The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability

Journal of Biological Chemistry

Volumn 280, Issue 21, 2005, Pages 20558-20564

  Dames, Sonja A ^a   Mulet, José M ^a   Rathgeb Szabo, Klara ^a   Hall, Michael N ^a   Grzesiek, Stephan ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CATALYSTS; CHEMICAL BONDS; OPTICAL RESOLVING POWER; REDOX REACTIONS; STRUCTURE (COMPOSITION); SUBSTRATES;

CELLULAR STABILITY; MULTIDOMAIN STRUCTURES; SOLUTION STRUCTURES; TARGET OF RAPAMYCIN (TOR);

ENZYMES;

CYSTEINE; MESSENGER RNA; SERINE; TARGET OF RAPAMYCIN KINASE;

ALPHA HELIX; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL GROWTH; CELL STRUCTURE; DISULFIDE BOND; ENZYME ACTIVITY; ENZYME BINDING; ENZYME REGULATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; MUTAGENESIS; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CONSERVED SEQUENCE; CYSTEINE; DISULFIDES; DRUG STABILITY; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; OXIDATION-REDUCTION; PEPTIDE FRAGMENTS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN STRUCTURE, SECONDARY; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; SERINE; SIROLIMUS; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 20144362478     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501116200     Document Type: Article

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