes. To further demonstrate the in vivo role of Shc in thymocyte development the authors use two genetic approaches. First, by conditional inactivation of the Shc1 genomic locus it is shown that Shc is required to transduce signals required for the transition from the DN3 to the DN4 stage through the pre-TCR. To further assess the role of Shc in T-cell development, the authors generated transgenic mice expressing a dominant-negative form of Shc in which the tyrosine residues Tyr239, Tyr240 and Tyr317 were mutated to phenylalanine. Similar to the conditional deletion, the expression of the dominant-negative Shc also results in a partial developmental block of DN thymocytes. The study thus demonstrates that Shc and signalling pathway(s) downstream of Shc are essential for optimal pre-TCR signalling and progression through the DN stage.
-
(2002)
Nat Immunol
, vol.3
, pp. 749-755
-
-
Zhang, L.1
Camerini, V.2
Bender, T.P.3
Ravichandran, K.S.4
-
9
-
-
0037007092
-
Genetic evidence for Shc requirement in TCR-induced c-Rel nuclear translocation and IL-2 expression
-
Iwashima M., Takamatsu M., Yamagishi H., Hatanaka Y., Huang Y.Y., McGinty C., Yamasaki S., Koike T. Genetic evidence for Shc requirement in TCR-induced c-Rel nuclear translocation and IL-2 expression. Proc Natl Acad Sci USA. 99:2002;4544-4549
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 4544-4549
-
-
Iwashima, M.1
Takamatsu, M.2
Yamagishi, H.3
Hatanaka, Y.4
Huang, Y.Y.5
McGinty, C.6
Yamasaki, S.7
Koike, T.8
-
10
-
-
0034303470
-
T cell: Getting a GRP on Ras
-
Roose J., Weiss A. T cell: getting a GRP on Ras. Nat Immunol. 1:2000;275-276
-
(2000)
Nat Immunol
, vol.1
, pp. 275-276
-
-
Roose, J.1
Weiss, A.2
-
11
-
-
0037306143
-
Transmembrane adapters: Attractant for cytoplasmic effectors
-
Lindquist J.A., Simeoni L., Schraven B. Transmembrane adapters: attractant for cytoplasmic effectors. Immunol Rev. 191:2003;165-182
-
(2003)
Immunol Rev
, vol.191
, pp. 165-182
-
-
Lindquist, J.A.1
Simeoni, L.2
Schraven, B.3
-
12
-
-
0031858649
-
Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice
-
Murphy M.A., Schnall R.G., Venter D.J., Barnett L., Bertoncello I., Thien C.B., Langdon W.Y., Bowtell D.D. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Mol Cell Biol. 18:1998;4872-4882
-
(1998)
Mol Cell Biol
, vol.18
, pp. 4872-4882
-
-
Murphy, M.A.1
Schnall, R.G.2
Venter, D.J.3
Barnett, L.4
Bertoncello, I.5
Thien, C.B.6
Langdon, W.Y.7
Bowtell, D.D.8
-
13
-
-
0032438114
-
Altered thymic positive selection and intracellular signals in Cbl-deficient mice
-
Naramura M., Kole H.K., Hu R.J., Gu H. Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc Natl Acad Sci USA. 95:1998;15547-15552
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 15547-15552
-
-
Naramura, M.1
Kole, H.K.2
Hu, R.J.3
Gu, H.4
-
14
-
-
0035854665
-
Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70
-
Wang H.Y., Altman Y., Fang D., Elly C., Dai Y., Shao Y., Liu Y.C. Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70. J Biol Chem. 276:2001;26004-26011
-
(2001)
J Biol Chem
, vol.276
, pp. 26004-26011
-
-
Wang, H.Y.1
Altman, Y.2
Fang, D.3
Elly, C.4
Dai, Y.5
Shao, Y.6
Liu, Y.C.7
-
15
-
-
0036499010
-
Cbl and Cbl-b in T-cell regulation
-
Liu Y.C., Gu H. Cbl and Cbl-b in T-cell regulation. Trends Immunol. 23:2002;140-143
-
(2002)
Trends Immunol
, vol.23
, pp. 140-143
-
-
Liu, Y.C.1
Gu, H.2
-
16
-
-
0033564933
-
Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes
-
Thien C.B., Bowtell D.D., Langdon W.Y. Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes. J Immunol. 162:1999;7133-7139
-
(1999)
J Immunol
, vol.162
, pp. 7133-7139
-
-
Thien, C.B.1
Bowtell, D.D.2
Langdon, W.Y.3
-
17
-
-
0034192088
-
The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells
-
Rao N., Lupher M.L. Jr., Ota S., Reedquist K.A., Druker B.J., Band H. The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells. J Immunol. 164:2000;4616-4626
-
(2000)
J Immunol
, vol.164
, pp. 4616-4626
-
-
Rao, N.1
Lupher Jr., M.L.2
Ota, S.3
Reedquist, K.A.4
Druker, B.J.5
Band, H.6
-
18
-
-
0037450822
-
A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase
-
By producing mice with a knock-in mutation (Gly304→Glu) in the TKB domain of c-Cbl, which abolishes the interaction with phosphorylated Tyr292 of ZAP-70, the authors investigate the functional requirement of the TKB domain in TCR-mediated signalling events in thymocytes. Conversely to c-Cbl-deficient mice, Gly304→Glu knock-in mice show normal surface levels of the TCR-CD3 complex and normal ZAP-70 activity. In contradiction to previous models, Thien and co-workers here show that the TKB domain is neither required to negatively regulate ZAP-70 activity nor to regulate TCR-CD3 expression in immature thymocytes.
