Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

Science

Volumn 332, Issue 6035, 2011, Pages 1322-1326

  Yu, Yonghao ^a   Yoon, Sang Oh ^a,d   Poulogiannis, George ^b   Yang, Qian ^a,c   Ma, Xiaoju Max ^a,e   Villén, Judit ^a,f   Kubica, Neil ^a,g   Hoffman, Gregory R ^a   Cantley, Lewis C ^b   Gygi, Steven P ^a   Blenis, John ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^e GENENTECH INC   (United States)

^f UNIVERSITY OF WASHINGTON   (United States)

^g NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 10; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; TUMOR SUPPRESSOR PROTEIN;

CANCER; ENZYME ACTIVITY; GENE EXPRESSION; INHIBITION; PROTEIN; PROTEOMICS; QUANTITATIVE ANALYSIS; SIGNAL; SUBSTRATE;

ARTICLE; DOWN REGULATION; EXPERIMENT; HUMAN; HUMAN CELL; NEGATIVE FEEDBACK; NEOPLASM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEOMICS; QUANTITATIVE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE; GRB10 ADAPTOR PROTEIN; HUMANS; INSULIN; MICE; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEINS; PROTEOME; SIGNAL TRANSDUCTION; SIROLIMUS;

MAMMALIA;

EID: 79958696336     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1199484     Document Type: Article

References (16)

1. D. R. Alessi, L. R. Pearce, J. M. García-Martínez, Sci. Signal. 2, pe27 (2009).
2. A. Y. Choo, J. Blenis, Cell Cycle 8, 567 (2009).
3. X. M. Ma, J. Blenis, Nat. Rev. Mol. Cell Biol. 10, 307 (2009).
4. T. F. Cloughesy et al., PLoS Med. 5, e8 (2008).
5. A. Carracedo et al., J. Clin. Invest. 118, 3065 (2008).
6. O. J. Shah, Z. Wang, T. Hunter, Curr. Biol. 14, 1650 (2004).
7. A. Y. Choo, S. O. Yoon, S. G. Kim, P. P. Roux, J. Blenis, Proc. Natl. Acad. Sci. U.S.A. 105, 17414 (2008).
8. P. Langlais et al., Biochemistry 44, 8890 (2005).
9. D. A. Guertin, D. M. Sabatini, Sci. Signal. 2, pe24 (2009).
10. M. Charalambous et al., Proc. Natl. Acad. Sci. U.S.A. 100, 8292 (2003).
11. L. Wang et al., Mol. Cell. Biol. 27, 6497 (2007).
12. M. A. Lim, H. Riedel, F. Liu, Front. Biosci. 9, 387 (2004).
13. A. Tzatsos, K. V. Kandror, Mol. Cell. Biol. 26, 63 (2006).
14. K. E. O'Reilly et al., Cancer Res. 66, 1500 (2006).
15. A. Y. Choo et al., Mol. Cell 38, 487 (2010).
16. L. H. Saal et al., Cancer Res. 65, 2554 (2005).