Regulation of B cell signal transduction by SH2-containing protein-tyrosine phosphatases

Seminars in Immunology

Volumn 10, Issue 4, 1998, Pages 329-347

  Siminovitch, Katherine ^a   Neel, Benjamin G ^b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Auto immunity; B lymphocytes; Co receptors; Protein tyrosine phosphatases; Signal transduction

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN TYROSINE PHOSPHATASE;

AUTOIMMUNITY; B LYMPHOCYTE; GENE MUTATION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0032147093     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.1998.0125     Document Type: Article

References (152)

1. 1. Cambier JC, Bedzyk W, Campbell K, Chien K, Friedrich J, Harwood A, Jensen W, Pleiman C, Clark MR (1993) The B cell antigen receptor: structure and function of primary, secondary, tertiary and quaternary components. Immunol Rev 132:85-105
2. 2. Cambier JC, Pleiman CM, Clark MR (1994) Signal transduction by the B cell antigen receptor and its coreceptors. Ann Rev Immunol 12:457-486
3. 3. Reth M (1995) The B cell antigen receptor complex and coreceptors. Immunol Today 16:310-313
4. 4. Tedder TF, Inaoki M, Sato S (1997) The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and auto-immunity. Immunity 6:107-118
5. 5. Law C-L, Sidorenko SP, Clark EA (1994) Regulation of lymphocyte activation by the cell-surface molecule CD22. Immunol Today 15:4420-4449
6. 6. Cyster JG, Goodnow CC (1997) Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment. Immunity 6:509-517
7. 7. Tedder TF, Tuscano J, Sato S, Kehrl JH (1997) CD22 a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. Ann Rev Immunol 15:481-504
8. 8. Gordon J (1994) B-cell signalling via the C-type lectins CD23 and CD72. Immunol Today 15:411-417
9. 9. Tonks NK, Neel BG (1996) From form to function: signaling by protein tyrosine phosphatases. Cell 87:365-368
10. 10. Neel BG, Tonks NK (1997) Protein tyrosine phosphatases in signal transduction. Curr Opin Cell Biol 9:193-204
11. 11. Trowbridge IS, Thomas ML (1994) CD45: An emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Annu Rev Immunol 12:85-116
12. 12. Okumura M, Thomas ML (1995) Regulation of immune function by protein tyrosine phosphatases. Curr Opin Immunol 7:312-319
13. 13. Neel BG (1997) Role of phosphatases in lymphocyte activation. Curr Opin Immunol 9:405-420
14. 14. Walton KM, Dixon JE (1993) Protein tyrosine phosphatases. Annu Rev Biochem 62:101-120
15. 15. Denu JE, Stuckey JA, Saper MA, Dixon JE (1996) Form and function in protein dephosphorylation. Cell 87:361-364
16. 16. Townley R, Shen S-H, Banville D, Ramachandran C (1993) Inhibition of the activity of protein tyrosine phosphatase 1C by its SH2 domains. Biochemistry 32:13414-13418
17. 17. Dechert U, Adam M, Harder KW, dark-Lewis I, Jirik F (1994) Characterization of protein tyrosine phosphatase SH-PTP2. Study of phosphopeptide substrates and possible regulatory role of SH2 domains. J Biol Chem 269:5602-5611
18. 18. Pei D, Lorenz U, Klingmuller U, Neel BG, Walsh CT (1994) Intramolecular regulation of protein tyrosine phosphatase SH-PTPl: a new function for Src homology 2 domains. Biochemistry 33:15483-15493
19. 19. Zhao Z, Larocque R, Ho W-T, Fischer EH, Shen S-H (1994) Purification and characterization of PTP2C, a widely-distributed protein tyrosine phosphatase containing two SH2 domains. J Biol Chem 269:8780-8785
20. 20. Lechleider RJ, Freeman RM, Neel BG (1993) Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2. J Biol Chem 268:13434-13438
21. 21. Sugimoto S, Wandless TJ, Shoelson SE, Neel BG, Walsh CT (1993) Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine containing peptides derived from insulin receptor substrate-1. J Biol Chem 268:2733-2736
