The Phosphoinositide-dependent Kinase, PDK-1, Phosphorylates Conventional Protein Kinase C Isozymes by a Mechanism That Is Independent of Phosphoinositide 3-Kinase

Journal of Biological Chemistry

Volumn 276, Issue 48, 2001, Pages 45289-45297

  Sonnenburg, Erica Dutil ^a   Gao, Tianyan ^a   Newton, Alexandra C ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGICAL MEMBRANES; CELLS; ENZYME INHIBITION;

HOMOLOGY;

ENZYMES;

2 MORPHOLINO 8 PHENYLCHROMONE; ISOENZYME; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT KINASE; PLECKSTRIN; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE C ALPHA; UNCLASSIFIED DRUG; WORTMANNIN; 3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE; ANDROSTANE DERIVATIVE; CHROMONE DERIVATIVE; CULTURE MEDIA, SERUM FREE; ENZYME INHIBITOR; ISOPROTEIN; MORPHOLINE DERIVATIVE; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASES; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CYTOSOL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; SYNTHESIS; ANIMAL; BINDING SITE; CELL FRACTIONATION; CELL MEMBRANE; CELL STRAIN 3T3; CELL STRAIN COS1; CHEMISTRY; CULTURE MEDIUM; GENE DELETION; GENE EXPRESSION REGULATION; METABOLISM; MOUSE; MUTATION; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; SERODIAGNOSIS; TIME; WESTERN BLOTTING;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ANDROSTADIENES; ANIMAL; BINDING SITES; BLOTTING, WESTERN; CELL MEMBRANE; CHROMONES; COS CELLS; CULTURE MEDIA, SERUM-FREE; CYTOSOL; ENZYME INHIBITORS; GENE DELETION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MICE; MORPHOLINES; MUTATION; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; SUBCELLULAR FRACTIONS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS;

EID: 0035976977     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M107416200     Document Type: Article

References (40)

