메뉴 건너뛰기




Volumn 421, Issue 6925, 2003, Pages 856-859

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; DISEASES; ENDOCRINOLOGY; GENETIC ENGINEERING;

EID: 0037456304     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01388     Document Type: Article
Times cited : (860)

References (25)
  • 1
    • 0030028959 scopus 로고    scopus 로고
    • Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
    • Chua, S. C. Jr et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 271, 994-996 (1996).
    • (1996) Science , vol.271 , pp. 994-996
    • Chua S.C., Jr.1
  • 2
    • 0030039272 scopus 로고    scopus 로고
    • Abnormal splicing of the leptin receptor in diabetic mice
    • Lee, G. H. et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379, 632-635 (1996).
    • (1996) Nature , vol.379 , pp. 632-635
    • Lee, G.H.1
  • 3
    • 13344259300 scopus 로고    scopus 로고
    • Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutatioan in the leptin receptor gene in db/db mice
    • Chen, H. et al. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutatioan in the leptin receptor gene in db/db mice. Cell 84, 491-495 (1996).
    • (1996) Cell , vol.84 , pp. 491-495
    • Chen, H.1
  • 4
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, OB-R
    • Tartaglia, L. A. et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 1263-1271 (1995).
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.A.1
  • 5
    • 0029776030 scopus 로고    scopus 로고
    • The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
    • Baumann, H. et al. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc. Natl. Acad. Sci. USA 93, 8374-8378 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 8374-8378
    • Baumann, H.1
  • 6
    • 0028931604 scopus 로고
    • Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
    • Stahl, N. et al. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267, 1349-1353 (1995).
    • (1995) Science , vol.267 , pp. 1349-1353
    • Stahl, N.1
  • 8
    • 0034640508 scopus 로고    scopus 로고
    • Activation of downstream signals by the long form of the leptin receptor
    • Banks, A. S., Davis, S. M., Bates, S. H. & Myers, M. G. Jr Activation of downstream signals by the long form of the leptin receptor. J. Biol. Chem. 275, 14563-14572 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 14563-14572
    • Banks, A.S.1    Davis, S.M.2    Bates, S.H.3    Myers M.G., Jr.4
  • 9
    • 0000430395 scopus 로고    scopus 로고
    • Divergent roles of SHP-2 in ERK activation by leptin receptors
    • Bjorbaek, C. et al. Divergent roles of SHP-2 in ERK activation by leptin receptors. J. Biol. Chem. 276, 4747-4755 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 4747-4755
    • Bjorbaek, C.1
  • 10
    • 0032177037 scopus 로고    scopus 로고
    • Unraveling the central nervous system pathways underlying responses to leptin
    • Elmquist, J. K., Maratos-Flier, E., Saper, C. B. & Flier, J. S. Unraveling the central nervous system pathways underlying responses to leptin. Nature Neurosci. 1, 445-449 (1998).
    • (1998) Nature Neurosci. , vol.1 , pp. 445-449
    • Elmquist, J.K.1    Maratos-Flier, E.2    Saper, C.B.3    Flier, J.S.4
  • 11
    • 0029896530 scopus 로고    scopus 로고
    • Role of leptin in the neuroendocrine response to fasting
    • Ahima, R. S. et al. Role of leptin in the neuroendocrine response to fasting. Nature 382, 250-252 (1996).
    • (1996) Nature , vol.382 , pp. 250-252
    • Ahima, R.S.1
  • 12
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the ofthe sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • Chehab, F. F., Lim, M., E. & Lu, R. Correction of the ofthe sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genet. 12, 318-320 (1996).
    • (1996) Nature Genet. , vol.12 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 13
    • 0030878110 scopus 로고    scopus 로고
    • Congenital leptin deficiency is associated with severe early onset obesity in humans
