-
1
-
-
67649379040
-
P90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling
-
Abe Y, Yoon SO, Kubota K, Mendoza MC, Gygi SP, Blenis J. 2009. p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling. J Biol Chem 284:14939-14948.
-
(2009)
J Biol Chem
, vol.284
, pp. 14939-14948
-
-
Abe, Y.1
Yoon, S.O.2
Kubota, K.3
Mendoza, M.C.4
Gygi, S.P.5
Blenis, J.6
-
2
-
-
3242882820
-
PI 3-kinase related kinases: 'Big' players in stress-induced signaling pathways
-
DOI 10.1016/j.dnarep.2004.04.002, PII S1568786404001181
-
Abraham RT. 2004. PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways. DNA Repair (Amst) 3:883-887. (Pubitemid 38997930)
-
(2004)
DNA Repair
, vol.3
, Issue.8-9
, pp. 883-887
-
-
Abraham, R.T.1
-
3
-
-
67651210833
-
Site-specifc mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth
-
Acosta-Jaquez HA, Keller JA, Foster KG, Ekim B, Soliman GA, Feener EP, Ballif BA, Fingar DC. 2009. Site-specifc mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. Mol Cell Biol 29:4308-4324.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 4308-4324
-
-
Acosta-Jaquez, H.A.1
Keller, J.A.2
Foster, K.G.3
Ekim, B.4
Soliman, G.A.5
Feener, E.P.6
Ballif, B.A.7
Fingar, D.C.8
-
4
-
-
34548205803
-
Rapamycin regulates the phosphorylation of rictor
-
DOI 10.1016/j.bbrc.2007.07.151, PII S0006291X07016464
-
Akcakanat A, Singh G, Hung MC, Meric-Bernstam F. 2007. Rapamycin regulates the phosphorylation of rictor. Biochem Biophys Res Commun 362:330-333. (Pubitemid 47332412)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.362
, Issue.2
, pp. 330-333
-
-
Akcakanat, A.1
Singh, G.2
Hung, M.-C.3
Meric-Bernstam, F.4
-
5
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA. 1996a. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15:6541-6551. (Pubitemid 26413787)
-
(1996)
EMBO Journal
, vol.15
, Issue.23
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
6
-
-
0030590875
-
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase
-
DOI 10.1016/S0014-5793(96)01370-1, PII S0014579396013701
-
Alessi DR, Caudwell FB, Andjelkovic M, Hemmings BA, Cohen P. 1996b. Molecular basis for the substrate specifcity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Lett 399:333-338. (Pubitemid 26426877)
-
(1996)
FEBS Letters
, vol.399
, Issue.3
, pp. 333-338
-
-
Alessi, D.R.1
Caudwell, F.B.2
Andjelkovic, M.3
Hemmings, B.A.4
Cohen, P.5
-
9
-
-
21244458013
-
Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site
-
DOI 10.1074/jbc.C500125200
-
Ali SM, Sabatini DM. 2005. Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. J Biol Chem 280:19445-19448. (Pubitemid 41379463)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.20
, pp. 19445-19448
-
-
Ali, S.M.1
Sabatini, D.M.2
-
10
-
-
37549002125
-
Live-cell molecular analysis of Akt activation reveals roles for activation loop phosphorylation
-
Ananthanarayanan B, Fosbrink M, Rahdar M, Zhang J. 2007. Live-cell molecular analysis of Akt activation reveals roles for activation loop phosphorylation. J Biol Chem 282:36634-36641.
-
(2007)
J Biol Chem
, vol.282
, pp. 36634-36641
-
-
Ananthanarayanan, B.1
Fosbrink, M.2
Rahdar, M.3
Zhang, J.4
-
11
-
-
0035846952
-
Regulation of glycogen synthesis by amino acids in cultured human muscle cells
-
DOI 10.1074/jbc.M004812200
-
Armstrong JL, Bonavaud SM, Toole BJ, Yeaman SJ. 2001. Regulation of glycogen synthesis by amino acids in cultured human muscle cells. J Biol Chem 276:952-956. (Pubitemid 32096514)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.2
, pp. 952-956
-
-
Armstrong, J.L.1
Bonavaud, S.M.2
Toole, B.J.3
Yeaman, S.J.4
-
12
-
-
0033594480
-
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
-
DOI 10.1016/S0960-9822(99)80186-9
-
Balendran A, Casamayor A, Deak M, Paterson A, Gafney P, Currie R, Downes CP, Alessi DR. 1999a. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. Curr Biol 9:393-404. (Pubitemid 29205782)
-
(1999)
Current Biology
, vol.9
, Issue.8
, pp. 393-404
-
-
Balendran, A.1
Casamayor, A.2
Deak, M.3
Paterson, A.4
Gaffney, P.5
Currie, R.6
Downes, C.P.7
Alessi, D.R.8
-
13
-
-
0033601217
-
Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Tr-412 as well as Tr-252
-
Balendran A, Currie R, Armstrong CG, Avruch J, Alessi DR. 1999b. Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Tr-412 as well as Tr-252. J Biol Chem 274:37400-37406.
-
(1999)
J Biol Chem
, vol.274
, pp. 37400-37406
-
-
Balendran, A.1
Currie, R.2
Armstrong, C.G.3
Avruch, J.4
Alessi, D.R.5
-
14
-
-
14144254701
-
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors
-
DOI 10.1073/pnas.0409143102
-
Ballif BA, Roux PP, Gerber SA, MacKeigan JP, Blenis J, Gygi SP. 2005. Quantitative phosphorylation profling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Proc Natl Acad Sci USA 102:667-672. (Pubitemid 40282723)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.3
, pp. 667-672
-
-
Ballif, B.A.1
Roux, P.P.2
Gerber, S.A.3
MacKeigan, J.P.4
Blenis, J.5
Gygi, S.P.6
-
15
-
-
0037131187
-
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function
-
DOI 10.1074/jbc.M206322200
-
Basso AD, Solit DB, Chiosis G, Giri B, Tsichlis P, Rosen N. 2002. Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J Biol Chem 277:39858-39866. (Pubitemid 35190971)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.42
, pp. 39858-39866
-
-
Basso, A.D.1
Solit, D.B.2
Chiosis, G.3
Giri, B.4
Tsichlis, P.5
Rosen, N.6
-
16
-
-
0033565608
-
The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation
-
DOI 10.1016/S0960-9822(99)80332-7
-
Behn-Krappa A, Newton AC. 1999. The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation. Curr Biol 9:728-737. (Pubitemid 29350851)
-
(1999)
Current Biology
, vol.9
, Issue.14
, pp. 728-737
-
-
Behn-Krappa, A.1
Newton, A.C.2
-
17
-
-
0035822699
-
Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase
-
DOI 10.1016/S0960-9822(01)00369-4
-
Belham C, Comb MJ, Avruch J. 2001. Identifcation of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase. Curr Biol 11:1155-1167. (Pubitemid 32722568)
-
(2001)
Current Biology
, vol.11
, Issue.15
, pp. 1155-1167
-
-
Belham, C.1
Comb, M.J.2
Avruch, J.3
-
18
-
-
0032560796
-
Akt activation by growth factors is a multiple-step process: The role of the PH domain
-
Bellacosa A, Chan TO, Ahmed NN, Datta K, Malstrom S, Stokoe D, McCormick F, Feng J, Tsichlis P. 1998. Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene 17:313-325. (Pubitemid 28383008)
-
(1998)
Oncogene
, vol.17
, Issue.3
, pp. 313-325
-
-
Bellacosa, A.1
Chan, T.O.2
Ahmed, N.N.3
Datta, K.4
Malstrom, S.5
Stokoe, D.6
McCormick, F.7
Feng, J.8
Tsichlis, P.9
-
19
-
-
49649095676
-
Hsp90 regulates the phosphorylation and activity of serum-and glucocorticoid-regulated kinase-1
-
Belova L, Brickley DR, Ky B, Sharma SK, Conzen SD. 2008. Hsp90 regulates the phosphorylation and activity of serum-and glucocorticoid-regulated kinase-1. J Biol Chem 283:18821-18831.
-
(2008)
J Biol Chem
, vol.283
, pp. 18821-18831
-
-
Belova, L.1
Brickley, D.R.2
Ky, B.3
Sharma, S.K.4
Conzen, S.D.5
-
20
-
-
54849426651
-
Skeletal muscle-specifc ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy
-
Bentzinger CF, Romanino K, Cloëtta D, Lin S, Mascarenhas JB, Oliveri F, Xia J, Casanova E, Costa CF, Brink M, Zorzato F, Hall MN, Rüegg MA. 2008. Skeletal muscle-specifc ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab 8:411-424.
-
(2008)
Cell Metab
, vol.8
, pp. 411-424
-
-
Bentzinger, C.F.1
Romanino, K.2
Cloëtta, D.3
Lin, S.4
Mascarenhas, J.B.5
Oliveri, F.6
Xia, J.7
Casanova, E.8
Costa, C.F.9
Brink, M.10
Zorzato, F.11
Hall, M.N.12
Ma, R.13
-
21
-
-
38849187293
-
CDK Inhibitors: Cell Cycle Regulators and Beyond
-
DOI 10.1016/j.devcel.2008.01.013, PII S1534580708000415
-
Besson A, Dowdy SF, Roberts JM. 2008. CDK inhibitors: cell cycle regulators and beyond. Dev Cell 14:159-169. (Pubitemid 351189186)
-
(2008)
Developmental Cell
, vol.14
, Issue.2
, pp. 159-169
-
-
Besson, A.1
Dowdy, S.F.2
Roberts, J.M.3
-
22
-
-
0035882103
-
The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
-
DOI 10.1093/emboj/20.16.4380
-
Biondi RM, Kieloch A, Currie RA, Deak M, Alessi DR. 2001. The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J 20:4380-4390. (Pubitemid 32772032)
-
(2001)
EMBO Journal
, vol.20
, Issue.16
, pp. 4380-4390
-
-
Biondi, R.M.1
Kieloch, A.2
Currie, R.A.3
Deak, M.4
Alessi, D.R.5
-
23
-
-
0037954572
-
Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions
-
DOI 10.1042/BJ20021641
-
Biondi RM, Nebreda AR. 2003. Signalling specifcity of Ser/Tr protein kinases through docking-site-mediated interactions. Biochem J 372:1-13. (Pubitemid 36609602)
-
(2003)
Biochemical Journal
, vol.372
, Issue.1
, pp. 1-13
-
-
Biondi, R.M.1
Nebreda, A.R.2
-
24
-
-
33745188921
-
A novel N-terminal hydrophobic motif mediates constitutive degradation of serum-and glucocorticoid-induced kinase-1 by the ubiquitin-proteasome pathway
-
Bogusz AM, Brickley DR, Pew T, Conzen SD. 2006. A novel N-terminal hydrophobic motif mediates constitutive degradation of serum-and glucocorticoid-induced kinase-1 by the ubiquitin-proteasome pathway. FEBS J 273:2913-2928.
-
(2006)
FEBS J
, vol.273
, pp. 2913-2928
-
-
Bogusz, A.M.1
Brickley, D.R.2
Pew, T.3
Conzen, S.D.4
-
25
-
-
0030250879
-
Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase C
-
DOI 10.1016/S0960-9822(02)70678-7
-
Bornancin F, Parker PJ. 1996. Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Calpha. Curr Biol 6:1114-1123. (Pubitemid 26368745)
-
(1996)
Current Biology
, vol.6
, Issue.9
, pp. 1114-1123
-
-
Bornancin, F.1
Parker, P.J.2
-
26
-
-
0034193150
-
FAT: A novel domain in PIK-related kinases
-
DOI 10.1016/S0968-0004(00)01563-2, PII S0968000400015632
-
Bosotti R, Isacchi A, Sonnhammer EL. 2000. FAT: a novel domain in PIK-related kinases. Trends Biochem Sci 25:225-227. (Pubitemid 30236217)
-
(2000)
Trends in Biochemical Sciences
, vol.25
, Issue.5
, pp. 225-227
-
-
Bosotti, R.1
Isacchi, A.2
Sonnhammer, E.L.L.3
-
27
-
-
77953763269
-
Rictor phosphorylation on the Tr-1135 site does not require mammalian target of rapamycin complex 2
-
Boulbes D, Chen CH, Shaikenov T, Agarwal NK, Peterson TR, Addona TA, Keshishian H, Carr SA, Magnuson MA, Sabatini DM, Sarbassov dos D. 2010. Rictor phosphorylation on the Tr-1135 site does not require mammalian target of rapamycin complex 2. Mol Cancer Res 8:896-906.
-
(2010)
Mol Cancer Res
, vol.8
, pp. 896-906
-
-
Boulbes, D.1
Chen, C.H.2
Shaikenov, T.3
Agarwal, N.K.4
Peterson, T.R.5
Addona, T.A.6
Keshishian, H.7
Carr, S.A.8
Magnuson, M.A.9
Sabatini, D.M.10
Sarbassov Dos, D.11
-
28
-
-
42949165854
-
PKB/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival
-
DOI 10.1016/j.molcel.2008.02.024, PII S1097276508001718
-
Bozulic L, Surucu B, Hynx D, Hemmings BA. 2008. PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol Cell 30:203-213. (Pubitemid 351626686)
-
(2008)
Molecular Cell
, vol.30
, Issue.2
, pp. 203-213
-
-
Bozulic, L.1
Surucu, B.2
Hynx, D.3
Hemmings, B.A.4
-
29
-
-
10044276783
-
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
-
DOI 10.1101/gad.1256804
-
Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, Kaelin WG Jr. 2004. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev 18:2893-2904. (Pubitemid 39602308)
-
(2004)
Genes and Development
, vol.18
, Issue.23
, pp. 2893-2904
-
-
Brugarolas, J.1
Lei, K.2
Hurley, R.L.3
Manning, B.D.4
Reiling, J.H.5
Hafen, E.6
Witters, L.A.7
Ellisen, L.W.8
Kaelin Jr., W.G.9
-
30
-
-
0032539664
-
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
-
DOI 10.1073/pnas.95.4.1432
-
Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM. 1998. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci USA 95:1432-1437. (Pubitemid 28103409)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.4
, pp. 1432-1437
-
-
Burnett, P.E.1
Barrow, R.K.2
Cohen, N.A.3
Snyder, S.H.4
Sabatini, D.M.5
-
31
-
-
33646111903
-
Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning
-
Cai SL, Tee AR, Short JD, Bergeron JM, Kim J, Shen J, Guo R, Johnson CL, Kiguchi K, Walker CL. 2006. Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning. J Cell Biol 173:279-289.
