Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584

Cell Growth and Differentiation

Volumn 7, Issue 12, 1996, Pages 1589-1597

  Vogel, Wolfgang ^a,b   Ullrich, Axel ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR; PHENYLALANINE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE P60; PROTEIN TYROSINE PHOSPHATASE; TYROSINE;

ANIMAL CELL; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CONSENSUS SEQUENCE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOTTING, WESTERN; CELL LINE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GRB2 ADAPTOR PROTEIN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; MUTAGENESIS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN-TYROSINE-PHOSPHATASE; PROTEINS; RABBITS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SERINE; SHP1 PROTEIN TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; THREONINE; TYROSINE;

ANIMALIA;

EID: 0029844431     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Schlessinger, J., and Ullrich, A. Growth factor signalling by receptor tyrosine kinases. Neuron, 9: 1-20, 1992.
2. Lowenstein, E. J., Daly, R. J., Batzer, A. G., Li, W., Margolis, B., Lammers, R., Ullrich, A., Skolnik, E. Y., Bar-Sagi, D., and Schlessinger, J. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell, 70: 431-442, 1992.
3. Downward, J. The Grb2/Sem-5 adaptor protein. FEBS Lett., 338: 113-117, 1994.
4. Vogel, W., Lammers, R., Huang, J., and Ullrich, A. Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Science (Washington DC), 259: 1611-1614, 1993.
5. Freeman, R. M., Plutzky, J., and Neel, B. G. Identification of a human src-homology 2-containing protein-tyrosine phosphatase: a putative homolog of Drosophila corkscrew. Proc. Natl. Acad. Sci. USA, 89: 11239-11243, 1992.
6. Adachi, M., Sekiya, M., Miyachi, T., Matsuno, K., Hinoda, Y., Imai, K., and Yachi, A. Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2. FEBS Lett., 314: 335-339, 1992.
7. Feng, G-S., Hiu, C-C., and Pawson, T. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science (Washington DC), 259: 1607-1611, 1993.
8. Ahmad, S., Banville, D., Zhao, Z., Fischer, E. H., and Shen, S-H. A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc. Natl. Acad. Sci. USA, 90: 2197-2201, 1993.
9. Shen, S-H., Bastien, L., Posner, B. I., and Chrétien, P. A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of protein-tyrosine kinases. Nature (Lond.), 352: 736-739, 1991.
10. Pawson, T. Protein modules and signalling networks. Nature (Lond.), 373: 573-580, 1995.
11. Waksman, G., Shoelson, S. E., Pant, N., Cowburn, D., and Kyriyan, J. Binding of a high-affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structure of complexed and peptide-free forms. Cell, 72: 779-790, 1993.
12. Songyang, Z., Shoelson, S. E., Chaudhuri, M., Gish, G., Pawson, T., Haser, W. G., King, F., Roberts, T., Ratnofsky, S., Lechleider, R. J., Neel, B. G., Birge, R. B., Fajardo, J. E., Chou, M. M., Hanafusa, H., Schaffhausen, B., and Cantley, L. C. SH2 domains recognize specific phosphopeptide sequences. Cell, 72: 767-778, 1993.
13. Songyang, Z., Shoelson, S. E., McGlade, J., Olivier, P., Pawson, T., Bustelo, X. R., Barbacid, M., Sabe, H., Hanafusa, H., Yi, T., Ren, R., Baltimore, D., Ratnofsky, S., Feldman, R. A., and Cantley, L. C. Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2HCP, SHC, Syk and Vav. Mol. Cell. Biol., 14: 2777-2785, 1994.
14. Lechleider, R. J., Freeman, R. M., and Neel, B. B. Tyrosyl phosphorylation and growth factor receptor activation of the human corkscrew homologue, SH-PTP2. J. Biol. Chem., 268: 13434-13438, 1993.
15. Feng, G-S., Shen, R., Heng, H. H. Q., Tsui, L-C., Kazlauskas, A., and Pawson, T. Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp. Oncogene, 9: 1545-1550, 1994.
16. Seedorf, K., Millauer, B., Kostka, G., Schlessinger, J., and Ullrich, A. Differential effects of carboxy-terminal sequence deletions on platelet-derived growth factor receptor signalling activities and interactions with cellular substrates. Mol. Cell. Biol., 12: 4347-4356, 1992.
