Turn motif phosphorylation negatively regulates activation loop phosphorylation in Akt

Oncogene

Volumn 30, Issue 44, 2011, Pages 4487-4497

  Hiraoka, D ^a   Okumura, E ^a   Kishimoto, T ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

activation loop; Akt; starfish oocytes; TOR; turn motif

Indexed keywords

1 METHYLADENINE; ALANINE; CYCLIN B; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; RAPAMYCIN; THREONINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL METABOLISM; CELL PROLIFERATION; CELL SURVIVAL; DEPHOSPHORYLATION; MEIOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STARFISH;

AMINO ACID MOTIFS; ANIMALS; ENZYME ACTIVATION; HUMANS; MEIOSIS; OKADAIC ACID; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIROLIMUS; STARFISH; TOR SERINE-THREONINE KINASES;

ASTEROIDEA; MAMMALIA;

EID: 80455155183     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.155     Document Type: Article

References (46)

1. Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P et al. (1996). Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15: 6541-6551. (Pubitemid 26413787)
2. Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG et al. (1997a). 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr Biol 7: 776-789. (Pubitemid 27441832)
3. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB et al. (1997b). Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 7: 261-269. (Pubitemid 27176852)
4. Andjelkovic M, Jakubowicz T, Cron P, Ming XF, Han JW, Hemmings BA. (1996). Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci USA 93: 5699-5704. (Pubitemid 26190743)
5. Basso AD, Solit DB, Chiosis G, Giri B, Tsichlis P, Rosen N. (2002). Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J Biol Chem 277: 39858-39866. (Pubitemid 35190971)
6. Bhaskar PT, Hay N. (2007). The two TORCs and Akt. Dev Cell 12: 487-502. (Pubitemid 46523652)
7. Borgatti P, Martelli AM, Tabellini G, Bellacosa A, Capitani S, Neri LM. (2003). Threonine 308 phosphorylated form of Akt translocates to the nucleus of PC12 cells under nerve growth factor stimulation and associates with the nuclear matrix protein nucleolin. J Cell Physiol 196: 79-88. (Pubitemid 36676445)
8. Brunn GJ, Hudson CC, Sekulic A, Williams JM, Hosoi H, Houghton PJ et al. (1997). Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 277: 99-101. (Pubitemid 27450655)
9. Chiba K, Kontani K, Tadenuma H, Katada T, Hoshi M. (1993). Induction of starfish oocyte maturation by the beta gamma subunit of starfish G protein and possible existence of the subsequent effector in cytoplasm. Mol Biol Cell 4: 1027-1034. (Pubitemid 23331542)
10. Du K, Herzig S, Kulkarni RN, Montminy M. (2003). TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300: 1574-1577. (Pubitemid 36682889)
11. Du K, Tsichlis PN. (2005). Regulation of the Akt kinase by interacting proteins. Oncogene 24: 7401-7409. (Pubitemid 41637980)
12. Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C et al. (2008). The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J 27: 1932-1943.
13. Fayard E, Tintignac LA, Baudry A, Hemmings BA. (2005). Protein kinase B/Akt at a glance. J Cell Sci 118: 5675-5678. (Pubitemid 43079259)
14. Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D et al. (2009). Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol 7: e38.
15. Goren I, Muller E, Pfeilschifter J, Frank S. (2008). Thr308 determines Akt1 nuclear localization in insulin-stimulated keratinocytes. Biochem Biophys Res Commun 372: 103-107.
16. Guerrier P, Doree M. (1975). Hormonal control of reinitiation of meiosis in starfish. The requirement of 1-methyladenine during nuclear maturation. Dev Biol 47: 341-348.
17. Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J et al. (2006). Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell 11: 859-871. (Pubitemid 44804279)
18. Hara M, Mori M, Wada T, Tachibana K, Kishimoto T. (2009). Start of the embryonic cell cycle is dually locked in unfertilized starfish eggs. Development 136: 1687-1696.
19. Hauge C, Antal TL, Hirschberg D, Doehn U, Thorup K, Idrissova L et al. (2007). Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation. EMBO J 26: 2251-2261. (Pubitemid 46685864)