-
Thien C.B., Scaife R.M., Papadimitriou J.M., Murphy M.A., Bowtell D.D., Langdon W.Y. A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase. J Exp Med. 197:2003;503-513 By producing mice with a knock-in mutation (Gly304→Glu) in the TKB domain of c-Cbl, which abolishes the interaction with phosphorylated Tyr292 of ZAP-70, the authors investigate the functional requirement of the TKB domain in TCR-mediated signalling events in thymocytes. Conversely to c-Cbl-deficient mice, Gly304→Glu knock-in mice show normal surface levels of the TCR-CD3 complex and normal ZAP-70 activity. In contradiction to previous models, Thien and co-workers here show that the TKB domain is neither required to negatively regulate ZAP-70 activity nor to regulate TCR-CD3 expression in immature thymocytes.
-
(2003)
J Exp Med
, vol.197
, pp. 503-513
-
-
Thien, C.B.1
Scaife, R.M.2
Papadimitriou, J.M.3
Murphy, M.A.4
Bowtell, D.D.5
Langdon, W.Y.6
-
19
-
-
0041429608
-
LAT links the pre-BCR to calcium signaling
-
2+ release to the Igα-SLP-65-PLCγ2 complex during pre-BCR signalling and in pre-B-cell development.
-
2+ release to the Igα-SLP-65-PLCγ2 complex during pre-BCR signalling and in pre-B-cell development.
-
(2003)
Immunity
, vol.19
, pp. 295-305
-
-
Su, Y.W.1
Jumaa, H.2
-
20
-
-
0037396717
-
Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion
-
Schweighoffer E., Vanes L., Mathiot A., Nakamura T., Tybulewicz V.L. Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion. Immunity. 18:2003;523-533
-
(2003)
Immunity
, vol.18
, pp. 523-533
-
-
Schweighoffer, E.1
Vanes, L.2
Mathiot, A.3
Nakamura, T.4
Tybulewicz, V.L.5
-
21
-
-
0034507903
-
BCAP: The tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
-
Okada T., Maeda A., Iwamatsu A., Gotoh K., Kurosaki T. BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity. 13:2000;817-827
-
(2000)
Immunity
, vol.13
, pp. 817-827
-
-
Okada, T.1
Maeda, A.2
Iwamatsu, A.3
Gotoh, K.4
Kurosaki, T.5
-
22
-
-
0037018096
-
Essential immunoregulatory role for BCAP in B cell development and function
-
Yamazaki T., Takeda K., Gotoh K., Takeshima H., Akira S., Kurosaki T. Essential immunoregulatory role for BCAP in B cell development and function. J Exp Med. 195:2002;535-545
-
(2002)
J Exp Med
, vol.195
, pp. 535-545
-
-
Yamazaki, T.1
Takeda, K.2
Gotoh, K.3
Takeshima, H.4
Akira, S.5
Kurosaki, T.6
-
23
-
-
0041695162
-
Contribution of BCAP to maintenance of mature B cells through c-Rel
-
In this paper the authors investigate the mechanisms underlying the previously described B-cell defect in BCAP-deficient mice. They find that BCAP determinates B-cell longevity by regulating c-Rel expression, and the induction of pro-survival molecules and factors such as cyclin D2 and Cdk4, which are required for cell-cycle progression.
-
Yamazaki T., Kurosaki T. Contribution of BCAP to maintenance of mature B cells through c-Rel. Nat Immunol. 4:2003;780-786 In this paper the authors investigate the mechanisms underlying the previously described B-cell defect in BCAP-deficient mice. They find that BCAP determinates B-cell longevity by regulating c-Rel expression, and the induction of pro-survival molecules and factors such as cyclin D2 and Cdk4, which are required for cell-cycle progression.