22. 22. Pluskey S, Wandless TJ, Walsh CT, Shoelson SE (1995) Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains. J Biol Chem 270:2987-2900
23. 23. Doody GM, Justement LB, Delibrias CC, Matthews RJ, Lin J, Thomas ML, Fearon DT (1995) A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. Science 269:242-244
24. 24. Burshtyn DN, Scharenberg AM, Wagtmann N, Rajagopalan S, Berrada K, Yi T, Kinet J-P, Long EO (1996) Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor. Immunity 4:77-85
25. 25. Pei D, Wang J, Walsh CT (1996) Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1. Proc Natl Acad Sci USA 93:1141-1145
26. 26. Burshtyn DN, Yang W, Yi T, Long EO (1997) A novel phosphotyrosine motif with a critical amino acid at position-2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1. J Biol Chem 272:13066-13072
27. 27. Hof P, Pluskey S, Dhe-Paganon S, Eck MJ, Shoelson SE (1998) Crystal structure of the SH2 domain phosphatase SHP-2. Cell 92:1-20
28. 28. Eck MJ, Pluskey S, Trub T, Harrison SC, Shoelson SE (1996) Spatial constraints on the recognition of phosphoproteinsby the tandem SH2 domains of the phosphatase SH-PTP2. Nature 379:277-280
29. 29. Zhao Z, Bouchard P, Diltz CD, Shen S, Fischer EH (1993) Purification and characterization of a protein tyrosine phosphatase containing SH2 domains. J Biol Chem 268:2816-2820
30. 30. Lorenz U, Ravichandran KS, Pei D, Walsh CT, Burakoff SJ, Neel BG (1994) Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells. Mol Cell Biol 14:1824-1834
31. 538 and the catalytic activity of PTP1C, a protein tyrosine phosphatase with Src homology-2 domains. J Biol Chem 269:12220-12228
32. 32. Bouchard P, Zhao Z, Banville D, Dumas F, Fischer EH, Shen S-H (1994) Phosphorylation and identification of a major tyrosine phosphorylation site in protein tyrosine phosphatase 1C. J Biol Chem 269:19585-19589
33. 33. Vogel W, Ullrich A (1996) Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via Tyrosine 584. Cell Growth Diff 7:1589-1597
34. 34. Carton AJ, Tonks NK (1994) PTP-PEST: a protein tyrosine phosphatase regulated by serine phosphorylation. EMBO J 13:3763-3771
35. 35. Flint AJ, Tiganis T, Barford D, Tonks NK (1997) Development of 'substrate trapping' mutants to identify physiological substrates of protein-tyrosine phosphatases. Proc Natl Acad Sci USA 94:1680-1685
36. 36. Sun H, Charles CH, Lau LF, Tonks NK (1993) MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell 75:487-493
37. 37. Shiozaki K, Russell P (1995) Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast. Nature 378:739-743
38. 38. Wurgler-Murphy SM, Maeda T, Witten EA, Saito H (1997) Regulation of the Saccharomyces cerevisiae HOG1 mitogenactivated protein kinase by the PTP2 and FTP3 protein tyrosine phosphatases. Mol Cell Biol 17:1289-1297
39. 39. Tsui HW, Siminovitch KA, deSouza L, Tsui FWL (1993) Motheatm and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nat Genet 4:124-129
40. 40. Shultz LD, Schweitzer PA, Rajan TV, Yi T, Ihle JN, Matthews RJ, Thomas ML, Beier DR (1993) Mutations at the murine motheaten locus are within the hematopoietic cell protein phosphatase (HCPH) gene. Cell 73:1445-1454
41. 41. Neel BG (1993) Structure and function of SH2 domain containing tyrosine phosphatases. Semin Cell Biol 4:419-432
42. 42. Bignon JS, Siminovitch KA (1994) Identification of PTP1C mutation as a genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function. Clin Immunol Immunopathol 73:168-179
43. 43. Tsui FWL, Tsui HW (1994) Molecular basis of the motheaten phenotype. Immunol Rev 136:185-206
44. 44. Kozlowski M, Mlinaric-Rascan I, Feng GS, Shen R, Pawson T, Siminovitch KA (1993) Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J Exp Med 178:2157-2163
