The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling

Science

Volumn 332, Issue 6035, 2011, Pages 1317-1322

  Hsu, Peggy P ^a,b   Kang, Seong A ^a   Rameseder, Jonathan ^b   Zhang, Yi ^c,d   Ottina, Kathleen A ^a,b   Lim, Daniel ^b   Peterson, Timothy R ^a,b   Choi, Yongmun ^c,e   Gray, Nathanael S ^c,e   Yaffe, Michael B ^b   Marto, Jarrod A ^c,d,e   Sabatini, David M ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d DFCI   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; GROWTH FACTOR; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; PEPTIDE LIBRARY; PHOSPHATIDYLINOSITOL 3 KINASE; PROLINE; PROTEOME; TUMOR SUPPRESSOR PROTEIN;

DRUG; ENZYME ACTIVITY; GROWTH; HORMONE; HYDROPHOBICITY; INHIBITION; MAMMAL; MASS SPECTROMETRY; MOLECULAR ANALYSIS; PEPTIDE; PROTEIN; PROTEOMICS; TUMOR;

ARTICLE; COMPLEX FORMATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; TUBEROUS SCLEROSIS;

ANIMALS; CELL LINE; GRB10 ADAPTOR PROTEIN; HUMANS; INSULIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MASS SPECTROMETRY; MICE; NAPHTHYRIDINES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEINS; PROTEOME; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

MAMMALIA;

EID: 79958696694     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1199498     Document Type: Article

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