Dual requirement for a newly identified phosphorylation site in p70(s6k)

Molecular and Cellular Biology

Volumn 17, Issue 9, 1997, Pages 5648-5655

  Moser, Bettina A ^a   Dennis, Patrick B ^a   Pullen, Nicholas ^a   Pearson, Richard B ^b   Williamson, Nicholas A ^c   Wettenhall, Richard E H ^c   Kozma, Sara C ^a   Thomas, George ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE; PROTEIN KINASE C;

AMINO ACID SUBSTITUTION; ARABIDOPSIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE;

ARABIDOPSIS; ARABIDOPSIS THALIANA; DROSOPHILA MELANOGASTER; MELANOGASTER; SACCHAROMYCES CEREVISIAE;

EID: 0030848939     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.9.5648     Document Type: Article

References (50)

1. Ballou, L. M., H. Luther, and G. Thomas. 1991. MAP2 kinase and 70k S6 kinase lie on distinct signalling pathways. Nature 349:348-350.
2. Bornancin, F., and P. J. Parker. 1996. Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Cα. Curr. Biol. 6:1114-1123.
3. Brown, E. J., M. A. Albers, T. B. Shin, K. Ichikawa, C. T. Keith, W. S. Lane, and S. L. Schreiber. 1994. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369:756-758.
4. s6k. Proc. Natl. Acad. Sci. USA 92:11696-11700.
5. Chou, M. M., and J. Blenis. 1995. The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling. Curr. Opin. Cell Biol. 7:806-814.
6. s6k activation mediated by phosphatidylinositol-3-OH kinase. Nature 370:71-75.
7. Chung, J., C. J. Kuo, G. R. Crabtree, and J. Blenis. 1992. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell 69:1227-1236.
8. Davis, J. R. 1993. The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 268:14553-14556.
9. s6k phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases. Mol. Cell. Biol. 16:6242-6251.
10. Dutil, E. M., L. M. Keranen, A. A. DePaoli-Roach, and A. C. Newton. 1994. In vivo regulation of protein kinase C by transphosphorylation followed by autophosphorylation. J. Biol. Chem. 269:29359-29362.
11. Edelmann, H. M. L., C. Kühne, C. Petritsch, and L. M. Ballou. 1996. Cell cycle regulation of p70 S6 kinase and p42/p44 mitogen-activated protein kinases in Swiss mouse 3T3 fibroblasts. J. Biol. Chem. 271:963-971.
12. Evan, G. I., G. K. Lewis, G. Ramsay, and J. M. Bishop. 1985. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell. Biol. 5:3610-3616.
13. s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs. Proc. Natl. Acad. Sci. USA 89:7282-7285.
14. s6k through dephosphorylation of a novel set of sites. J. Biol. Chem. 268:16091-16094.
15. s6k. Crit. Rev. Biochem. Mol. Biol. 29:385-413.
16. Flint, A. J., R. D. Paladini, and D. E. Koshland, Jr. 1990. Autophosphorylation of protein kinase C at three separated regions of its primary sequence. Science 249:408-411.
17. Flotow, H., and G. Thomas. 1992. Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver. J. Biol. Chem. 267:3074-3078.
18. s6k by inducing dephosphorylation of the same subset of sites. J. Biol. Chem. 36:21396-21403.
19. Hanks, S. K., and T. Hunter. 1995. The eukaryotic protein kinase superfamily, p. 7-47. In G. Hardie and S. K. Hanks (ed.), The protein kinase facts book. Protein-serine kinases. Academic Press, London, United Kingdom.
20. Heitman, J., N. R. Movva, and M. N. Hall. 1991. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253:905-909.
21. Hunter, T. 1995. When is a lipid kinase not a lipid kinase? When it is a protein kinase. Cell 83:1-4.
22. Jefferies, H. B. J., S. Fumagalli, P. B. Dennis, C. Reinhard, R. B. Pearson, and G. Thomas. 1977. Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k. EMBO J., 16:3693-3704.
23. Jefferies, H. B. J., C. Reinhard, S. C. Kozma, and G. Thomas. 1994. Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family. Proc. Natl. Acad. Sci. USA 91:4441-4445.
