-
1
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha
-
Alessi, D. R., S. R. James, C. P. Downes, A. B. Holmes, P. R. Gaffney, C. B. Reese, and P. Cohen. 1997. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha. Curr. Biol. 7:261-269.
-
(1997)
Curr. Biol.
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
Cohen, P.7
-
2
-
-
0032518467
-
3-phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 s6 kinase in vivo and in vitro
-
Alessi, D. R., M. T. Kozlowski, Q. P. Weng, N. Morrice, and J. Avruch. 1998. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr. Biol. 8:69-81.
-
(1998)
Curr. Biol.
, vol.8
, pp. 69-81
-
-
Alessi, D.R.1
Kozlowski, M.T.2
Weng, Q.P.3
Morrice, N.4
Avruch, J.5
-
3
-
-
0032482374
-
Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B
-
Anderson, K. E., J. Coadwell, L. R. Stephens, and P. T. Hawkins. 1998. Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr. Biol. 8:684-691.
-
(1998)
Curr. Biol.
, vol.8
, pp. 684-691
-
-
Anderson, K.E.1
Coadwell, J.2
Stephens, L.R.3
Hawkins, P.T.4
-
4
-
-
0031038052
-
Activation of protein kinasc C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport
-
Bandyopadhyay, G., M. L. Standaert, L. Zhao, B. Yu, A. Avignon, L. Galloway, P. Karnam, J. Moscat, and R. V. Farese. 1997. Activation of protein kinasc C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport. J. Biol. Chem. 272: 2551-2558.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 2551-2558
-
-
Bandyopadhyay, G.1
Standaert, M.L.2
Zhao, L.3
Yu, B.4
Avignon, A.5
Galloway, L.6
Karnam, P.7
Moscat, J.8
Farese, R.V.9
-
5
-
-
0027178812
-
Protein kinase C zeta isoform is critical for mitogenic signal transduction
-
Berra, E., M. T. Diaz-Meco, I. Dominguez, M. M. Municio, L. Sanz, J. Lozano, R. S. Chapkin, and J. Moscat. 1993. Protein kinase C zeta isoform is critical for mitogenic signal transduction. Cell 74:555-563.
-
(1993)
Cell
, vol.74
, pp. 555-563
-
-
Berra, E.1
Diaz-Meco, M.T.2
Dominguez, I.3
Municio, M.M.4
Sanz, L.5
Lozano, J.6
Chapkin, R.S.7
Moscat, J.8
-
6
-
-
0029617910
-
Evidence for a role of MEK MAPK during signal transduction by protein kinase C zeta
-
Berra, E., M. T. Diaz-Meco, J. Lozano, S. Frutos, M. M. Municio, P. Sanchez, L. Sanz, and J. Moscat. 1995. Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta. EMBO J. 14: 6157-6163.
-
(1995)
EMBO J.
, vol.14
, pp. 6157-6163
-
-
Berra, E.1
Diaz-Meco, M.T.2
Lozano, J.3
Frutos, S.4
Municio, M.M.5
Sanchez, P.6
Sanz, L.7
Moscat, J.8
-
7
-
-
0029160069
-
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
-
Burgering, B. M. T., and P. J. Coffer. 1995. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599-602.
-
(1995)
Nature
, vol.376
, pp. 599-602
-
-
Burgering, B.M.T.1
Coffer, P.J.2
-
8
-
-
0032539664
-
RAFT1 phosphorylation of the translational regulators p70 s6 kinase and 4E-BP1
-
Burnett, P. E., R. K. Barrow, N. A. Cohen, S. H. Snyder, and D. M. Sabatini. 1998. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc. Natl. Acad. Sci. USA 95:1432-1437.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 1432-1437
-
-
Burnett, P.E.1
Barrow, R.K.2
Cohen, N.A.3
Snyder, S.H.4
Sabatini, D.M.5
-
9
-
-
0028308412
-
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 s6 kinase. DNA synthesis, and glucose transporter translocation
-
Cheatham, B., C. J. Vlahos, L. Cheatham, L. Wang, J. Blenis, and C. R. Kahn. 1994. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase. DNA synthesis, and glucose transporter translocation. Mol. Cell. Biol. 14:4902-4911.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 4902-4911
-
-
Cheatham, B.1
Vlahos, C.J.2
Cheatham, L.3
Wang, L.4
Blenis, J.5
Kahn, C.R.6
-
10
-
-
0029608743
-
Structural and functional analysis of p70 s6 kinase
-
Cheatham, L., M. Monfar, M. M. Chou, and J. Blenis. 1995. Structural and functional analysis of p70 S6 kinase. Proc. Natl. Acad. Sci. USA 92:11696-11700.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 11696-11700
-
-
Cheatham, L.1
Monfar, M.2
Chou, M.M.3
Blenis, J.4
-
11
-
-
0029890229
-
The 70kD s6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Racl
-
Chou, M. M., and J. Blenis. 1996. The 70kD S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Racl. Cell 85:573-583.
