Specific SHP-2 partitioning in raft domains triggers integrin-mediated signaling via Rho activation

Journal of Cell Biology

Volumn 157, Issue 2, 2002, Pages 277-289

  Lacalle, Rosa Ana ^a   Mira, Emilia ^a   Gómez Moutón, Concepción ^a   Jiménez Baranda, Sonia ^a   Martínez A, Carlos ^a   Mañes, Santos ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

FAK; Integrin signaling; Lipid rafts; Rho; SHP 2

Indexed keywords

CHOLESTEROL; FOCAL ADHESION KINASE; GUANOSINE TRIPHOSPHATE; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; REGULATOR PROTEIN; RHO FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL MEMBRANE; CELL MIGRATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PHOSPHORYLATION; PRIORITY JOURNAL;

BLOTTING, WESTERN; CELL ADHESION; CELL LINE; CELL MEMBRANE; CELL SIZE; CLONING, MOLECULAR; ENZYME ACTIVATION; FIBRONECTINS; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GUANOSINE TRIPHOSPHATE; HUMANS; INTEGRINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE MICRODOMAINS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; RAC GTP-BINDING PROTEINS; RHO GTP-BINDING PROTEINS; SHP1 PROTEIN TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 0037092040     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200109031     Document Type: Article

References (47)

1. Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism
2. Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK
3. Requirement for Rho in integrin signalling
4. Protein tyrosine phosphatase SHPTP2 couples platelet-derived growth factor receptor β to RAS
5. Structure and function of sphingolipid- and cholesterol-rich membrane rafts
6. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
7. Integrin-mediated signals regulated by members of the rho family of GTPases
8. Drosophila terminal structure development is regulated by the compensatory activities of positive and negative phosphoryrosine signaling sites on the Torso RTK
9. Integrin signaling
10. Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization
11. 3 integrin-associated protein (CD47), and heterotrimeric G proteins
12. Crystal structure of the tyrosine phospharase SHP-2
13. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
14. Roles for the protein tyrosine phosphatase SHP-2 in cytoskeletal organization, cell adhesion and cell migration revealed by overexpression of a dominant negative mutant
15. SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility
16. S-acylarion of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes
17. Why cytoplasmic signalling proteins should be recruited to cell membranes
18. Signaling to Rho GTPases
19. Identification of a putative Syp substrate, the PDGFβ receptor
20. Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering
21. Integrin leukocyte function-associated antigen-1-mediated cell binding can be activated by clustering of membrane rafts
22. Role of p120 Ras-GAP in directed cell movement
23. Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: Implications for human disease
24. Membrane raft microdomains mediate front-rear polarity in migrating cells
25. Concerted activity of tyrosine phospharase SHP-2 and focal adhesion kinase in regulation of cell motility
26. Membrane raft microdomains in chemokine receptor function
27. A mutant form of the rho protein can restore stress fibers and adhesion plaques in v-src transformed fibroblasts
28. Localization of epidermal growth factor-stimulated Ras/Raf-1 interaction to caveolae membrane
29. Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps
30. Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2
31. The role of membrane lipids in regulation of integrin functions
32. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
33. Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover
34. Phosphotyrosine (p-Tyr)-dependent and -independent mechanisms of p190 RhoGAP-p120 RasGAP interaction: Tyr 1105 of p190, a substrate for c-Src, is the sole p-Tyr mediator of complex formation
35. The SH2 tyrosine phosphatase Shp2 is required for mammalian limb development
36. Abnormal mesoderm patterning in mouse embryos mutant for rhe SH2 tyrosine phosphatase Shp-2
37. Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src
38. Signaling through focal adhesion kinase
39. The protein tyrosine phosphatase Shp-2 regulates RhoA activity
40. 1 physically and functionally associate with CD36 in human melanoma cells
41. Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases
42. Genetic analysis of protein tyrosine phosphatases
43. Inhibition of RhoGAP activity is sufficient for the induction of Rho-mediated actin reorganization
44. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth
45. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signalling
46. Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion
47. Tyrosine phosphatase SHP-2 dephosphorylates the platelet-derived growth factor receptor but enhances its downstream signalling