45. 45. Shultz LD, Sidman CL (1987) Genetically determined murine models of immunodeficiency. Ann Rev Immunol 5:367-403
46. 46. Shultz LD (1991) Hematopoiesis and models of immunodeficiency. Semin Immunol 3:397-408
47. 47. Koo GC, Rosen H, Sirotina A, Ma XD, Shultz LD (1993) Anti-CD11b antibody prevents immunopathologic changes in viable motheaten bone marrow chimeric mice. J Immunol 151:6733-6741
48. 48. Yu CC, Tsui HW, Ngan BY, Shulman MJ, Wu GE, Tsui FW (1996) B and T cells are not required for the viable motheaten phenotype. J Exp Med 183:371-380
49. 49. Sidman CL, Shultz LD, Hardy RR, Hayakawa K, Herzenberg LA (1986) Production of immunoglobulin isotypes by Ly-1 + B cells in viable motheaten and normal mice. Science 232:1423-1425
50. 50. Herzenberg LA, Stall AM, Lalor PA, Sidman C, Moore WA Parks DR (1986) The Ly-1 B cell lineage. Immunol Rev 93:81-102
51. 51. Kantor AB (1991) The development and repertoire of B-1 cells. Immunol Today 12:389-391
52. 52. Kantor AB, Herzenberg LA (1993) Origin of murine B cell lineages. Annu Rev Immunol 11:501-538
53. 53. Hardy RR, Hayakawa K (1994) CD5 B cells, a fetal B cell lineage. Adv Immunol 55:297-339
54. 54. Kasturi K, Mayer R, Bona CA, Scott VE, Sidman CL (1990) Germline V genes encode viable motheaten mouse antiautobodies against thymocytes and red blood cells. J Immunol 145:2304-2311
55. 55. Saitoh Y, Kelsoe G, Bona C, Kaushik A (1995) Skewed VH and VK gene family expression and pairing among B lymphocytes in autoimmune motheaten mice. Autoimmunity 21:185-193
56. 56. Lipsanen V, Walter B, Emara M, Siminovitch K, Lam J, Kaushik A (1997) Restricted CDR3 length of the heavy chain is characteristic of six randomly isolated disease-associated VH J558 + IgM autoantibodies in lupus prone motheaten mice. Int Immunol 9:665-664
57. 57. Scribner CL, Hansen CT, Klinman DM, Steinberg AD (1987) The interaction of the xid and me genes. J Immunol 138:3611-3617
58. v) mutant mice. J Immunol 138:3590-3597
59. 59. Hayashi SI, Witte PL, Shultz LD, Kincade PW (1988) Lymphohemopoiesis in culture is prevented by interaction with adherent bone marrow cells from mutant viable motheaten mice. J Immunol 140:2139-2147
60. 60. Sidman CL, Marshall ID, Allen RD (1989) Murine 'viable motheaten' mutation reveals a gene critical to the development of both B and T lymphocytes. Proc Natl Acad Sci 86:6279-6282
61. 61. Kuntz L, Velin D, Pfhimio F, Loor F (1990) Adoptive transfer of viable motheaten humoral autoimmunity in cyclophosphamide-immunodepressed beige recipient mice. Immunol 70:520-526
62. 62. Kuntz L, Montecino-Rodriquez E, Jachez B, Roman D, Loor F (1991) Adoptive transfer of viable motheaten pathology in sublethally irradiated beige recipient mice. Immunology 73:356-362
63. 63. Cyster JG, GoodnowCC (1995) Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity 2:1-20
64. 64. Sidman CL, Shultz LD, Unanue ER (1978) The mouse mutant 'motheaten' II. Functional studies of the immune system. J Immunol 121:2399-2404
65. 65. Davidson WF, Morse HC, III, Sharrow SO, Chused TM (1979) Phenotype and functional effects of the motheaten gene on murine B and T lymphocytes. J Immunol 122:884-891
66. 66. Pani G, Kozlowski M, Gambier JC, Mills GB, Siminovitch KA (1995) Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J Exp Med 181:2077-2084
67. 67. Pani G, Siminovitch KA, Paige CJ (1997) The motheaten mutation rescues B cell signalling and development in CD45-deficient mice. J Exp Med 186:581-588
68. 68. Pani G, Fischer K-D, Rascan IM, Siminovitch KA (1996) Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. J Exp Med 184:839-852
69. 69. Lorenz U, Ravichandran KS, Burakoff SJ, Neel BG (1996) Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness. Proc Natl Acad Sci USA 93:9624-9629