-
(2003)
Nat Immunol
, vol.4
, pp. 780-786
-
-
Yamazaki, T.1
Kurosaki, T.2
-
24
-
-
0035314006
-
B1 cells: Similarities and differences with other B cell subsets
-
Martin F., Kearney J.F. B1 cells: similarities and differences with other B cell subsets. Curr Opin Immunol. 13:2001;195-201
-
(2001)
Curr Opin Immunol
, vol.13
, pp. 195-201
-
-
Martin, F.1
Kearney, J.F.2
-
25
-
-
0034613222
-
T-Independent immune response: New aspects of B cell biology
-
Fagarasan S., Honjo T. T-Independent immune response: new aspects of B cell biology. Science. 290:2000;89-92
-
(2000)
Science
, vol.290
, pp. 89-92
-
-
Fagarasan, S.1
Honjo, T.2
-
26
-
-
0041381357
-
Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells
-
Xue L., Morris S.W., Orihuela C., Tuomanen E., Cui X., Wen R., Wang D. Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells. Nat Immunol. 4:2003;857-865
-
(2003)
Nat Immunol
, vol.4
, pp. 857-865
-
-
Xue, L.1
Morris, S.W.2
Orihuela, C.3
Tuomanen, E.4
Cui, X.5
Wen, R.6
Wang, D.7
-
27
-
-
0038375851
-
Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation
-
Egawa T., Albrecht B., Favier B., Sunshine M.J., Mirchandani K., O'Brien W., Thome M., Littman D.R. Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol. 13:2003;1252-1258
-
(2003)
Curr Biol
, vol.13
, pp. 1252-1258
-
-
Egawa, T.1
Albrecht, B.2
Favier, B.3
Sunshine, M.J.4
Mirchandani, K.5
O'Brien, W.6
Thome, M.7
Littman, D.R.8
-
28
-
-
0038037580
-
Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes
-
Newton K., Dixit V.M. Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes. Curr Biol. 13:2003;1247-1251
-
(2003)
Curr Biol
, vol.13
, pp. 1247-1251
-
-
Newton, K.1
Dixit, V.M.2
-
29
-
-
0345374583
-
Regulation of NF-{kappa}B-dependent lymphocyte activation and development by Paracaspase
-
Ruefli-Brasse A.A., French D.M., Dixit V.M. Regulation of NF-{kappa}B-dependent lymphocyte activation and development by Paracaspase. Science. 302:2003;1581-1584
-
(2003)
Science
, vol.302
, pp. 1581-1584
-
-
Ruefli-Brasse, A.A.1
French, D.M.2
Dixit, V.M.3
-
30
-
-
0037121939
-
Non-T cell activation linker (NTAL): A transmembrane adaptor protein involved in immunoreceptor signaling
-
++ flux.
-
++ flux.
-
(2002)
J Exp Med
, vol.196
, pp. 1617-1626
-
-
Brdicka, T.1
Imrich, M.2
Angelisova, P.3
Brdickova, N.4
Horvath, O.5
Spicka, J.6
Hilgert, I.7
Luskova, P.8
Draber, P.9
Novak, P.10
-
32
-
-
0037077094
-
Induction of T helper type 2 immunity by a point mutation in the LAT adaptor
-
Aguado E., Richelme S., Nunez-Cruz S., Miazek A., Mura A.M., Richelme M., Guo X.J., Sainty D., He H.T., Malissen B., Malissen M. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science. 296:2002;2036-2040
-
(2002)
Science
, vol.296
, pp. 2036-2040
-
-
Aguado, E.1
Richelme, S.2
Nunez-Cruz, S.3
Miazek, A.4
Mura, A.M.5
Richelme, M.6
Guo, X.J.7
Sainty, D.8
He, H.T.9
Malissen, B.10
Malissen, M.11
-
33
-
-
0037076975
-
A LAT mutation that inhibits T cell development yet induces lymphoproliferation
-
Sommers C.L., Park C.S., Lee J., Feng C., Fuller C.L., Grinberg A., Hildebrand J.A., Lacana E., Menon R.K., Shores E.W., et al. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science. 296:2002;2040-2043
-
(2002)
Science
, vol.296
, pp. 2040-2043
-
-
Sommers, C.L.1
Park, C.S.2
Lee, J.3
Feng, C.4
Fuller, C.L.5
Grinberg, A.6
Hildebrand, J.A.7
Lacana, E.8
Menon, R.K.9
Shores, E.W.10
-
34
-
-
10744225431
-
LIME: A new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling
-
•]) describes LIME: a novel raft-associated transmembrane adaptor expressed in both T and NK cells. LIME is phosphorylated by Src kinases and is able to simultaneously bind Lck and Csk via their SH2 domains. As a consequence, Csk phosphorylates LIME-bound Lck on its carboxy-terminal tyrosine residue; however, as the SH2 domain of Lck is not available to induce the closed conformation (that normally inhibits Lck activity), Lck stays active. Whether the 'unbound' tyrosine of Lck is then capable of recruiting additional SH2-domain-containing molecules remains to be determined, but this may be a novel mechanism for signal amplification. Another interesting aspect of the paper is the finding that phosphorylation of LIME occurs selectively after coreceptor triggering, whereas TCR stimulation induces dephosphorylation of the molecule.
