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Volumn 31, Issue 6, 2006, Pages 342-348

Ribosomal protein S6 phosphorylation: from protein synthesis to cell size

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR 4E BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; S6 KINASE;

EID: 33745150462     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2006.04.003     Document Type: Review
Times cited : (648)

References (49)
  • 1
    • 5344251815 scopus 로고    scopus 로고
    • Growth regulation by insulin and TOR signaling in Drosophila
    • Hall M.N., et al. (Ed), Cold Spring Harbor Laboratory Press
    • Leevers S.J., and Hafen E. Growth regulation by insulin and TOR signaling in Drosophila. In: Hall M.N., et al. (Ed). Cell Growth: Control of Cell Size (2004), Cold Spring Harbor Laboratory Press 167-192
    • (2004) Cell Growth: Control of Cell Size , pp. 167-192
    • Leevers, S.J.1    Hafen, E.2
  • 2
    • 24944509055 scopus 로고    scopus 로고
    • Coordination of cell growth and cell-cycle progression in proliferating mammalian cells
    • Hall M.N., et al. (Ed), Cold Spring Harbor Laboratory Press
    • Conlon I., et al. Coordination of cell growth and cell-cycle progression in proliferating mammalian cells. In: Hall M.N., et al. (Ed). Cell Growth: Control of Cell Size (2004), Cold Spring Harbor Laboratory Press 85-99
    • (2004) Cell Growth: Control of Cell Size , pp. 85-99
    • Conlon, I.1
  • 3
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • Fingar D.C., and Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23 (2004) 3151-3171
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 4
    • 0037097863 scopus 로고    scopus 로고
    • Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
    • Fingar D.C., et al. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 16 (2002) 1472-1487
    • (2002) Genes Dev. , vol.16 , pp. 1472-1487
    • Fingar, D.C.1
  • 5
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N., and Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 18 (2004) 1926-1945
    • (2004) Genes Dev. , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 6
    • 0345732640 scopus 로고    scopus 로고
    • mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
    • Fingar D.C., et al. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol. Cell. Biol. 24 (2004) 200-216
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 200-216
    • Fingar, D.C.1
  • 7
    • 0001798492 scopus 로고    scopus 로고
    • S6 phosphorylation and signal transduction
    • Sonenberg N., et al. (Ed), Cold Spring Harbor Laboratory Press
    • Fumagalli S., and Thomas G. S6 phosphorylation and signal transduction. In: Sonenberg N., et al. (Ed). Translational Control of Gene Expression (2000), Cold Spring Harbor Laboratory Press 695-717
    • (2000) Translational Control of Gene Expression , pp. 695-717
    • Fumagalli, S.1    Thomas, G.2
  • 8
    • 0035896525 scopus 로고    scopus 로고
    • Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation
    • Martin K.A., et al. Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation. J. Biol. Chem. 276 (2001) 7892-7898
    • (2001) J. Biol. Chem. , vol.276 , pp. 7892-7898
    • Martin, K.A.1
  • 9
    • 0032843917 scopus 로고    scopus 로고
    • Drosophila S6 kinase: a regulator of cell size
    • Montagne J., et al. Drosophila S6 kinase: a regulator of cell size. Science 285 (1999) 2126-2129
    • (1999) Science , vol.285 , pp. 2126-2129
    • Montagne, J.1
  • 10
    • 0032538890 scopus 로고    scopus 로고
    • s6k gene reveals a small mouse phenotype and a new functional S6 kinase
    • s6k gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J. 17 (1998) 6649-6659
    • (1998) EMBO J. , vol.17 , pp. 6649-6659
    • Shima, H.1
  • 11
    • 0034700456 scopus 로고    scopus 로고
    • Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
    • Pende M., et al. Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice. Nature 408 (2000) 994-997
    • (2000) Nature , vol.408 , pp. 994-997
    • Pende, M.1
  • 12
    • 20044392290 scopus 로고    scopus 로고
    • -/- skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control