70. 70. Thomas ML (1995) Of ITAMs and ITIMs: Turning on and off the B cell antigen receptor. J Exp Med 181:1953-1956
71. 71. Gambier JC (1997) Inhibitory receptors abound? Proc Natl Acad Sci USA 94:5993-5995
72. 72. Scharenberg A, Kinet J (1996) The emerging field of receptor-mediated inhibitory signaling: SHP or SHIP? Cell 87:961-964
73. 73. Daeron M (1996) Building up the family of ITIM-bearing negative coreceptors. Immunol Lett 54:73-76
74. 74. Burshtyn DN, Long EO (1997) Regulation through inhibitory receptors: lessons from natural killer cells. Trends Cell Biol (in press)
75. 75. Vely F, Vivier E (1997) Conservation of structural features reveals the existence of a large family of inhibitory cell surface receptors and noninhibitory/activatory counterparts. J Immunol 159:2075-2977
76. 76. Ravetch JV (1994) Fc receptors: Rubor Redux. Cell 78:553-560
77. 77. Ono M, Okada H, Bolland S, Yanagi S, Kurosaki T, Ravetch JV (1997) Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling. Cell 90:293-301
78. 78. D'Ambrosio D, Hippen KL, Minskoff SA, Mellman I, Pani G, Siminovitch KA, Cambier JC (1995) Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. Science 268:293-297
79. 79. Ono M, Bolland S, Tempst P, Ravetch JV (1996) Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcyRIIB. Nature 383:263-266
80. 80. Nadler MJ, Chen B, Anderson S, Words H, Neel BG (1997) Protein-tyrosine phosphatase SHP-1 is dispensable for FcγRIIB-mediated inhibition of B cell antigen receptor activation. J Biol Chem 272:20038-20043
81. 81. Gupta N, Scharenberg AM, Burshtyn DN, Wagtmann N, Lioubin MN, Rohrschneider LA, Kinet JP, Long EO (1997) Negative signaling pathways of the killer cell inhibitory receptor and Fc gamma RIIb1 require distinct phosphatases. J Exp Med 186:473-478
82. 82. Lankester AC, van Schijndel GMW, van Lier RAW (1995) Hematopoietic cell phosphatase is recruited to CD22 following B cell antigen receptor ligation. J Biol Chem 270:20305-20308
83. 83. Campbell M-A, Klinman NR (1995) Phosphotyrosine-dependent association between CD22 and protein-tyrosine phosphatase 1C. Eur J Immunol 25:1573-1579
84. 84. Law CL, Sidorenko SP, Chandran KA, Zhao Z, Shen S-H, Fischer EH, Clark EA (1996) CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-γ 1 upon B cell activation. J Exp Med 183:547-560
85. 85. Doody GM, Dempsey PW, Fearon DT (1996) Activation of B lymphocytes: integrating signals from CD19, CD22 and FcγRIIb. Curr Opin Immunol 8:378-382
86. 86. O'Keefe T, Williams GT, Davies SL, Neuberger MS (1996) Hyperresponsive B cells in CD22-deficient mice. Science 274:798-801
87. 87. Sato S, Miller AS, Inaoki M, Bock CB, Jansen PJ, Tang LK, Tedder TF (1996) CD22 is both a positive and negative regulator of lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. Immunity 5:551-562
88. 88. Otipoby K, Andersson K, Draves K, Klaus S, Farr A, Kerner J, Perlmutter R, Law C-L, Clark E (1996) CD22 regulates thymus-independent responses and the lifespan of B cells. Nature 384:634-636
89. 89. Nitschke L, Carsetti R, Ocker B, Kohler G, Lamers MC (1997) CD22 is a negative regulator of B cell receptor signaling. Curr Biol 7:133-143
90. 90. Nadler MJS, McLean PA, Neel BG, Wortis HH (1997) B cell antigen receptor-evoked calcium influx is enhanced in CD22-deficient B cell lines. J Immunol 159:4233-4243
91. 91. Goodnow CC, Cyster JG, Hartley SB, Bell SE, Cooke MP, Healy JI, Akkaraju S, Rathmell JC, Pogue SL, Shokat KP (1995) Self-tolerance checkpoints in B lymphocyte development. Adv Immunol 59:279-368
92. 92. Goodnow CC (1996) Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. Proc Natl Acad Sci USA 93:2264-2271
