TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Nature Cell Biology

Volumn 4, Issue 9, 2002, Pages 648-657

  Inoki, Ken ^a   Li, Yong ^a   Zhu, Tianquan ^a   Wu, Jun ^a   Guan, Kun Liang ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CELL PROTEIN; HAMARTIN; INITIATION FACTOR 4E; INSULIN; PROTEIN KINASE B; RAPAMYCIN; RNA; S6 KINASE; TUBERIN;

ARTICLE; AUTOSOMAL DOMINANT DISORDER; CELL GROWTH; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REPRESSION; GENE DISRUPTION; GENE FUNCTION; GENE INTERACTION; GENE MUTATION; GENETIC STABILITY; GROWTH INHIBITION; HAMARTOMA; HUMAN; HUMAN CELL; IN VIVO STUDY; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RNA TRANSLATION; SIGNAL TRANSDUCTION; TRANSLATION INITIATION; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR GENE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BINDING SITES; CARRIER PROTEINS; CELL LINE; GENES, TUMOR SUPPRESSOR; HUMANS; INSULIN; MODELS, BIOLOGICAL; MUTATION; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; REPRESSOR PROTEINS; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR PROTEINS;

EUKARYOTA; MAMMALIA;

EID: 0036713778     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb839     Document Type: Article

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