Involvement of the SHP-1 tyrosine phosphatase in regulation of T cell selection

Journal of Immunology

Volumn 163, Issue 6, 1999, Pages 3012-3021

  Zhang, Jinyi ^a   Somani, Ally Khan ^a   Yuen, Darren ^a   Yang, Ye ^a   Love, Paul E ^b   Siminovitch, Katherine A ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; IMMUNOMODULATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD3; ANTIGENS, DIFFERENTIATION; CELL DIFFERENTIATION; FEMALE; GENE EXPRESSION REGULATION; H-Y ANTIGEN; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTORS, ANTIGEN, T-CELL; SHP1 PROTEIN TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; T-LYMPHOCYTE SUBSETS; TRANSGENES;

EID: 0033567943     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Ashton-Richardt, P. G., A. Bandeira, J. R. Delaney, L. Van Kaer, H. P. Pircher, R. M. Zinkernagel, and S. Tonegawa. 1994. Evidence for a differential avidity model of T cell selection in the thymus. Cell 76:651.
2. Jameson, S. C., K. A. Hogquist, and M. J. Bevan. 1995. Positive selection of thymocytes. Annu. Rev. Immunol. 13:93.
3. Kisielow, P., and H. von Boehmer. 1995. Development and selection of T cells: facts and puzzles. Adv. Immunol. 58:87.
4. Sebzda, E., T. M. Kündigm, C. T. Thomson, K. Aoki, S. Y. Mak, J. Mayer, T. M. Zamborelli, S. Nathenson, and P. S. Ohashi. 1996. Mature T cell reactivity altered by a peptide agonist that induces positive selection. J. Exp. Med. 183:1093.
5. Alam, S. M., P. J. Travers, J. L. Wung, W. Casholds, S. Redpath, S. C. Jameson, and D. R. J. Gascoigne. 1996. T-cell-receptor affinity and thymocyte positive selection. Nature 381:616.
6. Ohashi, P. S. 1996. T cell selection and autoimmunity: flexibility and tuning. Curr. Opin. Immunol. 8:808.
7. Chan, A. C., and A. S. Shaw. 1996. Regulation of antigen receptor signal transduction by protein tyrosine kinases. Curr. Opin. Immunol. 8:394.
8. Cantrell, D. 1996. T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 14:259.
9. Negishi, I., N. Motoyama, K. Nakayama, K. Nakayama, S. Senju, S. Hatakeyama, Q. Zhang, A. C. Chan, and D. Y. Loh. 1995. Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 376:435.
10. lck in thymopoiesis. EMBO J. 12:1671.
11. lck. Nature 357:161.
12. Groves, T., D. Smiley, M. P. Cooke, K. Forbush, R. M. Perlmutter, and C. J. Guidos. 1996. Fyn can partially substitute for Lck in T lymphocyte development. Immunity 5:417.
13. ras distinguishes positive and negative selection in thymocytes. EMBO J. 14:276.
14. Alberola-Ila, J., K. A. Forbush, R. Seger, E. G. Krebs, and R. M. Perlmutter. 1995. Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 373:620.
15. Crompton, T., K. C. Gilmour, and M. J. Owen. 1996. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte. Cell 86:243.
16. Alberola-Ila, J., K. A. Hogquist, K. A. Swan, M. J. Bevan, and R. M. Perlmutter. 1996. Positive and negative selection invoke distinct signaling pathways. J. Exp. Med. 184:9.
17. Tarakhovsky A., S. B. Kanner, J. Hombach, J. A. Ledbetter, W. Müller, N. Killeen, and K. Rajewsky. 1995. A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 269:535.
18. Chambers, C. A., M. F. Krummel, B. Boitel, A. Hurwitz, T. J. Sullivan, S. Fournier, D. Cassell, M. Brunner, and J. P. Allison. 1996. The role of CTLA-4 in the regulation and initiation of T-cell responses. Immunol. Rev. 153:27.
19. Pani, G., and K. A. Siminovitch. 1997. Protein tyrosine phosphatase roles in the regulation of lymphocyte signaling. Clin. Immunol. Immunopathol. 84:1.