-
(2006)
J Cell Biol
, vol.173
, pp. 279-289
-
-
Cai, S.L.1
Tee, A.R.2
Short, J.D.3
Bergeron, J.M.4
Kim, J.5
Shen, J.6
Guo, R.7
Johnson, C.L.8
Kiguchi, K.9
Walker, C.L.10
-
32
-
-
36749002266
-
Protein kinases, from B to C
-
DOI 10.1042/BST0351013
-
Cameron AJ, De Rycker M, Calleja V, Alcor D, Kjaer S, Kostelecky B, Saurin A, Faisal A, Laguerre M, Hemmings BA, McDonald N, Larijani B, Parker PJ. 2007. Protein kinases, from B to C. Biochem Soc Trans 35:1013-1017. (Pubitemid 350206416)
-
(2007)
Biochemical Society Transactions
, vol.35
, Issue.5
, pp. 1013-1017
-
-
Cameron, A.J.1
De Rycker, M.2
Calleja, V.3
Alcor, D.4
Kjaer, S.5
Kostelecky, B.6
Saurin, A.7
Faisal, A.8
Laguerre, M.9
Hemmings, B.A.10
McDonald, N.11
Larijani, B.12
Parker, P.J.13
-
33
-
-
77955443001
-
Critical roles for mTORC2-and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells
-
Carayol N, Vakana E, Sassano A, Kaur S, Goussetis DJ, Glaser H, Druker BJ, Donato NJ, Altman JK, Barr S, Platanias LC. 2010. Critical roles for mTORC2-and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells. Proc Natl Acad Sci USA 107:12469-12474.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 12469-12474
-
-
Carayol, N.1
Vakana, E.2
Sassano, A.3
Kaur, S.4
Goussetis, D.J.5
Glaser, H.6
Druker, B.J.7
Donato, N.J.8
Altman, J.K.9
Barr, S.10
Platanias, L.C.11
-
34
-
-
51049083138
-
Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation
-
Carrière A, Cargnello M, Julien LA, Gao H, Bonneil E, Tibault P, Roux PP. 2008. Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation. Curr Biol 18:1269-1277.
-
(2008)
Curr Biol
, vol.18
, pp. 1269-1277
-
-
Carrière, A.1
Cargnello, M.2
Julien, L.A.3
Gao, H.4
Bonneil, E.5
Tibault, P.6
Roux, P.P.7
-
35
-
-
78650943298
-
ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1)
-
Carriere A, Romeo Y, Acosta-Jaquez HA, Moreau J, Bonneil E, Tibault P, Fingar DC, Roux PP. 2011. ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1). J Biol Chem 286:567-577.
-
(2011)
J Biol Chem
, vol.286
, pp. 567-577
-
-
Carriere, A.1
Romeo, Y.2
Acosta-Jaquez, H.A.3
Moreau, J.4
Bonneil, E.5
Tibault, P.6
Fingar, D.C.7
Roux, P.P.8
-
37
-
-
79952119614
-
ER stress inhibits mTORC2 and Akt signaling through GSK-3ß-mediated phosphorylation of rictor
-
Chen CH, Shaikenov T, Peterson TR, Aimbetov R, Bissenbaev AK, Lee SW, Wu J, Lin HK, Sarbassov dos D. 2011. ER stress inhibits mTORC2 and Akt signaling through GSK-3ß-mediated phosphorylation of rictor. Sci Signal 4:ra10.
-
(2011)
Sci Signal
, vol.4
-
-
Chen, C.H.1
Shaikenov, T.2
Peterson, T.R.3
Aimbetov, R.4
Bissenbaev, A.K.5
Lee, S.W.6
Wu, J.7
Lin, H.K.8
Sarbassov Dos, D.9
-
38
-
-
63649122347
-
Regulation of a third conserved phosphorylation site in SGK1
-
Chen W, Chen Y, Xu BE, Juang YC, Stippec S, Zhao Y, Cobb MH. 2009. Regulation of a third conserved phosphorylation site in SGK1. J Biol Chem 284:3453-3460.
-
(2009)
J Biol Chem
, vol.284
, pp. 3453-3460
-
-
Chen, W.1
Chen, Y.2
Xu, B.E.3
Juang, Y.C.4
Stippec, S.5
Zhao, Y.6
Cobb, M.H.7
-
39
-
-
21744434031
-
Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation
-
DOI 10.1128/MCB.25.14.5955-5964.2005
-
Cheng J, Zhang D, Kim K, Zhao Y, Zhao Y, Su B. 2005. Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation. Mol Cell Biol 25:5955-5964. (Pubitemid 40946550)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.14
, pp. 5955-5964
-
-
Cheng, J.1
Zhang, D.2
Kim, K.3
Zhao, Y.4
Zhao, Y.5
Su, B.6
-
40
-
-
1942469564
-
2446 Is a Novel Mammalian Target of Rapamycin (mTOR) Phosphorylation Site Regulated by Nutrient Status
-
DOI 10.1074/jbc.C300534200
-
Cheng SW, Fryer LG, Carling D, Shepherd PR. 2004. Tr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. J Biol Chem 279:15719-15722. (Pubitemid 38509255)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.16
, pp. 15719-15722
-
-
Cheng, S.W.Y.1
Fryer, L.G.D.2
Carling, D.3
Shepherd, P.R.4
-
41
-
-
21844468767
-
Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase
-
DOI 10.1074/jbc.M501707200
-
Chiang GG, Abraham RT. 2005. Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J Biol Chem 280:25485-25490. (Pubitemid 40962253)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.27
, pp. 25485-25490
-
-
Chiang, G.G.1
Abraham, R.T.2
-
42
-
-
56249147509
-
Rapamycin diferentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specifc repression of mRNA translation
-
Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J. 2008. Rapamycin diferentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specifc repression of mRNA translation. Proc Natl Acad Sci USA 105:17414-17419.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 17414-17419
-
-
Choo, A.Y.1
Yoon, S.O.2
Kim, S.G.3
Roux, P.P.4
Blenis, J.5
-
43
-
-
62449266454
-
TORC-specifc phosphorylation of mammalian target of rapamycin (mTOR): Phospho-Ser2481 is a marker for intact mTOR signaling complex 2
-
Copp J, Manning G, Hunter T. 2009. TORC-specifc phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res 69:1821-1827.
-
(2009)
Cancer Res
, vol.69
, pp. 1821-1827
-
-
Copp, J.1
Manning, G.2
Hunter, T.3
-
44
-
-
20144362478
-
The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability
-
DOI 10.1074/jbc.M501116200
-
Dames SA, Mulet JM, Rathgeb-Szabo K, Hall MN, Grzesiek S. 2005. The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability. J Biol Chem 280:20558-20564. (Pubitemid 40776757)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.21
, pp. 20558-20564
-
-
Dames, S.A.1
Mulet, J.M.2
Rathgeb-Szabo, K.3
Hall, M.N.4
Grzesiek, S.5
-
45
-
-
27844520469
-
PI3K/AKT pathway regulates TSC tumor suppressor complex by phosphorylation of tuberin
-
Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Yeung RS, Halley DJ, Nicosia SV, Pledger WJ, Cheng JQ. 2002. PI3K/AKT pathway regulates TSC tumor suppressor complex by phosphorylation of tuberin. J Biol Chem, 11, 11.
-
(2002)
J Biol Chem
, vol.11
, pp. 11
-
-
Dan, H.C.1
Sun, M.2
Yang, L.3
Feldman, R.I.4
Sui, X.M.5
Yeung, R.S.6
Halley, D.J.7
Nicosia, S.V.8
Pledger, W.J.9
Cheng, J.Q.10
-
46
-
-
79952985551
-
The kinase mTOR regulates the diferentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
-
Delgofe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, Xiao B, Worley PF, Powell JD. 2011. The kinase mTOR regulates the diferentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol 12:295-303.
-
(2011)
Nat Immunol
, vol.12
, pp. 295-303
-
-
Delgofe, G.M.1
Pollizzi, K.N.2
Waickman, A.T.3
Heikamp, E.4
Meyers, D.J.5
Horton, M.R.6
Xiao, B.7
Worley, P.F.8
Powell, J.D.9
-
47
-
-
0029828590
-
The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases
-
Dennis PB, Pullen N, Kozma SC, Tomas G. 1996. The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are diferentially regulated by rapamycin-insensitive kinase kinases. Mol Cell Biol 16:6242-6251. (Pubitemid 26360984)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.11
, pp. 6242-6251
-
-
Dennis, P.B.1
Pullen, N.2
Kozma, S.C.3
Thomas, G.4
-
48
-
-
38349056675
-
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
-
DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW. 2008. Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev 22:239-251.
-
(2008)
Genes Dev
, vol.22
, pp. 239-251
-
-
Deyoung, M.P.1
Horak, P.2
Sofer, A.3
Sgroi, D.4
Ellisen, L.W.5
-
49
-
-
70350545722
-
Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1
-
Dibble CC, Asara JM, Manning BD. 2009. Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol Cell Biol 29:5657-5670.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 5657-5670
-
-
Dibble, C.C.1
Asara, J.M.2
Manning, B.D.3
-
50
-
-
23044467856
-
PDK2: The missing piece in the receptor tyrosine kinase signaling pathway puzzle
-
DOI 10.1152/ajpendo.00011.2005
-
Dong LQ, Liu F. 2005. PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle. Am J Physiol Endocrinol Metab 289:E187-E196. (Pubitemid 41076617)
-
(2005)
American Journal of Physiology - Endocrinology and Metabolism
, vol.289
, Issue.2
-
-
Dong, L.Q.1
Liu, F.2
-
51
-
-
33750325725
-
S6k1- and TRCP-mediated degradation of PDCD4 promotes protein translation and cell growth
-
DOI 10.1126/science.1130276
-
Dorrello NV, Peschiaroli A, Guardavaccaro D, Colburn NH, Sherman NE, Pagano M. 2006. S6K1-and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science 314:467-471. (Pubitemid 44628968)
-
(2006)
Science
, vol.314
, Issue.5798
, pp. 467-471
-
-
Dorrello, N.V.1
Peschiaroli, A.2
Guardavaccaro, D.3
Colburn, N.H.4
Sherman, N.E.5
Pagano, M.6
-
52
-
-
77952967459
-
MTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs
-
Dowling RJ, Topisirovic I, Alain T, Bidinosti M, Fonseca BD, Petroulakis E, Wang X, Larsson O, Selvaraj A, Liu Y, Kozma SC, Tomas G, Sonenberg N. 2010. mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science 328:1172-1176.
-
(2010)
Science
, vol.328
, pp. 1172-1176
-
-
Dowling, R.J.1
Topisirovic, I.2
Alain, T.3
Bidinosti, M.4
Fonseca, B.D.5
Petroulakis, E.6
Wang, X.7
Larsson, O.8
Selvaraj, A.9
Liu, Y.10
Kozma, S.C.11
Tomas, G.12
Sonenberg, N.13
-
53
-
-
79960014848
-
ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding
-
Dunlop EA, Hunt DK, Acosta-Jaquez HA, Fingar DC, Tee AR. 2011. ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding. Autophagy 7:737-747.
-
(2011)
Autophagy
, vol.7
, pp. 737-747
-
-
Dunlop, E.A.1
Hunt, D.K.2
Acosta-Jaquez, H.A.3
Fingar, D.C.4
Tee, A.R.5
-
54
-
-
62749096589
-
Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms
-
Dunlop EA, Tee AR. 2009. Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms. Cell Signal 21:827-835.
-
(2009)
Cell Signal
, vol.21
, pp. 827-835
-
-
Dunlop, E.A.1
Tee, A.R.2
-
55
-
-
79960349522
-
MTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression
-
Ekim B, Magnuson B, Acosta-Jaquez HA, Keller JA, Feener EP, Fingar DC. 2011. mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression. Mol Cell Biol 31:2787-2801.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 2787-2801
-
-
Ekim, B.1
Magnuson, B.2
Acosta-Jaquez, H.A.3
Keller, J.A.4
Feener, E.P.5
Fingar, D.C.6
-
56
-
-
0028840004
-
Inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells
-
Eldar-Finkelman H, Seger R, Vandenheede JR, Krebs EG. 1995. Inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells. J Biol Chem 270:987-990.
-
(1995)
J Biol Chem
, vol.270
, pp. 987-990
-
-
Eldar-Finkelman, H.1
Seger, R.2
Vandenheede, J.R.3
Krebs, E.G.4
-
57
-
-
79955818156
-
Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic efects in T-cell acute lymphoblastic leukemia
-
Evangelisti C, Ricci F, Tazzari P, Tabellini G, Battistelli M, Falcieri E, Chiarini F, Bortul R, Melchionda F, Pagliaro P, Pession A, McCubrey JA, Martelli AM. 2011. Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic efects in T-cell acute lymphoblastic leukemia. Leukemia 25:781-791.
-
(2011)
Leukemia
, vol.25
, pp. 781-791
-
-
Evangelisti, C.1
Ricci, F.2
Tazzari, P.3
Tabellini, G.4
Battistelli, M.5
Falcieri, E.6
Chiarini, F.7
Bortul, R.8
Melchionda, F.9
Pagliaro, P.10
Pession, A.11
McCubrey, J.A.12
Martelli, A.M.13
-
58
-
-
47949125486
-
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
-
Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E. 2008. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J 27:1932-1943.
-
(2008)
EMBO J
, vol.27
, pp. 1932-1943
-
-
Facchinetti, V.1
Ouyang, W.2
Wei, H.3
Soto, N.4
Lazorchak, A.5
Gould, C.6
Lowry, C.7
Newton, A.C.8
Mao, Y.9
Miao, R.Q.10
Sessa, W.C.11
Qin, J.12
Zhang, P.13
Su, B.14
Jacinto, E.15
-
59
-
-
62349110027
-
EGFR signals to mTOR through PKC and independently of Akt in glioma
-
Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA. 2009. EGFR signals to mTOR through PKC and independently of Akt in glioma. Sci Signal 2:ra4.
-
(2009)
Sci Signal
, vol.2
-
-
Fan, Q.W.1
Cheng, C.2
Knight, Z.A.3
Haas-Kogan, D.4
Stokoe, D.5
James, C.D.6
McCormick, F.7
Shokat, K.M.8
Weiss, W.A.9
-
60
-
-
61349141302
-
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
-
Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM. 2009. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol 7:e38.
-
(2009)
PLoS Biol
, vol.7
-
-
Feldman, M.E.1
Apsel, B.2
Uotila, A.3
Loewith, R.4
Knight, Z.A.5
Ruggero, D.6
Shokat, K.M.7
-
61
-
-
78650239404
-
Functions and regulation of the 70kDa ribosomal S6 kinases
-
Fenton TR, Gout IT. 2011. Functions and regulation of the 70kDa ribosomal S6 kinases. Int J Biochem Cell Biol 43:47-59.