17. Slamon, D. J., Godolphin, W., Jones, L. A., Holt, J. A., Wong, S. G., Keith, D. E., Levin, W. J., Stuart, S. G., Udove, J., Ullrich, A., and Press, M. F. Studies of the HER2/neu protooncogene in human breast and ovarian cancer. Science (Washington DC), 244: 707-712, 1989.
18. Peraldi, P., Zhao, Z., Filloux, C., Fischer, E. D., and Van Obberghen, E. Protein-tyrosine-phosphatase 2C is phosphorylated and inhibited by 44 kDa mitogen-activated protein kinase. Proc. Natl. Acad. Sci. USA, 91: 5002-5006, 1994.
19. Stein-Gerlach, M., Kharitonenkov, A., Vogel, W., Ali, S., and Ullrich A. Protein tyrosine phosphatase 1D modulates its own state of tyrosine phosphorylation. J. Biol. Chem., 270: 24635-24637, 1995.
20. Bennett, A. M., Tang, T. L., Sugimoto, S., Walsh, C. T., and Neel, B. G. Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor β to Ras. Proc. Natl. Acad. Sci. USA, 91: 7335-7339, 1994.
21. Lorenz, U., Ravichandran, K. S., Pei, D., Walsh, C. T., Burakoff, S. J., and Neel, B. G. Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells. Mol. Cell. Biol., 14: 1824-1834, 1994.
22. Bouchard, P., Zhao, Z., Banville, D., Dumas, F., Fischer, E. H., and Shen, S-H. Phosphorylation and identification of a major tyrosine phosphorylation site in protein tyrosine phosphatase 1C. J. Biol. Chem., 269: 19585-19589, 1994.
23. Lee, C-H., Kominos, D., Jacques, S., Margolis, B., Schlessinger, J., Shoelson, S. E., and Kyrian, J. Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. Structure, 2: 423-438, 1994.
24. Eck, M. J., Pluskey, S., Trüb, T., Harrison, S. C., and Shoelson, S. E. Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2. Nature (Lond.), 379: 277-280, 1996.
25. Soula, M., Rothut, B., Camoin, L., Guillaume, J-L., Strosberg, D., Vorher, Y., Burn, P., Meggio, F., Fischer, S., and Fagard, R. Anti-CD3 and phorbol ester induce distinct phosphorylation sites in the SH2 domain of p56lck. J. Biol. Chem., 268: 27420-27427, 1993.
26. Li, W., Nishimura, R., Kashishian, A., Batzer, A. G., Kim, W. J., Cooper, J. A., and Schlessinger, J. A new function for a phosphotyrosine phosphatase: linking Grb2-Sos to a receptor tyrosine kinase. Mol. Cell. Biol., 14: 509-517, 1994.
27. Tauchi, T., Feng, G-S., Marshall, M. S., Shen, R., Mantel, C., Pawson, T., and Broxmeyer, H. E. The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells. J. Biol. Chem., 269: 25206-25211, 1994.
28. den Hertog, J., Tracy, S., and Hunter, T. Phosphorylation of receptor protein-tyrosire phosphatase alpha on Tyr 789, a binding site for the SH3-SH2-SH3 adaptor protein GRB2 in vivo. EMBO J., 13: 3020-3032, 1994.
29. Welham, M. J., Dechert, U., Leslie, K. B., Jirik, F., and Schrader J. W. Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3′-kinase. J. Biol. Chem., 269: 23764-23768, 1994.
30. Peng, Z-Y., and Cartwright, C. A. Regulation of the Src tyrosine kinase and syp tyrosine phosphatase by their cellular association. Oncogene, 10: 1955-1962, 1995.
31. Cantley, L. C., Auger, K. R., Carpenter, C., Duckworth, B., Graziani, A., Kapeller, R., and Soltoff, S. Oncogenes and signal transduction. Cell, 64: 281-302, 1991.
32. Amrein, K., Panholzer, B., Flint, N., Bannwarth, W., and Bum, P. The src homology 2 domain of the protein-tyrosin kinase p56lck mediates both intermolecular and intramolecular interactions. Proc. Natl. Acad. Sci. USA, 90: 10285-10289, 1993.
33. Pei, D., Wang, J., and Walsh, C. T. Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1. Proc. Natl. Acad. Sci. USA, 93: 1141-1144, 1996.
34. Zipursky, S. L., and Rubin, G. M. Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila. Annu. Rev. Neurosci., 17: 373-397, 1994.
35. Perkins, L. A., Larsen, I., and Perrimon, N. Corkscrew encodes a putative protein-tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase Torso. Cell, 70: 225-236, 1992.
