Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase

Current Biology

Volumn 11, Issue 15, 2001, Pages 1155-1167

  Belham, Christopher ^a,b   Comb, Michael J ^c   Avruch, Joseph ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Beverly MA 01915 USA USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035822699     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00369-4     Document Type: Article

References (28)

1. The p70 S6 kinase integrates nutrient and growth signals to control translational capacity
2. Ribosomal S6 kinase signaling and the control of translation
3. Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region
4. Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase
5. Characterization of S6K2, a novel kinase homologous to S6K1
6. Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase
7. Insulin-activated protein kinases phosphorylate a pseudosubstrate synthetic peptide inhibitor of the p70 S6 kinase
8. Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs
9. Multiple independent inputs are required for activation of the p70 S6 kinase
10. Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies
11. s6k activation loop phosphorylation
12. Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation
13. The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain
14. The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases
15. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
16. Phosphorylation and activation of p70s6k by PDK1
17. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
18. Raft1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
19. Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
20. Amino acid sufficiency and mTOR regulate p70 S6 kinase and elF-4E BP1 through a common effector mechanism
21. Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252
22. Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and Nek7) related to the fungal mitotic regulator, NIMA
23. Mitotic kinases as regulators of cell division and its checkpoints
24. Substrate specificity and cell cycle regulation of the Nek2 protein kinase, a potential human homolog of the mitotic regulator NIMA of Aspergillus nidulans
25. Protein kinases in control of the centrosome cycle
26. Cloning and characterization of the murine Nek3 protein kinase, a novel member of the NIMA family of putative cell cycle regulators
27. Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
28. Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycin associated protein