93. 93. Law C-L, Torres RM, Sundberg HA, Parkhouse RME, Brannan CI, Copeland NG, Jenkins NA, Clark EA (1993) Organization of the murine CD22 locus. Mapping to chromosome 7 and characterization of two alleles. J Immunol 151:175-187
94. 94. Morel L, Rudofsky UH, Longmate JA, Schiffenbauer J, Wakeland EK (1994) Polygenic control of susceptibility to murine systemic lupus erythematosus. Immunity 1:219-229
95. 95. Sato S, Jansen PJ, Tedder TF (1997) CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling. Proc Natl Acad Sci USA 94:13158-13162
96. 96. Tominaga A, Takaki S, Koyama N, Katoh S, Matsumoto R, Migita M, Hitoshi Y, Hosuya Y, Yamauchi S, Kanai Y et al (1991) Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production. J Exp Med 173:429-437
97. 97. Dent LA, Strath M, Mellor AL, Sanderson CJ (1990) Eosinophilia in transgenic mice expressing interleukin 5. J Exp Med 172:1425-1431
98. 98. Hayami K, Fukuta D, Nishikawa Y, Yamashita Y, Inui M, Ohyama Y, Hikida M, Ohomori H, Takai T (1997) Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors. J Biol Chem 272:7320-7327
99. 99. Kubagawa H, Burrows P, Cooper MD (1997) A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Proc Natl Acad Sci USA 94:5261-5266
100. 100. Timms JF, Carlberg K, Gu H, Chen H, Kamatkar S, Rohrschneider LR, Neel BG (1998) Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages. Mol Cell Biol (submitted)
101. 101. Blery M, Kubagawa H, Chen C-C, Vely F, Cooper MD, Vivier E (1998) PIR-B is an inhibitory receptor that recruits SHP-1. Proc Natl Acad Sci (in press)
102. 102. Wu Y, Nadler MJS, Brennan LA, Gish GD, Timms JF, Fusaki N, Jongstra-Bilen J, Tada N, Pawson T, Wither J, Neel BG, Hozumi N (1998) SHP-1 acts on CD72 to regulate B cell negative selection. Nature (submitted)
103. 103. Bikah G, Carey J, Ciallella JR, Tarakhovsky A, Bondada S (1996) CDS-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells. Science 274:1906-1909
104. 104. Kon-Kozlowski M, Pani G, Pawson T, Siminovitch KA (1996) The tyrosine phosphatase PTP1C associates with Vav, Grb 2, and mSos1 in hematopoietic cells. J Biol Chem 271:3856-3862
105. 105. Wen-Kai W, Jarvis L, Le Bien TW (1994) Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors. J Biol Chem 269:32514-32521
106. 106. Ramos-Morales F, Druker BJ, Fischer S (1994) Vav binds to several SH2/SH3 containing proteins in activated lymphocytes. Oncogene 9:1917-1923
107. 107. Ramos-Morales F, Romero F, Schweighoffer F, Bismuth G, Camonis J, Tortolero M, Fischer S (1995) The proline-rich region of Vav binds to Grb2 and Grb3-3. Oncogene 11:1665-1669
108. 108. Deckert M, Tartare-Deckert S, Couture C, Mustelin T, Altman A (1996) Functional and physical interactions of Syk family kin äse s with the Vavproto-oncogene product. Immunity 5:591-604
109. 109. Lee I-S, Liu Y, Narazaki M, Hibi M, Kishimoto T, Taga T (1997) Vav is associated with signal transduction molecules gp130, Grb2 and Erk2 and is tyrosine phosphorylated in response to interleukin-6. FEES Lett 401:133-137
110. 110. Crespo P, Schuebel KE, Ostrom AA, Gutkind JS, Bustelo XR (1997) Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature 385:169-172
111. 111. Ridley AJ (1995) Intracellular regulation. Rac and Bcr regulate phagocytic phoxes. Curr Biol 7:710-712
112. 112. Nobes CD, Hall A (1995) Rho, rac, and cdc42 GTPases: regulators of actin structures, cell adhesion and motility. Biochem Soc Trans 23:456-459
113. 113. Tapon N, Hall A (1997) Rho, Rac, and Cdc42 GTPases regulate the organization of the actin cytoskeleton. Curr Opin Cell Biol 9
114. 114. Tarakhovsky A, Turner M, Schaal S, Mee RJ, Duddy LP, Rajewsky K, Tybulewicz LJ (1995) Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.