-
•]) describes LIME: a novel raft-associated transmembrane adaptor expressed in both T and NK cells. LIME is phosphorylated by Src kinases and is able to simultaneously bind Lck and Csk via their SH2 domains. As a consequence, Csk phosphorylates LIME-bound Lck on its carboxy-terminal tyrosine residue; however, as the SH2 domain of Lck is not available to induce the closed conformation (that normally inhibits Lck activity), Lck stays active. Whether the 'unbound' tyrosine of Lck is then capable of recruiting additional SH2-domain-containing molecules remains to be determined, but this may be a novel mechanism for signal amplification. Another interesting aspect of the paper is the finding that phosphorylation of LIME occurs selectively after coreceptor triggering, whereas TCR stimulation induces dephosphorylation of the molecule.
-
(2003)
J Exp Med
, vol.198
, pp. 1453-1462
-
-
Brdickova, N.1
Brdicka, T.2
Angelisova, P.3
Horvath, O.4
Spicka, J.5
Hilgert, I.6
Paces, J.7
Simeoni, L.8
Kliche, S.9
Merten, C.10
-
35
-
-
0345138999
-
LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation
-
•].
-
•].
-
(2003)
J Exp Med
, vol.198
, pp. 1463-1473
-
-
Hur, E.M.1
Son, M.2
Lee, O.H.3
Choi, Y.B.4
Park, C.5
Lee, H.6
Yun, Y.7
-
36
-
-
0342313755
-
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation
-
Brdicka T., Pavlistova D., Leo A., Bruyns E., Korinek V., Angelisova P., Scherer J., Shevchenko A., Hilgert I., Cerny J., et al. Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. J Exp Med. 191:2000;1591-1604
-
(2000)
J Exp Med
, vol.191
, pp. 1591-1604
-
-
Brdicka, T.1
Pavlistova, D.2
Leo, A.3
Bruyns, E.4
Korinek, V.5
Angelisova, P.6
Scherer, J.7
Shevchenko, A.8
Hilgert, I.9
Cerny, J.10
-
37
-
-
0037370491
-
Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor
-
This study uses transgenic mice overexpressing PAG to demonstrate the inhibitory effect of PAG upon T-cell activation. The inhibitory effect is alleviated in the Tyr314→Phe mutant, which abolishes the Csk binding site. Interestingly, this mutant appears to enhance TCR stimulation, suggesting that PAG may also possess positive regulatory activity.
-
Davidson D., Bakinowski M., Thomas M.L., Horejsi V., Veillette A. Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor. Mol Cell Biol. 23:2003;2017-2028 This study uses transgenic mice overexpressing PAG to demonstrate the inhibitory effect of PAG upon T-cell activation. The inhibitory effect is alleviated in the Tyr314→Phe mutant, which abolishes the Csk binding site. Interestingly, this mutant appears to enhance TCR stimulation, suggesting that PAG may also possess positive regulatory activity.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 2017-2028
-
-
Davidson, D.1
Bakinowski, M.2
Thomas, M.L.3
Horejsi, V.4
Veillette, A.5
-
38
-
-
0037369262
-
Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes
-
Baumgartner M., Angelisova P., Setterblad N., Mooney N., Werling D., Horejsi V., Langsley G. Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria- transformed B lymphocytes. Blood. 101:2003;1874-1881
-
(2003)
Blood
, vol.101
, pp. 1874-1881
-
-
Baumgartner, M.1
Angelisova, P.2
Setterblad, N.3
Mooney, N.4
Werling, D.5
Horejsi, V.6
Langsley, G.7
-
39
-
-
17744386318
-
Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure
-
Ruland J., Duncan G.S., Elia A., del Barco Barrantes I., Nguyen L., Plyte S., Millar D.G., Bouchard D., Wakeham A., Ohashi P.S., Mak T.W. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell. 104:2001;33-42
-
(2001)
Cell
, vol.104
, pp. 33-42
-
-
Ruland, J.1
Duncan, G.S.2
Elia, A.3
Del Barco Barrantes, I.4
Nguyen, L.5
Plyte, S.6
Millar, D.G.7
Bouchard, D.8
Wakeham, A.9
Ohashi, P.S.10
Mak, T.W.11
-
40
-
-
0037827638
-
Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis
-
Jun J.E., Wilson L.E., Vinuesa C.G., Lesage S., Blery M., Miosge L.A., Cook M.C., Kucharska E.M., Hara H., Penninger J.M., et al. Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity. 18:2003;751-762