20. Pani, G., K. D. Fischer, I. Mlinaric-Rascan, and K. A. Siminovitch. 1996. Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. J. Exp. Med. 184:839.
21. Plas, D. R., R. Johnson, J. T. Pingel, R. J. Matthews, M. Dolton, G. Roy, A. C. Chan, and M. L. Thomas. 1996. Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science 272:1173.
22. Lorenz, U., K. S. Ravichandran, S. J. Burakoff, and B. G. Neel. 1996. Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness. Proc. Natl. Acad. Sci. USA 93:9624.
23. Pani, G., M. Kozlowski, J. C. Cambier, G. B. Mills, and K. A. Siminovitch. 1995. Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor associated protein involved in the regulation of B cell signaling. J. Exp. Med. 181:2077.
24. Siminovitch, K. A., and B. G. Neel. 1998. Regulation of B cell signal transduction by SH2-containing protein tyrosine phosphatases. Semin. Immunol. 10:329.
25. - thymocytes. Nature 333:742.
26. Love, P. E., E. W. Shores, E. J. Lee, A. Grinberg, T. I. Munitz, H. Westphal, and A. Singer. 1994. Differential effects of ζ and η transgenes on early α/β T cell development. J. Exp. Med. 179:1485.
27. Waterhouse, P., M. F. Bachmann, J. M. Penninger, P. S. Ohashi, and T. W. Mak. 1997. Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice. Eur. J. Immunol. 27:1887.
28. Somani, A.-K., J. S. Bignon, G. B. Mills, K. A. Siminovitch, and D. R. Branch. 1997. Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase. J. Biol. Chem. 272:21113.
29. Hough, M. R., F. Takei, P. K. Humphries, and R. Kay. 1994. Defective development of thymocytes overexpressing the costimulatory molecule, heat stable antigen. J. Exp. Med. 179:177.
30. Kozlowski, M., I. Mlinaric-Rascan, G. S. Feng, R. Shen, T. Pawson, and K. A. Siminovitch. 1993. Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J. Exp. Med. 178:2157.
31. Feng, G.-S., C. C. Hui, and T. Pawson. 1993. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 259:1607.
32. Bluestone, J. A. 1995. New perspectives of CD28-B7-mediated T cell costimulation. Immunity 2:555.
33. Delibrias, C. C., J. E. Floettmann, M. Rowe, and D. T. Fearon. 1997. Down-regulated expression of SHP-1 in Burkitt lymphoma and germinal centre B lymphocytes. J. Exp. Med. 186:1575.
34. Borgulya, P., H. Kishi, Y. Uematsu, and H. von Boehmer. 1992. Exclusion and inclusion of α and β T cell receptor alleles. Cell 69:529.
35. Hough, M. R., M. S. Chappel, G. Sauvageau, F. Takei, R. Kay, and R. K. Humphries. 1996. Reduction of early B lymphocyte precursors in transgenic mice overexpressing the murine heat-stable antigen. J. Immunol. 156:479.
36. Kon-Kozlowski, M., G. Pani, T. Pawson, and K. A. Siminovitch. 1996. The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hemopoietic cells. J. Biol. Chem. 271:3856.
37. Imani, F., K. J. Rager, B. Catipovic, and D. G. March. 1997. Interleukin-4 (IL-4) induces phosphatidylinositol 3-kinase (p85) dephosphorylation. J. Biol. Chem. 272:7927.
38. Harr, J. L., J. D. Popp, and L. D. Shultz. 1989. Defective in vitro migratory capacity of bone marrow cells from viable motheaten mice in response to normal thymus culture supernatants. Exp. Hematol. 17:21.
39. Koo, G. C., H. Rosen, A. Sivotina, X.-D. Ma, and L. D. Shultz. 1993. Anti-CD116 antibody prevents immunopathologic changes in viable moth-eaten bone marrow chimeric mice. J. Immunol. 151:6733.
40. Cyster, J. G., and C. C. Goodnow. 1995. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity 2:13.
41. Teh, H. S., P. Kisielow, B. Scott, H. Kishi, Y. Uematsu, H. Bluthmann, and H. von Boehmer. 1988. Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature 335:229.