-
(1996)
Cell
, vol.85
, pp. 573-583
-
-
Chou, M.M.1
Blenis, J.2
-
12
-
-
0028788935
-
The 70kD S6 kinase: Regulation of a kinase with multiple roles in mitogenic signalling
-
Chou, M. M., and J. Blenis. 1995. The 70kD S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling. Curr. Opin. Cell Biol. 7:806-814.
-
(1995)
Curr. Opin. Cell Biol.
, vol.7
, pp. 806-814
-
-
Chou, M.M.1
Blenis, J.2
-
13
-
-
0032563936
-
Regulation of protein kinase C zeta hy PI 3-kinase and PDK-1
-
Chou, M. M., W. Hou, J. Johnson, L. K. Graham, M. H. Lee, C.-S. Chen, A. C. Newton, B. S. Schaffhausen, and A. Toker. 1998. Regulation of protein kinase C zeta hy PI 3-kinase and PDK-1. Curr. Biol. 8:1069-1077.
-
(1998)
Curr. Biol.
, vol.8
, pp. 1069-1077
-
-
Chou, M.M.1
Hou, W.2
Johnson, J.3
Graham, L.K.4
Lee, M.H.5
Chen, C.-S.6
Newton, A.C.7
Schaffhausen, B.S.8
Toker, A.9
-
14
-
-
0028178928
-
PDGF-and insulin-dependent pp70s6k activation mediated hy phosphatidylinositol-3-OH kinase
-
Chung, J., T. Grammer, K. Lemon, A. Kazlauskas, and J. Blenis. 1994. PDGF-and insulin-dependent pp70S6k activation mediated hy phosphatidylinositol-3-OH kinase. Nature 370:71-75.
-
(1994)
Nature
, vol.370
, pp. 71-75
-
-
Chung, J.1
Grammer, T.2
Lemon, K.3
Kazlauskas, A.4
Blenis, J.5
-
15
-
-
0026659046
-
Rapamycin-FKBP specifically blocks growth-dependent activation of and signalling by the 70kD S6 protein kinases
-
Chung, J., C. J. Kuo, G. R. Crabtree, and J. Blenis. 1992. Rapamycin-FKBP specifically blocks growth-dependent activation of and signalling by the 70kD S6 protein kinases. Cell 69:1227-1236.
-
(1992)
Cell
, vol.69
, pp. 1227-1236
-
-
Chung, J.1
Kuo, C.J.2
Crabtree, G.R.3
Blenis, J.4
-
16
-
-
0029973651
-
Studies of partially transforming polyomavirus mutants establish a role for phosphatidylinositol 3-kinase in activation of pp70 S6 kinase
-
Dahl, J., R. Freund, J. Blenis, and T. L. Benjamin. 1996. Studies of partially transforming polyomavirus mutants establish a role for phosphatidylinositol 3-kinase in activation of pp70 S6 kinase. Mol. Cell. Biol. 16:2728-2735.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 2728-2735
-
-
Dahl, J.1
Freund, R.2
Blenis, J.3
Benjamin, T.L.4
-
17
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta, S. R., H. Dudek, X. Tao, S. Masters, H. Ku, Y. Gotoh, and M. E. Greenberg. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Ku, H.5
Gotoh, Y.6
Greenberg, M.E.7
-
18
-
-
0026746481
-
Evidence for a role of protein kinase C ζ subspecies in maturation of Xenopus laevis oocytes
-
Dominguez, I., M. T. Diaz-Meco, M. M. Municio, E. Berra, A. García de Herreros, M. E. Cornet, L. Sanz, and J. Moscat. 1992. Evidence for a role of protein kinase C ζ subspecies in maturation of Xenopus laevis oocytes. Mol. Cell. Biol. 12:3776-3783.
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 3776-3783
-
-
Dominguez, I.1
Diaz-Meco, M.T.2
Municio, M.M.3
Berra, E.4
García De Herreros, A.5
Cornet, M.E.6
Sanz, L.7
Moscat, J.8
-
19
-
-
0032053709
-
Mechanisms and consequences of activation of protein kinase B/Akt
-
Downward, J. 1998. Mechanisms and consequences of activation of protein kinase B/Akt. Curr. Opin. Cell Biol. 10:262-267.
-
(1998)
Curr. Opin. Cell Biol.
