Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene

Cell

Volumn 87, Issue 2, 1996, Pages 307-317

  Holtschke, Thomas ^a   Löhler, Jürgen ^b   Kanno, Yuka ^c   Fehr, Thomas ^d   Giese, Nathalia ^e   Rosenbauer, Frank ^f   Lou, Jing ^c   Knobeloch, Klaus Peter ^f   Gabriele, Lucia ^e   Waring, Jeffrey F ^a   Bachmann, Martin F ^d   Zinkernagel, Rolf M ^d   Morse III, Herbert C ^e   Ozato, Keiko ^c   Horak, Ivan ^a,f  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^f LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CYTOKINE; GAMMA INTERFERON; POLYADENYLATED RNA; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLAST CELL CRISIS; BONE MARROW CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; GENE MUTATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; IMMUNE DEFICIENCY; IMMUNE RESPONSE; LYMPH NODE CELL; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; LYMPHOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; THYMOCYTE; VACCINIA VIRUS; VESICULAR STOMATITIS VIRUS; VIRUS INFECTION;

ANIMALIA; CHORIOMENINGITIS VIRUS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; VACCINIA; VACCINIA VIRUS; VESICULAR STOMATITIS VIRUS;

EID: 16044369709     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81348-3     Document Type: Article

References (41)