    • Montague, C. T. et al. Congenital leptin deficiency is associated with severe early onset obesity in humans. Nature 387, 903-908 (1997).
    • (1997) Nature , vol.387 , pp. 903-908
    • Montague, C.T.1
  • 14
    • 0344450708 scopus 로고    scopus 로고
    • A mutation in the human leptin receptor gene causes obesity, and pituitary dysfunction
    • Clement, K. et al. A mutation in the human leptin receptor gene causes obesity, and pituitary dysfunction. Nature 392, 398-401 (1998).
    • (1998) Nature , vol.392 , pp. 398-401
    • Clement, K.1
  • 15
    • 0029804743 scopus 로고    scopus 로고
    • Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
    • Erickson, J. C., Hollopeter, G. & Palmiter, R. D. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274, 1704-1707 (1996).
    • (1996) Science , vol.274 , pp. 1704-1707
    • Erickson, J.C.1    Hollopeter, G.2    Palmiter, R.D.3
  • 16
    • 0035214388 scopus 로고    scopus 로고
    • Leptin requirement for conception, implantation, and gestation in the mouse
    • Malik, N. M. et al. Leptin requirement for conception, implantation, and gestation in the mouse. Endocrinology 142, 5198-5202 (2001).
    • (2001) Endocrinology , vol.142 , pp. 5198-5202
    • Malik, N.M.1
  • 17
    • 0031014413 scopus 로고    scopus 로고
    • Early onset of reproductive function in normal female mice treated with leptin
    • Chehab, F. F., Mounzih, K., Lu, R. & Lim, M. E. Early onset of reproductive function in normal female mice treated with leptin. Science 275, 88-90 (1997).
    • (1997) Science , vol.275 , pp. 88-90
    • Chehab, F.F.1    Mounzih, K.2    Lu, R.3    Lim, M.E.4
  • 18
    • 0033180532 scopus 로고    scopus 로고
    • Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
    • Elias, C. F. et al. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23, 775-786 (1999).
    • (1999) Neuron , vol.23 , pp. 775-786
    • Elias, C.F.1
  • 19
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anotexigenic POMC neurons through a neural network in the arcuate nucleus
    • Cowley, M. A. et al. Leptin activates anotexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411, 480-484 (2001).
    • (2001) Nature , vol.411 , pp. 480-484
    • Cowley, M.A.1
  • 21
    • 0031440266 scopus 로고    scopus 로고
    • Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
    • Spanswick, D., Smith, M. A., Groppi, V. E., Logan, S. D. & Ashford, M. L. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390, 521-525 (1997).
    • (1997) Nature , vol.390 , pp. 521-525
    • Spanswick, D.1    Smith, M.A.2    Groppi, V.E.3    Logan, S.D.4    Ashford, M.L.5
  • 22
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agoutirelated protein
    • Ollmann, M. M. et al. Antagonism of central melanocortin receptors in vitro and in vivo by agoutirelated protein. Science 278, 135-138 (1997).
    • (1997) Science , vol.278 , pp. 135-138
    • Ollmann, M.M.1
  • 23
    • 0027475201 scopus 로고
    • Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats
    • Catzeflis, C. et al. Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats. Endocrinology 132, 224-234 (1993).
    • (1993) Endocrinology , vol.132 , pp. 224-234
    • Catzeflis, C.1
  • 24
    • 0032130554 scopus 로고    scopus 로고
    • Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
    • Hahn, T. M., Breininger, J. F., Baskin, D. G. & Schwartz, M. W. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nature Neurosci. 1, 271-272 (1998).
    • (1998) Nature Neurosci. , vol.1 , pp. 271-272
    • Hahn, T.M.1    Breininger, J.F.2    Baskin, D.G.3    Schwartz, M.W.4
  • 25
    • 0035950093 scopus 로고    scopus 로고
    • Intracellular signalling: Key enzyme in leptin-induced anorexia
    • Niswender, K. D. et al. Intracellular signalling: Key enzyme in leptin-induced anorexia. Nature 413, 794-795 (2001).
    • (2001) Nature , vol.413 , pp. 794-795
    • Niswender, K.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.