20. Higuchi M, Onishi K, Kikuchi C, Gotoh Y. (2008). Scaffolding function of PAK in the PDK1-Akt pathway. Nat Cell Biol 10: 1356-1364.
21. Hill MM, Andjelkovic M, Brazil DP, Ferrari S, Fabbro D, Hemmings BA. (2001). Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase. J Biol Chem 276: 25643-25646.
22. Hiraoka D, Hori-Oshima S, Fukuhara T, Tachibana K, Okumura E, Kishimoto T. (2004). PDK1 is required for the hormonal signaling pathway leading to meiotic resumption in starfish oocytes. Dev Biol 276: 330-336. (Pubitemid 39592397)
23. Ikenoue T, Inoki K, Yang Q, Zhou X, Guan KL. (2008). Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J 27: 1919-1931.
24. Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY et al. (2006). SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127: 125-137. (Pubitemid 44466632)
25. Jaffe LA, Gallo CJ, Lee RH, Ho YK, Jones TL. (1993). Oocyte maturation in starfish is mediated by the beta gamma-subunit complex of a G-protein. J Cell Biol 121: 775-783. (Pubitemid 23143539)
26. Jiang T, Qiu Y. (2003). Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation. J Biol Chem 278: 15789-15793. (Pubitemid 36799692)
27. Kalous J, Solc P, Baran V, Kubelka M, Schultz RM, Motlik J. (2006). PKB/AKT is involved in resumption of meiosis in mouse oocytes. Biol Cell 98: 111-123. (Pubitemid 43230621)
28. Kanatani H, Shirai H, Nakanishi K, Kurokawa T. (1969). Isolation and indentification on meiosis inducing substance in starfish Asterias amurensis. Nature 221: 273-274.
29. Kishimoto T. (1986). Microinjection and cytoplasmic transfer in starfish oocytes. Methods Cell Biol 27: 379-394.
30. Kishimoto T. (2003). Cell-cycle control during meiotic maturation. Curr Opin Cell Biol 15: 654-663. (Pubitemid 37487958)
31. Kohn AD, Takeuchi F, Roth RA. (1996). Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphoryla-tion. J Biol Chem 271: 21920-21926. (Pubitemid 26303815)
32. Kuo YC, Huang KY, Yang CH, Yang YS, Lee WY, Chiang CW. (2008). Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt. J Biol Chem 283: 1882-1892.
33. Lin TA, Kong X, Haystead TA, Pause A, Belsham G, Sonenberg N et al. (1994). PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science 266: 653-656. (Pubitemid 24363524)
34. Ma XM, Blenis J. (2009). Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 10: 307-318.
35. Manning BD, Cantley LC. (2007). AKT/PKB signaling: navigating downstream. Cell 129: 1261-1274. (Pubitemid 46962095)
36. Okumura E, Fukuhara T, Yoshida H, Hanada Si S, Kozutsumi R, Mori M et al. (2002). Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition. Nat Cell Biol 4: 111-116. (Pubitemid 34141476)
37. Pause A, Belsham GJ, Gingras AC, Donze O, Lin TA, Lawrence S. (1994). Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 50-cap function. Nature 371: 762-767.
38. Restuccia DF, Hemmings BA. (2010). From man to mouse and back again: advances in defining tumor AKTivities in vivo. Dis Model Mech 3: 705-720.
39. Sadler KC, Ruderman JV. (1998). Components of the signaling pathway linking the 1-methyladenine receptor to MPF activation and maturation in starfish oocytes. Dev Biol 197: 25-38. (Pubitemid 28224225)
40. Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF et al. (2006). Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 22: 159-168.
41. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101. (Pubitemid 40262113)
42. Sato S, Fujita N, Tsuruo T. (2000). Modulation of Akt kinase activity by binding to Hsp90. Proc Natl Acad Sci USA 97: 10832-10837.
43. Scheid MP, Marignani PA, Woodgett JR. (2002). Multiple phospho-inositide 3-kinase-dependent steps in activation of protein kinase B. Mol Cell Biol 22: 6247-6260. (Pubitemid 34857843)
44. Toker A, Newton AC. (2000). Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J Biol Chem 275: 8271-8274. (Pubitemid 30180163)
45. Tomek W, Smiljakovic T. (2005). Activation of Akt (protein kinase B) stimulates metaphase I to metaphase II transition in bovine oocytes. Reproduction 130: 423-430. (Pubitemid 41472468)
46. Ugi S, Imamura T, Maegawa H, Egawa K, Yoshizaki T, Shi K et al. (2004). Protein phosphatase 2A negatively regulates insulin0s metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes. Mol Cell Biol 24: 8778-8789. (Pubitemid 39245095)