24. Jenö, P., L. M. Ballou, I. Novak-Hofer, and G. Thomas. 1988. Identification and characterization of a mitogenic-activated S6 kinase. Proc. Natl. Acad. Sci. USA 85:406-410.
25. Keranen, L. M., E. M. Dutil, and A. C. Newton. 1995. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr. Biol. 5:1394-1403.
26. Kuo, C. J., J. Chung, D. F. Florentino, W. M. Flanagan, J. Blenis, and G. R. Crabtree. 1992. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 358:70-73.
27. s6k function is essential for G1 progression. Nature 363:170-172.
28. s6k following progesterone-induced meiotic maturation. EMBO J. 11:1743-1749.
29. Maurer, R. A. 1988. Isolation of a yeast protein kinase gene by screening with a mammalian protein kinase cDNA. DNA 7:469-474.
30. Meyuhas, O., D. Avni, and S. Shama. 1996. Translational control of ribosomal protein mRNAs in eukaryotes, p. 363-388. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
31. ras. Nature 371:426-429.
32. Mukhopadhayay, N. K., D. J. Price, J. M. Kyriakis, S. L. Pelech, J. Sanghera, and J. Avruch. 1992. An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase. J. Biol. Chem. 267:3325-3335.
33. Nasmyth, K. 1996. Another role rolls in. Nature 382:28-29.
34. Ohno, S., and K. Suzuki. 1995. Protein kinase C, p. 80-88. In G. Hardie and S. K. Hanks (ed.), The protein kinase facts book. Protein-serine kinases. Academic Press, London, United Kingdom.
35. Okayama, H., and C. A. Chen. 1988. Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA. BioTechniques 6:632-638.
36. Orr, J. W., and A. C. Newton. 1994. Intrapeptide regulation of protein kinase C. J. Biol. Chem. 269:8383-8387.
37. s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. EMBO J. 21:5279-5287.
38. Pelech, S. L., and E. G. Krebs. 1987. Mitogen-activated S6 kinase is stimulated via protein kinase C-dependent and -independent pathways in Swiss 3T3 cells. J. Biol. Chem. 262:11598-11606.
39. Price, D. J., J. R. Grove, V. Calvo, J. Avruch, and B. E. Bierer. 1992. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science 257:973-977.
40. Pullen, N., and G. Thomas. 1997. The modular phosphorylation and activation of p70s6k. FEBS Lett. 410:78-82.
41. s6k: functional requirement for entry into S phase. EMBO J. 13:1557-1565.
42. s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity. Proc. Natl. Acad. Sci. USA 93:10791-10796.
43. Stewart, M. J., and G. Thomas. 1994. Mitogenesis and protein synthesis: a role for ribosomal protein S6 phosphorylation? Bioessays 16:1-7.
44. 43a. Terada, N., H. R. Patel, K. Takase, K. Kohno, A. C. Nairn, and E. W. Gelfand. 1994. Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc. Natl. Acad. Sci. USA. 91:11477-11481.
45. Tsutakawa, S. E., K. F. Medzihradszky, A. J. Flint, A. L. Burlingame, and D. E. Koshland, Jr. 1995. Determination of in vivo phosphorylation sites in protein kinase C. J. Biol. Chem. 270:26807-26812.
46. s6k pathway and is independent of mitogen-activated protein kinase. Proc. Natl. Acad. Sci. USA 93:4076-4080.
47. Weng, Q.-P., K. Andrabi, A. Klippel, M. T. Kozlowski, L. T. Williams, and J. Avruch. 1995. Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site specific p70 phosphorylation. Proc. Natl. Acad. Sci. USA 92:5744-5748.
48. Weng, Q.-P., K. Andrabi, M. T. Kozlowski, J. R. Grove, and J. Avruch. 1995. Multiple independent inputs are required for activation of the p70 S6 kinase. Mol. Cell. Biol. 15:2333-2340.
49. Zhang, J., L. Wang, J. Schwartz, R. W. Bond, and W. R. Bishop. 1994. Phosphorylation of Thr642 is an early event in the processing of newly synthesized protein kinase Cβ1 and is essential for its activation. J. Biol. Chem. 269:19578-19584.
50. Zhang, S.-H., M. A. Lawton, T. Hunter, and C. J. Lamb. 1994. atpk1, a novel ribosomal protein kinase gene from Arabidopsis. J. Biol. Chem. 269:17586-17592.