115. 115. Zhang R, Alt FW, Davidson L, Orkin SH, Swat W (1995) Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 374:470-473
116. 116. Chen HE, Chang S, Trub T, Neel BG (1995) Regulation of CSF-1 receptor signaling in murine macrophages by the SH2-containing tyrosine phosphatase SHPTP1. Mol Cell Biol 16:3685-3697
117. 117. Tuosoto L, Michel F, Acuto O (1996) p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells. J Exp Med 184:1161-1166
118. 118. Onodera H, Motto DG, Koretzky GA, Rothstein DM (1996) Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine-phosphatase. J Biol Chem 271:22225-22230
119. 119. Mizuno K, Katagiri T, Hasegawa K, Ogimoto M, Yakura H (1996) Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells. J Exp Med 184:457-463
120. 120. Wu J, Motto DG, Koretzky GA, Weiss A (1996) Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity 4:593-602
121. 121. Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lech leider RJ, Neel BG, Birge RB, Fajardo JE, Chou MM, Hanafusa H, Schaffhausen B, Cantley LC (1993) SH2 domains recognize specific phosphopeptide sequences. Cell 72:767-778
122. 122. Jackman JK, Motto DG, Sun Q, Tanemoto M, Jurck CW, Peltz GA, Koretzky GA, Findell PR (1995) Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. J Biol Chem 270:7029-7032
123. 123. Leibson PJ (1995) MHC-recognizing receptors: they're not just for T cells anymore. Immunity 3:5-8
124. 124. Binstadt BA, Brumbaugh KM, Dick CJ, Scharenberg AM, Williams BL, Colonna M, Lanier LL, Kinet JP, Abraham RT, Leibson PJ (1996) Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Immunity 5:629-638
125. 125. Somani A-K, Bignon JS, Mills GB, Siminovitch KA, Branch DR (1997) Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase. J Biol Chem 272:21113-21119
126. 126. Plas DR, Johnson R, Pingel JT, Matthews RJ, Dalton M, Roy G, Chan AC, Thomas ML (1996) Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science 272:1173-1176
127. 127. Benatar T, Carsetti R, Furlonger C, Kamalia N, Mak T, Paige CJ (1996) Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice. J Exp Med 183:329-334
128. 128. Byth KF, Conroy LA Hewlett S, Smith AJ, May J, Alexander DR, Holmes N (1996) CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4 + CD8 + thymocytes, and B cell maturation. J Exp Med 183:1707-1718
129. 129. Cyster JG, Healy JI, Kishihara K, Mak TW, Thomas ML, Goodnow CC (1996) Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45. Nature 381:325-328
130. 130. Cong YZ, Rabin E, Words HH (1991) Treatment of murine CD5-B cells with anti-Ig, but not LPS, induces surface CD5: two B cell activation pathways. Int Immun 3:467-476
131. 131. Rickert RC, Rajewsky K, Roes J (1995) Impairment of T cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature (Lond) 376:352-355
132. 132. Engel P, Zhou LJ, Ord DC, Sato S, Koller B, Tedder TF (1995) Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity 3:39-50
133. 133. Sato S, Ono N, Steeber DA, Pisetsky DS, Tedder TF (1996) CD19 regulates B lymphocyte signaling thresholds critical for development of B-I lineage cells and auto-immunity. J Immunol 157:4371-4378
134. 134. Brown VK, Ogle EW, Burkhardt AL, Rowley RB, Bolen JB, Justement LB (1994) Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45. J Biol Chem 269:17238-17244