-
(2011)
Int J Biochem Cell Biol
, vol.43
, pp. 47-59
-
-
Fenton, T.R.1
Gout, I.T.2
-
62
-
-
2342545519
-
Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
-
DOI 10.1038/sj.onc.1207542
-
Fingar DC, Blenis J. 2004. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23:3151-3171. (Pubitemid 38638827)
-
(2004)
Oncogene
, vol.23
, Issue.18
, pp. 3151-3171
-
-
Fingar, D.C.1
Blenis, J.2
-
63
-
-
73649098283
-
Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation
-
Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA, Carriere A, Roux PP, Ballif BA, Fingar DC. 2010. Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation. J Biol Chem 285:80-94.
-
(2010)
J Biol Chem
, vol.285
, pp. 80-94
-
-
Foster, K.G.1
Acosta-Jaquez, H.A.2
Romeo, Y.3
Ekim, B.4
Soliman, G.A.5
Carriere, A.6
Roux, P.P.7
Ballif, B.A.8
Fingar, D.C.9
-
64
-
-
0035477020
-
GSK3 takes centre stage more than 20 years after its discovery
-
DOI 10.1042/0264-6021:3590001
-
Frame S, Cohen P. 2001. GSK3 takes centre stage more than 20 years after its discovery. Biochem J 359:1-16. (Pubitemid 32939202)
-
(2001)
Biochemical Journal
, vol.359
, Issue.1
, pp. 1-16
-
-
Frame, S.1
Cohen, P.2
-
65
-
-
33748471980
-
mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s
-
DOI 10.1016/j.cub.2006.08.001, PII S0960982206019749
-
Frias MA, Toreen CC, Jafe JD, Schroder W, Sculley T, Carr SA, Sabatini DM. 2006. mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms defne three distinct mTORC2s. Curr Biol 16:1865-1870. (Pubitemid 44354144)
-
(2006)
Current Biology
, vol.16
, Issue.18
, pp. 1865-1870
-
-
Frias, M.A.1
Thoreen, C.C.2
Jaffe, J.D.3
Schroder, W.4
Sculley, T.5
Carr, S.A.6
Sabatini, D.M.7
-
66
-
-
0037155901
-
Involvement of Hsp90 in signaling and stability of 3-phosphoinositide- dependent kinase-1
-
DOI 10.1074/jbc.M106736200
-
Fujita N, Sato S, Ishida A, Tsuruo T. 2002. Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1. J Biol Chem 277:10346-10353. (Pubitemid 34968152)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.12
, pp. 10346-10353
-
-
Fujita, N.1
Sato, S.2
Ishida, A.3
Tsuruo, T.4
-
67
-
-
77956548321
-
Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction
-
Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W. 2010. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell 39:797-808.
-
(2010)
Mol Cell
, vol.39
, pp. 797-808
-
-
Gao, D.1
Wan, L.2
Inuzuka, H.3
Berg, A.H.4
Tseng, A.5
Zhai, B.6
Shaik, S.7
Bennett, E.8
Tron, A.E.9
Gasser, J.A.10
Lau, A.11
Gygi, S.P.12
Harper, J.W.13
Decaprio, J.A.14
Toker, A.15
Wei, W.16
-
68
-
-
0037200043
-
The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C
-
DOI 10.1074/jbc.M204335200
-
Gao T, Newton AC. 2002. The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C. J Biol Chem 277:31585-31592. (Pubitemid 34968961)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.35
, pp. 31585-31592
-
-
Gao, T.1
Newton, A.C.2
-
69
-
-
58649092475
-
MTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum-and glucocorticoid-induced protein kinase 1 (SGK1)
-
García-Martínez JM, Alessi DR. 2008. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum-and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J 416:375-385.
-
(2008)
Biochem J
, vol.416
, pp. 375-385
-
-
García-Martínez, J.M.1
Alessi, D.R.2
-
70
-
-
50149094239
-
A link between SIN1 (MAPKAP1) and poly(rC) binding protein 2 (PCBP2) in counteracting environmental stress
-
Ghosh D, Srivastava GP, Xu D, Schulz LC, Roberts RM. 2008. A link between SIN1 (MAPKAP1) and poly(rC) binding protein 2 (PCBP2) in counteracting environmental stress. Proc Natl Acad Sci USA 105:11673-11678.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 11673-11678
-
-
Ghosh, D.1
Srivastava, G.P.2
Xu, D.3
Schulz, L.C.4
Roberts, R.M.5
-
71
-
-
34247368172
-
Lining the pockets of kinases and phosphatases
-
DOI 10.1016/j.sbi.2006.10.006, PII S0959440X06001783, Catalysis and Regulation / Proteins
-
Gold MG, Barford D, Komander D. 2006. Lining the pockets of kinases and phosphatases. Curr Opin Struct Biol 16:693-701. (Pubitemid 44827729)
-
(2006)
Current Opinion in Structural Biology
, vol.16
, Issue.6
, pp. 693-701
-
-
Gold, M.G.1
Barford, D.2
Komander, D.3
-
72
-
-
64149128633
-
The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail
-
Gould CM, Kannan N, Taylor SS, Newton AC. 2009. The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. J Biol Chem 284:4921-4935.
-
(2009)
J Biol Chem
, vol.284
, pp. 4921-4935
-
-
Gould, C.M.1
Kannan, N.2
Taylor, S.S.3
Newton, A.C.4
-
73
-
-
52249086787
-
PKCbetaII modulates translation independently from mTOR and through RACK1
-
Grosso S, Volta V, Sala LA, Vietri M, Marchisio PC, Ron D, Bifo S. 2008a. PKCbetaII modulates translation independently from mTOR and through RACK1. Biochem J 415:77-85.
-
(2008)
Biochem J
, vol.415
, pp. 77-85
-
-
Grosso, S.1
Volta, V.2
Sala, L.A.3
Vietri, M.4
Marchisio, P.C.5
Ron, D.6
Bifo, S.7
-
74
-
-
52249102866
-
Eukaryotic ribosomes host PKC activity
-
Grosso S, Volta V, Vietri M, Gorrini C, Marchisio PC, Bifo S. 2008b. Eukaryotic ribosomes host PKC activity. Biochem Biophys Res Commun 376:65-69.
-
(2008)
Biochem Biophys Res Commun
, vol.376
, pp. 65-69
-
-
Grosso, S.1
Volta, V.2
Vietri, M.3
Gorrini, C.4
Marchisio, P.C.5
Bifo, S.6
-
75
-
-
14544271905
-
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
-
DOI 10.1016/j.biochi.2004.10.019
-
Gual P, Le Marchand-Brustel Y, Tanti JF. 2005. Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 87:99-109. (Pubitemid 40298772)
-
(2005)
Biochimie
, vol.87
, Issue.1 SPEC. ISS.
, pp. 99-109
-
-
Gual, P.1
Le Marchand-Brustel, Y.2
Tanti, J.-F.3
-
77
-
-
58649114084
-
MTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice
-
Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM. 2009. mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell 15:148-159.
-
(2009)
Cancer Cell
, vol.15
, pp. 148-159
-
-
Guertin, D.A.1
Stevens, D.M.2
Saitoh, M.3
Kinkel, S.4
Crosby, K.5
Sheen, J.H.6
Mullholland, D.J.7
Magnuson, M.A.8
Wu, H.9
Sabatini, D.M.10
-
78
-
-
33751348056
-
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Revealsthat mTORC2 Is Required for Signaling to Akt-FOXO and PKC, but Not S6K1
-
DOI 10.1016/j.devcel.2006.10.007, PII S153458070600459X
-
Guertin DA, Stevens DM, Toreen CC, Burds AA, Kalaany NY, Mofat J, Brown M, Fitzgerald KJ, Sabatini DM. 2006. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell 11:859-871. (Pubitemid 44804279)
-
(2006)
Developmental Cell
, vol.11
, Issue.6
, pp. 859-871
-
-
Guertin, D.A.1
Stevens, D.M.2
Thoreen, C.C.3
Burds, A.A.4
Kalaany, N.Y.5
Moffat, J.6
Brown, M.7
Fitzgerald, K.J.8
Sabatini, D.M.9
-
79
-
-
42949139481
-
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
-
DOI 10.1016/j.molcel.2008.03.003, PII S109727650800169X
-
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. 2008. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30:214-226. (Pubitemid 351626684)
-
(2008)
Molecular Cell
, vol.30
, Issue.2
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
80
-
-
0242637318
-
mTOR-Dependent Regulation of Ribosomal Gene Transcription Requires S6K1 and Is Mediated by Phosphorylation of the Carboxy-Terminal Activation Domain of the Nucleolar Transcription Factor UBF
-
DOI 10.1128/MCB.23.23.8862-8877.2003
-
Hannan KM, Brandenburger Y, Jenkins A, Sharkey K, Cavanaugh A, Rothblum L, Moss T, Poortinga G, McArthur GA, Pearson RB, Hannan RD. 2003. mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. Mol Cell Biol 23:8862-8877. (Pubitemid 37433385)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.23
, pp. 8862-8877
-
-
Hannan, K.M.1
Brandenburger, Y.2
Jenkins, A.3
Sharkey, K.4
Cavanaugh, A.5
Rothblum, L.6
Moss, T.7
Poortinga, G.8
McArthur, G.A.9
Pearson, R.B.10
Hannan, R.D.11
-
81
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
DOI 10.1016/S0092-8674(02)00833-4
-
Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, Tokunaga C, Avruch J, Yonezawa K. 2002. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110:177-189. (Pubitemid 34876546)
-
(2002)
Cell
, vol.110
, Issue.2
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.-I.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
82
-
-
3342958797
-
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
-
DOI 10.1083/jcb.200403069
-
Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfeld S, Rebholz H, Barnett J, Leslie NR, Cheng S, Shepherd PR, Gout I, Downes CP, Lamb RF. 2004. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol 166:213-223. (Pubitemid 38988774)
-
(2004)
Journal of Cell Biology
, vol.166
, Issue.2
, pp. 213-223
-
-
Harrington, L.S.1
Findlay, G.M.2
Gray, A.3
Tolkacheva, T.4
Wigfield, S.5
Rebholz, H.6
Barnett, J.7
Leslie, N.R.8
Cheng, S.9
Shepherd, P.R.10
Gout, I.11
Downes, C.P.12
Lamb, R.F.13
-
83
-
-
34247572532
-
Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation
-
DOI 10.1038/sj.emboj.7601682, PII 7601682
-
Hauge C, Antal TL, Hirschberg D, Doehn U, Torup K, Idrissova L, Hansen K, Jensen ON, Jørgensen TJ, Biondi RM, Frödin M. 2007. Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation. EMBO J 26:2251-2261. (Pubitemid 46685864)
-
(2007)
EMBO Journal
, vol.26
, Issue.9
, pp. 2251-2261
-
-
Hauge, C.1
Antal, T.L.2
Hirschberg, D.3
Doehn, U.4
Thorup, K.5
Idrissova, L.6
Hansen, K.7
Jensen, O.N.8
Jorgensen, T.J.9
Biondi, R.M.10
Frodin, M.11
-
84
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
-
Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG. 2003. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2:28.
-
(2003)
J Biol
, vol.2
, pp. 28
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
Mustard, K.J.4
Udd, L.5
Mäkelä, T.P.6
Alessi, D.R.7
Hardie, D.G.8
-
85
-
-
80455155183
-
Turn motif phosphorylation negatively regulates activation loop phosphorylation in Akt
-
Hiraoka D, Okumura E, Kishimoto T. 2011. Turn motif phosphorylation negatively regulates activation loop phosphorylation in Akt. Oncogene.
-
(2011)
Oncogene
-
-
Hiraoka, D.1
Okumura, E.2
Kishimoto, T.3
-
86
-
-
22544455676
-
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
-
DOI 10.1074/jbc.M504045200
-
Holz MK, Blenis J. 2005. Identifcation of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem 280:26089-26093. (Pubitemid 41022201)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.28
, pp. 26089-26093
-
-
Holz, M.K.1
Blenis, J.2
-
87
-
-
44949201143
-
mTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation
-
DOI 10.1016/j.molcel.2008.04.027, PII S1097276508003377
-
Hong F, Larrea MD, Doughty C, Kwiatkowski DJ, Squillace R, Slingerland JM. 2008. mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol Cell 30:701-711. (Pubitemid 351815130)
-
(2008)
Molecular Cell
, vol.30
, Issue.6
, pp. 701-711
-
-
Hong, F.1
Larrea, M.D.2
Doughty, C.3
Kwiatkowski, D.J.4
Squillace, R.5
Slingerland, J.M.6
-
88
-
-
77956935673
-
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability
-
Horejsí Z, Takai H, Adelman CA, Collis SJ, Flynn H, Maslen S, Skehel JM, de Lange T, Boulton SJ. 2010. CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Mol Cell 39:839-850.
-
(2010)
Mol Cell
, vol.39
, pp. 839-850
-
-
Horejsí, Z.1
Takai, H.2
Adelman, C.A.3
Collis, S.J.4
Flynn, H.5
Maslen, S.6
Skehel, J.M.7
De Lange, T.8
Boulton, S.J.9
-
89
-
-
28844434558
-
473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
-
DOI 10.1074/jbc.M508361200
-
Hresko RC, Mueckler M. 2005. mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J Biol Chem 280:40406-40416. (Pubitemid 41780527)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.49
, pp. 40406-40416
-
-
Hresko, R.C.1
Mueckler, M.2
-
90
-
-
79958696694
-
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
-
Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, Peterson TR, Choi Y, Gray NS, Yafe MB, Marto JA, Sabatini DM. 2011. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332:1317-1322.
-
(2011)
Science
, vol.332
, pp. 1317-1322
-
-
Hsu, P.P.1
Kang, S.A.2
Rameseder, J.3
Zhang, Y.4
Ottina, K.A.5
Lim, D.6
Peterson, T.R.7
Choi, Y.8
Gray, N.S.9
Yafe, M.B.10
Marto, J.A.11
Sabatini, D.M.12
-
91
-
-
44449161481
-
The TSC1-TSC2 complex: A molecular switchboard controlling cell growth
-
DOI 10.1042/BJ20080281
-
Huang J, Manning BD. 2008. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J 412:179-190. (Pubitemid 351758225)
-
(2008)
Biochemical Journal
, vol.412
, Issue.2
, pp. 179-190
-
-
Huang, J.1
Manning, B.D.2
-
92
-
-
47949104258
-
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
-
Ikenoue T, Inoki K, Yang Q, Zhou X, Guan KL. 2008. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J 27:1919-1931.