42. Robey, E. A., F. Ramsdell, D. Kioussis, W. Sha, D. Loh, R. Axel, and B. J. Fowlkes. 1992. The level of CD8 expression can determine the outcome of thymic selection. Cell 69:1089.
43. Sherman, L. A., S. V. Hesse, M. J. Irwin, D. LaFace, and P. Peterson. 1992. Selecting T cell receptors with high affinity for self-MHC by decreasing the contribution of CD8. Science 258:815.
44. Hogquist, K. A., S. C. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76:17.
45. v). Exp. Hematol. 17:81.
46. Hayashi S.-I., P. L. Witte, L. D. Shultz, and P. W. Kincade. 1988. Lymphohemopoiesis in culture is prevented by interaction with adherent bone marrow cells from mutant viable motheaten mice. J. Immunol. 140:2139.
47. v) mutant mice. J. Immunol. 138:3590.
48. Dong, Q., K. A. Siminovitch, L. Fialkow, T. Fukushimi, and G. P. Downey. 1999. Negative regulation of myeloid cell proliferation and function by the SH2 domain-containing tyrosine phosphatase SHP-1. J. Immunol. 162:3220.
49. Yi, T., A. L. Mui, G. Krystal, and J. N. Ihle. 1993. Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor β chain and downregulates IL-3-induced tyrosine phosphorylation and mitogenesis. Mol. Cell. Biol. 13:7577.
50. Chen, H., S. Chang, T. Trub, and B. G. Neel. 1995. Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1. Mol. Cell. Biol. 16:3685.
51. Jiao, H., W. Yang, K. Berrada, M. Tibrizi, L. Shultz, and T. Yi. 1997. Macrophages from motheaten and viable motheaten mutant mice show increased proliferative response to GM-CSF: detection of potential HCP substrates in GM-SCF signal transduction Exp. Haematol. 25:592.
52. Timms, J. F., K. Carlberg, H. Gu, H. Chen, S. Kamatkar, M. J.-S. Nadler, L. R. Rohrschneider, and B. G. Neel. 1998. Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages. Mol. Cell. Biol. 18:3838.
53. Veillette, A., E. Thibaudear, and S. Latour. 1998. High expression of inhibitory receptor SHPs-1 and its association with protein tyrosine phosphatase SHP-1 in macrophages. J. Biol. Chem. 273:22719.
54. Berg, K. L., K. Carlberg, L. R. Rohrschneider, K. A. Siminovitch, and E. R. Stanley. 1998. The major SHP-1 binding, tyrosine-phosphorylated protein in macrophages is a member of the KIR/LIR family and an SHP-1 substrate. Oncogene 17:2535.
55. D'Ambrosio, D., K. L. Hippen, S. A. Minskoff, I. Mellman, G. Pani, K. A. Siminovitch, and J. C. Cambier. 1995. Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by FcγRIIB1. Science 268:293.
56. Doody, G. M., L. B. Justement, C. D. Delibrias, R. J. Matthews, J. Lin, M. L. Thomas, and D. T. Fearon. 1995. A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. Science 269:242.
57. Blery, M., H. Kubagawa, C.-C. Chen, F. Vely, M. D. Cooper, and E. Vivier. 1998. The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1. Proc. Natl. Acad. Sci. USA 95:2446.
58. Adachi, T., H. Flaswinkel, H. Yakura, M. Reth, and T. Tsubata. 1998. The B cell antigen surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation. J. Immunol. 160:4662.
59. + thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: implications for negative selection in the thymus. J. Exp. Med. 186:1911.
60. Marengere, L. E. M., P. Waterhouse, G. Duncan, H. W. Mittrucker, G.-S. Feng, and T. K. Mak. 1996. Regulation of T cell receptor signaling by tyrosine phosphatase Syp association with CTLA-4. Science 272:1170.
61. Yamazaki, T., H. Arase, S. Ono, H. Ohno, H. Watanabe, and T. Saito. 1997. A shift from negative to positive selection of autoreactive cells by the reduced level of TCR signal in TCR-transgenic CD3ζ-deficient mice. J. Immunol. 158:1639.
62. Von Boehmer, H., and H. J. Fehling. 1997. Structure and function of the pre-T cell receptor. Annu. Rev. Immunol. 15:433.