1. Toker, A., and Newton, A. (2000) Cell 103, 185-188
2. Vanhaesebroeck, B., and Alessi, D. R. (2000) Biochem. J. 346, 561-576
3. Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., and Cohen, P. (1997) Curr. Biol. 7, 261-269
4. Toker, A. (2000) Mol. Pharmacol. 57, 652-658
5. Nishizuka, Y. (1986) Science 233, 305-312
6. Dutil, E. M., Keranen, L. M., DePaoli-Roach, A. A., and Newton, A. C. (1994) J. Biol. Chem. 269, 29359-29362
7. Parekh, D. B., Ziegler, W., and Parker, P. J. (2000) EMBO J. 19, 496-503
8. Keranen, L. M., Dutil, E. M., and Newton, A. C. (1995) Curr. Biol. 5, 1394-1403
9. Tsutakawa, S. E., Medzihradszky, K. F., Flint, A. J., Burlingame, A. L., and Koshland, D. E., Jr. (1995) J. Biol. Chem. 270, 26807-26812
10. Dutil, E. M., Toker, A., and Newton, A. C. (1998) Curr. Biol. 8, 1366-1375
11. Chou, M. M., Hou, W., Johnson, J., Graham, L. K., Lee, M. H., Chen, C. S., Newton, A. C., Schaffhausen, B. S., and Toker, A. (1998) Curr. Biol. 8, 1069-1077
12. Le Good, J. A., Ziegler, W. H., Parekh, D. B., Alessi, D. R., Cohen, P., and Parker, P. J. (1998) Science 281, 2042-2045
13. Newton, A. C. (2001) Chem. Rev. 101, 2353-2364
14. Behn-Krappa, A., and Newton, A. C. (1999) Curr. Biol. 9, 728-737
15. Stephens, L., Anderson, K., Stokoe, D., Erdjument-Bromage, H., Painter, G. F., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., McCormick, F., Tempst, P., Coadwell, J., and Hawkins, P. T. (1998) Science 279, 710-714
16. Currie, R. A., Walker, K. S., Gray, A., Deak, M., Casamayor, A., Downes, C. P., Cohen, P., Alessi, D. R., and Lucocq, J. (1999) Biochem. J. 337, 575-583
17. Andjelkovic, M., Alessi, D. R., Meier, R., Fernandez, A., Lamb, N. J., Frech, M., Cron, P., Cohen, P., Lucocq, J. M., and Hemmings, B. A. (1997) J. Biol. Chem. 272, 31515-31524
18. Andjelkovic, M., Maira, S.-M., Cron, P., Parker, P. J., and Hemmings, B. A., (1999) Mol. Cell. Biol. 19, 5061-5072
19. Filippa, N., Sable, C. L., Hemmings, B. A., and Van Obberghen, E. (2000) Mol. Cell. Biol. 20, 5712-5721
20. Dutil, E. M., and Newton, A. C. (2000) J. Biol. Chem. 275, 10697-10701
21. Sweatt, J. D., Atkins, C. M., Johnson, J., English, J. D., Roberson, E. D., Chen, S. J., Newton, A., and Klann, E. (1998) J. Neurochem. 71, 1075-1085
22. Edwards, A. S., Faux, M. C., Scott, J. D., and Newton, A. C. (1999) J. Biol. Chem. 274, 6461-6468
23. Edwards, A. S., and Newton, A. C. (1997) J. Biol. Chem. 272, 18382-18390
24. Orr, J. W., and Newton, A. C. (1994) J. Biol. Chem. 269, 27715-27718
25. Cazaubon, S., Bornancin, F., and Parker, P. J. (1994) Biochem. J. 301, 443-448
26. Gao, T., Toker, A., and Newton, A. C. (2001) J. Biol. Chem. 276, 19588-19596
27. Dang, C. V., Yang, D. C., and Pollard, T. D. (1983) J. Cell Biol. 96, 1138-1147
28. Borner, C., Filipuzzi, I., Wartmann, M., Eppenberger, U., and Fabbro, D. (1989) J. Biol. Chem. 264, 13902-13909
29. Bornancin, F., and Parker, P. J. (1997) J. Biol. Chem. 272, 3544-3549
30. Junco, M., Webster, C., Crawford, C., Bosca, L., and Parker, P. J. (1994) Eur. J. Biochem. 223, 259-263
31. Gysin, S., and Imber, R. (1996) Eur. J. Biochem. 240, 747-750
32. Bornancin, F., and Parker, P. J. (1996) Curr. Biol. 6, 1114-1123
33. Balendran, A., Biondi, R. M., Cheung, P. C., Casamayor, A., Deak, M., and Alessi, D. R. (2000) J. Biol. Chem. 275, 20806-20813
34. Anderson, K. E., Coadwell, J., Stephens, L. R., and Hawkins, P. T. (1998) Curr. Biol. 8, 684-691
35. Standaert, M. L., Bandyopadhyay, G., Kanoh, Y., Sajan, M. P., and Farese, R. V. (2001) Biochemistry 40, 249-255
36. Nakanishi, H., Brewer, K. A., and Exton, J. H. (1993) J. Biol. Chem. 268, 13-26
37. Li, Y., Dowbenko, D., and Lasky, L. A. (2001) J. Biol. Chem. 276, 20323-20329
38. Balendran, A., Hare, G. R., Kieloch, A., Williams, M. R., and Alessi, D. R. (2000) FEBS Lett. 484, 217-223
39. Ziegler, W. H., Parekh, D. B., Le Good, J. A., Whelan, R. D., Kelly, J. J., Frech, M., Hemmings, B. A., and Parker, P. J. (1999) Curr. Biol. 9, 522-529
40. England, K., Watson, J., Beale, G., Warner, M., Cross, J. C., and Rumsby, M. (2000) J. Biol. Chem. 276, 10437-10442