, vol.10
, pp. 262-267
-
-
Downward, J.1
-
20
-
-
0032143922
-
The broad specificity of dominant inhibitory protein kinase C mutants infers a common step in phosphorylation
-
Garcia-Paramio, P., Y. Cabrerizo, F. Bornancin, and P. J. Parker. 1998. The broad specificity of dominant inhibitory protein kinase C mutants infers a common step in phosphorylation. Biochem. J. 333:631-636.
-
(1998)
Biochem. J.
, vol.333
, pp. 631-636
-
-
Garcia-Paramio, P.1
Cabrerizo, Y.2
Bornancin, F.3
Parker, P.J.4
-
22
-
-
0030985901
-
Phosphatidylinositol 3-kinase-dependent activation of protein kinase C-zeta in bacterial lipopolysaccharide-treated human monocytes
-
Herrera-Velit, P., K. L. Knutson, and N. E. Reiner. 1997. Phosphatidylinositol 3-kinase-dependent activation of protein kinase C-zeta in bacterial lipopolysaccharide-treated human monocytes. J. Biol. Chem. 272:16445-16452.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 16445-16452
-
-
Herrera-Velit, P.1
Knutson, K.L.2
Reiner, N.E.3
-
23
-
-
0028918408
-
Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase
-
Hu, Q., A. Klippel, A. J. Muslin, W. J. Fantl, and L. T. Williams. 1995. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science 268:100-102.
-
(1995)
Science
, vol.268
, pp. 100-102
-
-
Hu, Q.1
Klippel, A.2
Muslin, A.J.3
Fantl, W.J.4
Williams, L.T.5
-
24
-
-
0032566691
-
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
-
Le Good, J. A., W. H. Ziegler, D. B. Parekh, D. R. Alessi, P. Cohen, and P. J. Parker. 1998. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 281:2042-2045.
-
(1998)
Science
, vol.281
, pp. 2042-2045
-
-
Le Good, J.A.1
Ziegler, W.H.2
Parekh, D.B.3
Alessi, D.R.4
Cohen, P.5
Parker, P.J.6
-
25
-
-
0031893929
-
Activation of protein kinase C-zeta and phosphatidylinositol 3′-kinase and promotion of macrophage differentiation by insulin-like growth factor-I
-
Liu, Q., W. Ning, R. Dantzer, G. G. Freund, and K. W. Kelley. 1998. Activation of protein kinase C-zeta and phosphatidylinositol 3′-kinase and promotion of macrophage differentiation by insulin-like growth factor-I. J. Immunol. 160:1393-1401.
-
(1998)
J. Immunol.
, vol.160
, pp. 1393-1401
-
-
Liu, Q.1
Ning, W.2
Dantzer, R.3
Freund, G.G.4
Kelley, K.W.5
-
26
-
-
0030874374
-
Requirement of protein kinase Cζ for stimulation of protein synthesis by insulin
-
Mendez, R., G. Kollmorgen, M. F. White, and R. E. Rhoads. 1997. Requirement of protein kinase Cζ for stimulation of protein synthesis by insulin. Mol. Cell. Biol. 17:5184-5192.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 5184-5192
-
-
Mendez, R.1
Kollmorgen, G.2
White, M.F.3
Rhoads, R.E.4
-
27
-
-
0030848939
-
s6k
-
S6k. Mol. Cell. Biol. 17:5648-5655.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 5648-5655
-
-
Moser, B.A.1
Dennis, P.B.2
Pullen, N.3
Pearson, R.B.4
Williamson, N.A.5
Wettenhall, R.E.6
Kozma, S.C.7
Thomas, G.8
-
28
-
-
0026757270
-
An array of insulin-activated, proline-directed serine/ threonine protein kinases phosphorylate the p70 S6 kinase
-
Mukhopadhvay, N. K., D. J. Price, J. M. Kyriakis, S. Pelech, J. Sanghera, and J. Avruch. 1992. An array of insulin-activated, proline-directed serine/ threonine protein kinases phosphorylate the p70 S6 kinase. J. Biol. Chem. 267:3325-3335.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 3325-3335
-
-
Mukhopadhvay, N.K.1
Price, D.J.2
Kyriakis, J.M.3
Pelech, S.4
Sanghera, J.5
Avruch, J.6
-
29
-
-
0027535742
-
Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate
-
Nakanishi, H., K. A. Brewer, and J. H. Exton. 1993. Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 268:13-16.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 13-16
-
-
Nakanishi, H.1
Brewer, K.A.2
Exton, J.H.3
-
30
-
-
0028802451
-
The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain
-
Pearson, R. B., P. B. Dennis, J. W. Han, N. A. Williamson, S. C. Kozma, R. E. Wettenhall, and G. Thomas. 1995. The principal target of rapamycin-induced p70S6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. EMBO J. 14:5279-5287.