    • -/- skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control. Nat. Cell Biol. 7 (2005) 286-294
    • (2005) Nat. Cell Biol. , vol.7 , pp. 286-294
    • Ohanna, M.1
  • 13
    • 11144356304 scopus 로고    scopus 로고
    • -/- mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway
    • -/- mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol. Cell. Biol. 24 (2004) 3112-3124
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 3112-3124
    • Pende, M.1
  • 15
    • 14044276306 scopus 로고    scopus 로고
    • Lithium can relieve translational repression of TOP mRNAs elicited by various blocks along the cell cycle in a glycogen synthase kinase-3- and S6-kinase-independent manner
    • Stolovich M., et al. Lithium can relieve translational repression of TOP mRNAs elicited by various blocks along the cell cycle in a glycogen synthase kinase-3- and S6-kinase-independent manner. J. Biol. Chem. 280 (2005) 5336-5342
    • (2005) J. Biol. Chem. , vol.280 , pp. 5336-5342
    • Stolovich, M.1
  • 16
    • 0001320597 scopus 로고    scopus 로고
    • Mammalian ribosome: the structure and the evolution of the proteins
    • Hershey J.W.B., et al. (Ed), Cold Spring Harbor Laboratory Press
    • Wool I., et al. Mammalian ribosome: the structure and the evolution of the proteins. In: Hershey J.W.B., et al. (Ed). Translational Control (1996), Cold Spring Harbor Laboratory Press
    • (1996) Translational Control
    • Wool, I.1
  • 17
    • 0016251762 scopus 로고
    • The phosphorylation of liver ribosomal proteins in vivo. Evidence that only a single small subunit protein (S6) is phosphorylated
    • Gressner A.M., and Wool I.G. The phosphorylation of liver ribosomal proteins in vivo. Evidence that only a single small subunit protein (S6) is phosphorylated. J. Biol. Chem. 249 (1974) 6917-6925
    • (1974) J. Biol. Chem. , vol.249 , pp. 6917-6925
    • Gressner, A.M.1    Wool, I.G.2
  • 18
    • 0023726116 scopus 로고
    • Identification of the 40 S ribosomal protein S6 phosphorylation sites induced by cycloheximide
    • Krieg J., et al. Identification of the 40 S ribosomal protein S6 phosphorylation sites induced by cycloheximide. J. Biol. Chem. 263 (1988) 11473-11477
    • (1988) J. Biol. Chem. , vol.263 , pp. 11473-11477
    • Krieg, J.1
  • 19
    • 0026688510 scopus 로고
    • Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver
    • Flotow H., and Thomas G. Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver. J. Biol. Chem. 267 (1992) 3074-3078
    • (1992) J. Biol. Chem. , vol.267 , pp. 3074-3078
    • Flotow, H.1    Thomas, G.2
  • 20
    • 0023122945 scopus 로고
    • Phosphorylation of the Saccharomyces cerevisiae equivalent of ribosomal protein S6 has no detectable effect on growth
    • Johnson S., and Warner J. Phosphorylation of the Saccharomyces cerevisiae equivalent of ribosomal protein S6 has no detectable effect on growth. Mol. Cell. Biol. 7 (1987) 1338-1345
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 1338-1345
    • Johnson, S.1    Warner, J.2
  • 21
    • 24944464482 scopus 로고    scopus 로고
    • Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis
    • Ruvinsky I., et al. Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev. 19 (2005) 2199-2211
    • (2005) Genes Dev. , vol.19 , pp. 2199-2211
    • Ruvinsky, I.1
  • 22
    • 0035881470 scopus 로고    scopus 로고
    • RSK1 and p70 S6 kinase
    • RSK1 and p70 S6 kinase. EMBO J. 20 (2001) 4370-4379
    • (2001) EMBO J. , vol.20 , pp. 4370-4379
    • Wang, X.1
  • 23
    • 0035903136 scopus 로고    scopus 로고
    • Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F
    • Rogers G.W.J., et al. Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F. J. Biol. Chem. 276 (2001) 30914-30922
    • (2001) J. Biol. Chem. , vol.276 , pp. 30914-30922
    • Rogers, G.W.J.1
  • 24
    • 2442574729 scopus 로고    scopus 로고
    • Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases
    • Raught B., et al. Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. EMBO J. 23 (2004) 1761-1769
    • (2004) EMBO J. , vol.23 , pp. 1761-1769
    • Raught, B.1
  • 25
    • 27744569843 scopus 로고    scopus 로고
    • mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