-
(2003)
Immunity
, vol.18
, pp. 751-762
-
-
Jun, J.E.1
Wilson, L.E.2
Vinuesa, C.G.3
Lesage, S.4
Blery, M.5
Miosge, L.A.6
Cook, M.C.7
Kucharska, E.M.8
Hara, H.9
Penninger, J.M.10
-
41
-
-
0037490078
-
The MAGUK family protein CARD11 is essential for lymphocyte activation
-
Hara H., Wada T., Bakal C., Kozieradzki I., Suzuki S., Suzuki N., Nghiem M., Griffiths E.K., Krawczyk C., Bauer B., et al. The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity. 18:2003;763-775
-
(2003)
Immunity
, vol.18
, pp. 763-775
-
-
Hara, H.1
Wada, T.2
Bakal, C.3
Kozieradzki, I.4
Suzuki, S.5
Suzuki, N.6
Nghiem, M.7
Griffiths, E.K.8
Krawczyk, C.9
Bauer, B.10
-
42
-
-
0035843970
-
Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation
-
Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J. Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. FEBS Lett. 496:2001;121-127
-
(2001)
FEBS Lett
, vol.496
, pp. 121-127
-
-
Gaide, O.1
Martinon, F.2
Micheau, O.3
Bonnet, D.4
Thome, M.5
Tschopp, J.6
-
43
-
-
0035903154
-
Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction
-
McAllister-Lucas L.M., Inohara N., Lucas P.C., Ruland J., Benito A., Li Q., Chen S., Chen F.F., Yamaoka S., Verma I.M., et al. Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction. J Biol Chem. 276:2001;30589-30597
-
(2001)
J Biol Chem
, vol.276
, pp. 30589-30597
-
-
McAllister-Lucas, L.M.1
Inohara, N.2
Lucas, P.C.3
Ruland, J.4
Benito, A.5
Li, Q.6
Chen, S.7
Chen, F.F.8
Yamaoka, S.9
Verma, I.M.10
-
44
-
-
0036790507
-
CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex
-
Pomerantz J.L., Denny E.M., Baltimore D. CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex. EMBO J. 21:2002;5184-5194
-
(2002)
EMBO J
, vol.21
, pp. 5184-5194
-
-
Pomerantz, J.L.1
Denny, E.M.2
Baltimore, D.3
-
45
-
-
0036707522
-
CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation
-
Gaide O., Favier B., Legler D.F., Bonnet D., Brissoni B., Valitutti S., Bron C., Tschopp J., Thome M. CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation. Nat Immunol. 3:2002;836-843
-
(2002)
Nat Immunol
, vol.3
, pp. 836-843
-
-
Gaide, O.1
Favier, B.2
Legler, D.F.3
Bonnet, D.4
Brissoni, B.5
Valitutti, S.6
Bron, C.7
Tschopp, J.8
Thome, M.9
-
46
-
-
0036707520
-
A requirement for CARMA1 in TCR-induced NF-kappa B activation
-
Wang D., You Y., Case S.M., McAllister-Lucas L.M., Wang L., DiStefano P.S., Nunez G., Bertin J., Lin X. A requirement for CARMA1 in TCR-induced NF-kappa B activation. Nat Immunol. 3:2002;830-835
-
(2002)
Nat Immunol
, vol.3
, pp. 830-835
-
-
Wang, D.1
You, Y.2
Case, S.M.3
McAllister-Lucas, L.M.4
Wang, L.5
Distefano, P.S.6
Nunez, G.7
Bertin, J.8
Lin, X.9
-
47
-
-
0345358541
-
Differential requirement for malt1 in T and B cell antigen receptor signaling
-
Ruland J., Duncan G.S., Wakeham A., Mak T.W. Differential requirement for malt1 in T and B cell antigen receptor signaling. Immunity. 19:2003;749-758
-
(2003)
Immunity
, vol.19
, pp. 749-758
-
-
Ruland, J.1
Duncan, G.S.2
Wakeham, A.3
Mak, T.W.4
-
48
-
-
0242491039
-
Negative selection and autoimmunity
-
Ohashi P.S. Negative selection and autoimmunity. Curr Opin Immunol. 15:2003;668-676
-
(2003)
Curr Opin Immunol
, vol.15
, pp. 668-676
-
-
Ohashi, P.S.1
-
49
-
-
0034664756
-
T cell-specific adapter protein inhibits T cell activation by modulating Lck activity
-
Sundvold V., Torgersen K.M., Post N.H., Marti F., King P.D., Rottingen J.A., Spurkland A., Lea T. T cell-specific adapter protein inhibits T cell activation by modulating Lck activity. J Immunol. 165:2000;2927-2931
-
(2000)
J Immunol
, vol.165
, pp. 2927-2931
-
-
Sundvold, V.1
Torgersen, K.M.2
Post, N.H.3
Marti, F.4
King, P.D.5
Rottingen, J.A.6
Spurkland, A.7
Lea, T.8
-
50
-
-
0033452787
-
RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation
-