-
(2008)
EMBO J
, vol.27
, pp. 1919-1931
-
-
Ikenoue, T.1
Inoki, K.2
Yang, Q.3
Zhou, X.4
Guan, K.L.5
-
93
-
-
0043127125
-
Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
DOI 10.1101/gad.1110003
-
Inoki K, Li Y, Xu T, Guan KL. 2003a. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17:1829-1834. (Pubitemid 36944560)
-
(2003)
Genes and Development
, vol.17
, Issue.15
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.-L.4
-
94
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
DOI 10.1038/ncb839
-
Inoki K, Li Y, Zhu T, Wu J, Guan KL. 2002. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4:648-657. (Pubitemid 34993700)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.9
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.-L.5
-
95
-
-
0345167800
-
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
-
DOI 10.1016/S0092-8674(03)00929-2
-
Inoki K, Zhu T, Guan KL. 2003b. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115:577-590. (Pubitemid 37506046)
-
(2003)
Cell
, vol.115
, Issue.5
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.-L.3
-
96
-
-
33749076673
-
SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity
-
DOI 10.1016/j.cell.2006.08.033, PII S0092867406011470
-
Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B. 2006. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specifcity. Cell 127:125-137. (Pubitemid 44466632)
-
(2006)
Cell
, vol.127
, Issue.1
, pp. 125-137
-
-
Jacinto, E.1
Facchinetti, V.2
Liu, D.3
Soto, N.4
Wei, S.5
Jung, S.Y.6
Huang, Q.7
Qin, J.8
Su, B.9
-
98
-
-
76349104427
-
Efective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor
-
Janes MR, Limon JJ, So L, Chen J, Lim RJ, Chavez MA, Vu C, Lilly MB, Mallya S, Ong ST, Konopleva M, Martin MB, Ren P, Liu Y, Rommel C, Fruman DA. 2010. Efective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med 16:205-213.
-
(2010)
Nat Med
, vol.16
, pp. 205-213
-
-
Janes, M.R.1
Limon, J.J.2
So, L.3
Chen, J.4
Lim, R.J.5
Chavez, M.A.6
Vu, C.7
Lilly, M.B.8
Mallya, S.9
Ong, S.T.10
Konopleva, M.11
Martin, M.B.12
Ren, P.13
Liu, Y.14
Rommel, C.15
Fruman, D.A.16
-
99
-
-
79955847641
-
A phospho-proteomic screen identifes novel S6K1 and mTORC1 substrates revealing additional complexity in the signaling network regulating cell growth
-
Jastrzebski K, Hannan KM, House CM, Hung SS, Pearson RB, Hannan RD. 2011. A phospho-proteomic screen identifes novel S6K1 and mTORC1 substrates revealing additional complexity in the signaling network regulating cell growth. Cell Signal 23:1338-1347.
-
(2011)
Cell Signal
, vol.23
, pp. 1338-1347
-
-
Jastrzebski, K.1
Hannan, K.M.2
House, C.M.3
Hung, S.S.4
Pearson, R.B.5
Hannan, R.D.6
-
100
-
-
0037938847
-
Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation
-
DOI 10.1074/jbc.M212525200
-
Jiang T, Qiu Y. 2003. Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation. J Biol Chem 278:15789-15793. (Pubitemid 36799692)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.18
, pp. 15789-15793
-
-
Jiang, T.1
Qiu, Y.2
-
101
-
-
13844254274
-
PRR5 encodes a conserved proline-rich protein predominant in kidney: Analysis of genomic organization, expression, and mutation status in breast and colorectal carcinomas
-
DOI 10.1016/j.ygeno.2004.11.002
-
Johnstone CN, Castellví-Bel S, Chang LM, Sung RK, Bowser MJ, Piqué JM, Castells A, Rustgi AK. 2005. PRR5 encodes a conserved proline-rich protein predominant in kidney: analysis of genomic organization, expression, and mutation status in breast and colorectal carcinomas. Genomics 85:338-351. (Pubitemid 40249426)
-
(2005)
Genomics
, vol.85
, Issue.3
, pp. 338-351
-
-
Johnstone, C.N.1
Castellvi-Bel, S.2
Chang, L.M.3
Sung, R.K.4
Bowser, M.J.5
Pique, J.M.6
Castells, A.7
Rustgi, A.K.8
-
102
-
-
79251542927
-
Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1
-
Joung SM, Park ZY, Rani S, Takeuchi O, Akira S, Lee JY. 2011. Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1. J Immunol 186:499-507.
-
(2011)
J Immunol
, vol.186
, pp. 499-507
-
-
Joung, S.M.1
Park, Z.Y.2
Rani, S.3
Takeuchi, O.4
Akira, S.5
Lee, J.Y.6
-
103
-
-
75749105049
-
MTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
-
Julien LA, Carriere A, Moreau J, Roux PP. 2010. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol Cell Biol 30:908-921.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 908-921
-
-
Julien, L.A.1
Carriere, A.2
Moreau, J.3
Roux, P.P.4
-
104
-
-
77953800576
-
Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly
-
Kaizuka T, Hara T, Oshiro N, Kikkawa U, Yonezawa K, Takehana K, Iemura S, Natsume T, Mizushima N. 2010. Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. J Biol Chem 285:20109-20116.
-
(2010)
J Biol Chem
, vol.285
, pp. 20109-20116
-
-
Kaizuka, T.1
Hara, T.2
Oshiro, N.3
Kikkawa, U.4
Yonezawa, K.5
Takehana, K.6
Iemura, S.7
Natsume, T.8
Mizushima, N.9
-
105
-
-
23344448223
-
Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization
-
DOI 10.1128/MCB.25.16.7239-7248.2005
-
Kamada Y, Fujioka Y, Suzuki NN, Inagaki F, Wullschleger S, Loewith R, Hall MN, Ohsumi Y. 2005. Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization. Mol Cell Biol 25:7239-7248. (Pubitemid 41105919)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.16
, pp. 7239-7248
-
-
Kamada, Y.1
Fujioka, Y.2
Suzuki, N.N.3
Inagaki, F.4
Wullschleger, S.5
Loewith, R.6
Hall, M.N.7
Ohsumi, Y.8
-
106
-
-
33846590132
-
The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module
-
DOI 10.1073/pnas.0610251104
-
Kannan N, Haste N, Taylor SS, Neuwald AF. 2007. The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module. Proc Natl Acad Sci USA 104:1272-1277. (Pubitemid 46183994)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.4
, pp. 1272-1277
-
-
Kannan, N.1
Haste, N.2
Taylor, S.S.3
Neuwald, A.F.4
-
107
-
-
33845411885
-
The LKB1 tumor suppressor kinase in human disease
-
DOI 10.1016/j.bbcan.2006.08.003, PII S0304419X06000539
-
Katajisto P, Vallenius T, Vaahtomeri K, Ekman N, Udd L, Tiainen M, Mäkelä TP. 2007. The LKB1 tumor suppressor kinase in human disease. Biochim Biophys Acta 1775:63-75. (Pubitemid 44889272)
-
(2007)
Biochimica et Biophysica Acta - Reviews on Cancer
, vol.1775
, Issue.1
, pp. 63-75
-
-
Katajisto, P.1
Vallenius, T.2
Vaahtomeri, K.3
Ekman, N.4
Udd, L.5
Tiainen, M.6
Makela, T.P.7
-
108
-
-
79959568260
-
Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1)
-
Keshwani MM, von Daake S, Newton AC, Harris TK, Taylor SS. 2011. Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). J Biol Chem 286:23552-23558.
-
(2011)
J Biol Chem
, vol.286
, pp. 23552-23558
-
-
Keshwani, M.M.1
Von Daake, S.2
Newton, A.C.3
Harris, T.K.4
Taylor, S.S.5
-
109
-
-
0037178786
-
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
DOI 10.1016/S0092-8674(02)00808-5
-
Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. 2002. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110:163-175. (Pubitemid 34876545)
-
(2002)
Cell
, vol.110
, Issue.2
, pp. 163-175
-
-
Kim, D.-H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
110
-
-
0037623417
-
GL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
-
DOI 10.1016/S1097-2765(03)00114-X
-
Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H, Tempst P, Sabatini DM. 2003. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 11:895-904. (Pubitemid 36566312)
-
(2003)
Molecular Cell
, vol.11
, Issue.4
, pp. 895-904
-
-
Kim, D.-H.1
Sarbassov, D.D.2
Ali, S.M.3
Latek, R.R.4
Guntur, K.V.P.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
111
-
-
0033560707
-
Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2
-
DOI 10.1042/0264-6021:3390319
-
Kobayashi T, Cohen P. 1999. Activation of serum-and glucocorticoid- regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. Biochem J 339 (Pt 2):319-328. (Pubitemid 29209961)
-
(1999)
Biochemical Journal
, vol.339
, Issue.2
, pp. 319-328
-
-
Kobayashi, T.1
Cohen, P.2
-
112
-
-
0033571416
-
Characterization of the structure and regulation of two novel isoforms of serum-and glucocorticoid-induced protein kinase
-
Kobayashi T, Deak M, Morrice N, Cohen P. 1999. Characterization of the structure and regulation of two novel isoforms of serum-and glucocorticoid- induced protein kinase. Biochem J 344 Pt 1:189-197.
-
(1999)
Biochem J
, vol.344
, Issue.PART 1
, pp. 189-197
-
-
Kobayashi, T.1
Deak, M.2
Morrice, N.3
Cohen, P.4
-
113
-
-
5644271449
-
Protein kinase C alpha expression in breast and ovarian cancer
-
DOI 10.1159/000080279
-
Lahn M, Köhler G, Sundell K, Su C, Li S, Paterson BM, Bumol TF. 2004. Protein kinase C alpha expression in breast and ovarian cancer. Oncology 67:1-10. (Pubitemid 39370344)
-
(2004)
Oncology
, vol.67
, Issue.1
, pp. 1-10
-
-
Lahn, M.1
Kohler, G.2
Sundell, K.3
Su, C.4
Li, S.5
Paterson, B.M.6
Bumol, T.F.7
-
114
-
-
33749500123
-
(Patho)physiological signifcance of the serum-and glucocorticoid- inducible kinase isoforms
-
Lang F, Böhmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V. 2006. (Patho)physiological signifcance of the serum-and glucocorticoid-inducible kinase isoforms. Physiol Rev 86:1151-1178.
-
(2006)
Physiol Rev
, vol.86
, pp. 1151-1178
-
-
Lang, F.1
Böhmer, C.2
Palmada, M.3
Seebohm, G.4
Strutz-Seebohm, N.5
Vallon, V.6
-
115
-
-
79953206247
-
The identifcation of raptor as a substrate for p44/42 MAPK
-
Langlais P, Yi Z, Mandarino LJ. 2011. The identifcation of raptor as a substrate for p44/42 MAPK. Endocrinology 152:1264-1273.
-
(2011)
Endocrinology
, vol.152
, pp. 1264-1273
-
-
Langlais, P.1
Yi, Z.2
Mandarino, L.J.3
-
116
-
-
70350418625
-
MTOR signaling at a glance
-
Laplante M, Sabatini DM. 2009. mTOR signaling at a glance. J Cell Sci 122:3589-3594.
-
(2009)
J Cell Sci
, vol.122
, pp. 3589-3594
-
-
Laplante, M.1
Sabatini, D.M.2
-
117
-
-
77955488179
-
Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells
-
Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B. 2010. Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells. Mol Cell 39:433-443.
-
(2010)
Mol Cell
, vol.39
, pp. 433-443
-
-
Lazorchak, A.S.1
Liu, D.2
Facchinetti, V.3
Di Lorenzo, A.4
Sessa, W.C.5
Schatz, D.G.6
Su, B.7
-
118
-
-
77953897189
-
Mammalian target of rapamycin protein complex 2 regulates diferentiation of T1 and T2 cell subsets via distinct signaling pathways
-
Lee K, Gudapati P, Dragovic S, Spencer C, Joyce S, Killeen N, Magnuson MA, Boothby M. 2010. Mammalian target of rapamycin protein complex 2 regulates diferentiation of T1 and T2 cell subsets via distinct signaling pathways. Immunity 32:743-753.
-
(2010)
Immunity
, vol.32
, pp. 743-753
-
-
Lee, K.1
Gudapati, P.2
Dragovic, S.3
Spencer, C.4
Joyce, S.5
Killeen, N.6
Magnuson, M.A.7
Boothby, M.8
-
119
-
-
0036214616
-
Knockout of PKC enhances insulin signaling through PI3K
-
DOI 10.1210/me.16.4.847
-
Leitges M, Plomann M, Standaert ML, Bandyopadhyay G, Sajan MP, Kanoh Y, Farese RV, Letiges M. 2002. Knockout of PKC alpha enhances insulin signaling through PI3K. Mol Endocrinol 16:847-858. (Pubitemid 34297752)
-
(2002)
Molecular Endocrinology
, vol.16
, Issue.4
, pp. 847-858
-
-
Letiges, M.1
Plomann, M.2
Standaert, M.L.3
Bandyopadhyay, G.4
Sajan, M.P.5
Kanoh, Y.6
Farese, R.V.7
-
120
-
-
38049151149
-
PKC zeta mTOR pathway: A new target for rituximab therapy in follicular lymphoma
-
Leseux L, Laurent G, Laurent C, Rigo M, Blanc A, Olive D, Bezombes C. 2008. PKC zeta mTOR pathway: a new target for rituximab therapy in follicular lymphoma. Blood 111:285-291.
-
(2008)
Blood
, vol.111
, pp. 285-291
-
-
Leseux, L.1
Laurent, G.2
Laurent, C.3
Rigo, M.4
Blanc, A.5
Olive, D.6
Bezombes, C.7
-
121
-
-
8544233570
-
1101
-
DOI 10.1074/jbc.C400186200
-
Li Y, Soos TJ, Li X, Wu J, Degennaro M, Sun X, Littman DR, Birnbaum MJ, Polakiewicz RD. 2004. Protein kinase C Teta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). J Biol Chem 279:45304-45307. (Pubitemid 39491511)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.44
, pp. 45304-45307
-
-
Li, Y.1
Soos, T.J.2
Li, X.3
Wu, J.4
DeGennaro, M.5
Sun, X.6
Littman, D.R.7
Birnbaum, M.J.8
Polakiewicz, R.D.9
-
122
-
-
47549105527
-
Coordinated phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 and protein kinase C betaII in the diabetic fat tissue
-
Liberman Z, Plotkin B, Tennenbaum T, Eldar-Finkelman H. 2008. Coordinated phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 and protein kinase C betaII in the diabetic fat tissue. Am J Physiol Endocrinol Metab 294:E1169-E1177.
-
(2008)
Am J Physiol Endocrinol Metab
, vol.294
-
-
Liberman, Z.1
Plotkin, B.2
Tennenbaum, T.3
Eldar-Finkelman, H.4
-
123
-
-
33947145667
-
Endoplasmic reticulum and Golgi localization sequences for mammalian target of rapamycin
-
DOI 10.1091/mbc.E06-05-0406
-
Liu X, Zheng X F. 2007. Endoplasmic reticulum and Golgi localization sequences for mammalian target of rapamycin. Mol Biol Cell 18:1073-1082. (Pubitemid 46399510)
-
(2007)
Molecular Biology of the Cell
, vol.18
, Issue.3
, pp. 1073-1082
-
-
Liu, X.1
Zheng, X.F.S.2
-
124
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
DOI 10.1016/S1097-2765(02)00636-6
-
Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P, Hall MN. 2002. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10:457-468. (Pubitemid 35284167)
-
(2002)
Molecular Cell
, vol.10
, Issue.3
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
125
-
-
68249113593
-
Common mechanisms of PIKK regulation
-
Lovejoy CA, Cortez D. 2009. Common mechanisms of PIKK regulation. DNA Repair (Amst) 8:1004-1008.
