The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

EMBO Journal

Volumn 25, Issue 12, 2006, Pages 2781-2791

  Shahbazian, David ^a   Roux, Philippe P ^b   Mieulet, Virginie ^c   Cohen, Michael S ^d   Raught, Brian ^e   Taunton, Jack ^d   Hershey, John W B ^f   Blenis, John ^b   Pende, Mario ^c   Sonenberg, Nahum ^a,g  

^a MCGILL UNIVERSITY   (Canada)

^b HARVARD MEDICAL SCHOOL   (United States)

^c INSERM   (France)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e PRINCESS MARGARET HOSPITAL   (Canada)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g MCGILL UNIVERSITY   (Canada)

Author keywords

Crosstalk; eIF4B; Phosphorylation; Signaling; Translation

Indexed keywords

GROWTH FACTOR; INITIATION FACTOR 3; INITIATION FACTOR 4B; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL DEPENDENT KINASE 1; PROTEIN KINASE; RAPAMYCIN; S6 KINASE; SERINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RIBOSOME SUBUNIT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; EUKARYOTIC INITIATION FACTOR-3; EUKARYOTIC INITIATION FACTORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HELA CELLS; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SIROLIMUS;

EUKARYOTA;

EID: 33745570504     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601166     Document Type: Article

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