Rajagopal K., Sommers C.L., Decker D.C., Mitchell E.O., Korthauer U., Sperling A.I., Kozak C.A., Love P.E., Bluestone J.A. RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation. J Exp Med. 190:1999;1657-1668
-
(1999)
J Exp Med
, vol.190
, pp. 1657-1668
-
-
Rajagopal, K.1
Sommers, C.L.2
Decker, D.C.3
Mitchell, E.O.4
Korthauer, U.5
Sperling, A.I.6
Kozak, C.A.7
Love, P.E.8
Bluestone, J.A.9
-
51
-
-
0042886906
-
Impaired T cell death and lupus-like autoimmunity in T cell-specific adapter protein-deficient mice
-
Drappa J., Kamen L.A., Chan E., Georgiev M., Ashany D., Marti F., King P.D. Impaired T cell death and lupus-like autoimmunity in T cell-specific adapter protein-deficient mice. J Exp Med. 198:2003;809-821
-
(2003)
J Exp Med
, vol.198
, pp. 809-821
-
-
Drappa, J.1
Kamen, L.A.2
Chan, E.3
Georgiev, M.4
Ashany, D.5
Marti, F.6
King, P.D.7
-
52
-
-
0035132135
-
IL-15 and IL-2: A matter of life and death for T cells in vivo
-
Li X.C., Demirci G., Ferrari-Lacraz S., Groves C., Coyle A., Malek T.R., Strom T.B. IL-15 and IL-2: a matter of life and death for T cells in vivo. Nat Med. 7:2001;114-118
-
(2001)
Nat Med
, vol.7
, pp. 114-118
-
-
Li, X.C.1
Demirci, G.2
Ferrari-Lacraz, S.3
Groves, C.4
Coyle, A.5
Malek, T.R.6
Strom, T.B.7
-
53
-
-
0242413659
-
Cloning and characterization of ALX, an adaptor downstream of CD28
-
Greene T.A., Powell P., Nzerem C., Shapiro M.J., Shapiro V.S. Cloning and characterization of ALX, an adaptor downstream of CD28. J Biol Chem. 278:2003;45128-45134
-
(2003)
J Biol Chem
, vol.278
, pp. 45128-45134
-
-
Greene, T.A.1
Powell, P.2
Nzerem, C.3
Shapiro, M.J.4
Shapiro, V.S.5
-
54
-
-
0034141993
-
Cutting edge: A novel function of the SLAP-130/FYB adapter protein in β1 integrin signaling and T-lymphocyte migration
-
Hunter A.J., Ottoson N., Boerth N., Koretzky G.A., Shimizu Y. Cutting edge: a novel function of the SLAP-130/FYB adapter protein in β1 integrin signaling and T-lymphocyte migration. J Immunol. 164:2000;1143-1147
-
(2000)
J Immunol
, vol.164
, pp. 1143-1147
-
-
Hunter, A.J.1
Ottoson, N.2
Boerth, N.3
Koretzky, G.A.4
Shimizu, Y.5
-
55
-
-
0037385961
-
SKAP-55 regulates integrin adhesion and formation of T-cell-APC conjugates
-
The work described in this paper identifies SKAP-55 as a regulator of TCR-induced β1- and β2-integrin-mediated adhesion and T-cell-APC formation. The translocation of SKAP-55 into rafts connects this adaptor to TCR signalling.
-
Wang H., Moon E.Y., Azouz A., Wu X., Smith A., Schneider H., Hogg N., Rudd C.E. SKAP-55 regulates integrin adhesion and formation of T-cell-APC conjugates. Nat Immunol. 4:2003;366-374 The work described in this paper identifies SKAP-55 as a regulator of TCR-induced β1- and β2-integrin-mediated adhesion and T-cell-APC formation. The translocation of SKAP-55 into rafts connects this adaptor to TCR signalling.
-
(2003)
Nat Immunol
, vol.4
, pp. 366-374
-
-
Wang, H.1
Moon, E.Y.2
Azouz, A.3
Wu, X.4
Smith, A.5
Schneider, H.6
Hogg, N.7
Rudd, C.E.8
-
56
-
-
0033791898
-
The Yersinia tyrosine phosphatase YopH targets a novel adhesion-regulated signalling complex in macrophages
-
Black D.S., Marie-Cardine A., Schraven B., Bliska J.B. The Yersinia tyrosine phosphatase YopH targets a novel adhesion-regulated signalling complex in macrophages. Cell Microbiol. 2:2000;401-414
-
(2000)
Cell Microbiol
, vol.2
, pp. 401-414
-
-
Black, D.S.1
Marie-Cardine, A.2
Schraven, B.3
Bliska, J.B.4
-
57
-
-
0037592093
-
Negative regulation of T cell antigen receptor-mediated Crk-C3G signaling and cell adhesion by Cbl-b
-
The authors demonstrate that Cbl-b deficiency in T cells does not affect the stability and the expression of CRK-L, but rather its association with C3G. The enhanced interaction between CRK-L and C3G increases activation of the GTPase Rap1 to promote adhesion to LFA-1 in Cbl-b-deficient T cells. This suggests that Cbl-b plays a negative role in CRK-L-C3G-mediated Rap1 and β2-integrin activation in T cells.
