The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis

EMBO Journal

Volumn 20, Issue 12, 2001, Pages 3156-3166

  Zang, Heesuk ^a,b   Sato, Ken ^a   Nakajima, Hideaki ^a   McKay, Catriona ^a   Ney, Paul A ^a,b   Ihle, James N ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Cytokine signaling; Erythropoiesis; Erythropoietin; Jak2 kinase; Receptor

Indexed keywords

ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; PHENYLALANINE; TYROSINE;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; ERYTHROCYTOSIS; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; ERYTHROPOIESIS; JANUS KINASE 2; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RECEPTORS, ERYTHROPOIETIN;

ANIMALIA;

EID: 0035876167     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.12.3156     Document Type: Article

References (37)

1. Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver
2. Familial erythrocytosis associated with a short deletion in the erythropoietin receptor gene
3. Tyrosine residues within the intracellular domain of the erythropoietin receptor mediate activation of AP-1 transcription factors
4. Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway
5. Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation
6. 503 in the erythropoietin receptor (EpR) is essential for binding the p85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR associated PI 3-kinase activity
7. The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains
8. Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis
9. Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene
10. Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation
11. Erythropoietin receptor and STAT5-specific pathways promote SKT6 cell hemoglobinization
12. STAT5 activation correlates with erythropoietin receptor-mediated erythroid differentiation of an erythroleukemia cell line
13. Direct association and dephosphorylation of Jak2 kinase by SH2 domain-containing protein tyrosine phosphatase SHP-1
14. Specific recruitment of the hematopoietic protein tyrosine phosphatase SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals
15. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors
16. Splenic erythroblasts in anemia-inducing Friend disease: A source of cells for studies of erythropoietin-mediated differentiation
17. Erythropoietin
18. Redundant and selective roles for erythropoietin receptor tyrosines in erythropoiesis in vivo
19. SOCS3 is essential in the regulation of fetal liver erythropoiesis
20. Identification of the erythropoietin receptor domain required for calcium channel activation
21. Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus
22. Stat5 is required for IL-2 induced cell cycle progression of peripheral T cells
23. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
24. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
25. Jak2 is essential for signaling through a variety of cytokine receptors
26. Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response
27. Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse
28. Mutations at the murine motheaten locus are within the hematopoietic cell protein tyrosine phosphatase (Hcph) gene
29. -/- mice: A direct role for Stat5 in Bcl-X(L) induction
30. Primary familial polycythemia: A frameshift mutation in the erythropoietin receptor gene and increased sensitivity of erythroid progenitors to erythropoietin
31. Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis
32. Stat5a and Stat5b proteins have essential and non-essential, or redundant, roles in cytokine responses
33. Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity
34. Engagement of Gab1 and Gab2 in erythropoietin signaling
35. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following EPO stimulation
36. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
37. Hematopoietic cell phosphatase (HCP) associates with the erythropoietin receptor following Epo induced receptor tyrosine phosphorylation: Identification of potential binding sites