-
(2009)
DNA Repair (Amst)
, vol.8
, pp. 1004-1008
-
-
Lovejoy, C.A.1
Cortez, D.2
-
126
-
-
77952565472
-
MTOR complex-2 activates ENaC by phosphorylating SGK1
-
Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashraf K, Pearce D. 2010. mTOR complex-2 activates ENaC by phosphorylating SGK1. J Am Soc Nephrol 21:811-818.
-
(2010)
J Am Soc Nephrol
, vol.21
, pp. 811-818
-
-
Lu, M.1
Wang, J.2
Jones, K.T.3
Ives, H.E.4
Feldman, M.E.5
Yao, L.J.6
Shokat, K.M.7
Ashraf, K.8
Pearce, D.9
-
127
-
-
17444431201
-
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
-
DOI 10.1016/j.cell.2005.02.031
-
Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolf PP. 2005. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121:179-193. (Pubitemid 40546387)
-
(2005)
Cell
, vol.121
, Issue.2
, pp. 179-193
-
-
Ma, L.1
Chen, Z.2
Erdjument-Bromage, H.3
Tempst, P.4
Pandolfi, P.P.5
-
128
-
-
67349217986
-
Molecular mechanisms of mTOR-mediated translational control
-
Ma XM, Blenis J. 2009. Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 10:307-318.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 307-318
-
-
Ma, X.M.1
Blenis, J.2
-
129
-
-
41949101770
-
SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs
-
DOI 10.1016/j.cell.2008.02.031, PII S0092867408002821
-
Ma XM, Yoon SO, Richardson CJ, Jülich K, Blenis J. 2008. SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efciency of spliced mRNAs. Cell 133:303-313. (Pubitemid 351508301)
-
(2008)
Cell
, vol.133
, Issue.2
, pp. 303-313
-
-
Ma, X.M.1
Yoon, S.-O.2
Richardson, C.J.3
Julich, K.4
Blenis, J.5
-
130
-
-
33750142818
-
Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway
-
DOI 10.1111/j.1365-2443.2006.01016.x
-
Makino C, Sano Y, Shinagawa T, Millar JB, Ishii S. 2006. Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway. Genes Cells 11:1239-1251. (Pubitemid 44594296)
-
(2006)
Genes to Cells
, vol.11
, Issue.11
, pp. 1239-1251
-
-
Makino, C.1
Sano, Y.2
Shinagawa, T.3
Millar, J.B.A.4
Ishii, S.5
-
132
-
-
34250788809
-
AKT/PKB Signaling: Navigating Downstream
-
DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
-
Manning BD, Cantley LC. 2007. AKT/PKB signaling: navigating downstream. Cell 129:1261-1274. (Pubitemid 46962095)
-
(2007)
Cell
, vol.129
, Issue.7
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
133
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway
-
DOI 10.1016/S1097-2765(02)00568-3
-
Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. 2002a. Identifcation of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 10:151-162. (Pubitemid 34876569)
-
(2002)
Molecular Cell
, vol.10
, Issue.1
, pp. 151-162
-
-
Manning, B.D.1
Tee, A.R.2
Logsdon M.Nicole3
Blenis, J.4
Cantley, L.C.5
-
134
-
-
0037032835
-
The protein kinase complement of the human genome
-
DOI 10.1126/science.1075762
-
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. 2002b. The protein kinase complement of the human genome. Science 298:1912-1934. (Pubitemid 35425239)
-
(2002)
Science
, vol.298
, Issue.5600
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
135
-
-
45449114764
-
Hsp70 associates with Rictor and is required for mTORC2 formation and activity
-
Martin J, Masri J, Bernath A, Nishimura RN, Gera J. 2008. Hsp70 associates with Rictor and is required for mTORC2 formation and activity. Biochem Biophys Res Commun 372:578-583.
-
(2008)
Biochem Biophys Res Commun
, vol.372
, pp. 578-583
-
-
Martin, J.1
Masri, J.2
Bernath, A.3
Nishimura, R.N.4
Gera, J.5
-
136
-
-
37549048521
-
MTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor
-
Masri J, Bernath A, Martin J, Jo OD, Vartanian R, Funk A, Gera J. 2007. mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. Cancer Res 67:11712-11720.
-
(2007)
Cancer Res
, vol.67
, pp. 11712-11720
-
-
Masri, J.1
Bernath, A.2
Martin, J.3
Jo, O.D.4
Vartanian, R.5
Funk, A.6
Gera, J.7
-
137
-
-
40949083412
-
Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival
-
DOI 10.1158/0008-5472.CAN-07-5869
-
McDonald PC, Oloumi A, Mills J, Dobreva I, Maidan M, Gray V, Wederell ED, Bally MB, Foster LJ, Dedhar S. 2008. Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Res 68:1618-1624. (Pubitemid 351416544)
-
(2008)
Cancer Research
, vol.68
, Issue.6
, pp. 1618-1624
-
-
McDonald, P.C.1
Oloumi, A.2
Mills, J.3
Dobreva, I.4
Maidan, M.5
Gray, V.6
Wederell, E.D.7
Bally, M.B.8
Foster, L.J.9
Dedhar, S.10
-
138
-
-
24644488646
-
Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif
-
DOI 10.1016/j.jmb.2005.07.060, PII S0022283605008612
-
Messerschmidt A, Macieira S, Velarde M, Bädeker M, Benda C, Jestel A, Brandstetter H, Neuefeind T, Blaesse M. 2005. Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif. J Mol Biol 352:918-931. (Pubitemid 41267077)
-
(2005)
Journal of Molecular Biology
, vol.352
, Issue.4
, pp. 918-931
-
-
Messerschmidt, A.1
Macieira, S.2
Velarde, M.3
Badeker, M.4
Benda, C.5
Jestel, A.6
Brandstetter, H.7
Neuefeind, T.8
Blaesse, M.9
-
139
-
-
2942623679
-
318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1
-
DOI 10.1074/jbc.M402477200
-
Moeschel K, Beck A, Weigert C, Lammers R, Kalbacher H, Voelter W, Schleicher ED, Häring HU, Lehmann R. 2004. Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1. J Biol Chem 279:25157-25163. (Pubitemid 38756765)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.24
, pp. 25157-25163
-
-
Moeschel, K.1
Beck, A.2
Weigert, C.3
Lammers, R.4
Kalbacher, H.5
Voelter, W.6
Schleicher, E.D.7
Haring, H.-U.8
Lehmann, R.9
-
140
-
-
0030848939
-
Dual requirement for a newly identified phosphorylation site in p70(s6k)
-
Moser BA, Dennis PB, Pullen N, Pearson RB, Williamson NA, Wettenhall RE, Kozma SC, Tomas G. 1997. Dual requirement for a newly identifed phosphorylation site in p70s6k. Mol Cell Biol 17:5648-5655. (Pubitemid 27357661)
-
(1997)
Molecular and Cellular Biology
, vol.17
, Issue.9
, pp. 5648-5655
-
-
Moser, B.A.1
Dennis, P.B.2
Pullen, N.3
Pearson, R.B.4
Williamson, N.A.5
Wettenhall, R.E.H.6
Kozma, S.C.7
Thomas, G.8
-
141
-
-
0026757270
-
An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase
-
Mukhopadhyay NK, Price DJ, Kyriakis JM, Pelech S, Sanghera J, Avruch J. 1992. An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase. J Biol Chem 267:3325-3335.
-
(1992)
J Biol Chem
, vol.267
, pp. 3325-3335
-
-
Mukhopadhyay, N.K.1
Price, D.J.2
Kyriakis, J.M.3
Pelech, S.4
Sanghera, J.5
Avruch, J.6
-
142
-
-
33746594548
-
Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: Role of serine 24 phosphorylation
-
DOI 10.1210/me.2005-0536
-
Nawaratne R, Gray A, Jørgensen CH, Downes CP, Siddle K, Sethi JK. 2006. Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation. Mol Endocrinol 20:1838-1852. (Pubitemid 44148088)
-
(2006)
Molecular Endocrinology
, vol.20
, Issue.8
, pp. 1838-1852
-
-
Nawaratne, R.1
Gray, A.2
Jorgensen, C.H.3
Downes, C.P.4
Siddle, K.5
Sethi, J.K.6
-
143
-
-
0037337159
-
Regulation of the ABC kinases by phosphorylation: Protein kinase C as a paradigm
-
DOI 10.1042/BJ20021626
-
Newton AC. 2003. Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J 370:361-371. (Pubitemid 36315124)
-
(2003)
Biochemical Journal
, vol.370
, Issue.2
, pp. 361-371
-
-
Newton, A.C.1
-
145
-
-
0031012892
-
Determination of the specific substrate sequence motifs of protein kinase C isozymes
-
DOI 10.1074/jbc.272.2.952
-
Nishikawa K, Toker A, Johannes FJ, Songyang Z, Cantley LC. 1997. Determination of the specifc substrate sequence motifs of protein kinase C isozymes. J Biol Chem 272:952-960. (Pubitemid 27034586)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.2
, pp. 952-960
-
-
Nishikawa, K.1
Toker, A.2
Johannes, F.-J.3
Songyang, Z.4
Cantley, L.C.5
-
146
-
-
78649712949
-
MTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
-
Oh WJ, Wu CC, Kim SJ, Facchinetti V, Julien LA, Finlan M, Roux PP, Su B, Jacinto E. 2010. mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J 29:3939-3951.
-
(2010)
EMBO J
, vol.29
, pp. 3939-3951
-
-
Oh, W.J.1
Wu, C.C.2
Kim, S.J.3
Facchinetti, V.4
Julien, L.A.5
Finlan, M.6
Roux, P.P.7
Su, B.8
Jacinto, E.9
-
147
-
-
57649137958
-
Isolation of hyperactive mutants of mammalian target of rapamycin
-
Ohne Y, Takahara T, Hatakeyama R, Matsuzaki T, Noda M, Mizushima N, Maeda T. 2008. Isolation of hyperactive mutants of mammalian target of rapamycin. J Biol Chem 283:31861-31870.
-
(2008)
J Biol Chem
, vol.283
, pp. 31861-31870
-
-
Ohne, Y.1
Takahara, T.2
Hatakeyama, R.3
Matsuzaki, T.4
Noda, M.5
Mizushima, N.6
Maeda, T.7
-
148
-
-
79951494608
-
TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation
-
Ou YH, Torres M, Ram R, Formstecher E, Roland C, Cheng T, Brekken R, Wurz R, Tasker A, Polverino T, Tan SL, White MA. 2011. TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. Mol Cell 41:458-470.
-
(2011)
Mol Cell
, vol.41
, pp. 458-470
-
-
Ou, Y.H.1
Torres, M.2
Ram, R.3
Formstecher, E.4
Roland, C.5
Cheng, T.6
Brekken, R.7
Wurz, R.8
Tasker, A.9
Polverino, T.10
Tan, S.L.11
Ma, W.12
-
149
-
-
40649104735
-
Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis
-
DOI 10.1016/j.molcel.2007.12.023, PII S109727650800066X
-
Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD,
-
(2008)
Molecular Cell
, vol.29
, Issue.5
, pp. 541-551
-
-
Ozcan, U.1
Ozcan, L.2
Yilmaz, E.3
Duvel, K.4
Sahin, M.5
Manning, B.D.6
Hotamisligil, G.S.7
-
150
-
-
70350544118
-
MTORbeta splicing isoform promotes cell proliferation and tumorigenesis
-
Panasyuk G, Nemazanyy I, Zhyvoloup A, Filonenko V, Davies D, Robson M, Pedley RB, Waterfeld M, Gout I. 2009. mTORbeta splicing isoform promotes cell proliferation and tumorigenesis. J Biol Chem 284:30807-30814.
-
(2009)
J Biol Chem
, vol.284
, pp. 30807-30814
-
-
Panasyuk, G.1
Nemazanyy, I.2
Zhyvoloup, A.3
Filonenko, V.4
Davies, D.5
Robson, M.6
Pedley, R.B.7
Waterfeld, M.8
Gout, I.9
-
151
-
-
0033520995
-
Mammalian TOR controls one of two kinase pathways acting upon nPKC and nPKC
-
Parekh D, Ziegler W, Yonezawa K, Hara K, Parker PJ. 1999. Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon. J Biol Chem 274:34758-34764. (Pubitemid 129509518)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.49
, pp. 34758-34764
-
-
Parekh, D.1
Ziegler, W.2
Yonezawa, K.3
Hara, K.4
Parker, P.J.5
-
152
-
-
0033151832
-
Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway
-
DOI 10.1093/emboj/18.11.3024
-
Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA. 1999. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J 18:3024-3033. (Pubitemid 29255611)
-
(1999)
EMBO Journal
, vol.18
, Issue.11
, pp. 3024-3033
-
-
Park, J.1
Leong, M.L.L.2
Buse, P.3
Maiyar, A.C.4
Firestone, G.L.5
Hemmings, B.A.6
-
153
-
-
53149083731
-
Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells
-
Partovian C, Ju R, Zhuang ZW, Martin KA, Simons M. 2008. Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells. Mol Cell 32:140-149.
-
(2008)
Mol Cell
, vol.32
, pp. 140-149
-
-
Partovian, C.1
Ju, R.2
Zhuang, Z.W.3
Martin, K.A.4
Simons, M.5
-
154
-
-
0033214461
-
Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function
-
Paz K, Liu YF, Shorer H, Hemi R, LeRoith D, Quan M, Kanety H, Seger R, Zick Y. 1999. Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function. J Biol Chem 274:28816-28822.
-
(1999)
J Biol Chem
, vol.274
, pp. 28816-28822
-
-
Paz, K.1
Liu, Y.F.2
Shorer, H.3
Hemi, R.4
Leroith, D.5
Quan, M.6
Kanety, H.7
Seger, R.8
Zick, Y.9
-
155
-
-
34347210090
-
Identification of Protor as a novel Rictor-binding component of mTOR complex-2
-
DOI 10.1042/BJ20070540
-
Pearce LR, Huang X, Boudeau J, Pawlowski R, Wullschleger S, Deak M, Ibrahim AF, Gourlay R, Magnuson MA, Alessi DR. 2007. Identifcation of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J 405:513-522. (Pubitemid 47172049)
-
(2007)
Biochemical Journal
, vol.405
, Issue.3
, pp. 513-522
-
-
Pearce, L.R.1
Huang, X.2
Boudeau, J.3
Pawlowski, R.4
Wullschleger, S.5
Deak, M.6
Ibrahim, A.F.M.7
Gourlay, R.8
Magnuson, M.A.9
Alessi, D.R.10
-
156
-
-
0028802451
-
The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain
-
Pearson RB, Dennis PB, Han JW, Williamson NA, Kozma SC, Wettenhall RE, Tomas G. 1995. The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. EMBO J 14:5279-5287.