-
Zhang W., Shao Y., Fang D., Huang J., Leon M.S., Liu Y.C. Negative regulation of T cell antigen receptor-mediated Crk-C3G signaling and cell adhesion by Cbl-b. J Biol Chem. 278:2003;23978-23983 The authors demonstrate that Cbl-b deficiency in T cells does not affect the stability and the expression of CRK-L, but rather its association with C3G. The enhanced interaction between CRK-L and C3G increases activation of the GTPase Rap1 to promote adhesion to LFA-1 in Cbl-b-deficient T cells. This suggests that Cbl-b plays a negative role in CRK-L-C3G-mediated Rap1 and β2-integrin activation in T cells.
-
(2003)
J Biol Chem
, vol.278
, pp. 23978-23983
-
-
Zhang, W.1
Shao, Y.2
Fang, D.3
Huang, J.4
Leon, M.S.5
Liu, Y.C.6
-
58
-
-
0036604987
-
Communication between the TCR and integrins: Role of the molecular adapter ADAP/Fyb/Slap
-
Griffiths E.K., Penninger J.M. Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap. Curr Opin Immunol. 14:2002;317-322
-
(2002)
Curr Opin Immunol
, vol.14
, pp. 317-322
-
-
Griffiths, E.K.1
Penninger, J.M.2
-
59
-
-
0035929128
-
Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap
-
Griffiths E.K., Krawczyk C., Kong Y.-Y., Raab M., Hyduk S.J., Bouchard D., Chan V.S., Kozieradzki I., Oliveira-dos-Santos A.J., Wakeham A., et al. Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Science. 293:2001;2260-2263
-
(2001)
Science
, vol.293
, pp. 2260-2263
-
-
Griffiths, E.K.1
Krawczyk, C.2
Kong, Y.-Y.3
Raab, M.4
Hyduk, S.J.5
Bouchard, D.6
Chan, V.S.7
Kozieradzki, I.8
Oliveira-Dos-Santos, A.J.9
Wakeham, A.10
-
60
-
-
0035929222
-
Coupling of the TCR to integrin activation by SLAP-130/Fyb
-
Peterson E.J., Woods M.L., Dmowski S.A., Derimanov G., Jordan M.S., Wu J.N., Myung P.S., Liu Q.-H., Pribila J.P., Freedman B.D., et al. Coupling of the TCR to integrin activation by SLAP-130/Fyb. Science. 293:2001;2263-2265
-
(2001)
Science
, vol.293
, pp. 2263-2265
-
-
Peterson, E.J.1
Woods, M.L.2
Dmowski, S.A.3
Derimanov, G.4
Jordan, M.S.5
Wu, J.N.6
Myung, P.S.7
Liu, Q.-H.8
Pribila, J.P.9
Freedman, B.D.10
-
61
-
-
0034599541
-
Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP-130), Ena/Vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton
-
Krause M., Sechi A.S., Konradt M., Monner D., Gertler F.B., Wehland J. Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP-130), Ena/Vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. J Cell Biol. 149:2000;181-193
-
(2000)
J Cell Biol
, vol.149
, pp. 181-193
-
-
Krause, M.1
Sechi, A.S.2
Konradt, M.3
Monner, D.4
Gertler, F.B.5
Wehland, J.6
-
62
-
-
0030910820
-
Molecular cloning of SKAP-55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes
-
Marie-Cardine A., Bruyns E., Eckerskorn C., Kirchgessner H., Meuer S.C., Schraven B. Molecular cloning of SKAP-55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes. J Biol Chem. 272:1997;16077-16080
-
(1997)
J Biol Chem
, vol.272
, pp. 16077-16080
-
-
Marie-Cardine, A.1
Bruyns, E.2
Eckerskorn, C.3
Kirchgessner, H.4
Meuer, S.C.5
Schraven, B.6
-
63
-
-
0032508602
-
SKAP-HOM, a novel adaptor protein homologous to the Fyn-associated protein SKAP-55
-
Marie-Cardine A., Verhagen A.M., Eckerskorn C.H., Schraven B. SKAP-HOM, a novel adaptor protein homologous to the Fyn-associated protein SKAP-55. FEBS Lett. 435:1998a;55-60
-
(1998)
FEBS Lett
, vol.435
, pp. 55-60
-
-
Marie-Cardine, A.1
Verhagen, A.M.2
Eckerskorn, C.H.3
Schraven, B.4
-
64
-
-
0032475935
-
Molecular interaction between the Fyn-associated protein SKAP-55 and the SLP76-associated phosphoprotein SLAP-130
-
Marie-Cardine A., Hendricks-Taylor R.L., Boerth N.J., Zhao H., Schraven B., Koretzky G.A. Molecular interaction between the Fyn-associated protein SKAP-55 and the SLP76-associated phosphoprotein SLAP-130. J Biol Chem. 273:1998b;25789-25795