-
(1995)
EMBO J.
, vol.14
, pp. 5279-5287
-
-
Pearson, R.B.1
Dennis, P.B.2
Han, J.W.3
Williamson, N.A.4
Kozma, S.C.5
Wettenhall, R.E.6
Thomas, G.7
-
31
-
-
0032578998
-
Phosphorylation and activation of p70s6k by PDK1
-
Pullen, N., P. B. Dennis, M. Andjelkovic, A. Dufner, S. C. Kozma, B. A. Hemmings, and G. Thomas. 1998. Phosphorylation and activation of p70s6k by PDK1. Science 279:707-710.
-
(1998)
Science
, vol.279
, pp. 707-710
-
-
Pullen, N.1
Dennis, P.B.2
Andjelkovic, M.3
Dufner, A.4
Kozma, S.C.5
Hemmings, B.A.6
Thomas, G.7
-
32
-
-
0030740005
-
The modular phosphorylation and activation of p70s6k
-
Pullen, N., and G. Thomas. 1997. The modular phosphorylation and activation of p70S6k. FEBS Lett. 410:78-82.
-
(1997)
FEBS Lett.
, vol.410
, pp. 78-82
-
-
Pullen, N.1
Thomas, G.2
-
34
-
-
0039791449
-
Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
-
Schonwasser, D. C., R. M. Marais, C. J. Marshall, and P. J. Parker. 1998. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol. Cell. Biol. 18:790-798.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 790-798
-
-
Schonwasser, D.C.1
Marais, R.M.2
Marshall, C.J.3
Parker, P.J.4
-
35
-
-
0030810216
-
Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport
-
Standaert, M. L., L. Galloway, P. Karnam, G. Bandyopadhyay, J. Moscat, and R. V. Farese. 1997. Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport. J. Biol. Chem. 272:30075-30082.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 30075-30082
-
-
Standaert, M.L.1
Galloway, L.2
Karnam, P.3
Bandyopadhyay, G.4
Moscat, J.5
Farese, R.V.6
-
36
-
-
0032578999
-
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
-
Stephens, L., K. Anderson, D. Stokoe, H. Erdjument-Bromage, G. F. Painter, A. B. Holmes, P. R. Gaffney, C. B. Reese, F. McCormick, P. Tempst, J. Coadwell, and P. T. Hawkins. 1998. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science 279:710-714.
-
(1998)
Science
, vol.279
, pp. 710-714
-
-
Stephens, L.1
Anderson, K.2
Stokoe, D.3
Erdjument-Bromage, H.4
Painter, G.F.5
Holmes, A.B.6
Gaffney, P.R.7
Reese, C.B.8
McCormick, F.9
Tempst, P.10
Coadwell, J.11
Hawkins, P.T.12
-
37
-
-
0030808066
-
Platelet-derived growth factor activation of mitogen-activated protein kinase depends on the sequential activation of phosphatidylcholine-specific phospholipase C, protein kinase C-zeta and Raf-1
-
van Dijk, M. C., H. Hilkmann, and W. J. van Blitterswijk. 1997. Platelet-derived growth factor activation of mitogen-activated protein kinase depends on the sequential activation of phosphatidylcholine-specific phospholipase C, protein kinase C-zeta and Raf-1. Biochem. J. 325:303-307.
-
(1997)
Biochem. J.
, vol.325
, pp. 303-307
-
-
Van Dijk, M.C.1
Hilkmann, H.2
Van Blitterswijk, W.J.3
-
38
-
-
0028999052
-
Phosphalidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation
-
Weng, Q., K. Andrabi, A. Klippel, M. T. Kozlowski, L. T. Williams, and J. Avruch. 1995. Phosphalidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation. Proc. Natl. Acad. Sci. USA 92:5744-5748.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 5744-5748
-
-
Weng, Q.1
Andrabi, K.2
Klippel, A.3
Kozlowski, M.T.4
Williams, L.T.5
Avruch, J.6
-
39
-
-
0028939115
-
Multiple independent inputs are required for activation of the p70 S6 kinase
-
Weng, Q., K. Andrabi, M. T. Kozlowski, J. R. Grove, and J. Avruch. 1995. Multiple independent inputs are required for activation of the p70 S6 kinase. Mol. Cell. Biol. 15:2333-2340.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 2333-2340
-
-
Weng, Q.1
Andrabi, K.2
Kozlowski, M.T.3
Grove, J.R.4
Avruch, J.5
|