-
(1995)
EMBO J
, vol.14
, pp. 5279-5287
-
-
Pearson, R.B.1
Dennis, P.B.2
Han, J.W.3
Williamson, N.A.4
Kozma, S.C.5
Wettenhall, R.E.6
Tomas, G.7
-
157
-
-
11144356304
-
-/- Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway
-
DOI 10.1128/MCB.24.8.3112-3124.2004
-
Pende M, Um SH, Mieulet V, Sticker M, Goss VL, Mestan J, Mueller M, Fumagalli S, Kozma SC, Tomas G. 2004. S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol Cell Biol 24:3112-3124. (Pubitemid 38452057)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.8
, pp. 3112-3124
-
-
Pende, M.1
Um, S.H.2
Mieulet, V.3
Sticker, M.4
Goss, V.L.5
Mestan, J.6
Mueller, M.7
Fumagalli, S.8
Kozma, S.C.9
Thomas, G.10
-
158
-
-
0035920145
-
Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: Critical roles for kinase activity and amino acids arginine 211 and serine 343
-
Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S. 2001. Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. J Biol Chem 276:27462-27469.
-
(2001)
J Biol Chem
, vol.276
, pp. 27462-27469
-
-
Persad, S.1
Attwell, S.2
Gray, V.3
Mawji, N.4
Deng, J.T.5
Leung, D.6
Yan, J.7
Sanghera, J.8
Walsh, M.P.9
Dedhar, S.10
-
159
-
-
0034629365
-
FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions
-
DOI 10.1074/jbc.275.10.7416
-
Peterson RT, Beal PA, Comb MJ, Schreiber SL. 2000. FKBP12-rapamycin- associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions. J Biol Chem 275:7416-7423. (Pubitemid 30146297)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.10
, pp. 7416-7423
-
-
Peterson, R.T.1
Beal, P.A.2
Comb, M.J.3
Schreiber, S.L.4
-
160
-
-
67349241955
-
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
-
Peterson TR, Laplante M, Toreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM. 2009. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 137:873-886.
-
(2009)
Cell
, vol.137
, pp. 873-886
-
-
Peterson, T.R.1
Laplante, M.2
Toreen, C.C.3
Sancak, Y.4
Kang, S.A.5
Kuehl, W.M.6
Gray, N.S.7
Sabatini, D.M.8
-
161
-
-
54849431380
-
Adipose-specifc knockout of raptor results in lean mice with enhanced mitochondrial respiration
-
Polak P, Cybulski N, Feige JN, Auwerx J, Rüegg MA, Hall MN. 2008. Adipose-specifc knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab 8:399-410.
-
(2008)
Cell Metab
, vol.8
, pp. 399-410
-
-
Polak, P.1
Cybulski, N.2
Feige, J.N.3
Auwerx, J.4
Rüegg, M.A.5
Hall, M.N.6
-
162
-
-
63749105226
-
MTOR and the control of whole body metabolism
-
Polak P, Hall MN. 2009. mTOR and the control of whole body metabolism. Curr Opin Cell Biol 21:209-218.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 209-218
-
-
Polak, P.1
Hall, M.N.2
-
163
-
-
34247118887
-
Signalling to translation: How signal transduction pathways control the protein synthetic machinery
-
DOI 10.1042/BJ20070024
-
Proud CG. 2007. Signalling to translation: how signal transduction pathways control the protein synthetic machinery. Biochem J 403:217-234. (Pubitemid 46596577)
-
(2007)
Biochemical Journal
, vol.403
, Issue.2
, pp. 217-234
-
-
Proud, C.G.1
-
164
-
-
0030740005
-
The modular phosphorylation and activation of p70s6k
-
Pullen N, Tomas G. 1997. The modular phosphorylation and activation of p70s6k. FEBS Lett 410:78-82.
-
(1997)
FEBS Lett
, vol.410
, pp. 78-82
-
-
Pullen, N.1
Tomas, G.2
-
165
-
-
77956260496
-
MTORC1 links protein quality and quantity control by sensing chaperone availability
-
Qian SB, Zhang X, Sun J, Bennink JR, Yewdell JW, Patterson C. 2010. mTORC1 links protein quality and quantity control by sensing chaperone availability. J Biol Chem 285:27385-27395.
-
(2010)
J Biol Chem
, vol.285
, pp. 27385-27395
-
-
Qian, S.B.1
Zhang, X.2
Sun, J.3
Bennink, J.R.4
Yewdell, J.W.5
Patterson, C.6
-
166
-
-
79953154067
-
Regulation of mTORC1 complex assembly and signaling by GRp58/ERp57
-
Ramírez-Rangel I, Bracho-Valdés I, Vázquez- Macías A, Carretero-Ortega J, Reyes-Cruz G, Vázquez-Prado J. 2011. Regulation of mTORC1 complex assembly and signaling by GRp58/ERp57. Mol Cell Biol 31:1657-1671.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 1657-1671
-
-
Ramírez-Rangel, I.1
Bracho-Valdés, I.2
Vázquez- Macías, A.3
Carretero-Ortega, J.4
Reyes-Cruz, G.5
Vázquez-Prado, J.6
-
167
-
-
77953378969
-
Mitotic raptor promotes mTORC1 activity, G(2)/M cell cycle progression, and internal ribosome entry site-mediated mRNA translation
-
Ramírez-Valle F, Badura ML, Braunstein S, Narasimhan M, Schneider RJ. 2010. Mitotic raptor promotes mTORC1 activity, G(2)/M cell cycle progression, and internal ribosome entry site-mediated mRNA translation. Mol Cell Biol 30:3151-3164.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 3151-3164
-
-
Ramírez-Valle, F.1
Badura, M.L.2
Braunstein, S.3
Narasimhan, M.4
Schneider, R.J.5
-
168
-
-
2442574729
-
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases
-
DOI 10.1038/sj.emboj.7600193
-
Raught B, Peiretti F, Gingras AC, Livingstone M, Shahbazian D, Mayeur GL, Polakiewicz RD, Sonenberg N, Hershey JW. 2004. Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. EMBO J 23:1761-1769. (Pubitemid 38649639)
-
(2004)
EMBO Journal
, vol.23
, Issue.8
, pp. 1761-1769
-
-
Raught, B.1
Peiretti, F.2
Gingras, A.-C.3
Livingstone, M.4
Shahbazian, D.5
Mayeur, G.L.6
Polakiewicz, R.D.7
Sonenberg, N.8
Hershey, J.W.B.9
-
169
-
-
64149103614
-
Protein kinase C intervention: The state of play
-
Rofey J, Rosse C, Linch M, Hibbert A, McDonald NQ, Parker PJ. 2009. Protein kinase C intervention: the state of play. Curr Opin Cell Biol 21:268-279.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 268-279
-
-
Rofey, J.1
Rosse, C.2
Linch, M.3
Hibbert, A.4
McDonald, N.Q.5
Parker, P.J.6
-
170
-
-
0037174828
-
389 in p70 S6 kinase 1
-
DOI 10.1074/jbc.M205168200
-
Romanelli A, Dreisbach VC, Blenis J. 2002. Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Tr(389) in p70 S6 kinase 1. J Biol Chem 277:40281-40289. (Pubitemid 35215600)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.43
, pp. 40281-40289
-
-
Romanelli, A.1
Dreisbach, V.C.2
Blenis, J.3
-
171
-
-
0032932198
-
p70 S6 kinase is regulated by protein kinase C and participates in a phosphoinositide 3-kinase-regulated signalling complex
-
Romanelli A, Martin KA, Toker A, Blenis J. 1999. p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex. Mol Cell Biol 19:2921-2928. (Pubitemid 29144537)
-
(1999)
Molecular and Cellular Biology
, vol.19
, Issue.4
, pp. 2921-2928
-
-
Romanelli, A.1
Martin, K.A.2
Toker, A.3
Blenis, J.4
-
172
-
-
33748657821
-
The tuberous sclerosis genes and regulation of the cyclin-dependent kinase inhibitor p27
-
DOI 10.1016/j.mrrev.2006.03.001, PII S1383574206000226
-
Rosner M, Freilinger A, Hengstschläger M. 2006. The tuberous sclerosis genes and regulation of the cyclin-dependent kinase inhibitor p27. Mutat Res 613:10-16. (Pubitemid 44382645)
-
(2006)
Mutation Research - Reviews in Mutation Research
, vol.613
, Issue.1
, pp. 10-16
-
-
Rosner, M.1
Freilinger, A.2
Hengstschlager, M.3
-
173
-
-
33846475008
-
Akt regulates nuclear/cytoplasmic localization of tuberin
-
DOI 10.1038/sj.onc.1209812, PII 1209812
-
Rosner M, Freilinger A, Hengstschläger M. 2007. Akt regulates nuclear/cytoplasmic localization of tuberin. Oncogene 26:521-531. (Pubitemid 46160966)
-
(2007)
Oncogene
, vol.26
, Issue.4
, pp. 521-531
-
-
Rosner, M.1
Freilinger, A.2
Hengstschlager, M.3
-
174
-
-
52949137425
-
Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: Rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1
-
Rosner M, Hengstschläger M. 2008. Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1. Hum Mol Genet 17:2934-2948.
-
(2008)
Hum Mol Genet
, vol.17
, pp. 2934-2948
-
-
Rosner, M.1
Hengstschläger, M.2
-
175
-
-
75149161903
-
PKC and the control of localized signal dynamics
-
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ. 2010. PKC and the control of localized signal dynamics. Nat Rev Mol Cell Biol 11:103-112.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 103-112
-
-
Rosse, C.1
Linch, M.2
Kermorgant, S.3
Cameron, A.J.4
Boeckeler, K.5
Parker, P.J.6
-
176
-
-
4544384577
-
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
-
DOI 10.1073/pnas.0405659101
-
Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J. 2004. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci USA 101:13489-13494. (Pubitemid 39238430)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.37
, pp. 13489-13494
-
-
Roux, P.P.1
Ballif, B.A.2
Anjum, R.3
Gygi, S.P.4
Blenis, J.5
-
177
-
-
34347242470
-
RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation
-
DOI 10.1074/jbc.M700906200
-
Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N, Blenis J. 2007. RAS/ERK signaling promotes site-specifc ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem 282:14056-14064. (Pubitemid 47100467)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.19
, pp. 14056-14064
-
-
Roux, P.P.1
Shahbazian, D.2
Vu, H.3
Holz, M.K.4
Cohen, M.S.5
Taunton, J.6
Sonenberg, N.7
Blenis, J.8
-
178
-
-
33745150462
-
Ribosomal protein S6 phosphorylation: from protein synthesis to cell size
-
DOI 10.1016/j.tibs.2006.04.003, PII S0968000406001137
-
Ruvinsky I, Meyuhas O. 2006. Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem Sci 31:342-348. (Pubitemid 43903237)
-
(2006)
Trends in Biochemical Sciences
, vol.31
, Issue.6
, pp. 342-348
-
-
Ruvinsky, I.1
Meyuhas, O.2
-
179
-
-
0037205409
-
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
-
DOI 10.1074/jbc.M201745200
-
Saitoh M, Pullen N, Brennan P, Cantrell D, Dennis PB, Tomas G. 2002. Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site. J Biol Chem 277:20104-20112. (Pubitemid 34967534)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.22
, pp. 20104-20112
-
-
Saitoh, M.1
Pullen, N.2
Brennan, P.3
Cantrell, D.4
Dennis, P.B.5
Thomas, G.6
-
180
-
-
0038168557
-
Differing roles of Akt and serum- and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity
-
DOI 10.1074/jbc.M301127200
-
Sakoda H, Gotoh Y, Katagiri H, Kurokawa M, Ono H, Onishi Y, Anai M, Ogihara T, Fujishiro M, Fukushima Y, Abe M, Shojima N, Kikuchi M, Oka Y, Hirai H, Asano T. 2003. Difering roles of Akt and serum-and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity. J Biol Chem 278:25802-25807. (Pubitemid 36835338)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.28
, pp. 25802-25807
-
-
Sakoda, H.1
Gotoh, Y.2
Katagiri, H.3
Kurokawa, M.4
Ono, H.5
Onishi, Y.6
Anai, M.7
Ogihara, T.8
Fujishiro, M.9
Fukushima, Y.10
Abe, M.11
Shojima, N.12
Kikuchi, M.13
Oka, Y.14
Hirai, H.15
Asano, T.16
-
181
-
-
33847404482
-
Inhibition of protein kinase C prevents hepatic insulin resistance in nonalcoholic fatty liver disease
-
DOI 10.1172/JCI30400
-
Samuel VT, Liu ZX, Wang A, Beddow SA, Geisler JG, Kahn M, Zhang XM, Monia BP, Bhanot S, Shulman GI. 2007. Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease. J Clin Invest 117:739-745. (Pubitemid 46348532)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.3
, pp. 739-745
-
-
Samuel, V.T.1
Liu, Z.-X.2
Wang, A.3
Beddow, S.A.4
Geisler, J.G.5
Kahn, M.6
Zhang, X.-M.7
Monia, B.P.8
Bhanot, S.9
Shulman, G.I.10
-
182
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. 2010. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141:290-303.
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
Bar-Peled, L.2
Zoncu, R.3
Markhard, A.L.4
Nada, S.5
Sabatini, D.M.6
-
183
-
-
45849105156
-
The rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
DOI 10.1126/science.1157535
-
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Toreen CC, Bar-Peled L, Sabatini DM. 2008. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320:1496-1501. (Pubitemid 351929429)
-
(2008)
Science
, vol.320
, Issue.5882
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-Peled, L.6
Sabatini, D.M.7
-
184
-
-
33947264077
-
PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1 Protein Kinase
-
DOI 10.1016/j.molcel.2007.03.003, PII S1097276507001487
-
Sancak Y, Toreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM. 2007. PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell 25:903-915. (Pubitemid 46436534)
-
(2007)
Molecular Cell
, vol.25
, Issue.6
, pp. 903-915
-
-
Sancak, Y.1
Thoreen, C.C.2
Peterson, T.R.3
Lindquist, R.A.4
Kang, S.A.5
Spooner, E.6
Carr, S.A.7
Sabatini, D.M.8
-
185
-
-
0035375261
-
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth
-
Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, Morrice N, Deak M, Alessi DR. 2001. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth. J Biol Chem 276:19469-19482.