    • Holz M.K., et al. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 123 (2005) 569-580
    • (2005) Cell , vol.123 , pp. 569-580
    • Holz, M.K.1
  • 26
    • 0035859956 scopus 로고    scopus 로고
    • p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD
    • Harada H., et al. p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 9666-9670
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 9666-9670
    • Harada, H.1
  • 27
    • 3342958797 scopus 로고    scopus 로고
    • The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
    • Harrington L.S., et al. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell Biol. 166 (2004) 213-223
    • (2004) J. Cell Biol. , vol.166 , pp. 213-223
    • Harrington, L.S.1
  • 28
    • 4544343980 scopus 로고    scopus 로고
    • Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
    • Shah O.J., et al. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr. Biol. 14 (2004) 1650-1656
    • (2004) Curr. Biol. , vol.14 , pp. 1650-1656
    • Shah, O.J.1
  • 29
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
    • Um S.H., et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431 (2004) 200-205
    • (2004) Nature , vol.431 , pp. 200-205
    • Um, S.H.1
  • 30
    • 21844468767 scopus 로고    scopus 로고
    • Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase
    • Chiang G.G., and Abraham R.T. Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J. Biol. Chem. 280 (2005) 25485-25490
    • (2005) J. Biol. Chem. , vol.280 , pp. 25485-25490
    • Chiang, G.G.1    Abraham, R.T.2
  • 31
    • 22544455676 scopus 로고    scopus 로고
    • Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
    • Holz M.K., and Blenis J. Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J. Biol. Chem. 280 (2005) 26089-26093
    • (2005) J. Biol. Chem. , vol.280 , pp. 26089-26093
    • Holz, M.K.1    Blenis, J.2
  • 32
    • 0027983480 scopus 로고
    • Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression
    • de Groot R., et al. Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression. Cell 79 (1994) 81-91
    • (1994) Cell , vol.79 , pp. 81-91
    • de Groot, R.1
  • 33
    • 0742323558 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics
    • Maquat L.E. Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. Nat. Rev. Mol. Cell Biol. 5 (2004) 89-99
    • (2004) Nat. Rev. Mol. Cell Biol. , vol.5 , pp. 89-99
    • Maquat, L.E.1
  • 34
    • 4644303065 scopus 로고    scopus 로고
    • SKAR is a specific target of S6 kinase 1 in cell growth control
    • Richardson C.J., et al. SKAR is a specific target of S6 kinase 1 in cell growth control. Curr. Biol. 14 (2004) 1540-1549
    • (2004) Curr. Biol. , vol.14 , pp. 1540-1549
    • Richardson, C.J.1
  • 35
    • 0025291205 scopus 로고
    • Translational dynamics. Interactions between the translational factors, tRNA and ribosomes during eukaryotic protein synthesis
    • Nygard O., and Nilsson L. Translational dynamics. Interactions between the translational factors, tRNA and ribosomes during eukaryotic protein synthesis. Eur. J. Biochem. 191 (1990) 1-17
    • (1990) Eur. J. Biochem. , vol.191 , pp. 1-17
    • Nygard, O.1    Nilsson, L.2
  • 36
    • 0025068922 scopus 로고
    • TPA stimulates S6 phosphorylation but not protein synthesis in Ehrlich cells
    • Montine K.S., and Henshaw E.C. TPA stimulates S6 phosphorylation but not protein synthesis in Ehrlich cells. Biochem. Biophys. Res. Commun. 166 (1990) 1340-1345
    • (1990) Biochem. Biophys. Res. Commun. , vol.166 , pp. 1340-1345
    • Montine, K.S.1    Henshaw, E.C.2
  • 37
    • 0035787712 scopus 로고    scopus 로고
    • Mitogenic and nutritional signals are transduced into translational efficiency of TOP mRNAs
    • Hornstein E., et al. Mitogenic and nutritional signals are transduced into translational efficiency of TOP mRNAs. Cold Spring Harb. Symp. Quant. Biol. 66 (2001) 477-484
    • (2001) Cold Spring Harb. Symp. Quant. Biol. , vol.66 , pp. 477-484
    • Hornstein, E.1
  • 38
    • 0028207001 scopus 로고
    • Rapamycin selectively represses translation of the 'polypyrimidine tract' mRNA family