-
(1998)
J Biol Chem
, vol.273
, pp. 25789-25795
-
-
Marie-Cardine, A.1
Hendricks-Taylor, R.L.2
Boerth, N.J.3
Zhao, H.4
Schraven, B.5
Koretzky, G.A.6
-
65
-
-
0037323858
-
The role of Rap1 in integrin-mediated cell adhesion
-
Bos J.L., de Bruyn K., Enserik J., Kuiperij B., Rangarajan S., Rehmann H., Riedl J., de Rooij J., van Mansfels F., Zwartkruis F. The role of Rap1 in integrin-mediated cell adhesion. Biochem Soc Trans. 31:2003;83-86
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 83-86
-
-
Bos, J.L.1
De Bruyn, K.2
Enserik, J.3
Kuiperij, B.4
Rangarajan, S.5
Rehmann, H.6
Riedl, J.7
De Rooij, J.8
Van Mansfels, F.9
Zwartkruis, F.10
-
66
-
-
0036009116
-
Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocytes signaling
-
Using transgenic mice that constitutively express an active form of Rap1 within the T-cell lineage, the authors show that both thymocytes and mature T cells exhibit increased integrin-induced cell adhesion and enhanced T-cell-receptor-mediated responses.
-
Sebzda E., Bracke M., Tugal T., Hogg N., Cantrell D.A. Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocytes signaling. Nat Immunol. 3:2002;251-258 Using transgenic mice that constitutively express an active form of Rap1 within the T-cell lineage, the authors show that both thymocytes and mature T cells exhibit increased integrin-induced cell adhesion and enhanced T-cell-receptor-mediated responses.
-
(2002)
Nat Immunol
, vol.3
, pp. 251-258
-
-
Sebzda, E.1
Bracke, M.2
Tugal, T.3
Hogg, N.4
Cantrell, D.A.5
-
67
-
-
0037900000
-
Negative regulation of Rap1 activation by the Cbl E3 ubiquit ligase
-
Shao Y., Elly C., Liu Y.C. Negative regulation of Rap1 activation by the Cbl E3 ubiquit ligase. EMBO Rep. 4:2003;425-431
-
(2003)
EMBO Rep
, vol.4
, pp. 425-431
-
-
Shao, Y.1
Elly, C.2
Liu, Y.C.3
-
68
-
-
0345826149
-
Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO
-
63-dependent manner, that results in enhanced NF-κB reporter activity.
-
63-dependent manner, that results in enhanced NF-κB reporter activity.
-
(2004)
Nature
, vol.427
, pp. 167-171
-
-
Zhou, H.1
Wertz, I.2
O'Rourke, K.3
Ultsch, M.4
Seshagiri, S.5
Eby, M.6
Xiao, W.7
Dixit, V.M.8
-
69
-
-
1942469524
-
MALT1/Paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-kappa B activation
-
in press.
-
Che T, You Y, Wang D, Tanner MJ, Dixit VM, Lin X: MALT1/Paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-kappa B activation. J Biol Chem 2004, in press.
-
(2004)
J Biol Chem
-
-
Che, T.1
You, Y.2
Wang, D.3
Tanner, M.J.4
Dixit, V.M.5
Lin, X.6
-
70
-
-
0742270964
-
Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation
-
Schaefer B.C., Kappler J.W., Kupfer A., Marrack P. Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation. Proc Natl Acad Sci USA. 101:2004;1004-1009
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 1004-1009
-
-
Schaefer, B.C.1
Kappler, J.W.2
Kupfer, A.3
Marrack, P.4
-
71
-
-
0346993668
-
CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1
-
Wang D., Matsumoto R., You Y., Che T., Lin X.Y., Gaffen S.L., Lin X. CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1. Mol Cell Biol. 24:2004;164-171
-
(2004)
Mol Cell Biol
, vol.24
, pp. 164-171
-
-
Wang, D.1
Matsumoto, R.2
You, Y.3
Che, T.4
Lin, X.Y.5
Gaffen, S.L.6
Lin, X.7
-
72
-
-
0037208074
-
Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor
-
Weil R., Schwamborn K., Alcover A., Bessia C., Di Bartolo V., Israel A. Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor. Immunity. 18:2003;13-26
-
(2003)
Immunity
, vol.18
, pp. 13-26
-
-
Weil, R.1
Schwamborn, K.2
Alcover, A.3
Bessia, C.4
Di Bartolo, V.5
Israel, A.6
|