36. Herbst, R., Carroll, P. M., Allard, J. D., Schilling, J., Raabe, T., and Simon, M. A. Daughter of sevenless is a substrate of the phosphotyrosine phosphatase corkscrew and functions during sevenless signaling. Cell, 85: 899-909, 1995.
37. Raabe, T., Riesgo-Escovar, J., Liu, X., Bausenwein, B. S., Deak, P., Maröy, P., and Hafen, E. DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and ras1 in Drosophila. Cell, 85: 911-920, 1996.
38. Milarski, K. L., and Saltiel A. R. Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin. J. Biol. Chem., 269: 21239-21243, 1994.
39. Noguchi, T., Matozaki, T., Horita, K., Fujioka, Y., and Kasuga, M. Role of SH-PTP2, a protein-tyrosine phosphatase with src homology 2 domains, in insulin-stimulated Ras activation. Mol. Cell. Biol., 14: 6674-6682, 1994.
40. Xiao, S., Rose, D. W., Sasaoka, T., Maegawa, H., Burke, T. R., Roller, P. P., Shoelson, S. E., and Olefsky, J. M. Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction. J. Biol. Chem., 269: 21244-21248, 1994.
41. Yamauchi, K., Milarski, K. L., Saltiel, A. R., and Pessin, J. E. Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling. Proc. Natl. Acad. Sci. USA, 92: 664-668, 1995.
42. Zhao, Z., Tan, Z., Wright, J. C., Diltz, C. D., Shen, S-H., Krebs, E. G., and Fischer, E. H. Altered expression of protein-tyrosine phosphatase 2C in 293 cells affects protein tyrosine phosphorylation and mitogen-activated protein kinase activation. J. Biol. Chem., 270: 11765-11769, 1995.
43. Rivard, N., McKenzie, F. R., Brondello, J-M., and Pouyssegur, J. The phosphotyrosine phosphatase SHP-2, but not PTP1C, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G-protein-coupled receptors. J. Biol. Chem., 270: 11017-11024, 1995.
44. Sawada, T., Milarski, K. L., and Saltiel, A. R. Expression of a catalytically inert syp blocks activation of MAP kinase pathway downstream of p21ras. Biochem. Biophys. Res. Commun., 214: 737-743, 1995.
45. Ali, S., Chen, Z., Lebrun, J-J., Vogel, W., Kharitonenkov, A., Kelly, P. A., and Ullrich, A. SHP-2 is a positive regulator of the prolactin signal leading to β-casein promotor activation. EMBO J., 15: 135-142, 1996.
46. Kharitonenkov, A., Schnekenburger, J., Chen, Z., Knyazev, P., Ali, S., Zwick, E., White, M., and Ullrich, A. Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction. J. Biol. Chem., 270: 29189-29193, 1995.
47. Bennett, A. M., Hausdorff, S. F., O'Reilly, A. M., Freeman, R. M., and Neel, B. G. Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression. Mol. Cell. Biol., 16: 1189-1202, 1996.
48. Cossette, L. J., Hoglinger, O., Mou, L., and Shen, S-H. Localization and down-regulating role of the protein tyrosine phosphatase PTP2C in membrane ruffles of PDGF-stimulated cells. Exp. Cell Res., 223: 459-466, 1996.
49. Tang, T. L., Freeman, R. M., O'Reilly, A. M., Neel, B. G., and Sokol, S. Y. The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development. Cell, 80: 473-483, 1995.
50. Lammers, R., Bossenmaier, B., Cool, D., Tonks, N. K., Schlessinger, J., Fischer, E. H., and Ullrich, A. Differential activities of protein tyrosine phosphatases in intact cells. J. Biol. Chem., 268: 22456-22462, 1993.
51. Kunkel, T. A. Rapid and efficient site-directed mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA, 82: 488-492, 1985.
52. Coussens, L., Yang-Feng, T. L., Liao, Y-C., Chen, E., Gray, A., McGrath, J., Seeburg, P., Libermann, T. A., Schlessinger, J., Francke, U., Levinson, A., and Ullrich, A. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science (Washington DC), 230: 1132-1139, 1985.
53. Fendly, B. M., Winget, M., Hudziak, R. M., Lipari, M. T., Napier, M. A., and Ullrich, A. Characterization of murine monoclonal antibodies reactive to either human epidermal growth factor receptor or HER2/neu gene product. Cancer Res., 50: 1550-1558, 1990.
54. Chen, C., and Okayama, H. High efficiency transformation of mammalian cells by plasmid DMA. Mol. Cell. Biol., 7: 2745-2752, 1987.