-
(2001)
J Biol Chem
, vol.276
, pp. 19469-19482
-
-
Sapkota, G.P.1
Kieloch, A.2
Lizcano, J.M.3
Lain, S.4
Arthur, J.S.5
Williams, M.R.6
Morrice, N.7
Deak, M.8
Alessi, D.R.9
-
186
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
DOI 10.1016/j.cub.2004.06.054, PII S0960982204004713
-
Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. 2004. Rictor, a novel binding partner of mTOR, defnes a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14:1296-1302. (Pubitemid 38991819)
-
(2004)
Current Biology
, vol.14
, Issue.14
, pp. 1296-1302
-
-
Dos D. Sarbassov1
Ali, S.M.2
Kim, D.-H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
187
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL, Sabatini DM. 2006. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 22:159-168.
-
(2006)
Mol Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
188
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
DOI 10.1126/science.1106148
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. 2005. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307:1098-1101. (Pubitemid 40262113)
-
(2005)
Science
, vol.307
, Issue.5712
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
189
-
-
28244469041
-
Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex
-
DOI 10.1074/jbc.M506096200
-
Sarbassov DD, Sabatini DM. 2005. Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex. J Biol Chem 280:39505-39509. (Pubitemid 41713908)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.47
, pp. 39505-39509
-
-
Sarbassov, D.D.1
Sabatini, D.M.2
-
190
-
-
0038643484
-
Rheb promotes cell growth as a component of the insulin/TOR signalling network
-
DOI 10.1038/ncb996
-
Saucedo LJ, Gao X, Chiarelli DA, Li L, Pan D, Edgar BA. 2003. Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat Cell Biol 5:566-571. (Pubitemid 36781092)
-
(2003)
Nature Cell Biology
, vol.5
, Issue.6
, pp. 566-571
-
-
Saucedo, L.J.1
Gao, X.2
Chiarelli, D.A.3
Li, L.4
Pan, D.5
Edgar, B.A.6
-
191
-
-
0037117409
-
Identification of a conserved motif required for mTOR signaling
-
DOI 10.1016/S0960-9822(02)00762-5, PII S0960982202007625
-
Schalm SS, Blenis J. 2002. Identifcation of a conserved motif required for mTOR signaling. Curr Biol 12:632-639. (Pubitemid 34315846)
-
(2002)
Current Biology
, vol.12
, Issue.8
, pp. 632-639
-
-
Schalm, S.S.1
Blenis, J.2
-
192
-
-
15744396300
-
Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation
-
DOI 10.1074/jbc.M413995200
-
Schalm SS, Tee AR, Blenis J. 2005. Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation. J Biol Chem 280:11101-11106. (Pubitemid 40418414)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.12
, pp. 11101-11106
-
-
Schalm, S.S.1
Tee, A.R.2
Blenis, J.3
-
193
-
-
67650917394
-
Akt phosphorylates both Tsc1 and Tsc2 in Drosophila, but neither phosphorylation is required for normal animal growth
-
Schleich S, Teleman AA. 2009. Akt phosphorylates both Tsc1 and Tsc2 in Drosophila, but neither phosphorylation is required for normal animal growth. PLoS ONE 4:e6305.
-
(2009)
PLoS ONE
, vol.4
-
-
Schleich, S.1
Teleman, A.A.2
-
194
-
-
13844294205
-
The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins
-
DOI 10.1016/j.cellsig.2004.10.015
-
Schroder W, Bushell G, Sculley T. 2005. The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins. Cell Signal 17:761-767. (Pubitemid 40250176)
-
(2005)
Cellular Signalling
, vol.17
, Issue.6
, pp. 761-767
-
-
Schroder, W.1
Bushell, G.2
Sculley, T.3
-
195
-
-
34147097962
-
Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling
-
DOI 10.1016/j.cellsig.2007.01.013, PII S0898656807000241
-
Schroder WA, Buck M, Cloonan N, Hancock JF, Suhrbier A, Sculley T, Bushell G. 2007. Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling. Cell Signal 19:1279-1289. (Pubitemid 46561564)
-
(2007)
Cellular Signalling
, vol.19
, Issue.6
, pp. 1279-1289
-
-
Schroder, W.A.1
Buck, M.2
Cloonan, N.3
Hancock, J.F.4
Suhrbier, A.5
Sculley, T.6
Bushell, G.7
-
196
-
-
0034234924
-
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
-
Sekulic A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham RT. 2000. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res 60:3504-3513. (Pubitemid 30482170)
-
(2000)
Cancer Research
, vol.60
, Issue.13
, pp. 3504-3513
-
-
Sekulic, A.1
Hudson, C.C.2
Homme, J.L.3
Yin, P.4
Otterness, D.M.5
Karnitz, L.M.6
Abraham, R.T.7
-
197
-
-
2442700142
-
Critical role of T-loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the tuberous sclerosis complex
-
DOI 10.1074/jbc.M400957200
-
Shah OJ, Hunter T. 2004. Critical role of T-loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the tuberous sclerosis complex. J Biol Chem 279:20816-20823. (Pubitemid 38656478)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.20
, pp. 20816-20823
-
-
Shah, O.J.1
Hunter, T.2
-
198
-
-
33747808579
-
Turnover of the active fraction of IRS1 involves Raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis
-
DOI 10.1128/MCB.01254-05
-
Shah OJ, Hunter T. 2006. Turnover of the active fraction of IRS1 involves raptor-mTOR-and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis. Mol Cell Biol 26:6425-6434. (Pubitemid 44277883)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.17
, pp. 6425-6434
-
-
Shah, O.J.1
Hunter, T.2
-
199
-
-
33745570504
-
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity
-
DOI 10.1038/sj.emboj.7601166, PII 7601166
-
Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J, Hershey JW, Blenis J, Pende M, Sonenberg N. 2006. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J 25:2781-2791. (Pubitemid 43980385)
-
(2006)
EMBO Journal
, vol.25
, Issue.12
, pp. 2781-2791
-
-
Shahbazian, D.1
Roux, P.P.2
Mieulet, V.3
Cohen, M.S.4
Raught, B.5
Taunton, J.6
Hershey, J.W.B.7
Blenis, J.8
Pende, M.9
Sonenberg, N.10
-
200
-
-
3142594193
-
The LKB1 tumor suppressor negatively regulates mTOR signaling
-
DOI 10.1016/j.ccr.2004.06.007, PII S1535610804001771
-
Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. 2004. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6:91-99. (Pubitemid 38903165)
-
(2004)
Cancer Cell
, vol.6
, Issue.1
, pp. 91-99
-
-
Shaw, R.J.1
Bardeesy, N.2
Manning, B.D.3
Lopez, L.4
Kosmatka, M.5
DePinho, R.A.6
Cantley, L.C.7
-
201
-
-
33748950810
-
Multiallelic Disruption of the rictor Gene in Mice Reveals that mTOR Complex 2 Is Essential for Fetal Growth and Viability
-
DOI 10.1016/j.devcel.2006.08.013, PII S1534580706003935
-
Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA. 2006. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell 11:583-589. (Pubitemid 44430900)
-
(2006)
Developmental Cell
, vol.11
, Issue.4
, pp. 583-589
-
-
Shiota, C.1
Woo, J.-T.2
Lindner, J.3
Shelton, K.D.4
Magnuson, M.A.5
-
202
-
-
77950900079
-
MTOR Ser-2481 autophosphorylation monitors mTORC-specifc catalytic activity and clarifes rapamycin mechanism of action
-
Soliman GA, Acosta-Jaquez HA, Dunlop EA, Ekim B, Maj NE, Tee AR, Fingar DC. 2010. mTOR Ser-2481 autophosphorylation monitors mTORC-specifc catalytic activity and clarifes rapamycin mechanism of action. J Biol Chem 285:7866-7879.
-
(2010)
J Biol Chem
, vol.285
, pp. 7866-7879
-
-
Soliman, G.A.1
Acosta-Jaquez, H.A.2
Dunlop, E.A.3
Ekim, B.4
Maj, N.E.5
Tee, A.R.6
Fingar, D.C.7
-
203
-
-
60149091189
-
Regulation of translation initiation in eukaryotes: Mechanisms and biological targets
-
Sonenberg N, Hinnebusch AG. 2009. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell 136:731-745.
-
(2009)
Cell
, vol.136
, pp. 731-745
-
-
Sonenberg, N.1
Hinnebusch, A.G.2
-
204
-
-
0035976977
-
The phosphoinositide-dependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase
-
Sonnenburg ED, Gao T, Newton AC. 2001. The phosphoinositide-dependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase. J Biol Chem 276:45289-45297.
-
(2001)
J Biol Chem
, vol.276
, pp. 45289-45297
-
-
Sonnenburg, E.D.1
Gao, T.2
Newton, A.C.3
-
205
-
-
0033305732
-
Effects of knockout of the protein kinase C gene on glucose transport and glucose homeostasis
-
Standaert ML, Bandyopadhyay G, Galloway L, Soto J, Ono Y, Kikkawa U, Farese RV, Leitges M. 1999. Efects of knockout of the protein kinase C beta gene on glucose transport and glucose homeostasis. Endocrinology 140:4470-4477. (Pubitemid 30666110)
-
(1999)
Endocrinology
, vol.140
, Issue.10
, pp. 4470-4477
-
-
Standaert, M.L.1
Bandyopadhyay, G.2
Galloway, L.3
Soto, J.4
Ono, Y.5
Kikkawa, U.6
Farese, R.V.7
Leitges, M.8
-
206
-
-
54149107123
-
MTOR signaling: PLD takes center stage
-
Sun Y, Chen J. 2008. mTOR signaling: PLD takes center stage. Cell Cycle 7:3118-3123.
-
(2008)
Cell Cycle
, vol.7
, pp. 3118-3123
-
-
Sun, Y.1
Chen, J.2
-
207
-
-
46149098447
-
Phospholipase D1 is an effector of Rheb in the mTOR pathway
-
DOI 10.1073/pnas.0712268105
-
Sun Y, Fang Y, Yoon MS, Zhang C, Roccio M, Zwartkruis FJ, Armstrong M, Brown HA, Chen J. 2008. Phospholipase D1 is an efector of Rheb in the mTOR pathway. Proc Natl Acad Sci USA 105:8286-8291. (Pubitemid 351904748)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.24
, pp. 8286-8291
-
-
Sun, Y.1
Fang, Y.2
Yoon, M.-S.3
Zhang, C.4
Roccio, M.5
Zwartkruis, F.J.6
Armstrong, M.7
Brown, H.A.8
Chen, J.9
-
208
-
-
33749406921
-
Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region
-
DOI 10.1074/jbc.M606087200
-
Takahara T, Hara K, Yonezawa K, Sorimachi H, Maeda T. 2006. Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region. J Biol Chem 281:28605-28614. (Pubitemid 44507003)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.39
, pp. 28605-28614
-
-
Takahara, T.1
Hara, K.2
Yonezawa, K.3
Sorimachi, H.4
Maeda, T.5
-
209
-
-
37349014081
-
Tel2 Regulates the Stability of PI3K-Related Protein Kinases
-
DOI 10.1016/j.cell.2007.10.052, PII S0092867407014158
-
Takai H, Wang RC, Takai KK, Yang H, de Lange T. 2007. Tel2 regulates the stability of PI3K-related protein kinases. Cell 131:1248-1259. (Pubitemid 350297416)
-
(2007)
Cell
, vol.131
, Issue.7
, pp. 1248-1259
-
-
Takai, H.1
Wang, R.C.2
Takai, K.K.3
Yang, H.4
De Lange, T.5
-
210
-
-
77956856907
-
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes
-
Takai H, Xie Y, de Lange T, Pavletich NP. 2010. Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev 24:2019-2030.
-
(2010)
Genes Dev
, vol.24
, pp. 2019-2030
-
-
Takai, H.1
Xie, Y.2
De Lange, T.3
Pavletich, N.P.4
-
211
-
-
33244464562
-
Critical nodes in signalling pathways: Insights into insulin action
-
DOI 10.1038/nrm1837, PII NRM1837
-
Taniguchi CM, Emanuelli B, Kahn CR. 2006. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7:85-96. (Pubitemid 43278292)
-
(2006)
Nature Reviews Molecular Cell Biology
, vol.7
, Issue.2
, pp. 85-96
-
-
Taniguchi, C.M.1
Emanuelli, B.2
Kahn, C.R.3
-
212
-
-
77957278976
-
Steady-state kinetic and inhibition studies of the mammalian target of rapamycin (mTOR) kinase domain and mTOR complexes
-
Tao Z, Barker J, Shi SD, Gehring M, Sun S. 2010. Steady-state kinetic and inhibition studies of the mammalian target of rapamycin (mTOR) kinase domain and mTOR complexes. Biochemistry 49:8488-8498.
-
(2010)
Biochemistry
, vol.49
, pp. 8488-8498
-
-
Tao, Z.1
Barker, J.2
Shi, S.D.3
Gehring, M.4
Sun, S.5
-
213
-
-
79953211540
-
Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling
-
Tato I, Bartrons R, Ventura F, Rosa JL. 2011. Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling. J Biol Chem 286:6128-6142.
-
(2011)
J Biol Chem
, vol.286
, pp. 6128-6142
-
-
Tato, I.1
Bartrons, R.2
Ventura, F.3
Rosa, J.L.4
-
214
-
-
38149061122
-
Signaling through cAMP and cAMP-dependent protein kinase: Diverse strategies for drug design
-
Taylor SS, Kim C, Cheng CY, Brown SH, Wu J, Kannan N. 2008. Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design. Biochim Biophys Acta 1784:16-26.
-
(2008)
Biochim Biophys Acta
, vol.1784
, pp. 16-26
-
-
Taylor, S.S.1
Kim, C.2
Cheng, C.Y.3
Brown, S.H.4
Wu, J.5
Kannan, N.6
-
215
-
-
33746552164
-
Serum and glucocorticoid-regulated protein kinases: Variations on a theme
-
DOI 10.1002/jcb.20894
-
Tessier M, Woodgett JR. 2006. Serum and glucocorticoid-regulated protein kinases: variations on a theme. J Cell Biochem 98:1391-1407. (Pubitemid 44141846)
-
(2006)
Journal of Cellular Biochemistry
, vol.98
, Issue.6
, pp. 1391-1407
-
-
Tessier, M.1
Woodgett, J.R.2
-
216
-
-
43249124698
-
PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis
-
Tedieck K, Polak P, Kim ML, Molle KD, Cohen A, Jenö P, Arrieumerlou C, Hall MN. 2007. PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS ONE 2:e1217.
-
(2007)
PLoS ONE
, vol.2
-
-
Tedieck, K.1
Polak, P.2
Kim, M.L.3
Molle, K.D.4
Cohen, A.5
Jenö, P.6
Arrieumerlou, C.7
Hall, M.N.8
-
217
-
-
65549145048
-
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
-
Toreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS. 2009. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 284:8023-8032.