    • Jefferies H.B.J., et al. Rapamycin selectively represses translation of the 'polypyrimidine tract' mRNA family. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 4441-4445
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 4441-4445
    • Jefferies, H.B.J.1
  • 39
    • 0036889291 scopus 로고    scopus 로고
    • Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the PI3-kinase-mediated pathway, but requires neither S6K1 nor rpS6 phosphorylation
    • Stolovich M., et al. Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the PI3-kinase-mediated pathway, but requires neither S6K1 nor rpS6 phosphorylation. Mol. Cell. Biol. 22 (2002) 8101-8113
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 8101-8113
    • Stolovich, M.1
  • 40
    • 0035200856 scopus 로고    scopus 로고
    • Amino acid-induced translation of TOP mRNAs is fully dependent on PI3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation
    • Tang H., et al. Amino acid-induced translation of TOP mRNAs is fully dependent on PI3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation. Mol. Cell. Biol. 21 (2001) 8671-8683
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 8671-8683
    • Tang, H.1
  • 41
    • 0036566786 scopus 로고    scopus 로고
    • S6 phosphorylation-independent pathways regulate translation of 5′-terminal oligopyrimidine tract containing mRNAs in differentiating hematopoietic cells
    • Barth-Baus D., et al. S6 phosphorylation-independent pathways regulate translation of 5′-terminal oligopyrimidine tract containing mRNAs in differentiating hematopoietic cells. Nucleic Acids Res. 30 (2002) 1919-1928
    • (2002) Nucleic Acids Res. , vol.30 , pp. 1919-1928
    • Barth-Baus, D.1
  • 42
    • 4644276766 scopus 로고    scopus 로고
    • A 32 kDa protein - whose phosphorylation correlates with oncogenic Ras-induced cell cycle arrest in activated Xenopus egg extracts - is identified as ribosomal protein S6
    • Pian J.P., et al. A 32 kDa protein - whose phosphorylation correlates with oncogenic Ras-induced cell cycle arrest in activated Xenopus egg extracts - is identified as ribosomal protein S6. J. Cell. Physiol. 201 (2004) 305-319
    • (2004) J. Cell. Physiol. , vol.201 , pp. 305-319
    • Pian, J.P.1
  • 43
    • 23944483135 scopus 로고    scopus 로고
    • Post-transcriptional control of gene expression: a genome-wide perspective
    • Mata J., et al. Post-transcriptional control of gene expression: a genome-wide perspective. Trends Biochem. Sci. 30 (2005) 506-514
    • (2005) Trends Biochem. Sci. , vol.30 , pp. 506-514
    • Mata, J.1
  • 45
    • 0029974453 scopus 로고    scopus 로고
    • Extraribosomal functions of ribosomal proteins
    • Wool I.G. Extraribosomal functions of ribosomal proteins. Trends Biochem. Sci. 21 (1996) 164-165
    • (1996) Trends Biochem. Sci. , vol.21 , pp. 164-165
    • Wool, I.G.1
  • 46
    • 0025215702 scopus 로고
    • Hormonally inducible phosphorylation of a nuclear pool of ribosomal protein S6
    • Franco R., and Rosenfeld M. Hormonally inducible phosphorylation of a nuclear pool of ribosomal protein S6. J. Biol. Chem. 265 (1990) 4321-4325
    • (1990) J. Biol. Chem. , vol.265 , pp. 4321-4325
    • Franco, R.1    Rosenfeld, M.2
  • 47
    • 33745180980 scopus 로고    scopus 로고
    • Interaction of hsp90 to ribosomal proteins protects from ubiquitination and proteasome-dependent degradation
    • Kim T.S., et al. Interaction of hsp90 to ribosomal proteins protects from ubiquitination and proteasome-dependent degradation. Mol. Biol. Cell. (2005)
    • (2005) Mol. Biol. Cell.
    • Kim, T.S.1
  • 48
    • 0142227209 scopus 로고    scopus 로고
    • Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control
    • Mazumder B., et al. Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control. Cell 115 (2003) 187-198
    • (2003) Cell , vol.115 , pp. 187-198
    • Mazumder, B.1
  • 49
    • 0033761629 scopus 로고    scopus 로고
    • Synthesis of the translational apparatus is regulated at the translational level
    • Meyuhas O. Synthesis of the translational apparatus is regulated at the translational level. Eur. J. Biochem. 267 (2000) 6321-6330
    • (2000) Eur. J. Biochem. , vol.267 , pp. 6321-6330
    • Meyuhas, O.1


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