1. Antalis, T.M., and Godbolt, D. (1991). Isolation of intact nuclei from hematopoietic cell types. Nucl. Acids Res. 19, 4301.
2. Au, W.-C., Moore, P.A., Lowther, W., Juang, Y.-T., and Pitha, P.M. (1995). Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. Proc. Natl. Acad. Sci. USA 92, 11657-11661.
3. Bovolenta, C., Driggers, P.H., Marks, M.S., Medin, J.A., Poltis, A.D., Vogel, S.N., Levy, D.E., Sakaguchi, K., Appella, E., Coligan, J.E., and Ozato, K. (1994). Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family. Proc. Natl. Acad. Sci. USA 91, 5046-5050.
4. Carlesso, N., Frank, D., and Griffin, J.D. (1996). Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by bcr/abl. J. Exp. Med. 183, 811-820.
5. Danial, N.N., Pernis, A., and Rothman, P.B. (1995). Jak-STAT signaling induced by the v-abl oncogene. Science, 269, 1875-1877.
6. Darnell, J.D., Jr., Kerr, I.M., and Stark, G.R. (1994). Jak-STAT pathways and transcriptional activation in response to IFN and other extracellular signaling proteins. Science 264, 1415-1421.
7. Driggers, P.H., Elenbaas, B.A., An, J.-B., Lee, I.J., and Ozato, K. (1992). Two upstream elements activate transcription of major histocompatibility complex class I gene in vitro. Nucl. Acids Res. 20, 2533-2540.
8. Eisenbeis, C.F., Singh, H., and Storb, U. (1995). Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev. 9, 1377-1387.
9. Gazzinelli, R.T., Hieny, S., Wynn, T.A., Wolf, S., and Sher, A. (1993). Interleukin 12 is required for theT-lymphocyte-independent induction of interferon γ by an intracellular parasite and induces resistance in T-cell-deficient mice. Proc. Natl. Acad. Sci. USA 90, 6115-6119.
10. Giese, N.A., Gazzinelli, R.T., Actor, J.K., Morawetz, R.A., and Morse, H.C., III. (1996). Retrovirus-elicited interleukin-12 and tumour necrosis factor-α as inducers of interferon-γ-mediated pathology in mouse AIDS. Immunology 87, 467-474.
11. Gutterman, J.U. (1994). Cytokine therapeutics: lessons from interferon α. Proc. Natl. Acad. Sci. USA 91, 1198-1205.
12. Harada, H., Fujita, T., Miyamoto, M., Kimura, Y., Marayama, M., Furia, A., Miyata, T., and Taniguchi, T. (1989). Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell 58, 729-739.
13. Harada, H., Kitagawa, M., Tanaka, N., Yamamoto, H., Harada, K., Ishihara, M., and Taniguchi, T. (1993). Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2. Science 259, 971-974.
14. Hawley, R.G., Fong, A.Z.C., Burns, B.F., and Hawley, T.S. (1992). Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus. J. Exp. Med. 176, 1149-1163.
15. Hsu, S.M., Raine, L., and Fanger, H. (1981). Use of avidin-biotinperoxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedure. Hisochem. Cytochem. 29, 577-580.
16. Huang, S., Hendriks, W., Althage, A., Hemmi, S., Bluethmann, H., Kamijo, R., Vilcek, J., Zinkernagel, R.M., and Aguet, M. (1993). Immune response in mice that lack the interferon-gamma receptor. Science 259, 1742-1745.
17. Hwang, S.Y., Hertzog, P.J., Holland, K.A., Sumarsono, S.H., Tymms, M. J., Hamilton, J.A., Whitty, G., Bertoncello, I., and Kola, I. (1995). A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons α and β and alters macrophage responses. Proc. Natl. Acad. Sci. USA 92, 11284-11288.
18. Johnson, G.R., Gonda, T.J., Metcalf, D., Hariharan, I.K., and Cory, S. (1989). A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor. EMBO J. 8, 441-448.
19. Kanno, Y., Kozak, C.A., Schindler, C., Driggers, P.H., Ennist, D.L., Gleason, S.L., Darnell, J.E., Jr., and Ozato, K. (1993). The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3α subunit (or similar) molecule binds. Mol. Cell. Biol. 13, 3951-3963.
20. Maniatis, T., Whittemore, L., Du, W., Fan, C., Keller, A.D., Palombella, V.J., and Thanos, D.N. (1992). Positive and negative control of interferon-β gene expression. In Transcription Regulation, S.L. McKnight and K.R. Yamamoto, eds. (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press), pp. 1193-1220.
21. Matsuyama, T., Kimura, T., Kitagawa, M., Pfeffer, K., Kawakami, T., Watanabe, N., Kündig, T.M., Amakawa, R., Kishihara, K., Wakeham, A., Potter, J., Furlonger, C.L., Naredran, A., Suzuki, H., Ohashi, P.S., Paige, C.J., Taniguchi, T., and Mak, T.W. (1993). Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell 75, 83-97.
22. Metcalf, D. (1989). The molecular control of cell division, differentiation commitment and maturation in hemopoietic cells. Nature 339, 27-30.
23. Miyamoto, M., Fujita, T., Kimura, Y., Maruyama, M., Harada, H., Sudo, Y., Miyata, T., and Taniguchi, T. (1988). Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements. Cell 54, 903-913.
24. Moskophidis, D., Lechner, F., Pircher, H.P., and Zinkernagel, R.M. (1993). Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 362, 758-761.
25. Müller, U., Steinhoff, U., Reis, L.F.M., Hemmi, S., Pavlovic, J., Zinkernagel, R.M., and Aguet, M. (1994). Functional role of type I and type II interferons in antiviral defense. Science 264, 1918-1921.
26. Nelson, N., Marks, M.S., Driggers, P.H., and Ozato, K. (1993). Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription. Mol. Cell. Biol. 13, 588-599.
27. Nelson, N., Kanno, Y., Hong, C., Contursi, C., Fujita, T., Fowlkes, B.J., O'Connell, E., Hu-Li, J., Paul, W.E., Jankovic, D., Sher, A.F., Coligan, J.E., Thornton, A., Appella, E., Yang, Y., and Ozato, K. (1996). Expression of interferon regulatory factor family proteins in lymphocytes: induction of Stat 1 and ICSBP expression by T cell activation. J. Immunol. 156, 3711-3720.
28. Palombella, V.J., and Maniatis, T. (1992). Inducible processing of interferon regulatory factor-2. Mol. Cell. Biol. 12, 3325-3336.
29. Pine, R., Canova, A., and Schindler, C. (1994). Tyrosine phosphorylated p91 binds to single element in the ISGF.IRF-1 promoter to mediate induction by IFNα and IFNγ, and is likely to autoregulate the p91 gene. EMBO J. 13, 158-167.
30. Rabbitts, T.H. (1991). Translocations, master genes and differences between the origins of acute and chronic leukemias. Cell 67, 641-644.
31. Rabbitts, T.H. (1994). Chromosomal translocations in human cancer. Nature 372, 143-149.
32. Rudnicki, M.A., Braun, T., Hinuma, S., and Jaenisch, R. (1992). Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development. Cell 71, 383-390.
33. Sawyers, C.L., Denny, C.T., and Witte O.N. (1991). Leukemia and the disruption of normal hematopoiesis. Cell 64, 337-350.
34. Schorle, H., Holtschke, T., Hünig, T., Schimpl, A., and Horak, I. (1991). Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352, 621-624.
35. Shivdasani, R.A., and Orkin, S.H. (1996). The transcriptional control of hematopoiesis. Blood 87, 4025-4039.
36. Thornton, A.M., Buller, R.M., DeVico, A.L., Wang, I.-M., and Ozato, K. (1996). Inhibition of HIV and vaccinia virus infection by a dominant negative factor of the IRF family expressed in monocytic cells. Proc. Natl. Acad. Sci. USA 93, 383-387.
37. Trinchieri, G. (1995). Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13, 251-276.
38. Veals, S.A., Schindler, C., Leonard, D., Fu, X.-Y., Aebersold, R., Darnell, J.E., Jr., and Levy, D.E. (1992). Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins. Mol. Cell. Biol. 12, 3315-3324.
39. Weissman, I.L. (1994). Stem cells, clonal progenitors, and commitment to the three lymphocyte lineages: T, B, and NK cells. Immunity 1, 529-531.
40. Wong, P.M.C., Chung, S.-W., Dunbar, C.E., Bodine, D.M., Ruscetti, S., and Nienhuis, A.W. (1989). Retrovirus-mediated transfer and expression of the interleukin-3 gene in mouse hematopoietic cells results in a myeloproliferative disorder. Mol. Cell. Biol. 9, 798-808.
41. Zinkernagel, R.M., Haenseler, E., Leist, T.P., Cerny, A., Hengartner, H., and Althage, A. (1986). T cell mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. J. Exp. Med. 164, 1057-1092.