Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1

Nature Immunology

Volumn 9, Issue 5, 2008, Pages 542-550

  An, Huazhang ^a   Hou, Jin ^a   Zhou, Jun ^a   Zhao, Wei ^a   Xu, Hongmei ^a   Zheng, Yuejuan ^a   Yu, Yizhi ^a   Liu, Shuxun ^a   Cao, Xuetao ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; HELICASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; REGULATOR PROTEIN; RIG 1 HELICASE; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REGULATION; HOMEOSTASIS; IMMUNE RESPONSE; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION;

ANIMALS; CATALYTIC DOMAIN; CYTOKINES; HOMEOSTASIS; IMMUNITY, NATURAL; INTERFERON REGULATORY FACTOR-1; INTERFERON TYPE I; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MACROPHAGES, PERITONEAL; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NERVE TISSUE PROTEINS; NF-KAPPA B; PROTEIN BINDING; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 42449121356     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1604     Document Type: Article

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