-
(2009)
J Biol Chem
, vol.284
, pp. 8023-8032
-
-
Toreen, C.C.1
Kang, S.A.2
Chang, J.W.3
Liu, Q.4
Zhang, J.5
Gao, Y.6
Reichling, L.J.7
Sim, T.8
Sabatini, D.M.9
Gray, N.S.10
-
218
-
-
77149163803
-
Rictor is a novel target of p70 S6 kinase-1
-
Treins C, Warne PH, Magnuson MA, Pende M, Downward J. 2010. Rictor is a novel target of p70 S6 kinase-1. Oncogene 29:1003-1016.
-
(2010)
Oncogene
, vol.29
, pp. 1003-1016
-
-
Treins, C.1
Warne, P.H.2
Magnuson, M.A.3
Pende, M.4
Downward, J.5
-
219
-
-
35348832340
-
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance
-
DOI 10.1073/pnas.0706517104
-
Tremblay F, Brûlé S, Hee Um S, Li Y, Masuda K, Roden M, Sun XJ, Krebs M, Polakiewicz RD, Tomas G, Marette A. 2007. Identifcation of IRS-1 Ser-1101 as a target of S6K1 in nutrient-and obesity-induced insulin resistance. Proc Natl Acad Sci USA 104:14056-14061. (Pubitemid 350003334)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.35
, pp. 14056-14061
-
-
Tremblay, F.1
Brule, S.2
Sung, H.U.3
Li, Y.4
Masuda, K.5
Roden, M.6
Xiao, J.S.7
Krebs, M.8
Polakiewicz, R.D.9
Thomas, G.10
Marette, A.11
-
220
-
-
33644886769
-
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
-
Tzatsos A, Kandror KV. 2006. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol 26:63-76.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 63-76
-
-
Tzatsos, A.1
Kandror, K.V.2
-
221
-
-
4544220704
-
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
-
DOI 10.1038/nature02866
-
Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, Fumagalli S, Allegrini PR, Kozma SC, Auwerx J, Tomas G. 2004. Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity. Nature 431:200-205. (Pubitemid 39243474)
-
(2004)
Nature
, vol.431
, Issue.7005
, pp. 200-205
-
-
Um, S.H.1
Frigerio, F.2
Watanabe, M.3
Picard, F.4
Joaquin, M.5
Sticker, M.6
Fumagalli, S.7
Allegrini, P.R.8
Kozma, S.C.9
Auwerx, J.10
Thomas, G.11
-
222
-
-
33847397874
-
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
-
DOI 10.1038/ncb1547, PII NCB1547
-
Vander Haar E, Lee SI, Bandhakavi S, Grifn TJ, Kim DH. 2007. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol 9:316-323. (Pubitemid 46344611)
-
(2007)
Nature Cell Biology
, vol.9
, Issue.3
, pp. 316-323
-
-
Haar, E.V.1
Lee, S.2
Bandhakavi, S.3
Griffin, T.J.4
Kim, D.-H.5
-
223
-
-
20044390541
-
Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM
-
DOI 10.1074/jbc.M410344200
-
Viniegra JG, Martínez N, Modirassari P, Losa JH, Parada Cobo C, Lobo VJ, Luquero CI, Alvarez-Vallina L, Ramón y Cajal S, Rojas JM, Sánchez-Prieto R. 2005. Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM. J Biol Chem 280:4029-4036. (Pubitemid 40288566)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.6
, pp. 4029-4036
-
-
Guinea Viniegra, J.1
Martinez, N.2
Modirassari, P.3
Hernandez Losa, J.4
Parada Cobo, C.5
Sanchez-Arevalo Lobo, V.J.6
Aceves Luquero, C.I.7
Alvarez-Vallina, L.8
Ramon Y Cajal, S.9
Rojas, J.M.10
Sanchez-Prieto, R.11
-
224
-
-
67649344456
-
Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR
-
Wang L, Lawrence JC Jr, Sturgill TW, Harris TE. 2009. Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR. J Biol Chem 284:14693-14697.
-
(2009)
J Biol Chem
, vol.284
, pp. 14693-14697
-
-
Wang, L.1
Lawrence Jr., J.C.2
Sturgill, T.W.3
Harris, T.E.4
-
225
-
-
0035881470
-
RSK1 and p70 S6 kinase
-
DOI 10.1093/emboj/20.16.4370
-
Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG. 2001. Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J 20:4370-4379. (Pubitemid 32772031)
-
(2001)
EMBO Journal
, vol.20
, Issue.16
, pp. 4370-4379
-
-
Wang, X.1
Li, W.2
Williams, M.3
Terada, N.4
Alessi, D.R.5
Proud, C.G.6
-
226
-
-
66349138676
-
Nutrient control of TORC1, a cell-cycle regulator
-
Wang X, Proud CG. 2009. Nutrient control of TORC1, a cell-cycle regulator. Trends Cell Biol 19:260-267.
-
(2009)
Trends Cell Biol
, vol.19
, pp. 260-267
-
-
Wang, X.1
Proud, C.G.2
-
227
-
-
45549089352
-
Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse efects of protein kinase C-delta on insulin action in skeletal muscle cells
-
Waraich RS, Weigert C, Kalbacher H, Hennige AM, Lutz SZ, Häring HU, Schleicher ED, Voelter W, Lehmann R. 2008. Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse efects of protein kinase C-delta on insulin action in skeletal muscle cells. J Biol Chem 283:11226-11233.
-
(2008)
J Biol Chem
, vol.283
, pp. 11226-11233
-
-
Waraich, R.S.1
Weigert, C.2
Kalbacher, H.3
Hennige, A.M.4
Lutz, S.Z.5
Häring, H.U.6
Schleicher, E.D.7
Voelter, W.8
Lehmann, R.9
-
228
-
-
0028939115
-
Multiple independent inputs are required for activation of the p70 S6 kinase
-
Weng QP, Andrabi K, Kozlowski MT, Grove JR, Avruch J. 1995. Multiple independent inputs are required for activation of the p70 S6 kinase. Mol Cell Biol 15:2333-2340.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 2333-2340
-
-
Weng, Q.P.1
Andrabi, K.2
Kozlowski, M.T.3
Grove, J.R.4
Avruch, J.5
-
229
-
-
34548509880
-
PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor expression and signaling
-
DOI 10.1074/jbc.M704343200
-
Woo SY, Kim DH, Jun CB, Kim YM, Haar EV, Lee SI, Hegg JW, Bandhakavi S, Grifn TJ, Kim DH. 2007. PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling. J Biol Chem 282:25604-25612. (Pubitemid 47372842)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.35
, pp. 25604-25612
-
-
Woo, S.-Y.1
Kim, D.-H.2
Jun, C.-B.3
Kim, Y.-M.4
Haar, E.V.5
Lee, S.-I.6
Hegg, J.W.7
Bandhakavi, S.8
Griffin, T.J.9
Kim, D.-H.10
-
230
-
-
10744230065
-
LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade
-
DOI 10.1016/j.cub.2003.10.031
-
Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LG, Neumann D, Schlattner U, Wallimann T, Carlson M, Carling D. 2003. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 13:2004-2008. (Pubitemid 37425212)
-
(2003)
Current Biology
, vol.13
, Issue.22
, pp. 2004-2008
-
-
Woods, A.1
Johnstone, S.R.2
Dickerson, K.3
Leiper, F.C.4
Fryer, L.G.D.5
Neumann, D.6
Schlattner, U.7
Wallimann, T.8
Carlson, M.9
Carling, D.10
-
231
-
-
79954600448
-
MTOR Complex 2 Targets Akt for Proteasomal Degradation via Phosphorylation at the Hydrophobic Motif
-
Wu YT, Ouyang W, Lazorchak AS, Liu D, Shen HM, Su B. 2011. mTOR Complex 2 Targets Akt for Proteasomal Degradation via Phosphorylation at the Hydrophobic Motif. J Biol Chem 286:14190-14198.
-
(2011)
J Biol Chem
, vol.286
, pp. 14190-14198
-
-
Wu, Y.T.1
Ouyang, W.2
Lazorchak, A.S.3
Liu, D.4
Shen, H.M.5
Su, B.6
-
232
-
-
32044465506
-
TOR signaling in growth and metabolism
-
DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
-
Wullschleger S, Loewith R, Hall MN. 2006. TOR signaling in growth and metabolism. Cell 124:471-484. (Pubitemid 43199434)
-
(2006)
Cell
, vol.124
, Issue.3
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
233
-
-
24744439255
-
Molecular organization of target of rapamycin complex 2
-
DOI 10.1074/jbc.M505553200
-
Wullschleger S, Loewith R, Oppliger W, Hall MN. 2005. Molecular organization of target of rapamycin complex 2. J Biol Chem 280:30697-30704. (Pubitemid 41291798)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.35
, pp. 30697-30704
-
-
Wullschleger, S.1
Loewith, R.2
Oppliger, W.3
Hall, M.N.4
-
234
-
-
79955615939
-
IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation
-
Xie X, Zhang D, Zhao B, Lu MK, You M, Condorelli G, Wang CY, Guan KL. 2011. IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc Natl Acad Sci USA 108:6474-6479.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 6474-6479
-
-
Xie, X.1
Zhang, D.2
Zhao, B.3
Lu, M.K.4
You, M.5
Condorelli, G.6
Wang, C.Y.7
Guan, K.L.8
-
235
-
-
0036295728
-
Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation
-
DOI 10.1016/S1097-2765(02)00550-6
-
Yang J, Cron P, Tompson V, Good VM, Hess D, Hemmings BA, Barford D. 2002. Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. Mol Cell 9:1227-1240. (Pubitemid 34722302)
-
(2002)
Molecular Cell
, vol.9
, Issue.6
, pp. 1227-1240
-
-
Yang, J.1
Cron, P.2
Thompson, V.3
Good, V.M.4
Hess, D.5
Hemmings, B.A.6
Barford, D.7
-
236
-
-
33751079895
-
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
-
DOI 10.1101/gad.1461206
-
Yang Q, Inoki K, Ikenoue T, Guan KL. 2006. Identifcation of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev 20:2820-2832. (Pubitemid 44771744)
-
(2006)
Genes and Development
, vol.20
, Issue.20
, pp. 2820-2832
-
-
Yang, Q.1
Inoki, K.2
Ikenoue, T.3
Guan, K.-L.4
-
237
-
-
77953091045
-
Structure of the human mTOR complex i and its implications for rapamycin inhibition
-
Yip CK, Murata K, Walz T, Sabatini DM, Kang SA. 2010. Structure of the human mTOR complex I and its implications for rapamycin inhibition. Mol Cell 38:768-774.
-
(2010)
Mol Cell
, vol.38
, pp. 768-774
-
-
Yip, C.K.1
Murata, K.2
Walz, T.3
Sabatini, D.M.4
Kang, S.A.5
-
238
-
-
80052736325
-
Redox regulates mTORC1 activity by modulating the TSC1/TSC2-Rheb pathway
-
Yoshida S, Hong S, Suzuki T, Nada S, Mannan AM, Wang J, Okada M, Guan KL, Inoki K. 2011. Redox regulates mTORC1 activity by modulating the TSC1/TSC2-Rheb pathway. J Biol Chem 286:32651-32660.
-
(2011)
J Biol Chem
, vol.286
, pp. 32651-32660
-
-
Yoshida, S.1
Hong, S.2
Suzuki, T.3
Nada, S.4
Mannan, A.M.5
Wang, J.6
Okada, M.7
Guan, K.L.8
Inoki, K.9
-
239
-
-
68049137608
-
Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin
-
Yu K, Toral-Barza L, Shi C, Zhang WG, Lucas J, Shor B, Kim J, Verheijen J, Curran K, Malwitz DJ, Cole DC, Ellingboe J, Ayral-Kaloustian S, Mansour TS, Gibbons JJ, Abraham RT, Nowak P, Zask A. 2009. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res 69:6232-6240.
-
(2009)
Cancer Res
, vol.69
, pp. 6232-6240
-
-
Yu, K.1
Toral-Barza, L.2
Shi, C.3
Zhang, W.G.4
Lucas, J.5
Shor, B.6
Kim, J.7
Verheijen, J.8
Curran, K.9
Malwitz, D.J.10
Cole, D.C.11
Ellingboe, J.12
Ayral-Kaloustian, S.13
Mansour, T.S.14
Gibbons, J.J.15
Abraham, R.T.16
Nowak, P.17
Zask, A.18
-
240
-
-
79958696336
-
Phosphoproteomic analysis identifes Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
-
Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, Kubica N, Hofman GR, Cantley LC, Gygi SP, Blenis J. 2011. Phosphoproteomic analysis identifes Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332:1322-1326.
-
(2011)
Science
, vol.332
, pp. 1322-1326
-
-
Yu, Y.1
Yoon, S.O.2
Poulogiannis, G.3
Yang, Q.4
Ma, X.M.5
Villén, J.6
Kubica, N.7
Hofman, G.R.8
Cantley, L.C.9
Gygi, S.P.10
Blenis, J.11
-
241
-
-
33750040886
-
S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt
-
DOI 10.1016/j.molcel.2006.09.019, PII S1097276506006678
-
Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD. 2006b. S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol Cell 24:185-197. (Pubitemid 44574477)
-
(2006)
Molecular Cell
, vol.24
, Issue.2
, pp. 185-197
-
-
Zhang, H.H.1
Lipovsky, A.I.2
Dibble, C.C.3
Sahin, M.4
Manning, B.D.5
-
242
-
-
33644781670
-
Drosophila target of rapamycin kinase functions as a multimer
-
DOI 10.1534/genetics.105.051979
-
Zhang Y, Billington CJ Jr, Pan D, Neufeld TP. 2006b. Drosophila target of rapamycin kinase functions as a multimer. Genetics 172:355-362. (Pubitemid 43345497)
-
(2006)
Genetics
, vol.172
, Issue.1
, pp. 355-362
-
-
Zhang, Y.1
Billington Jr., C.J.2
Pan, D.3
Neufeld, T.P.4
-
243
-
-
58649110598
-
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation
-
Zheng B, Jeong JH, Asara JM, Yuan YY, Granter SR, Chin L, Cantley LC. 2009. Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. Mol Cell 33:237-247.
-
(2009)
Mol Cell
, vol.33
, pp. 237-247
-
-
Zheng, B.1
Jeong, J.H.2
Asara, J.M.3
Yuan, Y.Y.4
Granter, S.R.5
Chin, L.6
Cantley, L.C.7
-
244
-
-
79952293503
-
Activation of mTORC2 by association with the ribosome
-
Zinzalla V, Stracka D, Oppliger W, Hall MN. 2011. Activation of mTORC2 by association with the ribosome. Cell 144:757-768.
-
(2011)
Cell
, vol.144
, pp. 757-768
-
-
Zinzalla, V.1
Stracka, D.2
Oppliger, W.3
Hall, M.N.4
-
245
-
-
78650510609
-
MTOR: From growth signal integration to cancer, diabetes and ageing
-
Zoncu R, Efeyan A, Sabatini DM. 2011. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12:21-35.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
|