135. 135. Pao LI, Cambier JC (1997) Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45-B cells. J Immunol 158:2663-2669
136. 136. Pao LI, Bedzyk WD, Persin C, Cambier JC (1997) Molecular targets of CD45 in B cell antigen receptor signal transduction. J Immunol 158:1116-1124
137. 137. Klingmuller U, Lorenz U, Cantley LC, Neel BG, Lodish HF (1995) Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 80:729-738
138. 138. David M, Chen HE, Ling L, Goelz S, Lamer AC, Neel BG (1995) Differential regulation of the α/β interferon-stimulated Jak/Stat pathway by the SH2 domain containing tyrosine phosphatase SHPTP1. Mol Cell Biol 15:7050-7058
139. 139. Yetter A, Uddin S, Krolewski JJ, Jiao H, Yi T, Platanias LC (1995) Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase. J Biol Chem 270:18179-18182
140. 140. Yi T, Mui AL-F, Krystal G, Ihle JN (1993) Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor β chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis. Mol Cell Biol 13:7577-7586
141. 141. Yi T, Ihle JN (1993) Association of hematopoietic cell phosphatase with c-kit after stimulation with c-kit ligand. Mol Cell Biol 13:3350-3358
142. 142. Paulson RF, Vesely S, Siminovitch KA, Bernstein A (1996) Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1. Nat Genet 13:309-315
143. 143. Lorenz U, Bergemann AD, Steinberg HN, Flanagan JG, Li X, Galli SJ, Neel BG (1996) Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1. J Exp Med 184:1111-1126
144. 144. Frearson JA, Yi T, Alexander DR (1996) A tyrosine-phosphorylated 110-120-kDa protein associates with the C-terminal SH2 domain of phosphotyrosine phosphatase-1D in T cell receptor-stimulated T cells. Eur J Immunol 26:1539-1543
145. 145. Gu H, Griffin JD, Neel BG (1997) Characterization of two SHP-2-associated binding proteins and potential substrates in hematopoietic cells. J Biol Chem 272:16421-16430
146. 146. Carlberg K, Rohrschneider LR (1997) Characterization of a novel tyrosine phosphorylated 100 kD protein that binds to tyrosyl phosphorylated SHP-2 and the 85 kDa subunit of PI3'-kinase in response to M-CSF and other cytokines. J Biol Chem 272:15943-15940
147. 147. Herbst R, Carroll PM, Allard JD, Schilling J, Raabe T, Simon MA (1996) Daughter of Sevenless is a substrate of the phosphotyrosine phosphatase corkscrew and functions during Sevenless signaling. Cell 85:899-909
148. 148. Raabe T, Riesgo-Escovar J, Liu X, Bausenwein BS, Deak P, Maroy P, Hafen E (1996) DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Rasl in Drosophila. Cell 85:911-920
149. 149. Pazdrak K, Adachi T, Alam R (1997) Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to prolongation of eosinophil survival. J Exp Med 186:561-568
150. 150. Saxton TM, Henkemeyer M, Gasca S, Shen R, Rossi DJ, Shalaby F, Feng G-S, Pawson T (1997) Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase SHP-2. EMBO J 16:2352-2364
151. 151. Symes A, Stahl N, Reeves SA, Farruggella T, Servidel T, Gearan T, Yancopoulos G, Fink JS (1997) The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression. Curr Biol 7:687-700
152. 152. Marengere LEM, Waterhouse P, Duncan GS, Mittrucker H-W, Feng G-S, Mak TW (1996) Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA4. Science 272:1170-1173